SIMILAR PATTERNS OF AMINO ACIDS FOR 2WKO_F_CUF154_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  60
HIS A 106
HIS A 104
HIS A 450
 CU  A 557 ( 3.1A)
CU  A 555 (-3.3A)
CU  A 556 (-3.1A)
CU  A 555 ( 3.2A)
 0.95A 2wkoF-1asoA:
undetectable		 2wkoF-1asoA:
13.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b4t PROTEIN (CU/ZN
SUPEROXIDE
DISMUTASE)

(Saccharomyces
cerevisiae) 		PF00080
(Sod_Cu) 		4 HIS A  46
HIS A  63
VAL A 118
HIS A 120
 CU  A 154 ( 3.0A)
ZN  A 155 (-3.0A)
None
CU  A 154 (-3.3A)
 0.32A 2wkoF-1b4tA:
29.8		 2wkoF-1b4tA:
52.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A 240
HIS A 244
VAL A 277
HIS A 274
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
 0.89A 2wkoF-1bt2A:
undetectable		 2wkoF-1bt2A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqs PROTEIN
(3-DEHYDROQUINATE
SYNTHASE)

(Aspergillus
nidulans) 		PF01761
(DHQ_synthase) 		4 HIS A 275
HIS A 271
VAL A 291
HIS A 287
 CRB  A 401 (-4.2A)
ZN  A 402 ( 3.1A)
None
ZN  A 402 (-3.3A)
 0.98A 2wkoF-1dqsA:
undetectable		 2wkoF-1dqsA:
17.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eqw CU,ZN SUPEROXIDE
DISMUTASE

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		4 HIS A  44
HIS A  46
HIS A  61
HIS A 118
 CU  A 502 (-3.3A)
CU  A 502 (-3.2A)
ZN  A 501 ( 3.2A)
CU  A 502 (-3.1A)
 0.34A 2wkoF-1eqwA:
18.8		 2wkoF-1eqwA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eso CU, ZN SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00080
(Sod_Cu) 		4 HIS A  44
HIS A  46
HIS A  61
HIS A 118
 CU  A 150 ( 3.2A)
CU  A 150 ( 3.3A)
ZN  A 149 ( 3.2A)
CU  A 150 ( 3.2A)
 0.23A 2wkoF-1esoA:
19.3		 2wkoF-1esoA:
32.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A 111
HIS A 109
HIS A 400
 CU  A1502 (-3.1A)
CU  A1501 (-3.4A)
CU  A1500 (-3.3A)
CU  A1501 ( 3.2A)
 1.03A 2wkoF-1gycA:
undetectable		 2wkoF-1gycA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A 111
HIS A 109
HIS A 401
 CU  A 703 (-4.7A)
CU  A 702 (-3.2A)
CU  A 703 (-3.2A)
CU  A 702 (-3.2A)
 1.04A 2wkoF-1hfuA:
undetectable		 2wkoF-1hfuA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00465
(Fe-ADH) 		4 HIS A 259
HIS A 256
VAL A 278
HIS A 274
 None
ZN  A 371 (-3.2A)
None
ZN  A 371 (-3.3A)
 0.94A 2wkoF-1jpuA:
undetectable		 2wkoF-1jpuA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 HIS A 255
HIS A 252
VAL A 273
HIS A 269
 None
ZN  A 401 (-3.2A)
None
ZN  A 401 ( 3.3A)
 1.06A 2wkoF-1kq3A:
undetectable		 2wkoF-1kq3A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00903
(Glyoxalase) 		4 HIS A 146
HIS A 195
VAL A 148
HIS A 210
 FE2  A 500 ( 3.5A)
BP6  A 300 (-4.2A)
BP6  A 300 (-4.4A)
FE2  A 500 ( 3.5A)
 0.99A 2wkoF-1lkdA:
undetectable		 2wkoF-1lkdA:
16.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oal SUPEROXIDE DISMUTASE

