SIMILAR PATTERNS OF AMINO ACIDS FOR 2WM3_A_NFLA1300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05368
(NmrA) 		7 CYH A 154
ASN A 158
HIS A 162
PHE A 163
TYR A 246
LEU A 257
TYR A 264
 None
 0.82A 2wm3A-3e5mA:
44.9		 2wm3A-3e5mA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05368
(NmrA) 		7 LEU A 114
CYH A 154
ASN A 158
HIS A 162
PHE A 163
LEU A 257
TYR A 264
 None
 0.67A 2wm3A-3e5mA:
44.9		 2wm3A-3e5mA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05368
(NmrA) 		5 LEU A 114
HIS A 129
CYH A 154
ASN A 158
HIS A 162
 None
 1.48A 2wm3A-3e5mA:
44.9		 2wm3A-3e5mA:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esr HALOALKANE
DEHALOGENASE

(Caulobacter
vibrioides) 		PF00561
(Abhydrolase_1) 		5 TRP A 108
LEU A  81
PHE A 140
LEU A  50
MET A  52
 None
 1.26A 2wm3A-5esrA:
4.5		 2wm3A-5esrA:
22.74