SIMILAR PATTERNS OF AMINO ACIDS FOR 2WLJ_A_SPMA1303

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3x PYRUVATE KINASE

(Saccharomyces
cerevisiae)
PF00224
(PK)
PF02887
(PK_C)
3 ARG A  20
ARG A 415
PRO A 416
None
1.05A 2wljA-1a3xA:
0.0
2wljA-1a3xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3x PYRUVATE KINASE

(Saccharomyces
cerevisiae)
PF00224
(PK)
PF02887
(PK_C)
3 ARG A 431
ARG A 428
PRO A 427
None
1.01A 2wljA-1a3xA:
0.0
2wljA-1a3xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)


(Rattus
norvegicus)
PF00043
(GST_C)
PF02798
(GST_N)
3 ARG A 107
ARG A  10
PRO A  15
None
0.87A 2wljA-1b4pA:
0.0
2wljA-1b4pA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
3 ARG A 181
ARG A 127
PRO A 121
None
0.94A 2wljA-1ciyA:
0.3
2wljA-1ciyA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3b GLUTATHIONE
S-TRANSFERASE YA
CHAIN


(Mus musculus)
PF00043
(GST_C)
PF02798
(GST_N)
3 ARG A  12
ARG A  19
PRO A 205
None
1.11A 2wljA-1f3bA:
3.0
2wljA-1f3bA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5a POLY(A) POLYMERASE

(Bos taurus)
PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central)
3 ARG A 196
ARG A 199
PRO A 155
None
1.08A 2wljA-1f5aA:
0.0
2wljA-1f5aA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g70 RSG-1.2 PEPTIDE

(Human
immunodeficiency
virus 1)
no annotation 3 ARG B  17
ARG B  14
PRO B   9
U  A  66 ( 2.7A)
G  A  70 ( 3.2A)
U  A  66 ( 3.9A)
0.99A 2wljA-1g70B:
undetectable
2wljA-1g70B:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa)
PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target)
3 ARG A 392
ARG A 563
PRO A 559
None
0.84A 2wljA-1ikpA:
2.5
2wljA-1ikpA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE


(Thermus
thermophilus)
PF01293
(PEPCK_ATP)
3 ARG A 340
ARG A 420
PRO A 419
PO4  A2004 (-2.4A)
None
None
1.08A 2wljA-1j3bA:
undetectable
2wljA-1j3bA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli)
PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12)
3 ARG A 896
ARG A 900
PRO A 899
None
1.09A 2wljA-1k7yA:
2.5
2wljA-1k7yA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kn6 PROHORMONE
CONVERTASE 1


(Mus musculus)
PF16470
(S8_pro-domain)
3 ARG A  51
ARG A  50
PRO A  49
None
1.02A 2wljA-1kn6A:
undetectable
2wljA-1kn6A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lsh LIPOVITELLIN (LV-2)

(Ichthyomyzon
unicuspis)
PF09175
(DUF1944)
3 ARG B1505
ARG B1506
PRO B1504
None
0.98A 2wljA-1lshB:
undetectable
2wljA-1lshB:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE


(Methylococcus
capsulatus)
PF02332
(Phenol_Hydrox)
3 ARG B  42
ARG B 103
PRO B 101
None
0.88A 2wljA-1mtyB:
2.1
2wljA-1mtyB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opg OPG2 FAB (HEAVY
CHAIN)


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
3 ARG H 200
ARG H 225
PRO H 138
None
1.08A 2wljA-1opgH:
3.4
2wljA-1opgH:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qm9 POLYPYRIMIDINE
TRACT-BINDING
PROTEIN


(Homo sapiens)
PF00076
(RRM_1)
PF13893
(RRM_5)
3 ARG A 158
ARG A  72
PRO A  70
None
0.84A 2wljA-1qm9A:
undetectable
2wljA-1qm9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3d CRYPTOCHROME 1
APOPROTEIN


(Arabidopsis
thaliana)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
3 ARG A 313
ARG A 378
PRO A 314
None
1.09A 2wljA-1u3dA:
undetectable
2wljA-1u3dA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)


(Escherichia
coli)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
3 ARG A 501
ARG A 380
PRO A 381
None
1.00A 2wljA-1uaaA:
undetectable
2wljA-1uaaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf1 GLUTATHIONE
S-TRANSFERASE 3