(Photobacterium
leiognathi) 		PF00080
(Sod_Cu) 		4 HIS A  45
HIS A  47
HIS A  70
HIS A 125
 CU  A 153 (-3.0A)
CU  A 153 (-3.1A)
ZN  A 152 ( 3.1A)
CU  A 153 (-3.2A)
 0.19A 2wkoF-1oalA:
20.3		 2wkoF-1oalA:
31.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p1v SUPEROXIDE DISMUTASE
[CU-ZN]

(Homo sapiens) 		PF00080
(Sod_Cu) 		5 HIS A  46
HIS A  48
HIS A  63
VAL A 118
HIS A 120
 ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
ZN  A 202 (-3.1A)
None
ZN  A 201 ( 3.2A)
 0.35A 2wkoF-1p1vA:
30.7		 2wkoF-1p1vA:
98.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER
PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides;
Rhodobacter
sphaeroides) 		PF00124
(Photo_RC)
PF00124
(Photo_RC) 		4 HIS M 219
HIS L 190
HIS L 230
HIS M 266
 FE  M 302 ( 3.3A)
FE  M 302 ( 3.3A)
FE  M 302 (-3.4A)
FE  M 302 (-3.3A)
 1.01A 2wkoF-1pssM:
undetectable		 2wkoF-1pssM:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzs SUPEROXIDE DISMUTASE
[CU-ZN]

(Mycobacterium
tuberculosis) 		PF00080
(Sod_Cu) 		4 HIS A  47
HIS A  49
HIS A  75
HIS A 126
 CU  A 172 (-3.1A)
CU  A 172 (-3.2A)
CU  A 172 (-4.1A)
CU  A 172 (-3.2A)
 0.19A 2wkoF-1pzsA:
18.6		 2wkoF-1pzsA:
27.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1srd COPPER,ZINC
SUPEROXIDE DISMUTASE

(Spinacia
oleracea) 		PF00080
(Sod_Cu) 		5 HIS A  46
HIS A  48
HIS A  63
VAL A 118
HIS A 120
 CU  A 155 (-3.0A)
CU  A 155 (-3.2A)
CU  A 155 ( 3.2A)
None
CU  A 155 (-3.0A)
 0.38A 2wkoF-1srdA:
28.9		 2wkoF-1srdA:
55.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sxz PROTEIN (CU-ZN
SUPEROXIDE
DISMUTASE)

(Bos taurus) 		PF00080
(Sod_Cu) 		5 HIS A  44
HIS A  46
HIS A  61
VAL A 116
HIS A 118
 CU  A 152 ( 3.1A)
CU  A 152 (-3.4A)
ZN  A 153 ( 3.1A)
None
CU  A 152 (-3.2A)
 0.28A 2wkoF-1sxzA:
31.2		 2wkoF-1sxzA:
81.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta9 GLYCEROL
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00465
(Fe-ADH) 		4 HIS A 318
HIS A 315
VAL A 337
HIS A 333
 None
ZN  A1502 (-3.4A)
None
ZN  A1502 ( 3.4A)
 1.01A 2wkoF-1ta9A:
undetectable		 2wkoF-1ta9A:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1to5 SUPEROXIDE DISMUTASE

(Schistosoma
mansoni) 		PF00080
(Sod_Cu) 		5 HIS A  45
HIS A  47
HIS A  62
VAL A 117
HIS A 119
 CU  A 712 (-3.3A)
CU  A 712 (-3.4A)
ZN  A 711 ( 3.1A)
CU  A 712 ( 4.7A)
CU  A 712 (-3.2A)
 0.22A 2wkoF-1to5A:
30.3		 2wkoF-1to5A:
57.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		4 HIS A 190
HIS A 194
VAL A 219
HIS A 216
 CU  A 401 ( 3.2A)
CU  A 401 ( 3.2A)
None
CU  A 401 ( 3.4A)
 0.98A 2wkoF-1wx4A:
undetectable		 2wkoF-1wx4A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xaj 3-DEHYDROQUINATE
SYNTHASE

