SIMILAR PATTERNS OF AMINO ACIDS FOR 2WLK_B_SPMB1302
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ais | PROTEIN(TRANSCRIPTIONINITIATION FACTORIIB) (Pyrococcuswoesei) |
PF00382(TFIIB) | 4 | ALA B1254TYR B1286ALA B1258TYR B1256 | None | 1.16A | 2wlkA-1aisB:undetectable2wlkB-1aisB:undetectable | 2wlkA-1aisB:21.592wlkB-1aisB:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1awj | ITK (Mus musculus) |
PF00018(SH3_1) | 4 | ALA A 70TYR A 74ALA A 27TYR A 29 | None | 1.22A | 2wlkA-1awjA:undetectable2wlkB-1awjA:undetectable | 2wlkA-1awjA:12.372wlkB-1awjA:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cv8 | STAPHOPAIN (Staphylococcusaureus) |
PF05543(Peptidase_C47) | 4 | ALA A 35TYR A 37ALA A 31TYR A 42 | None | 1.18A | 2wlkA-1cv8A:undetectable2wlkB-1cv8A:undetectable | 2wlkA-1cv8A:17.282wlkB-1cv8A:17.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g3p | MINOR COAT PROTEIN (Escherichiavirus M13) |
PF05357(Phage_Coat_A) | 4 | ALA A 175TYR A 110ALA A 179TYR A 177 | None | 1.28A | 2wlkA-1g3pA:undetectable2wlkB-1g3pA:undetectable | 2wlkA-1g3pA:20.812wlkB-1g3pA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gae | D-GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE (Escherichiacoli) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 4 | ALA O 41TYR O 42ALA O 37TYR O 39 | None | 1.26A | 2wlkA-1gaeO:1.42wlkB-1gaeO:0.0 | 2wlkA-1gaeO:22.132wlkB-1gaeO:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h4v | HISTIDYL-TRNASYNTHETASE (Thermusthermophilus) |
PF03129(HGTP_anticodon)PF13393(tRNA-synt_His) | 4 | ALA B 177TYR B 178ALA B 173TYR B 175 | None | 1.14A | 2wlkA-1h4vB:0.02wlkB-1h4vB:0.0 | 2wlkA-1h4vB:21.332wlkB-1h4vB:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hcu | ALPHA-1,2-MANNOSIDASE (Trichodermareesei) |
PF01532(Glyco_hydro_47) | 4 | ALA A 461TYR A 460ALA A 414TYR A 399 | None | 1.21A | 2wlkA-1hcuA:0.02wlkB-1hcuA:0.0 | 2wlkA-1hcuA:19.882wlkB-1hcuA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hkh | GAMMA LACTAMASE (Microbacterium) |
PF00561(Abhydrolase_1) | 4 | ALA A 109TYR A 111ALA A 105TYR A 107 | None | 0.99A | 2wlkA-1hkhA:0.02wlkB-1hkhA:undetectable | 2wlkA-1hkhA:23.552wlkB-1hkhA:23.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1js4 | ENDO/EXOCELLULASE E4 (Thermobifidafusca) |
PF00759(Glyco_hydro_9)PF00942(CBM_3) | 4 | ALA A 182TYR A 186ALA A 226TYR A 232 | None | 1.11A | 2wlkA-1js4A:3.52wlkB-1js4A:3.2 | 2wlkA-1js4A:19.282wlkB-1js4A:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nl3 | PREPROTEINTRANSLOCASE SECA 1SUBUNIT (Mycobacteriumtuberculosis) |
PF01043(SecA_PP_bind)PF07516(SecA_SW)PF07517(SecA_DEAD) | 4 | ALA A 294TYR A 290ALA A 239TYR A 235 | None | 1.04A | 2wlkA-1nl3A:3.22wlkB-1nl3A:2.8 | 2wlkA-1nl3A:15.602wlkB-1nl3A:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ta3 | XYLANASE INHIBITORPROTEIN I (Triticumaestivum) |
PF00704(Glyco_hydro_18) | 4 | ALA A 241TYR A 237ALA A 274TYR A 273 | NoneNoneNoneEDO B1007 ( 4.9A) | 1.25A | 2wlkA-1ta3A:undetectable2wlkB-1ta3A:0.0 | 2wlkA-1ta3A:20.622wlkB-1ta3A:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uqw | PUTATIVE BINDINGPROTEIN YLIB (Escherichiacoli) |
PF00496(SBP_bac_5) | 4 | ALA A 298TYR A 297ALA A 396TYR A 441 | None | 1.30A | 2wlkA-1uqwA:undetectable2wlkB-1uqwA:undetectable | 2wlkA-1uqwA:19.652wlkB-1uqwA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vzm | OSTEOCALCIN (Argyrosomusregius) |
