SIMILAR PATTERNS OF AMINO ACIDS FOR 2WM3_A_NFLA1301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddb PROTEIN (BID)

(Mus musculus) 		PF06393
(BID) 		4 THR A 152
PHE A  24
LEU A  90
ASP A  95
 None
 0.80A 2wm3A-1ddbA:
undetectable		 2wm3A-1ddbA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxx DYSTROPHIN

(Homo sapiens) 		PF00307
(CH) 		4 LEU A 108
THR A 107
PHE A  41
ASP A  15
 None
 1.11A 2wm3A-1dxxA:
undetectable		 2wm3A-1dxxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei5 D-AMINOPEPTIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase)
PF07930
(DAP_B) 		4 THR A 393
ARG A 511
PHE A 373
LEU A 359
 None
 0.98A 2wm3A-1ei5A:
undetectable		 2wm3A-1ei5A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 LEU A 208
THR A 207
LEU A 238
ASP A 169
 None
None
None
ZN  A 401 (-2.4A)
 1.00A 2wm3A-1kq3A:
3.5		 2wm3A-1kq3A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 LEU X 234
THR X 226
ARG X 271
LEU X 422
 None
 0.89A 2wm3A-1mw9X:
3.3		 2wm3A-1mw9X:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgq FORMYL-COENZYME A
TRANSFERASE

(Oxalobacter
formigenes) 		PF02515
(CoA_transf_3) 		4 THR A 405
ARG A  46
LEU A  72
ASP A  43
 None
 1.06A 2wm3A-1vgqA:
6.7		 2wm3A-1vgqA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7d ORNITHINE
AMINOTRANSFERASE

(Plasmodium
yoelii) 		PF00202
(Aminotran_3) 		4 LEU A 121
THR A 117
LEU A 258
ASP A 255
 None
 1.07A 2wm3A-1z7dA:
3.2		 2wm3A-1z7dA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2byf PHOSPHOLIPASE C,
EPSILON 1

(Homo sapiens) 		PF00788
(RA) 		4 LEU A  39
THR A  38
LEU A  59
ASP A  56
 None
 0.95A 2wm3A-2byfA:
undetectable		 2wm3A-2byfA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4a MALATE DEHYDROGENASE

(Aeropyrum
pernix) 		no annotation 4 LEU B  18
THR B  14
LEU B  28
ASP B  25
 None
 1.12A 2wm3A-2d4aB:
9.2		 2wm3A-2d4aB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmy CARBON MONOXIDE
OXIDATION SYSTEM
TRANSCRIPTION
REGULATOR COOA-1

(Carboxydothermus
hydrogenoformans) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 LEU A 135
PHE A  68
LEU A  61
ASP A  65
 None
 1.05A 2wm3A-2fmyA:
undetectable		 2wm3A-2fmyA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		4 LEU A 175
THR A 176
LEU A 214
ASP A 141
 None
 1.06A 2wm3A-2g02A:
undetectable		 2wm3A-2g02A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		4 LEU A 117
PHE A  31
LEU A  55
ASP A  50
 None
 0.84A 2wm3A-2gj4A:
3.3		 2wm3A-2gj4A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gop TRILOBED PROTEASE

(Pyrococcus
furiosus) 		PF07676
(PD40) 		4 LEU A 326
THR A 337
LEU A  31
ASP A  19
 None
 0.91A 2wm3A-2gopA:
undetectable		 2wm3A-2gopA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gvk HEME PEROXIDASE

(Bacteroides
thetaiotaomicron) 		PF04261
(Dyp_perox) 		4 LEU A 276
THR A 272
PHE A 188
LEU A 302
 None
 1.09A 2wm3A-2gvkA:
undetectable		 2wm3A-2gvkA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5e HYPOTHETICAL PROTEIN
MM_2497

(Methanosarcina
mazei) 		PF01983
(CofC) 		4 LEU A 178
PHE A  28
LEU A  31
ASP A  94
 None
 1.11A 2wm3A-2i5eA:
3.4		 2wm3A-2i5eA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kwp TRANSCRIPTION
ELONGATION PROTEIN
NUSA

(Escherichia
coli) 		PF08529
(NusA_N) 		4 LEU A   6
PHE A  24
LEU A  27
ASP A  50
 None
 1.13A 2wm3A-2kwpA:
undetectable		 2wm3A-2kwpA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrd ACANTHAPORIN