(Gallus gallus)
PF02798
(GST_N)
PF14497
(GST_C_3)
3 ARG A  13
ARG A  20
PRO A 206
None
1.08A 2wljA-1vf1A:
undetectable
2wljA-1vf1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg6 HYPOTHETICAL PROTEIN
(RIKEN CDNA
2810455B10)


(Mus musculus)
PF00595
(PDZ)
3 ARG A 120
ARG A 121
PRO A 124
None
1.03A 2wljA-1wg6A:
undetectable
2wljA-1wg6A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlk FMN-BINDING PROTEIN

(Desulfovibrio
vulgaris)
PF01243
(Putative_PNPOx)
3 ARG A  43
ARG A  92
PRO A  96
None
1.09A 2wljA-1wlkA:
undetectable
2wljA-1wlkA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbo HYPOTHETICAL PROTEIN
BPP1347


(Bordetella
parapertussis)
PF02190
(LON_substr_bdg)
3 ARG A 155
ARG A 165
PRO A 153
None
0.96A 2wljA-1zboA:
undetectable
2wljA-1zboA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E


(Pyrococcus
abyssi)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD)
3 ARG C 340
ARG C 412
PRO C 408
None
0.89A 2wljA-1zq1C:
undetectable
2wljA-1zq1C:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE


(Thermus
thermophilus)
PF01053
(Cys_Met_Meta_PP)
3 ARG A  93
ARG A 142
PRO A 227
None
1.04A 2wljA-2cb1A:
undetectable
2wljA-2cb1A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cja SERYL-TRNA
SYNTHETASE


(Methanosarcina
barkeri)
no annotation 3 ARG A 143
ARG A 147
PRO A 145
None
0.74A 2wljA-2cjaA:
undetectable
2wljA-2cjaA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dnm SRP46 SPLICING
FACTOR


(Homo sapiens)
PF00076
(RRM_1)
3 ARG A  47
ARG A  55
PRO A  54
None
1.11A 2wljA-2dnmA:
undetectable
2wljA-2dnmA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE


(Escherichia
coli)
PF01019
(G_glu_transpept)
3 ARG A 114
ARG A 459
PRO A 460
None
1.01A 2wljA-2e0wA:
undetectable
2wljA-2e0wA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eke UBIQUITIN-LIKE
PROTEIN SMT3


(Saccharomyces
cerevisiae)
PF11976
(Rad60-SLD)
3 ARG C1046
ARG C1047
PRO C1044
None
1.01A 2wljA-2ekeC:
undetectable
2wljA-2ekeC:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtl EXTRACELLULAR
HEMOGLOBIN LINKER L2
SUBUNIT
EXTRACELLULAR
HEMOGLOBIN LINKER L3
SUBUNIT


(Lumbricus
terrestris)
PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C)
3 ARG O  38
ARG O  43
PRO N  43
None
0.85A 2wljA-2gtlO:
undetectable
2wljA-2gtlO:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A)
PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C)
3 ARG A 923
ARG A 604
PRO A 545
None
1.11A 2wljA-2inyA:
undetectable
2wljA-2inyA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens)
PF01979
(Amidohydro_1)
3 ARG A 369
ARG A 318
PRO A 315
None
0.99A 2wljA-2oodA:
undetectable
2wljA-2oodA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1n PROTEIN KIN HOMOLOG

(Homo sapiens)
PF10357
(Kin17_mid)
3 ARG A 101
ARG A 102
PRO A  97
None
0.97A 2wljA-2v1nA:
undetectable
2wljA-2v1nA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa)
PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc)
3 ARG A 728
ARG A 708
PRO A 707
None
0.94A 2wljA-2vz9A:
undetectable
2wljA-2vz9A:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274)
PF00067
(p450)
3 ARG A 145
ARG A 144
PRO A 146
None
1.12A 2wljA-2z3tA:
undetectable
2wljA-2z3tA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN


(Solanum
tuberosum)
PF00225
(Kinesin)
3 ARG A 897
ARG A 895
PRO A 898
None
ADP  A 600 (-4.0A)
ADP  A 600 (-4.7A)
1.12A 2wljA-3cobA:
undetectable
2wljA-3cobA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlv SIGNAL RECOGNITION
PARTICLE 19 KDA
PROTEIN