no annotation | 4 | ALA A 38TYR A 40ALA A 34TYR A 36 | None | 1.10A | 2wlkA-1vzmA:undetectable2wlkB-1vzmA:undetectable | 2wlkA-1vzmA:9.222wlkB-1vzmA:9.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yr2 | PROLYLOLIGOPEPTIDASE (Novosphingobiumcapsulatum) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 4 | ALA A 42TYR A 40ALA A 80TYR A 84 | None | 1.20A | 2wlkA-1yr2A:undetectable2wlkB-1yr2A:undetectable | 2wlkA-1yr2A:17.252wlkB-1yr2A:17.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a1r | POLY(A)-SPECIFICRIBONUCLEASE PARN (Homo sapiens) |
PF01424(R3H)PF04857(CAF1) | 4 | ALA A 383TYR A 384ALA A 379TYR A 381 | None | 1.11A | 2wlkA-2a1rA:undetectable2wlkB-2a1rA:undetectable | 2wlkA-2a1rA:19.872wlkB-2a1rA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a2o | HYPOTHETICAL PROTEINBT3146 (Bacteroidesthetaiotaomicron) |
no annotation | 4 | ALA A 146TYR A 147ALA A 142TYR A 144 | None | 1.15A | 2wlkA-2a2oA:2.02wlkB-2a2oA:2.1 | 2wlkA-2a2oA:21.102wlkB-2a2oA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2acv | TRITERPENEUDP-GLUCOSYLTRANSFERASE UGT71G1 (Medicagotruncatula) |
PF00201(UDPGT) | 4 | ALA A 201TYR A 203ALA A 191TYR A 199 | None | 0.99A | 2wlkA-2acvA:undetectable2wlkB-2acvA:undetectable | 2wlkA-2acvA:20.432wlkB-2acvA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cuy | MALONYL COA-[ACYLCARRIER PROTEIN]TRANSACYLASE (Thermusthermophilus) |
PF00698(Acyl_transf_1) | 4 | ALA A 70TYR A 71ALA A 66TYR A 68 | None | 1.12A | 2wlkA-2cuyA:undetectable2wlkB-2cuyA:undetectable | 2wlkA-2cuyA:21.542wlkB-2cuyA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gki | NUCLEASE (Mus musculus) |
PF07686(V-set) | 4 | ALA A 122TYR A 123ALA A 128TYR A 127 | None | 0.70A | 2wlkA-2gkiA:2.92wlkB-2gkiA:2.5 | 2wlkA-2gkiA:19.882wlkB-2gkiA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hms | YUAA PROTEIN (Bacillussubtilis) |
PF02254(TrkA_N) | 4 | ALA A 49TYR A 48ALA A 52TYR A 45 | None | 1.11A | 2wlkA-2hmsA:undetectable2wlkB-2hmsA:undetectable | 2wlkA-2hmsA:17.942wlkB-2hmsA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w5o | ALPHA-L-ARABINOFURANOSIDASE (Fusariumgraminearum) |
no annotation | 4 | ALA A 356TYR A 44ALA A 336TYR A 337 | NoneAHR A 501 ( 4.8A)NoneNone | 1.02A | 2wlkA-2w5oA:undetectable2wlkB-2w5oA:undetectable | 2wlkA-2w5oA:19.782wlkB-2w5oA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w9p | MULTICYSTATIN (Solanumtuberosum) |
PF00031(Cystatin) | 4 | ALA A 23TYR A 27ALA A 71TYR A 69 | None | 1.05A | 2wlkA-2w9pA:undetectable2wlkB-2w9pA:undetectable | 2wlkA-2w9pA:13.452wlkB-2w9pA:13.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w9p | MULTICYSTATIN (Solanumtuberosum) |
PF00031(Cystatin) | 4 | ALA A 71TYR A 69ALA A 23TYR A 27 | None | 1.01A | 2wlkA-2w9pA:undetectable2wlkB-2w9pA:undetectable | 2wlkA-2w9pA:13.452wlkB-2w9pA:13.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b8l | UNCHARACTERIZEDPROTEIN (Novosphingobiumaromaticivorans) |
PF13577(SnoaL_4) | 4 | ALA A 125TYR A 18ALA A 39TYR A 128 | NoneGOL A 145 (-4.7A)NoneGOL A 145 (-4.7A) | 1.24A | 2wlkA-3b8lA:undetectable2wlkB-3b8lA:undetectable | 2wlkA-3b8lA:18.582wlkB-3b8lA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d45 | POLY(A)-SPECIFICRIBONUCLEASE PARN (Mus musculus) |
PF01424(R3H)PF04857(CAF1)PF08675(RNA_bind) | 4 | ALA A 376TYR A 377ALA A 372TYR A 374 | None | 1.20A | 2wlkA-3d45A:undetectable2wlkB-3d45A:undetectable | 2wlkA-3d45A:20.122wlkB-3d45A:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dhu | ALPHA-AMYLASE (Lactobacillusplantarum) |