(Acanthamoeba
culbertsoni) 		no annotation 4 LEU A  58
PHE A  46
LEU A  36
ASP A  28
 None
 0.99A 2wm3A-2lrdA:
undetectable		 2wm3A-2lrdA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogf HYPOTHETICAL PROTEIN
MJ0408

(Methanocaldococcus
jannaschii) 		PF04038
(DHNA) 		4 LEU A  33
THR A  29
LEU A 101
ASP A  87
 None
 1.08A 2wm3A-2ogfA:
undetectable		 2wm3A-2ogfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 LEU A 142
PHE A 167
LEU A 166
ASP A 163
 None
 1.09A 2wm3A-2ohhA:
7.5		 2wm3A-2ohhA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozz HYPOTHETICAL PROTEIN
YHFZ

(Shigella
flexneri) 		PF14503
(YhfZ_C) 		4 LEU A 139
ARG A 111
LEU A 145
ASP A 152
 None
 0.99A 2wm3A-2ozzA:
undetectable		 2wm3A-2ozzA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis) 		no annotation 4 LEU A 143
PHE A 168
LEU A 167
ASP A 164
 None
 1.07A 2wm3A-2q9uA:
7.8		 2wm3A-2q9uA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato bushy
stunt virus) 		PF00729
(Viral_coat) 		4 THR A 216
PHE A 180
LEU A 134
ASP A 183
 None
None
None
CA  A 388 (-3.9A)
 1.12A 2wm3A-2tbvA:
undetectable		 2wm3A-2tbvA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		4 LEU A 165
THR A 162
PHE A 176
LEU A 173
 None
 1.06A 2wm3A-2v9iA:
undetectable		 2wm3A-2v9iA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfk AKAP18 DELTA

(Homo sapiens) 		PF10469
(AKAP7_NLS) 		4 LEU A 267
PHE A 208
LEU A 156
ASP A 151
 None
 0.99A 2wm3A-2vfkA:
undetectable		 2wm3A-2vfkA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2weu TRYPTOPHAN
5-HALOGENASE

(Streptomyces
rugosporus) 		PF04820
(Trp_halogenase) 		4 LEU A  21
THR A  17
LEU A  33
ASP A  30
 None
 0.99A 2wm3A-2weuA:
4.1		 2wm3A-2weuA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 LEU A 406
THR A 808
ARG A 462
PHE A 404
ASP A 456
 None
 1.34A 2wm3A-2wyhA:
undetectable		 2wm3A-2wyhA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ydl SH3
DOMAIN-CONTAINING
KINASE-BINDING
PROTEIN 1

(Homo sapiens) 		PF14604
(SH3_9) 		4 LEU A 296
THR A 295
LEU A 286
ASP A 320
 None
 1.10A 2wm3A-2ydlA:
undetectable		 2wm3A-2ydlA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 LEU A 651
THR A 652
LEU A 695
ASP A 699
 None
 1.12A 2wm3A-2zxqA:
2.7		 2wm3A-2zxqA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1

(Aquifex
aeolicus) 		PF02005
(TRM) 		4 LEU A 146
ARG A 229
LEU A 201
ASP A 206
 None
 1.06A 2wm3A-3axsA:
2.1		 2wm3A-3axsA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9p CG5977-PA, ISOFORM A

(Drosophila
melanogaster) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 LEU A 625
PHE A 544
LEU A 545
ASP A 582
 None
 1.12A 2wm3A-3b9pA:
undetectable		 2wm3A-3b9pA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI

(Pseudomonas
putida) 		PF10778
(DehI) 		4 LEU A 208
THR A 204
PHE A 190
ASP A 271
 None
 1.10A 2wm3A-3bjxA:
undetectable		 2wm3A-3bjxA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 LEU A 117
PHE A  31
LEU A  55
ASP A  50
 None
 0.66A 2wm3A-3cemA:
4.2		 2wm3A-3cemA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkt MARITIMACIN

(Thermotoga
maritima) 		PF04454
(Linocin_M18) 		4 LEU A 134
PHE A 255
LEU A 227
ASP A 224
 None
 1.10A 2wm3A-3dktA:
undetectable		 2wm3A-3dktA:
23.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05368
(NmrA) 		6 LEU A 120
THR A 121
ARG A 151
PHE A 263
LEU A 266
ASP A 269
 None
 0.83A 2wm3A-3e5mA:
44.9		 2wm3A-3e5mA:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hul HOMOSERINE KINASE