(Pyrococcus
furiosus)
no annotation 3 ARG B  17
ARG B  25
PRO B  24
None
1.03A 2wljA-3dlvB:
undetectable
2wljA-3dlvB:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edl KINESIN13 MOTOR
DOMAIN


(Drosophila
melanogaster)
PF00225
(Kinesin)
3 ARG D  80
ARG D  78
PRO D  81
None
ANP  D 500 ( 3.7A)
ANP  D 500 ( 4.7A)
1.05A 2wljA-3edlD:
undetectable
2wljA-3edlD:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE


(Bacteroides
vulgatus)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
3 ARG A 188
ARG A 399
PRO A 433
None
1.04A 2wljA-3gm8A:
4.1
2wljA-3gm8A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE


(Thermus
thermophilus)
PF00271
(Helicase_C)
3 ARG A 444
ARG A 449
PRO A 443
None
1.12A 2wljA-3i32A:
undetectable
2wljA-3i32A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izq ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN


(Saccharomyces
cerevisiae)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF08938
(HBS1_N)
3 ARG 1 540
ARG 1 537
PRO 1 521
None
0.92A 2wljA-3izq1:
undetectable
2wljA-3izq1:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2u KINESIN-LIKE PROTEIN
KLP10A


(Drosophila
melanogaster)
PF00225
(Kinesin)
3 ARG K 286
ARG K 284
PRO K 287
None
1.04A 2wljA-3j2uK:
undetectable
2wljA-3j2uK:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j70 ENVELOPE
GLYCOPROTEIN GP120


(Human
immunodeficiency
virus 1)
PF00516
(GP120)
3 ARG D 311
ARG D 308
PRO D 313
None
0.76A 2wljA-3j70D:
undetectable
2wljA-3j70D:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4p TERMINASE SUBUNIT
UL89 PROTEIN


(Human
betaherpesvirus
5)
PF02499
(DNA_pack_C)
3 ARG A 670
ARG A 672
PRO A 567
None
1.12A 2wljA-3n4pA:
undetectable
2wljA-3n4pA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB


(Thermus
thermophilus)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
3 ARG A 305
ARG A 222
PRO A 302
None
0.93A 2wljA-3oa0A:
undetectable
2wljA-3oa0A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olq UNIVERSAL STRESS
PROTEIN E


(Proteus
mirabilis)
PF00582
(Usp)
3 ARG A  22
ARG A  23
PRO A  19
UNL  A 321 ( 3.4A)
UNL  A 321 ( 4.6A)
None
1.08A 2wljA-3olqA:
undetectable
2wljA-3olqA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9b VIPERA RUSSELLI
PROTEINASE RVV-V
GAMMA


(Daboia
siamensis)
PF00089
(Trypsin)
3 ARG A 110
ARG A  86
PRO A 111
None
0.85A 2wljA-3s9bA:
undetectable
2wljA-3s9bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0q AGR253WP

(Eremothecium
gossypii)
PF00225
(Kinesin)
3 ARG A 374
ARG A 372
PRO A 375
ADP  A 999 (-4.6A)
ADP  A 999 (-3.2A)
ADP  A 999 (-4.4A)
1.11A 2wljA-3t0qA:
1.3
2wljA-3t0qA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdw GENTAMICIN
RESISTANCE PROTEIN


(Enterococcus
gallinarum)
PF01636
(APH)
3 ARG A 115
ARG A 209
PRO A 212
None
1.11A 2wljA-3tdwA:
undetectable
2wljA-3tdwA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A


(Coxiella
burnetii)
PF00398
(RrnaAD)
3 ARG A 214
ARG A 241
PRO A 242
None
0.93A 2wljA-3tqsA:
undetectable
2wljA-3tqsA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tts BETA-GALACTOSIDASE

(Bacillus
circulans)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
3 ARG A 394
ARG A 295
PRO A 302
None
1.13A 2wljA-3ttsA:
undetectable
2wljA-3ttsA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1


(Cyanidioschyzon
merolae)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
3 ARG A 424
ARG A 493
PRO A 511
None
1.06A 2wljA-3wmeA:
4.0
2wljA-3wmeA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdb PROTEIN XNI