PF00128(Alpha-amylase) | 4 | ALA A 354TYR A 356ALA A 372TYR A 370 | None | 1.21A | 2wlkA-3dhuA:undetectable2wlkB-3dhuA:undetectable | 2wlkA-3dhuA:21.112wlkB-3dhuA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwb | ENDOTHELIN-CONVERTING ENZYME 1 (Homo sapiens) |
PF01431(Peptidase_M13)PF05649(Peptidase_M13_N) | 4 | ALA A 681TYR A 682ALA A 677TYR A 679 | None | 1.18A | 2wlkA-3dwbA:undetectable2wlkB-3dwbA:undetectable | 2wlkA-3dwbA:19.632wlkB-3dwbA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ei8 | LL-DIAMINOPIMELATEAMINOTRANSFERASE (Arabidopsisthaliana) |
PF00155(Aminotran_1_2) | 4 | ALA A 241TYR A 243ALA A 266TYR A 240 | GOL A 436 ( 3.7A)NoneGOL A 436 (-3.4A)PLP A 433 (-4.5A) | 1.29A | 2wlkA-3ei8A:undetectable2wlkB-3ei8A:undetectable | 2wlkA-3ei8A:22.732wlkB-3ei8A:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ekg | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Azotobactervinelandii) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ALA A 83TYR A 85ALA A 13TYR A 394 | None | 1.01A | 2wlkA-3ekgA:undetectable2wlkB-3ekgA:undetectable | 2wlkA-3ekgA:23.612wlkB-3ekgA:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i8b | XYLULOSE KINASE (Bifidobacteriumadolescentis) |
PF00370(FGGY_N)PF02782(FGGY_C) | 4 | ALA A 500TYR A 501ALA A 496TYR A 498 | None | 1.16A | 2wlkA-3i8bA:undetectable2wlkB-3i8bA:undetectable | 2wlkA-3i8bA:20.082wlkB-3i8bA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l42 | PEREGRIN (Homo sapiens) |
PF00855(PWWP) | 4 | ALA A1091TYR A1096ALA A1101TYR A1099 | None | 1.13A | 2wlkA-3l42A:undetectable2wlkB-3l42A:undetectable | 2wlkA-3l42A:16.222wlkB-3l42A:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ls2 | S-FORMYLGLUTATHIONEHYDROLASE (Pseudoalteromonashaloplanktis) |
PF00756(Esterase) | 4 | ALA A 153TYR A 49ALA A 167TYR A 164 | None | 1.25A | 2wlkA-3ls2A:undetectable2wlkB-3ls2A:undetectable | 2wlkA-3ls2A:19.572wlkB-3ls2A:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1u | PUTATIVEGAMMA-D-GLUTAMYL-L-DIAMINO ACIDENDOPEPTIDASE (Desulfovibriovulgaris) |
PF00877(NLPC_P60)PF12912(N_NLPC_P60)PF12913(SH3_6)PF12914(SH3_7) | 4 | ALA A 197TYR A 205ALA A 137TYR A 141 | None | 1.00A | 2wlkA-3m1uA:undetectable2wlkB-3m1uA:undetectable | 2wlkA-3m1uA:21.222wlkB-3m1uA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3my2 | LIPOPOLYSACCHARIDEEXPORT SYSTEMPROTEIN LPTC (Escherichiacoli) |
PF06835(LptC) | 4 | ALA A 134TYR A 110ALA A 98TYR A 112 | None | 1.19A | 2wlkA-3my2A:undetectable2wlkB-3my2A:undetectable | 2wlkA-3my2A:19.082wlkB-3my2A:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nlc | UNCHARACTERIZEDPROTEIN VP0956 (Vibrioparahaemolyticus) |
no annotation | 4 | ALA A 408TYR A 406ALA A 398TYR A 399 | None | 0.88A | 2wlkA-3nlcA:undetectable2wlkB-3nlcA:undetectable | 2wlkA-3nlcA:22.452wlkB-3nlcA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pnw | TUDORDOMAIN-CONTAININGPROTEIN 3 (Homo sapiens) |
PF00567(TUDOR) | 4 | ALA C 564TYR C 566ALA C 575TYR C 573 | NoneUNX C1855 ( 4.1A)NoneNone | 1.19A | 2wlkA-3pnwC:undetectable2wlkB-3pnwC:undetectable | 2wlkA-3pnwC:12.762wlkB-3pnwC:12.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3poh | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE F1 (Bacteroidesthetaiotaomicron) |
PF08522(DUF1735) | 4 | ALA A 378TYR A 359ALA A 383TYR A 385 | None | 1.26A | 2wlkA-3pohA:undetectable2wlkB-3pohA:undetectable | 2wlkA-3pohA:20.042wlkB-3pohA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pwv | MHC CLASS I ANTIGEN (Bos taurus) |