(Listeria
monocytogenes) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 LEU A  25
THR A  24
LEU A 276
ASP A 273
 None
 1.07A 2wm3A-3hulA:
undetectable		 2wm3A-3hulA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4r A-KINASE ANCHOR
PROTEIN 18

(Homo sapiens) 		PF10469
(AKAP7_NLS)
PF10470
(AKAP7_RIRII_bdg) 		4 LEU A 267
PHE A 208
LEU A 156
ASP A 151
 None
 1.01A 2wm3A-3j4rA:
undetectable		 2wm3A-3j4rA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom) 		4 LEU A2208
THR A2207
LEU A1900
ASP A2412
 None
 1.07A 2wm3A-3jbzA:
undetectable		 2wm3A-3jbzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY

(Chlorobaculum
tepidum) 		PF00294
(PfkB) 		4 LEU A 284
ARG A 292
LEU A 286
ASP A 291
 None
 0.99A 2wm3A-3kd6A:
6.2		 2wm3A-3kd6A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg0 ORNITHINE
AMINOTRANSFERASE

(Plasmodium
falciparum) 		PF00202
(Aminotran_3) 		4 LEU A 122
THR A 118
LEU A 259
ASP A 256
 None
 1.09A 2wm3A-3lg0A:
3.1		 2wm3A-3lg0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvy CARBOXYMUCONOLACTONE
DECARBOXYLASE FAMILY

(Streptococcus
mutans) 		PF02627
(CMD) 		4 LEU A 118
THR A 117
PHE A 140
ASP A 152
 None
 1.10A 2wm3A-3lvyA:
undetectable		 2wm3A-3lvyA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbe RICIN B-LIKE LECTIN

(Clitocybe
nebularis) 		PF14200
(RicinB_lectin_2) 		4 LEU A 117
THR A 116
LEU A  84
ASP A  20
 None
None
None
DLD  A 580 (-2.8A)
 0.90A 2wm3A-3nbeA:
undetectable		 2wm3A-3nbeA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyb TBC1 DOMAIN FAMILY
MEMBER 4

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 LEU A 956
PHE A1029
LEU A 995
ASP A1003
 None
 0.94A 2wm3A-3qybA:
undetectable		 2wm3A-3qybA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd7 ACYL-COA
THIOESTERASE

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		4 LEU A 205
THR A 204
PHE A 244
LEU A 200
 None
 0.95A 2wm3A-3rd7A:
undetectable		 2wm3A-3rd7A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7z PUTATIVE ASPARTATE
RACEMASE

(Salmonella
enterica) 		PF01177
(Asp_Glu_race) 		4 LEU A 218
THR A 215
PHE A  23
LEU A  26
 None
 1.12A 2wm3A-3s7zA:
3.2		 2wm3A-3s7zA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slz GAG-PRO-POL
POLYPROTEIN

(Murine leukemia
virus) 		PF00077
(RVP) 		4 LEU A  40
THR A  41
PHE A  29
LEU A  92
 None
None
None
3TL  A 126 (-4.6A)
 0.91A 2wm3A-3slzA:
undetectable		 2wm3A-3slzA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09272
(Hepsin-SRCR) 		4 LEU A 269
THR A 270
LEU A 230
ASP A 196
 None
 1.04A 2wm3A-3t2nA:
undetectable		 2wm3A-3t2nA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl2 MALATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A  24
THR A  20
LEU A  34
ASP A  31
 None
 1.01A 2wm3A-3tl2A:
10.6		 2wm3A-3tl2A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2h S-LAYER PROTEIN
MA0829

(Methanosarcina
acetivorans) 		PF07752
(S-layer) 		4 LEU A 525
THR A 351
PHE A 375
ASP A 510
 None
 1.02A 2wm3A-3u2hA:
undetectable		 2wm3A-3u2hA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 287
THR A 288
LEU A 277
ASP A 284
 None
 1.09A 2wm3A-4bgqA:
undetectable		 2wm3A-4bgqA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bil DNA MATURASE B