(Escherichia
coli)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
3 ARG A  15
ARG A  70
PRO A  71
None
1.01A 2wljA-3zdbA:
undetectable
2wljA-3zdbA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zj0 ACETYLTRANSFERASE

(Oceanicola
granulosus)
PF00583
(Acetyltransf_1)
3 ARG A  93
ARG A 118
PRO A 119
None
1.11A 2wljA-3zj0A:
undetectable
2wljA-3zj0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ab4 XENOBIOTIC REDUCTASE
B


(Pseudomonas
putida)
PF00724
(Oxidored_FMN)
3 ARG A 348
ARG A 320
PRO A 315
None
1.13A 2wljA-4ab4A:
undetectable
2wljA-4ab4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad8 DNA REPAIR PROTEIN
RECN


(Deinococcus
radiodurans)
PF02463
(SMC_N)
3 ARG A 496
ARG A  33
PRO A  32
None
0.97A 2wljA-4ad8A:
3.0
2wljA-4ad8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2


(Homo sapiens)
PF10250
(O-FucT)
3 ARG A 295
ARG A 303
PRO A 307
None
1.06A 2wljA-4ap5A:
undetectable
2wljA-4ap5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awl NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT ALPHA


(Homo sapiens)
PF02045
(CBFB_NFYA)
3 ARG A 267
ARG A 266
PRO A 263
None
0.75A 2wljA-4awlA:
undetectable
2wljA-4awlA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE


(Burkholderia
thailandensis)
PF00795
(CN_hydrolase)
PF02540
(NAD_synthase)
3 ARG A 501
ARG A  57
PRO A  58
None
1.14A 2wljA-4f4hA:
undetectable
2wljA-4f4hA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc8 TRANSCRIPTION
PROTEIN RTR1


(Kluyveromyces
lactis)
PF04181
(RPAP2_Rtr1)
3 ARG A  53
ARG A 134
PRO A 144
None
1.01A 2wljA-4fc8A:
undetectable
2wljA-4fc8A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri)
PF13412
(HTH_24)
PF14520
(HHH_5)
3 ARG A 231
ARG A 436
PRO A 220
None
0.98A 2wljA-4gfjA:
2.9
2wljA-4gfjA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hj2 GLUTATHIONE
S-TRANSFERASE A1


(Homo sapiens)
PF00043
(GST_C)
PF02798
(GST_N)
3 ARG A  13
ARG A  20
PRO A 206
None
1.09A 2wljA-4hj2A:
undetectable
2wljA-4hj2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inq OXYSTEROL-BINDING
PROTEIN HOMOLOG 3


(Saccharomyces
cerevisiae)
PF01237
(Oxysterol_BP)
3 ARG A 713
ARG A 716
PRO A 667
None
0.99A 2wljA-4inqA:
undetectable
2wljA-4inqA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jed GLUTATHIONE
S-TRANSFERASE


(Methylobacterium
radiotolerans)
PF13410
(GST_C_2)
PF13417
(GST_N_3)
3 ARG A 116
ARG A 174
PRO A 176
None
None
GOL  A 301 (-4.5A)
1.06A 2wljA-4jedA:
undetectable
2wljA-4jedA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA


(Mycobacterium
tuberculosis)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
3 ARG A 392
ARG A 276
PRO A 277
None
1.05A 2wljA-4kbmA:
undetectable
2wljA-4kbmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kng E3 UBIQUITIN-PROTEIN
LIGASE RNF43


(Homo sapiens)
no annotation 3 ARG E 113
ARG E 114
PRO E 112
None
0.89A 2wljA-4kngE:
undetectable
2wljA-4kngE:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ljp E3 UBIQUITIN-PROTEIN
LIGASE RNF31


(Homo sapiens)
no annotation 3 ARG A 928
ARG A1032
PRO A 927
None
1.03A 2wljA-4ljpA:
undetectable
2wljA-4ljpA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m3o KLLA0F12672P

(Kluyveromyces
lactis)
PF04181
(RPAP2_Rtr1)
3 ARG A  53
ARG A 134
PRO A 144
None
0.98A 2wljA-4m3oA:
undetectable
2wljA-4m3oA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4r LPS-ASSEMBLY
LIPOPROTEIN LPTE
LPS-ASSEMBLY PROTEIN
LPTD