PF00129(MHC_I)PF07654(C1-set) | 4 | ALA A 70TYR A 66ALA A 10TYR A 8 | None | 0.96A | 2wlkA-3pwvA:3.42wlkB-3pwvA:3.1 | 2wlkA-3pwvA:22.362wlkB-3pwvA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qky | OUTER MEMBRANEASSEMBLY LIPOPROTEINYFIO (Rhodothermusmarinus) |
PF13525(YfiO) | 4 | ALA A 41TYR A 45ALA A 73TYR A 76 | None | 1.25A | 2wlkA-3qkyA:undetectable2wlkB-3qkyA:undetectable | 2wlkA-3qkyA:21.842wlkB-3qkyA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qqc | DNA-DIRECTED RNAPOLYMERASE, SUBUNITE'' (Pyrococcusfuriosus) |
PF06093(Spt4) | 4 | ALA E 57TYR E 56ALA E 5TYR E 11 | None | 1.27A | 2wlkA-3qqcE:undetectable2wlkB-3qqcE:undetectable | 2wlkA-3qqcE:10.772wlkB-3qqcE:10.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qz5 | CO-TYPE NITRILEHYDRATASE ALPHASUBUNIT (Pseudomonasputida) |
PF02979(NHase_alpha) | 4 | ALA A 132TYR A 135ALA A 128TYR A 130 | GOL A 212 ( 3.8A)NoneNoneNone | 0.95A | 2wlkA-3qz5A:undetectable2wlkB-3qz5A:undetectable | 2wlkA-3qz5A:23.292wlkB-3qz5A:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rkl | STIV-A81 (Sulfolobusturretedicosahedralvirus 1) |
no annotation | 4 | ALA A 65TYR A 64ALA A 69TYR A 67 | None | 1.26A | 2wlkA-3rklA:2.92wlkB-3rklA:2.6 | 2wlkA-3rklA:14.852wlkB-3rklA:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6w | TUDORDOMAIN-CONTAININGPROTEIN 3 (Homo sapiens) |
PF00567(TUDOR) | 4 | ALA A 564TYR A 566ALA A 575TYR A 573 | NoneIPA A 609 (-3.9A)NoneIPA A 609 (-4.0A) | 1.10A | 2wlkA-3s6wA:undetectable2wlkB-3s6wA:undetectable | 2wlkA-3s6wA:11.532wlkB-3s6wA:11.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ufx | SUCCINYL-COASYNTHETASE BETASUBUNIT (Thermusaquaticus) |
PF00549(Ligase_CoA)PF08442(ATP-grasp_2) | 4 | ALA B 178TYR B 179ALA B 174TYR B 176 | None | 1.05A | 2wlkA-3ufxB:undetectable2wlkB-3ufxB:undetectable | 2wlkA-3ufxB:21.032wlkB-3ufxB:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uk1 | TRANSKETOLASE (Burkholderiathailandensis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | ALA A 335TYR A 337ALA A 331TYR A 333 | None | 1.22A | 2wlkA-3uk1A:undetectable2wlkB-3uk1A:undetectable | 2wlkA-3uk1A:18.172wlkB-3uk1A:18.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vas | PUTATIVE ADENOSINEKINASE (Schistosomamansoni) |
PF00294(PfkB) | 4 | ALA A 244TYR A 246ALA A 226TYR A 229 | None | 1.11A | 2wlkA-3vasA:undetectable2wlkB-3vasA:undetectable | 2wlkA-3vasA:21.042wlkB-3vasA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zoy | CYTOCHROME C-552 (Nitrosomonaseuropaea) |
PF00034(Cytochrom_C) | 4 | ALA A 39TYR A 32ALA A 43TYR A 41 | NoneHEC A1082 (-4.4A)NoneHEC A1082 (-4.5A) | 1.25A | 2wlkA-3zoyA:undetectable2wlkB-3zoyA:undetectable | 2wlkA-3zoyA:13.152wlkB-3zoyA:13.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4by9 | NOP5/NOP56 RELATEDPROTEIN (Pyrococcusfuriosus) |
PF01798(Nop) | 4 | ALA C 225TYR C 153ALA C 172TYR C 170 | None | 1.26A | 2wlkA-4by9C:3.62wlkB-4by9C:3.4 | 2wlkA-4by9C:20.412wlkB-4by9C:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c95 | DNA POLYMERASEALPHA-BINDINGPROTEIN (Saccharomycescerevisiae) |
PF12341(Mcl1_mid) | 4 | ALA A 865TYR A 827ALA A 861TYR A 862 | None | 1.06A | 2wlkA-4c95A:undetectable2wlkB-4c95A:undetectable | 2wlkA-4c95A:20.282wlkB-4c95A:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cj0 | ENDOGLUCANASE D (Ruminiclostridiumthermocellum) |
PF00759(Glyco_hydro_9)PF02927(CelD_N) | 4 | ALA A 368TYR A 379ALA A 304TYR A 332 | NoneNoneNoneGOL A1580 ( 4.7A) | 1.30A | 2wlkA-4cj0A:undetectable2wlkB-4cj0A:undetectable | 2wlkA-4cj0A:18.602wlkB-4cj0A:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dqd | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Rhodopseudomonaspalustris) |