(Escherichia
virus T7) 		no annotation 4 LEU A 402
THR A 401
LEU A 313
ASP A 459
 None
 1.11A 2wm3A-4bilA:
2.9		 2wm3A-4bilA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Neurospora
crassa) 		no annotation 4 LEU A 573
PHE A 625
LEU A 616
ASP A 620
 None
 1.02A 2wm3A-4bwkA:
undetectable		 2wm3A-4bwkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnl PUTATIVE
PNEUMOCOCCAL SURFACE
PROTEIN

(Streptococcus
pneumoniae) 		PF01473
(CW_binding_1) 		4 LEU A 226
THR A 227
LEU A 243
ASP A 217
 None
GOL  A1282 (-4.0A)
None
None
 1.14A 2wm3A-4cnlA:
undetectable		 2wm3A-4cnlA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddi UBIQUITIN-CONJUGATIN
G ENZYME E2 D2,
UBIQUITIN
THIOESTERASE OTUB1

(Homo sapiens) 		PF00179
(UQ_con)
PF10275
(Peptidase_C65) 		4 LEU A1171
THR A1167
PHE A1162
LEU A1047
 None
 1.07A 2wm3A-4ddiA:
undetectable		 2wm3A-4ddiA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkb DEOXYURIDINE
TRIPHOSPHATASE

(Trypanosoma
brucei) 		PF08761
(dUTPase_2) 		4 LEU A  77
THR A  78
PHE A 199
ASP A 196
 None
 1.01A 2wm3A-4dkbA:
undetectable		 2wm3A-4dkbA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 LEU A 862
THR A 863
ARG A 991
LEU A 988
 None
 0.93A 2wm3A-4f7zA:
undetectable		 2wm3A-4f7zA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		4 LEU A 148
PHE A 152
LEU A  22
ASP A  26
 None
 1.14A 2wm3A-4gfhA:
undetectable		 2wm3A-4gfhA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193

(Streptomyces
coelicolor) 		PF04261
(Dyp_perox) 		4 LEU A 126
PHE A 105
LEU A  24
ASP A 102
 None
 0.94A 2wm3A-4gu7A:
undetectable		 2wm3A-4gu7A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 421
THR A 332
PHE A 178
LEU A 181
 None
 1.07A 2wm3A-4h7uA:
4.9		 2wm3A-4h7uA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		4 LEU B 325
THR B 336
LEU B  31
ASP B  19
 None
 1.04A 2wm3A-4hxeB:
3.4		 2wm3A-4hxeB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2g KLTH0A00704P

(Lachancea
thermotolerans) 		PF10033
(ATG13) 		4 LEU A 116
THR A  80
LEU A 165
ASP A 253
 None
 1.09A 2wm3A-4j2gA:
undetectable		 2wm3A-4j2gA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlr MOTAVIZUMAB FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 LEU H   4
THR H   3
PHE H  27
ASP H  95
 None
 1.11A 2wm3A-4jlrH:
undetectable		 2wm3A-4jlrH:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
oryzae) 		PF01156
(IU_nuc_hydro) 		4 LEU A  89
THR A  90
ARG A 101
LEU A 444
 None
 1.10A 2wm3A-4kl0A:
6.8		 2wm3A-4kl0A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksa MALONYL-COA
DECARBOXYLASE

(Rhodopseudomonas
palustris) 		PF05292
(MCD)
PF17408
(MCD_N) 		4 LEU A 142
THR A 139
PHE A 170
LEU A 281
 None
 1.14A 2wm3A-4ksaA:
undetectable		 2wm3A-4ksaA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1

(Homo sapiens) 		PF02205
(WH2)
PF05994
(FragX_IP)
PF07159
(DUF1394) 		4 LEU D 111
PHE A 699
LEU A 757
ASP A 763
 None
 1.14A 2wm3A-4n78D:
undetectable		 2wm3A-4n78D:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ARG A1149
PHE A1048
LEU A1071
ASP A1074
 None
 1.14A 2wm3A-4o9xA:
undetectable		 2wm3A-4o9xA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rul DNA TOPOISOMERASE 1

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01396
(zf-C4_Topoisom)
PF01751
(Toprim)
PF08272
(Topo_Zn_Ribbon) 		4 LEU A 234
THR A 226
ARG A 271
LEU A 422
 None
 0.92A 2wm3A-4rulA:
undetectable		 2wm3A-4rulA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tma DNA GYRASE SUBUNIT B