(Salmonella
enterica)
PF04390
(LptE)
PF04453
(OstA_C)
3 ARG A 326
ARG B  49
PRO B  46
None
1.10A 2wljA-4n4rA:
undetectable
2wljA-4n4rA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
3 ARG A 505
ARG A 124
PRO A 122
None
1.08A 2wljA-4oqjA:
undetectable
2wljA-4oqjA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D


(Homo sapiens)
PF12706
(Lactamase_B_2)
3 ARG A 164
ARG A 167
PRO A 169
None
SO4  A 508 (-2.6A)
None
1.11A 2wljA-4qn9A:
undetectable
2wljA-4qn9A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN


(Nitratireductor
pacificus)
PF12838
(Fer4_7)
PF13486
(Dehalogenase)
3 ARG A   9
ARG A   2
PRO A  15
None
1.13A 2wljA-4rasA:
0.7
2wljA-4rasA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rul DNA TOPOISOMERASE 1

(Escherichia
coli)
PF01131
(Topoisom_bac)
PF01396
(zf-C4_Topoisom)
PF01751
(Toprim)
PF08272
(Topo_Zn_Ribbon)
3 ARG A 207
ARG A 476
PRO A 474
None
1.10A 2wljA-4rulA:
undetectable
2wljA-4rulA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ug4 CHOLINE SULFATASE

(Sinorhizobium
meliloti)
PF00884
(Sulfatase)
PF12411
(Choline_sulf_C)
3 ARG A 510
ARG A 507
PRO A 509
None
1.05A 2wljA-4ug4A:
undetectable
2wljA-4ug4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us7 PILD PROCESSED
PROTEIN


(Shewanella
oneidensis)
PF16732
(ComP_DUS)
3 ARG A  64
ARG A   5
PRO A  40
None
1.09A 2wljA-4us7A:
undetectable
2wljA-4us7A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqe THIOSULFATE
DEHYDROGENASE


(Allochromatium
vinosum)
PF13442
(Cytochrome_CBB3)
3 ARG A 177
ARG A  50
PRO A  36
None
1.11A 2wljA-4wqeA:
undetectable
2wljA-4wqeA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE


(Candida
albicans)
PF02358
(Trehalose_PPase)
3 ARG A 143
ARG A 142
PRO A  37
None
TRE  A 403 (-3.8A)
TRE  A 403 (-4.0A)
1.07A 2wljA-5dxiA:
3.1
2wljA-5dxiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis)
PF05147
(LANC_like)
PF13575
(DUF4135)
3 ARG A 514
ARG A 510
PRO A 511
None
1.05A 2wljA-5dztA:
1.9
2wljA-5dztA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkc BETA-FRUCTOFURANOSID
ASE


(Xanthophyllomyces
dendrorhous)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
3 ARG A 387
ARG A 459
PRO A 462
None
0.96A 2wljA-5fkcA:
undetectable
2wljA-5fkcA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri)
PF13412
(HTH_24)
PF14520
(HHH_5)
3 ARG A 231
ARG A 436
PRO A 220
None
1.12A 2wljA-5hm5A:
2.1
2wljA-5hm5A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
no annotation 3 ARG A 497
ARG A 481
PRO A 474
None
SO4  A 704 (-4.0A)
None
1.11A 2wljA-5ic7A:
undetectable
2wljA-5ic7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip4 NEURONAL MIGRATION
PROTEIN DOUBLECORTIN


(Homo sapiens)
PF03607
(DCX)
3 ARG D 267
ARG D 273
PRO D 272
None
1.06A 2wljA-5ip4D:
undetectable
2wljA-5ip4D:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE


(Mycobacterium
tuberculosis)
PF12697
(Abhydrolase_6)
3 ARG A 228
ARG A 230
PRO A 128
None
1.04A 2wljA-5jzbA:
undetectable
2wljA-5jzbA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN


(Pyrococcus
abyssi)
PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI)
3 ARG B 304
ARG B 570
PRO B 566
None
0.99A 2wljA-5lw7B:
undetectable
2wljA-5lw7B:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN


(Pyrococcus
abyssi)
PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI)
3 ARG B 304
ARG B 572
PRO B 566
None
1.00A 2wljA-5lw7B:
undetectable
2wljA-5lw7B:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens)
PF03098
(An_peroxidase)
3 ARG A 529
ARG A 536
PRO A 526
None
1.06A 2wljA-5mfaA:
undetectable
2wljA-5mfaA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN


(Bacteroides
thetaiotaomicron)
PF17132
(Glyco_hydro_106)
3 ARG A 714
ARG A 753
PRO A 751
None
1.03A 2wljA-5mqmA:
undetectable
2wljA-5mqmA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oq3 CWP19

(Clostridioides
difficile)
no annotation 3 ARG A 132
ARG A  79
PRO A  80
None
0.99A 2wljA-5oq3A:
undetectable
2wljA-5oq3A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovy PUTATIVE
TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY


(Mycobacteroides
abscessus)
no annotation 3 ARG B 197
ARG B 148
PRO B 149
None
1.01A 2wljA-5ovyB:
undetectable
2wljA-5ovyB:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t06 ACYL-COA THIOESTER
HYDROLASE YBGC


(Escherichia
coli)
PF03061
(4HBT)
3 ARG A  54
ARG A 122
PRO A 116
None
1.06A 2wljA-5t06A:
undetectable
2wljA-5t06A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1


(Alicyclobacillus
acidoterrestris)
no annotation 3 ARG A  50
ARG A  51
PRO A  53
None
0.91A 2wljA-5u30A:
3.5
2wljA-5u30A:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 1


(Homo sapiens)
PF00004
(AAA)
PF09079
(Cdc6_C)
3 ARG A 720
ARG A 721
PRO A 536
ATP  A 900 (-3.9A)
None
ATP  A 900 (-4.0A)
1.00A 2wljA-5uj7A:
undetectable
2wljA-5uj7A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1


(Homo sapiens)
PF00004
(AAA)
PF09079
(Cdc6_C)
3 ARG A 720
ARG A 721
PRO A 536
ATP  A 901 (-3.9A)
None
ATP  A 901 (-4.0A)
1.00A 2wljA-5ujmA:
undetectable
2wljA-5ujmA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE


(Streptococcus
pneumoniae)
no annotation 3 ARG A  30
ARG A 334
PRO A 333
None
1.01A 2wljA-5wpkA:
undetectable
2wljA-5wpkA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq8 TYPE II SECRETION
SYSTEM PROTEIN D


(Vibrio cholerae)
PF00263
(Secretin)
PF03958
(Secretin_N)
3 ARG A 633
ARG A 634
PRO A 627
None
0.87A 2wljA-5wq8A:
undetectable
2wljA-5wq8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7u TREHALOSE SYNTHASE

(Thermobaculum
terrenum)
no annotation 3 ARG A 343
ARG A 307
PRO A 347
None
0.89A 2wljA-5x7uA:
undetectable
2wljA-5x7uA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN


(SFTS
phlebovirus)
PF07243
(Phlebovirus_G1)
3 ARG C 332
ARG C 132
PRO C 120
None
0.84A 2wljA-5y10C:
undetectable
2wljA-5y10C:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5


(Homo sapiens)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N)
3 ARG B 502
ARG B 497
PRO B 501
None
1.05A 2wljA-5y3rB:
undetectable
2wljA-5y3rB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans)
no annotation 3 ARG A 352
ARG A 316
PRO A 356
None
0.86A 2wljA-5ykbA:
undetectable
2wljA-5ykbA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f71 GLUTATHIONE
TRANSFERASE


(Trametes
versicolor)
no annotation 3 ARG A 174
ARG A  20
PRO A  18
None
1.07A 2wljA-6f71A:
undetectable
2wljA-6f71A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fbt LYTIC MUREIN
TRANSGLYCOSYLASE


(Pseudomonas
aeruginosa)
no annotation 3 ARG A 426
ARG A 459
PRO A 456
None
1.02A 2wljA-6fbtA:
undetectable
2wljA-6fbtA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gww PEROXIREDOXIN

(Sulfolobus
islandicus)
no annotation 3 ARG A 155
ARG A 158
PRO A 175
None
1.13A 2wljA-6gwwA:
undetectable
2wljA-6gwwA:
13.56