PF13458(Peripla_BP_6) | 4 | ALA A 265TYR A 241ALA A 146TYR A 150 | None | 1.24A | 2wlkA-4dqdA:undetectable2wlkB-4dqdA:undetectable | 2wlkA-4dqdA:21.202wlkB-4dqdA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ep5 | CROSSOVER JUNCTIONENDODEOXYRIBONUCLEASE RUVC (Thermusthermophilus) |
PF02075(RuvC) | 4 | ALA A 155TYR A 157ALA A 151TYR A 105 | None | 1.18A | 2wlkA-4ep5A:undetectable2wlkB-4ep5A:undetectable | 2wlkA-4ep5A:20.002wlkB-4ep5A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fin | ETTA (YJJK) ABCFFAMILY PROTEIN (Escherichiacoli) |
PF00005(ABC_tran)PF12848(ABC_tran_Xtn) | 4 | ALA A 109TYR A 108ALA A 112TYR A 111 | None | 1.00A | 2wlkA-4finA:undetectable2wlkB-4finA:undetectable | 2wlkA-4finA:18.132wlkB-4finA:18.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fk1 | PUTATIVE THIOREDOXINREDUCTASE (Bacillusanthracis) |
PF07992(Pyr_redox_2) | 4 | ALA C 7TYR C 76ALA C 103TYR C 101 | None | 1.25A | 2wlkA-4fk1C:undetectable2wlkB-4fk1C:undetectable | 2wlkA-4fk1C:23.452wlkB-4fk1C:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fnq | ALPHA-GALACTOSIDASEAGAB (Geobacillusstearothermophilus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 4 | ALA A 570TYR A 566ALA A 320TYR A 315 | None | 1.32A | 2wlkA-4fnqA:undetectable2wlkB-4fnqA:undetectable | 2wlkA-4fnqA:17.122wlkB-4fnqA:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hwv | PECTATE LYASE/AMBALLERGEN (Acidovoraxcitrulli) |
PF00544(Pec_lyase_C) | 4 | ALA A 141TYR A 139ALA A 147TYR A 143 | None | 1.26A | 2wlkA-4hwvA:undetectable2wlkB-4hwvA:undetectable | 2wlkA-4hwvA:20.712wlkB-4hwvA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hz4 | GLUTATHIONE-S-TRANSFERASE (Actinobacilluspleuropneumoniae) |
PF00043(GST_C)PF02798(GST_N) | 4 | ALA A 93TYR A 97ALA A 88TYR A 94 | None | 1.13A | 2wlkA-4hz4A:undetectable2wlkB-4hz4A:undetectable | 2wlkA-4hz4A:23.322wlkB-4hz4A:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i96 | RYANODINE RECEPTOR 1 (Oryctolaguscuniculus) |
PF01365(RYDR_ITPR)PF02815(MIR) | 4 | ALA A 504TYR A 506ALA A 500TYR A 497 | None | 1.09A | 2wlkA-4i96A:undetectable2wlkB-4i96A:undetectable | 2wlkA-4i96A:23.822wlkB-4i96A:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j20 | CYTOCHROME C-555 (Chlorobaculumtepidum) |
PF13442(Cytochrome_CBB3) | 4 | ALA A 10TYR A 12ALA A 7TYR A 82 | None | 1.23A | 2wlkA-4j20A:undetectable2wlkB-4j20A:undetectable | 2wlkA-4j20A:12.792wlkB-4j20A:12.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j91 | KTR SYSTEM POTASSIUMUPTAKE PROTEIN A (Bacillussubtilis) |
PF02080(TrkA_C)PF02254(TrkA_N) | 4 | ALA A 49TYR A 48ALA A 52TYR A 45 | None | 1.08A | 2wlkA-4j91A:undetectable2wlkB-4j91A:undetectable | 2wlkA-4j91A:21.792wlkB-4j91A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jer | HEMOPHORE HASA (Yersinia pestis) |
PF06438(HasA) | 4 | ALA A 12TYR A 11ALA A 168TYR A 14 | None | 1.24A | 2wlkA-4jerA:undetectable2wlkB-4jerA:undetectable | 2wlkA-4jerA:18.482wlkB-4jerA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kly | BLUE-LIGHT ABSORBINGPROTEORHODOPSIN (gammaproteobacterium'Hot 75m4') |
PF01036(Bac_rhodopsin) | 4 | ALA A 206TYR A 208ALA A 202TYR A 204 | NoneNoneNoneRET A 301 (-4.1A) | 1.09A | 2wlkA-4klyA:undetectable2wlkB-4klyA:2.0 | 2wlkA-4klyA:23.872wlkB-4klyA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lcy | HLA CLASS IHISTOCOMPATIBILITYANTIGEN, B-46 ALPHACHAIN (Homo sapiens) |