(Staphylococcus
aureus) 		PF01761
(DHQ_synthase) 		4 HIS A 246
HIS A 242
VAL A 260
HIS A 256
 CRB  A 500 (-4.1A)
CRB  A 500 ( 3.9A)
None
ZN  A 600 ( 3.5A)
 1.06A 2wkoF-1xajA:
undetectable		 2wkoF-1xajA:
23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xso COPPER,ZINC
SUPEROXIDE DISMUTASE

(Xenopus laevis) 		PF00080
(Sod_Cu) 		5 HIS A  44
HIS A  46
HIS A  61
VAL A 116
HIS A 118
 CU  A   1 ( 3.0A)
CU  A   1 ( 3.4A)
ZN  A 152 (-3.1A)
None
CU  A   1 ( 3.3A)
 0.37A 2wkoF-1xsoA:
30.6		 2wkoF-1xsoA:
65.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9n SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		4 HIS A  70
HIS A  72
HIS A  95
HIS A 151
 CU  A 200 (-3.1A)
CU  A 200 (-3.2A)
ZN  A 201 ( 3.1A)
CU  A 200 (-3.2A)
 0.19A 2wkoF-1z9nA:
18.9		 2wkoF-1z9nA:
29.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z9p SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		4 HIS A  70
HIS A  72
HIS A  95
HIS A 151
 CU  A 200 (-3.1A)
CU  A 200 (-3.2A)
ZN  A 201 ( 3.1A)
CU  A 200 (-3.2A)
 0.20A 2wkoF-1z9pA:
18.9		 2wkoF-1z9pA:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  81
HIS A 128
HIS A 126
VAL A  96
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1003 (-3.2A)
None
CU1  A1002 ( 3.3A)
 0.99A 2wkoF-1zpuA:
undetectable		 2wkoF-1zpuA:
14.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aps PROTEIN (CU,ZN
SUPEROXIDE
DISMUTASE)

(Actinobacillus
pleuropneumoniae) 		PF00080
(Sod_Cu) 		4 HIS A  60
HIS A  62
HIS A  85
HIS A 141
 CU  A 402 ( 3.3A)
CU  A 402 ( 3.4A)
ZN  A 400 (-3.2A)
CU  A 402 ( 3.1A)
 0.29A 2wkoF-2apsA:
18.9		 2wkoF-2apsA:
31.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aqt SUPEROXIDE DISMUTASE
[CU-ZN]

(Neisseria
meningitidis) 		no annotation 4 HIS C  79
HIS C  81
HIS C 104
HIS C 160
 CU1  C 200 (-3.1A)
CU1  C 200 (-3.3A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.2A)
 0.18A 2wkoF-2aqtC:
19.4		 2wkoF-2aqtC:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2e47 TIME INTERVAL
MEASURING ENZYME
TIME

(Bombyx mori) 		PF00080
(Sod_Cu) 		5 HIS A  50
HIS A  52
HIS A  67
VAL A 122
HIS A 124
 CU  A 171 (-3.1A)
CU  A 171 (-3.2A)
ZN  A 172 ( 3.1A)
None
CU  A 171 (-3.2A)
 0.29A 2wkoF-2e47A:
28.4		 2wkoF-2e47A:
51.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqp HYPOTHETICAL PROTEIN
BP2299