(Escherichia
coli) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 LEU B 509
THR B 508
PHE B 777
LEU B 780
 None
 1.03A 2wm3A-4tmaB:
undetectable		 2wm3A-4tmaB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uup MALATE DEHYDROGENASE

(synthetic
construct) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 137
THR A 134
PHE A 328
LEU A 331
 None
 1.08A 2wm3A-4uupA:
4.9		 2wm3A-4uupA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v16 SVP1-LIKE PROTEIN 2

(Kluyveromyces
lactis) 		no annotation 4 LEU A 284
ARG A 334
PHE A 316
LEU A 303
 None
 1.14A 2wm3A-4v16A:
undetectable		 2wm3A-4v16A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xef PROTEIN-TYROSINE
KINASE 2-BETA

(Homo sapiens) 		PF03623
(Focal_AT) 		4 LEU A 887
THR A 916
LEU A 950
ASP A 986
 None
 1.09A 2wm3A-4xefA:
undetectable		 2wm3A-4xefA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F

(Pseudomonas
aeruginosa) 		PF00497
(SBP_bac_3)
PF01464
(SLT) 		4 LEU B 201
THR B 200
ARG B 227
LEU B 207
 None
 1.12A 2wm3A-5aa4B:
undetectable		 2wm3A-5aa4B:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ako TSE2

(Pseudomonas
aeruginosa) 		no annotation 4 THR C  80
PHE C 144
LEU C 108
ASP C   5
 None
 1.04A 2wm3A-5akoC:
undetectable		 2wm3A-5akoC:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9d APRICK PROTEASE

(Rickettsia
conorii) 		PF13975
(gag-asp_proteas) 		4 LEU A 148
THR A 149
PHE A 137
LEU A 208
 None
 0.89A 2wm3A-5c9dA:
undetectable		 2wm3A-5c9dA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw8 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 LEU A  22
THR A  25
PHE A  57
LEU A  53
 None
 0.99A 2wm3A-5cw8A:
undetectable		 2wm3A-5cw8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		4 LEU A 439
THR A 327
PHE A 275
ASP A 432
 None
HEM  A 501 (-4.6A)
None
None
 1.11A 2wm3A-5e78A:
undetectable		 2wm3A-5e78A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqd UDP-GALACTOPYRANOSE
MUTASE

(Mycolicibacterium
smegmatis) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 LEU A 279
THR A 281
ARG A 323
PHE A 284
 None
None
NO3  A 505 (-4.2A)
None
 1.10A 2wm3A-5eqdA:
2.5		 2wm3A-5eqdA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa1 PUTATIVE N-ACETYL
GLUCOSAMINYL
TRANSFERASE

(Raoultella
terrigena) 		PF05159
(Capsule_synth) 		4 LEU A 106
THR A 107
ARG A  12
ASP A 232
 None
 0.89A 2wm3A-5fa1A:
undetectable		 2wm3A-5fa1A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Mus musculus) 		PF00149
(Metallophos) 		4 LEU A 371
THR A 372
ARG A 333
LEU A 345
 None
 1.09A 2wm3A-5fcaA:
undetectable		 2wm3A-5fcaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuk MROUPO

(Marasmius
rotula) 		PF01328
(Peroxidase_2) 		4 LEU A  80
THR A  83
ARG A  68
LEU A 232
 None
 1.10A 2wm3A-5fukA:
undetectable		 2wm3A-5fukA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsz NUCLEOID OCCLUSION
FACTOR SLMA

(Klebsiella
pneumoniae) 		PF00440
(TetR_N) 		4 LEU A 105
THR A 106
PHE A  98
ASP A  68
 None
 0.97A 2wm3A-5hszA:
undetectable		 2wm3A-5hszA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3e PUTATIVE
DEOXYRIBONUCLEASE-2

(Burkholderia
thailandensis) 		PF03265
(DNase_II) 		4 LEU A  24
THR A  25
LEU A 136
ASP A 278
 None
 1.13A 2wm3A-5i3eA:
undetectable		 2wm3A-5i3eA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 LEU A 117
PHE A  31
LEU A  55
ASP A  50
 None
 0.80A 2wm3A-5ikpA:
4.7		 2wm3A-5ikpA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9c PEROXIREDOXIN ASP F3