PF00129(MHC_I)PF07654(C1-set) | 4 | ALA A 71TYR A 67ALA A 11TYR A 9 | None | 1.00A | 2wlkA-4lcyA:undetectable2wlkB-4lcyA:undetectable | 2wlkA-4lcyA:21.022wlkB-4lcyA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lsm | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE,CYTOSOLIC (Trypanosomacruzi) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 4 | ALA A 48TYR A 49ALA A 44TYR A 46 | None | 1.24A | 2wlkA-4lsmA:1.42wlkB-4lsmA:1.2 | 2wlkA-4lsmA:20.592wlkB-4lsmA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lzi | MULTICYSTATIN (Solanumtuberosum) |
PF00031(Cystatin) | 4 | ALA A 120TYR A 124ALA A 167TYR A 165 | None | 1.24A | 2wlkA-4lziA:undetectable2wlkB-4lziA:undetectable | 2wlkA-4lziA:20.182wlkB-4lziA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lzi | MULTICYSTATIN (Solanumtuberosum) |
PF00031(Cystatin) | 4 | ALA A 167TYR A 165ALA A 120TYR A 124 | None | 1.06A | 2wlkA-4lziA:undetectable2wlkB-4lziA:undetectable | 2wlkA-4lziA:20.182wlkB-4lziA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lzi | MULTICYSTATIN (Solanumtuberosum) |
PF00031(Cystatin) | 4 | ALA A 214TYR A 218ALA A 261TYR A 259 | None | 1.25A | 2wlkA-4lziA:undetectable2wlkB-4lziA:undetectable | 2wlkA-4lziA:20.182wlkB-4lziA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lzi | MULTICYSTATIN (Solanumtuberosum) |
PF00031(Cystatin) | 4 | ALA A 261TYR A 259ALA A 214TYR A 218 | None | 0.93A | 2wlkA-4lziA:undetectable2wlkB-4lziA:undetectable | 2wlkA-4lziA:20.182wlkB-4lziA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nuz | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE F2 (Streptococcuspyogenes) |
no annotation | 4 | ALA A 684TYR A 685ALA A 680TYR A 682 | None | 1.00A | 2wlkA-4nuzA:2.62wlkB-4nuzA:2.4 | 2wlkA-4nuzA:15.252wlkB-4nuzA:15.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nxk | ABP, A GH27BETA-L-ARABINOPYRANOSIDASE (Geobacillusstearothermophilus) |
PF16499(Melibiase_2) | 4 | ALA A 52TYR A 54ALA A 48TYR A 50 | None | 1.08A | 2wlkA-4nxkA:undetectable2wlkB-4nxkA:undetectable | 2wlkA-4nxkA:23.272wlkB-4nxkA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u83 | ACYL-COADEHYDROGENASE (Brucellaabortus) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 4 | ALA A 258TYR A 345ALA A 332TYR A 262 | None | 1.31A | 2wlkA-4u83A:2.92wlkB-4u83A:2.7 | 2wlkA-4u83A:21.942wlkB-4u83A:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xeu | TRANSKETOLASE (Pseudomonasaeruginosa) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | ALA A 610TYR A 622ALA A 616TYR A 618 | None | 1.23A | 2wlkA-4xeuA:undetectable2wlkB-4xeuA:undetectable | 2wlkA-4xeuA:16.002wlkB-4xeuA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yxz | DTOR_9X31L (syntheticconstruct) |
no annotation | 4 | ALA A 17TYR A 21ALA A 268TYR A 269 | None | 1.31A | 2wlkA-4yxzA:undetectable2wlkB-4yxzA:undetectable | 2wlkA-4yxzA:21.822wlkB-4yxzA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z0b | ANTIBODY HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | ALA H 49TYR H 50ALA H 61TYR H 59 | None | 1.24A | 2wlkA-4z0bH:2.52wlkB-4z0bH:2.1 | 2wlkA-4z0bH:20.332wlkB-4z0bH:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zky | PYRIDOXAMINE5-PHOSPHATE OXIDASE (Mycolicibacteriumsmegmatis) |
PF01243(Putative_PNPOx) | 4 | ALA A 115TYR A 117ALA A 111TYR A 120 | None | 1.26A | 2wlkA-4zkyA:undetectable2wlkB-4zkyA:undetectable | 2wlkA-4zkyA:16.722wlkB-4zkyA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aao | FAD3210 (syntheticconstruct) |