(Bordetella
pertussis) 		PF07883
(Cupin_2) 		4 HIS A  33
HIS A  35
VAL A  74
HIS A  76
 ZN  A 100 (-3.2A)
ZN  A 100 (-3.2A)
None
ZN  A 100 ( 3.5A)
 0.94A 2wkoF-2fqpA:
undetectable		 2wkoF-2fqpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A 111
HIS A 109
HIS A 400
 CU  A 604 ( 3.1A)
CU  A 602 (-3.2A)
CU  A 603 (-3.4A)
CU  A 602 ( 3.2A)
 1.03A 2wkoF-2hzhA:
undetectable		 2wkoF-2hzhA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  64
HIS A 200
VAL A  62
HIS A  67
 None
PPF  A 500 (-3.9A)
None
None
 1.00A 2wkoF-2it4A:
undetectable		 2wkoF-2it4A:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jlp EXTRACELLULAR
SUPEROXIDE DISMUTASE
(CU-ZN)

(Homo sapiens) 		PF00080
(Sod_Cu) 		5 HIS A  96
HIS A  98
HIS A 113
VAL A 161
HIS A 163
 CU  A 225 (-3.2A)
CU  A 225 (-3.2A)
ZN  A 226 ( 3.1A)
CU  A 225 ( 4.6A)
CU  A 225 (-3.2A)
 0.22A 2wkoF-2jlpA:
24.4		 2wkoF-2jlpA:
30.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2k4w SUPEROXIDE DISMUTASE
[CU-ZN]

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		4 HIS A  48
HIS A  50
HIS A  73
HIS A 128
 CU1  A 155 (-3.1A)
CU1  A 155 (-3.3A)
ZN  A 156 ( 3.2A)
CU1  A 155 (-3.0A)
 0.69A 2wkoF-2k4wA:
14.7		 2wkoF-2k4wA:
31.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A 239
HIS A 243
VAL A 275
HIS A 272
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
C2O  A 340 (-3.1A)
 0.93A 2wkoF-2p3xA:
undetectable		 2wkoF-2p3xA:
17.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q2l SUPEROXIDE DISMUTASE

(Potentilla
atrosanguinea) 		PF00080
(Sod_Cu) 		5 HIS A  45
HIS A  47
HIS A  62
VAL A 117
HIS A 119
 None
None
ZN  A1001 (-3.1A)
None
None
 0.28A 2wkoF-2q2lA:
29.3		 2wkoF-2q2lA:
55.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A 111
HIS A 109
HIS A 399
 CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
CU  A 502 (-3.2A)
CU  A 501 ( 3.2A)
 1.00A 2wkoF-2qt6A:
undetectable		 2wkoF-2qt6A:
15.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wwo SUPEROXIDE DISMUTASE
[CU-ZN]

(Yersinia
pseudotuberculosis) 		PF00080
(Sod_Cu) 		4 HIS A  54
HIS A  56
HIS A  79
HIS A 135
 ZN  A1165 (-3.3A)
ZN  A1165 (-3.4A)
ZN  A1162 ( 3.2A)
ZN  A1165 (-3.3A)
 0.28A 2wkoF-2wwoA:
19.3		 2wkoF-2wwoA:
31.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A 111
HIS A 109
HIS A 400
 CU  A 504 ( 3.1A)
CU  A 502 (-3.2A)
CU  A 503 ( 3.2A)
CU  A 502 (-3.2A)
 1.02A 2wkoF-2xybA:
undetectable		 2wkoF-2xybA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 HIS A 259
HIS A 263
VAL A 299
HIS A 296
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
None
CU  A 401 (-3.2A)
 0.86A 2wkoF-2y9xA:
undetectable		 2wkoF-2y9xA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC

(Mycobacterium
tuberculosis) 		PF00903
(Glyoxalase) 		4 HIS A 145
HIS A 200
VAL A 147
HIS A 215
 FE2  A 701 ( 3.3A)
SDT  A 702 (-4.0A)
None
FE2  A 701 ( 3.3A)
 0.92A 2wkoF-2zi8A:
undetectable		 2wkoF-2zi8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  94
HIS A 136
HIS A 134
HIS A 403
 CU  A 703 (-3.0A)
CU  A 701 (-3.2A)
CU  A 702 (-3.1A)
CU  A 701 ( 3.1A)
 1.01A 2wkoF-3abgA:
undetectable		 2wkoF-3abgA:
15.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce1 SUPEROXIDE DISMUTASE
[CU-ZN]