(Aspergillus
fumigatus) 		PF08534
(Redoxin) 		4 LEU A 110
ARG A  77
LEU A  50
ASP A  82
 None
 1.06A 2wm3A-5j9cA:
2.1		 2wm3A-5j9cA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8k UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE

(Haemophilus
influenzae) 		PF00149
(Metallophos) 		4 LEU A  19
THR A  20
LEU A  43
ASP A 215
 None
None
None
MN  A 302 ( 4.9A)
 1.10A 2wm3A-5k8kA:
2.7		 2wm3A-5k8kA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU B 758
THR B 763
LEU B 747
ASP B 753
 None
 1.11A 2wm3A-5kkrB:
undetectable		 2wm3A-5kkrB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kmx PUTATIVE
UNCHARACTERIZED
PROTEIN
TCIL3000_10_9440

(Trypanosoma
congolense) 		no annotation 4 LEU A 192
THR A 191
LEU A 214
ASP A 219
 None
 1.08A 2wm3A-5kmxA:
undetectable		 2wm3A-5kmxA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1)
PF00301
(Rubredoxin)
PF00753
(Lactamase_B) 		4 LEU A 138
PHE A 163
LEU A 162
ASP A 159
 None
 1.09A 2wm3A-5lmcA:
undetectable		 2wm3A-5lmcA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		4 LEU A  21
THR A  17
LEU A  33
ASP A  30
 None
 1.00A 2wm3A-5lv9A:
6.9		 2wm3A-5lv9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 137
THR A 134
PHE A 327
LEU A 330
 None
 1.04A 2wm3A-5mdhA:
4.4		 2wm3A-5mdhA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1

(Saccharomyces
cerevisiae) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		4 LEU A1818
THR A1819
PHE A1669
ASP A1842
 None
 1.14A 2wm3A-5mznA:
2.7		 2wm3A-5mznA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osh INTERAPTIN

(Legionella
pneumophila) 		no annotation 4 LEU C 128
THR C 125
LEU C 202
ASP C 196
 None
 0.98A 2wm3A-5oshC:
undetectable		 2wm3A-5oshC:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot4 INTERAPTIN

(Legionella
pneumophila) 		no annotation 4 LEU A 128
THR A 125
LEU A 202
ASP A 196
 None
 1.04A 2wm3A-5ot4A:
undetectable		 2wm3A-5ot4A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t89 VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF00047
(ig)
PF07679
(I-set)
PF13927
(Ig_3) 		4 THR X 643
ARG X 637
LEU X 583
ASP X 586
 None
 0.95A 2wm3A-5t89X:
undetectable		 2wm3A-5t89X:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9b MUSCLEBLIND-LIKE
PROTEIN 1

(Homo sapiens) 		no annotation 4 LEU A  14
THR A  15
LEU A  69
ASP A  55
 C  B 101 ( 4.0A)
None
None
C  B 101 ( 3.4A)
 1.09A 2wm3A-5u9bA:
undetectable		 2wm3A-5u9bA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ua2 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A  43
THR A  46
PHE A  78
LEU A  74
 None
 1.12A 2wm3A-5ua2A:
undetectable		 2wm3A-5ua2A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wkn NUCLEOPROTEIN

(Mammalian
rubulavirus 5) 		no annotation 4 LEU A  74
THR A  75
LEU A  85
ASP A  92
 None
 0.84A 2wm3A-5wknA:
undetectable		 2wm3A-5wknA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxu 11S GLOBULIN

(Wrightia
tinctoria) 		no annotation 4 LEU A 405
THR A 407
PHE A 386
LEU A 385
 None
 1.06A 2wm3A-5wxuA:
undetectable		 2wm3A-5wxuA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpc DNAATION
FACTOR-RELATED
PROTEIN 4

(Drosophila
melanogaster) 		PF02017
(CIDE-N) 		4 LEU A 109
THR A 108
LEU A  86
ASP A  54
 None
 1.13A 2wm3A-5xpcA:
undetectable		 2wm3A-5xpcA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 4 THR A 300
ARG A 320
LEU A 144
ASP A 310
 None
None
None
FAD  A 502 (-2.9A)
 1.12A 2wm3A-6cmzA:
4.0		 2wm3A-6cmzA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ewy PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A  49
THR A  45
LEU A 229
ASP A 223
 None
 1.11A 2wm3A-6ewyA:
undetectable		 2wm3A-6ewyA:
17.42