PF12796(Ank_2)PF13637(Ank_4) | 4 | ALA A 55TYR A 57ALA A 63TYR A 59 | None | 1.11A | 2wlkA-5aaoA:undetectable2wlkB-5aaoA:undetectable | 2wlkA-5aaoA:19.802wlkB-5aaoA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5but | KTR SYSTEM POTASSIUMUPTAKE PROTEIN A,KTRSYSTEM POTASSIUMUPTAKE PROTEIN A (Bacillussubtilis) |
PF02254(TrkA_N) | 4 | ALA A 49TYR A 48ALA A 52TYR A 45 | None | 1.12A | 2wlkA-5butA:undetectable2wlkB-5butA:undetectable | 2wlkA-5butA:23.312wlkB-5butA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5but | KTR SYSTEM POTASSIUMUPTAKE PROTEIN A,KTRSYSTEM POTASSIUMUPTAKE PROTEIN A (Bacillussubtilis) |
PF02254(TrkA_N) | 4 | ALA A 191TYR A 190ALA A 194TYR A 187 | None | 1.13A | 2wlkA-5butA:undetectable2wlkB-5butA:undetectable | 2wlkA-5butA:23.312wlkB-5butA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cxp | POSSIBLE XYLANDEGRADATION ENZYME(GLYCOSYL HYDROLASEFAMILY 30-LIKEDOMAIN AND RICINB-LIKE DOMAIN) (Clostridiumacetobutylicum) |
PF02055(Glyco_hydro_30) | 4 | ALA A 117TYR A 118ALA A 113TYR A 115 | None | 1.02A | 2wlkA-5cxpA:undetectable2wlkB-5cxpA:undetectable | 2wlkA-5cxpA:20.152wlkB-5cxpA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5efr | BAMA-BAMD FUSIONPROTEIN (Rhodothermusmarinus) |
PF07244(POTRA)PF13525(YfiO) | 4 | ALA A1041TYR A1045ALA A1073TYR A1076 | None | 1.18A | 2wlkA-5efrA:undetectable2wlkB-5efrA:undetectable | 2wlkA-5efrA:19.532wlkB-5efrA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fnu | KELCH-LIKEECH-ASSOCIATEDPROTEIN 1 (Mus musculus) |
PF01344(Kelch_1) | 4 | ALA A 331TYR A 329ALA A 376TYR A 396 | None | 1.10A | 2wlkA-5fnuA:undetectable2wlkB-5fnuA:undetectable | 2wlkA-5fnuA:21.702wlkB-5fnuA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gin | C/D BOX METHYLATIONGUIDERIBONUCLEOPROTEINCOMPLEX ANOP56SUBUNITFIBRILLARIN-LIKERRNA/TRNA2'-O-METHYLTRANSFERASE (Sulfolobussolfataricus) |
PF01269(Fibrillarin)PF01798(Nop) | 4 | ALA E 167TYR A 86ALA E 163TYR E 165 | None | 1.20A | 2wlkA-5ginE:undetectable2wlkB-5ginE:undetectable | 2wlkA-5ginE:21.042wlkB-5ginE:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h35 | MEMBRANE PROTEINTRIC (Sulfolobussolfataricus) |
PF03458(UPF0126) | 4 | ALA C 112TYR C 113ALA C 126TYR C 164 | NoneGOL C 302 (-4.1A)NoneNone | 1.04A | 2wlkA-5h35C:2.32wlkB-5h35C:2.0 | 2wlkA-5h35C:22.882wlkB-5h35C:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jpn | COMPLEMENT C4-A (Homo sapiens) |
PF01759(NTR)PF07677(A2M_recep) | 4 | ALA C1484TYR C1559ALA C1486TYR C1525 | None | 1.27A | 2wlkA-5jpnC:3.32wlkB-5jpnC:3.2 | 2wlkA-5jpnC:21.052wlkB-5jpnC:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kuy | DESIGNED INFLUENZAINHIBITOR HSB.2A (syntheticconstruct) |
PF00031(Cystatin) | 4 | ALA G 23TYR G 27ALA G 68TYR G 66 | None | 1.13A | 2wlkA-5kuyG:undetectable2wlkB-5kuyG:undetectable | 2wlkA-5kuyG:16.892wlkB-5kuyG:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kuy | DESIGNED INFLUENZAINHIBITOR HSB.2A (syntheticconstruct) |
PF00031(Cystatin) | 4 | ALA G 68TYR G 66ALA G 23TYR G 27 | None | 0.89A | 2wlkA-5kuyG:undetectable2wlkB-5kuyG:undetectable | 2wlkA-5kuyG:16.892wlkB-5kuyG:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5na7 | PUTATIVEDIPEPTIDYL-PEPTIDASEIII (Bacteroidesthetaiotaomicron) |