(Naganishia
liquefaciens) 		PF00080
(Sod_Cu) 		5 HIS A  50
HIS A  52
HIS A  67
VAL A 122
HIS A 124
 CU  A 201 (-3.6A)
CU  A 201 (-3.2A)
ZN  A 202 ( 3.1A)
None
CU  A 201 (-3.1A)
 0.25A 2wkoF-3ce1A:
29.9		 2wkoF-3ce1A:
60.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE

(Alvinella
pompejana) 		PF00080
(Sod_Cu) 		5 HIS A  44
HIS A  46
HIS A  61
VAL A 116
HIS A 118
 CU  A 202 ( 2.9A)
CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 4.4A)
CU1  A 201 ( 3.2A)
 0.17A 2wkoF-3f7lA:
30.4		 2wkoF-3f7lA:
61.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcm HYDROLASE, NUDIX
FAMILY

(Clostridium
perfringens) 		PF00293
(NUDIX) 		4 HIS A  43
HIS A 129
HIS A  75
HIS A 127
 MN  A 201 (-3.4A)
MN  A 201 (-3.5A)
MN  A 201 (-3.3A)
MN  A 201 (-3.6A)
 1.06A 2wkoF-3fcmA:
undetectable		 2wkoF-3fcmA:
22.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gtt SUPEROXIDE DISMUTASE
[CU-ZN]

(Mus musculus) 		PF00080
(Sod_Cu) 		5 HIS A  46
HIS A  48
HIS A  63
VAL A 118
HIS A 120
 None
None
ZN  A 155 (-3.2A)
None
None
 0.40A 2wkoF-3gttA:
31.7		 2wkoF-3gttA:
83.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS B 366
HIS B 370
VAL B 409
HIS B 406
 CU  B   1 (-3.3A)
CU  B   1 (-3.2A)
None
CU  B   1 (-3.1A)
 1.01A 2wkoF-3hhsB:
3.9		 2wkoF-3hhsB:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 368
HIS A 372
VAL A 411
HIS A 408
 CU  A 697 (-3.2A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.1A)
 1.00A 2wkoF-3hhsA:
3.0		 2wkoF-3hhsA:
13.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kbe SUPEROXIDE DISMUTASE
[CU-ZN]

(Caenorhabditis
elegans) 		PF00080
(Sod_Cu) 		5 HIS A  45
HIS A  47
HIS A  62
VAL A 117
HIS A 119
 None
 0.62A 2wkoF-3kbeA:
20.0		 2wkoF-3kbeA:
55.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3km2 SUPEROXIDE DISMUTASE
[CU-ZN],
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00080
(Sod_Cu) 		5 HIS A  46
HIS A  48
HIS A  63
VAL A 118
HIS A 120
 None
None
ZN  A 155 (-3.2A)
None
None
 0.32A 2wkoF-3km2A:
29.9		 2wkoF-3km2A:
54.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A 111
HIS A 109
HIS A 405
 CU  A 602 (-3.1A)
CU  A 603 (-3.2A)
CU  A 604 (-3.2A)
CU  A 603 ( 3.0A)
 0.96A 2wkoF-3kw7A:
undetectable		 2wkoF-3kw7A:
16.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l9y SUPEROXIDE DISMUTASE
[CU-ZN]

(Bombyx mori) 		PF00080
(Sod_Cu) 		5 HIS A  45
HIS A  47
HIS A  62
VAL A 118
HIS A 120
 CU  A 156 (-3.2A)
CU  A 156 (-3.2A)
ZN  A 155 ( 3.1A)
CU  A 156 ( 4.4A)
CU  A 156 (-3.1A)
 0.15A 2wkoF-3l9yA:
29.9		 2wkoF-3l9yA:
63.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lag UNCHARACTERIZED
PROTEIN RPA4178

(Rhodopseudomonas
palustris) 		PF07883
(Cupin_2) 		4 HIS A  32
HIS A  34
VAL A  74
HIS A  76
 NI  A  98 ( 3.3A)
NI  A  98 ( 3.2A)
None
NI  A  98 ( 3.4A)
 0.98A 2wkoF-3lagA:
undetectable		 2wkoF-3lagA:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mnd SUPEROXIDE DISMUTASE
[CU-ZN]

(Taenia solium) 		PF00080
(Sod_Cu) 		5 HIS A  43
HIS A  45
HIS A  60
VAL A 115
HIS A 117
 CU  A 155 (-3.1A)
CU  A 155 (-3.5A)
ZN  A 153 ( 3.1A)
None
CU  A 155 (-3.4A)
 0.25A 2wkoF-3mndA:
29.5		 2wkoF-3mndA:
56.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A 111
HIS A 109
HIS A 400
 CU  A1502 ( 3.0A)
CU  A1500 (-3.2A)
CU  A1501 (-3.2A)
CU  A1500 ( 3.2A)
 1.03A 2wkoF-3pxlA:
undetectable		 2wkoF-3pxlA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  65
HIS A 112
HIS A 110
HIS A 402
 CU  A 504 (-3.1A)
CU  A 503 (-3.4A)
CU  A 502 ( 3.5A)
CU  A 503 ( 3.2A)
 1.00A 2wkoF-3t6wA:
undetectable		 2wkoF-3t6wA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		4 HIS A 281
HIS A 278
VAL A 299
HIS A 295
 None
ZN  A 388 (-3.4A)
None
ZN  A 388 ( 3.6A)
 1.03A 2wkoF-3uhjA:
undetectable		 2wkoF-3uhjA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  87
HIS A 133
VAL A 102
HIS A 431
 CU  A 602 ( 4.7A)
CU  A 602 (-3.3A)
None
CU  A 602 (-3.1A)
 0.79A 2wkoF-3v9eA:
undetectable		 2wkoF-3v9eA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Sphingomonas
wittichii) 		PF00903
(Glyoxalase) 		4 HIS A 147
HIS A 191
VAL A 149
HIS A 209
 FE2  A 301 (-3.3A)
None
None
FE2  A 301 (-3.4A)
 1.00A 2wkoF-3vb0A:
undetectable		 2wkoF-3vb0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 HIS A 103
HIS A 328
HIS A 372
HIS A  94
 None
 1.04A 2wkoF-3w6qA:
undetectable		 2wkoF-3w6qA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  85
HIS A 132
HIS A 130
HIS A 422
 CU  A 614 (-3.1A)
CU  A 616 (-3.2A)
CU  A 615 (-3.2A)
CU  A 616 ( 3.2A)
 1.00A 2wkoF-3x1bA:
undetectable		 2wkoF-3x1bA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 179
HIS A 183
VAL A 213
HIS A 210
 CUO  A9001 (-3.4A)
CUO  A9001 (-3.4A)
None
CUO  A9001 (-3.3A)
 1.04A 2wkoF-4bedA:
undetectable		 2wkoF-4bedA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 602
HIS A 606
VAL A 636
HIS A 633
 CUO  A9002 (-3.4A)
CUO  A9002 (-3.3A)
None
CUO  A9002 (-3.3A)
 1.00A 2wkoF-4bedA:
undetectable		 2wkoF-4bedA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2260
HIS B2264
VAL B2294
HIS B2291
 CUO  B9006 (-3.2A)
CUO  B9006 (-3.2A)
None
CUO  B9006 (-3.5A)
 1.03A 2wkoF-4bedB:
undetectable		 2wkoF-4bedB:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2974
HIS B3075
HIS B3106
HIS B2965
 CUO  B9008 (-2.9A)
CUO  B9008 (-2.8A)
CUO  B9008 (-3.3A)
CUO  B9008 (-3.2A)
 0.83A 2wkoF-4bedB:
undetectable		 2wkoF-4bedB:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A 111
HIS A 109
HIS A 399
 CU  A 504 ( 2.8A)
CU  A 501 (-3.2A)
CU  A 502 (-3.2A)
CU  A 501 ( 3.2A)
 1.04A 2wkoF-4jhvA:
undetectable		 2wkoF-4jhvA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l05 SUPEROXIDE DISMUTASE
[CU-ZN]