no annotation | 4 | ALA A 506TYR A 508ALA A 503TYR A 504 | None | 1.30A | 2wlkA-5na7A:undetectable2wlkB-5na7A:undetectable | 2wlkA-5na7A:16.762wlkB-5na7A:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nd5 | TRANSKETOLASE (Chlamydomonasreinhardtii) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | ALA A 371TYR A 373ALA A 367TYR A 369 | None | 1.17A | 2wlkA-5nd5A:undetectable2wlkB-5nd5A:undetectable | 2wlkA-5nd5A:18.732wlkB-5nd5A:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ot1 | PULLULANASE TYPE II,GH13 FAMILY (Thermococcuskodakarensis) |
no annotation | 4 | ALA A 583TYR A 581ALA A 194TYR A 585 | None | 1.27A | 2wlkA-5ot1A:3.62wlkB-5ot1A:3.3 | 2wlkA-5ot1A:16.422wlkB-5ot1A:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vrb | TRANSKETOLASE (Neisseriagonorrhoeae) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | ALA A 313TYR A 315ALA A 309TYR A 311 | None | 1.19A | 2wlkA-5vrbA:undetectable2wlkB-5vrbA:undetectable | 2wlkA-5vrbA:19.162wlkB-5vrbA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wx1 | SERINE PROTEASE NS3 (Pestivirus C) |
PF00271(Helicase_C)PF05578(Peptidase_S31)PF07652(Flavi_DEAD) | 4 | ALA A 450TYR A 427ALA A 453TYR A 429 | None | 0.95A | 2wlkA-5wx1A:undetectable2wlkB-5wx1A:undetectable | 2wlkA-5wx1A:17.302wlkB-5wx1A:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xbf | UNCONVENTIONALMYOSIN-VIIB (Homo sapiens) |
PF00373(FERM_M)PF00784(MyTH4) | 4 | ALA A1935TYR A1939ALA A1981TYR A1982 | None | 1.18A | 2wlkA-5xbfA:undetectable2wlkB-5xbfA:undetectable | 2wlkA-5xbfA:19.582wlkB-5xbfA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zvs | VP2 (Aquareovirus C) |
no annotation | 4 | ALA 2 955TYR 2 879ALA 2 951TYR 2 953 | None | 1.31A | 2wlkA-5zvs2:undetectable2wlkB-5zvs2:undetectable | 2wlkA-5zvs2:13.472wlkB-5zvs2:13.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6aoj | CEG4 (Legionellapneumophila) |
no annotation | 4 | ALA A 60TYR A 62ALA A 56TYR A 116 | None | 1.19A | 2wlkA-6aojA:undetectable2wlkB-6aojA:undetectable | 2wlkA-6aojA:14.432wlkB-6aojA:14.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfw | MONOVALENT CATION/H+ANTIPORTER SUBUNIT D (Pyrococcusfuriosus) |
no annotation | 4 | ALA H 154TYR H 150ALA H 165TYR H 169 | None | 1.24A | 2wlkA-6cfwH:2.52wlkB-6cfwH:2.2 | 2wlkA-6cfwH:16.722wlkB-6cfwH:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cmj | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE KINASE 2 (Homo sapiens) |
no annotation | 4 | ALA A 182TYR A 183ALA A 192TYR A 190 | NoneNoneF6J A 501 (-3.4A)None | 1.28A | 2wlkA-6cmjA:undetectable2wlkB-6cmjA:undetectable | 2wlkA-6cmjA:10.962wlkB-6cmjA:10.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cp7 | ATP SYNTHASE SUBUNITF, MITOCHONDRIAL (Saccharomycescerevisiae) |
no annotation | 4 | ALA U 53TYR U 55ALA U 49TYR U 51 | None | 1.29A | 2wlkA-6cp7U:undetectable2wlkB-6cp7U:undetectable | 2wlkA-6cp7U:15.982wlkB-6cp7U:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dde | SCFV16 (Mus musculus) |
no annotation | 4 | ALA E 49TYR E 50ALA E 61TYR E 59 | None | 1.30A | 2wlkA-6ddeE:3.42wlkB-6ddeE:3.1 | 2wlkA-6ddeE:15.022wlkB-6ddeE:15.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en3 | ENDO-BETA-N-ACETYLGLUCOSAMINIDASEF2,MULTIFUNCTIONAL-AUTOPROCESSINGREPEATS-IN-TOXIN (Streptococcuspyogenes;Vibrio cholerae) |
no annotation | 4 | ALA A 684TYR A 685ALA A 680TYR A 682 | None | 1.02A | 2wlkA-6en3A:2.52wlkB-6en3A:2.2 | 2wlkA-6en3A:10.962wlkB-6en3A:10.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fmq | - (-) |
no annotation | 4 | ALA A 331TYR A 329ALA A 376TYR A 396 | None | 1.09A | 2wlkA-6fmqA:undetectable2wlkB-6fmqA:undetectable | 2wlkA-6fmqA:undetectable2wlkB-6fmqA:undetectable |