(Brucella
abortus) 		PF00080
(Sod_Cu) 		4 HIS A  48
HIS A  50
HIS A  73
HIS A 128
 CU1  A 201 ( 3.1A)
CU1  A 201 ( 3.2A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.27A 2wkoF-4l05A:
19.9		 2wkoF-4l05A:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE

(Serratia
plymuthica) 		PF00465
(Fe-ADH) 		4 HIS A 257
HIS A 254
VAL A 275
HIS A 271
 None
ZN  A1000 (-3.1A)
None
ZN  A1000 ( 3.3A)
 1.02A 2wkoF-4mcaA:
undetectable		 2wkoF-4mcaA:
17.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oja SUPEROXIDE DISMUTASE
[CU-ZN]

(Hydra vulgaris) 		PF00080
(Sod_Cu) 		5 HIS A  45
HIS A  47
HIS A  62
VAL A 117
HIS A 119
 CU  A 201 (-3.4A)
CU  A 201 (-3.3A)
ZN  A 202 ( 3.2A)
CU  A 201 ( 4.6A)
CU  A 201 (-3.2A)
 0.21A 2wkoF-4ojaA:
28.0		 2wkoF-4ojaA:
49.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 HIS B 251
HIS B 255
VAL B 286
HIS B 283
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
None
CU1  B 602 (-3.0A)
 0.94A 2wkoF-4ouaB:
undetectable		 2wkoF-4ouaB:
13.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rvp SUPEROXIDE DISMUTASE

(Sedum alfredii) 		PF00080
(Sod_Cu) 		5 HIS A  58
HIS A  60
HIS A  75
VAL A 130
HIS A 132
 None
None
ZN  A 201 (-3.2A)
None
None
 0.31A 2wkoF-4rvpA:
29.1		 2wkoF-4rvpA:
56.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u4i CU/ZN SUPEROXIDE
DISMUTASE

(Megavirus
chiliensis) 		PF00080
(Sod_Cu) 		5 HIS A  54
HIS A  56
HIS A  71
VAL A 126
HIS A 128
 None
 0.52A 2wkoF-4u4iA:
19.7		 2wkoF-4u4iA:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		4 HIS A 116
HIS A 121
HIS A 153
HIS A 297
 ZN  A 401 ( 3.5A)
ZN  A 401 (-3.4A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.2A)
 0.98A 2wkoF-4ymkA:
undetectable		 2wkoF-4ymkA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		4 HIS A 157
HIS A 156
HIS A 153
HIS A 298
 ZN  A 401 (-3.3A)
ZN  A 402 (-3.4A)
ZN  A 401 ( 3.2A)
ZN  A 402 (-3.4A)
 0.88A 2wkoF-4ymkA:
undetectable		 2wkoF-4ymkA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		4 HIS A 298
HIS A 297
HIS A 294
HIS A 157
 ZN  A 402 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.1A)
ZN  A 401 (-3.3A)
 0.85A 2wkoF-4ymkA:
undetectable		 2wkoF-4ymkA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		4 HIS A 252
HIS A 256
VAL A 289
HIS A 286
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
CU  A 701 (-3.1A)
 0.94A 2wkoF-4z11A:
undetectable		 2wkoF-4z11A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 244
HIS A 249
HIS A 268
HIS A 348
 ZN  A 402 (-3.7A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
 0.80A 2wkoF-4zr0A:
undetectable		 2wkoF-4zr0A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 272
HIS A 271
HIS A 268
HIS A 349
 ZN  A 402 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.2A)
 0.97A 2wkoF-4zr0A:
undetectable		 2wkoF-4zr0A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 326
HIS A 330
HIS A 345
HIS A 271
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.2A)
 0.85A 2wkoF-4zr0A:
undetectable		 2wkoF-4zr0A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 345
HIS A 330
HIS A 349
HIS A 326
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 0.96A 2wkoF-4zr0A:
undetectable		 2wkoF-4zr0A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 345
HIS A 348
VAL A 359
HIS A 244
 ZN  A 401 (-3.5A)
ZN  A 402 (-3.3A)
None
ZN  A 402 (-3.7A)
 1.00A 2wkoF-4zr0A:
undetectable		 2wkoF-4zr0A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 348
HIS A 345
VAL A 359
HIS A 244
 ZN  A 402 (-3.3A)
ZN  A 401 (-3.5A)
None
ZN  A 402 (-3.7A)
 0.92A 2wkoF-4zr0A:
undetectable		 2wkoF-4zr0A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 349
HIS A 348
HIS A 345
HIS A 272
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.5A)
ZN  A 402 (-3.4A)
 0.85A 2wkoF-4zr0A:
undetectable		 2wkoF-4zr0A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 244
HIS A 249
HIS A 268
HIS A 348
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.3A)
 0.86A 2wkoF-4zr1A:
undetectable		 2wkoF-4zr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 272
HIS A 271
HIS A 268
HIS A 349
 ZN  A 402 (-3.5A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
 0.90A 2wkoF-4zr1A:
undetectable		 2wkoF-4zr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 326
HIS A 330
HIS A 345
HIS A 271
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 401 ( 3.4A)
 0.89A 2wkoF-4zr1A:
undetectable		 2wkoF-4zr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 345
HIS A 330
HIS A 349
HIS A 326
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
 0.99A 2wkoF-4zr1A:
undetectable		 2wkoF-4zr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 348
HIS A 345
VAL A 359
HIS A 244
 ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
None
ZN  A 402 (-3.5A)
 0.97A 2wkoF-4zr1A:
undetectable		 2wkoF-4zr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 349
HIS A 348
HIS A 345
HIS A 272
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
 1.04A 2wkoF-4zr1A:
undetectable		 2wkoF-4zr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 HIS A 120
HIS A 125
HIS A 157
HIS A 301
 ZN  A 401 ( 3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.4A)
 0.99A 2wkoF-4zyoA:
undetectable		 2wkoF-4zyoA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 HIS A 161
HIS A 160
HIS A 157
HIS A 302
 ZN  A 401 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 402 (-3.5A)
 0.89A 2wkoF-4zyoA:
undetectable		 2wkoF-4zyoA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 HIS A 302
HIS A 301
HIS A 298
HIS A 161
 ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.3A)
 0.97A 2wkoF-4zyoA:
undetectable		 2wkoF-4zyoA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce9 POLYPHENOL OXIDASE

(Juglans regia) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A 239
HIS A 243
VAL A 276
HIS A 273
 CU  A 401 ( 3.2A)
CU  A 401 ( 3.2A)
None
CU  A 401 ( 3.2A)
 0.92A 2wkoF-5ce9A:
undetectable		 2wkoF-5ce9A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A 111
HIS A 109
HIS A 400
 CU  A 509 (-3.2A)
CU  A 507 ( 3.3A)
CU  A 508 (-3.3A)
CU  A 507 ( 3.1A)
 0.98A 2wkoF-5ehfA:
undetectable		 2wkoF-5ehfA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		4 HIS A 204
HIS A 208
VAL A 234
HIS A 231
 ZN  A 302 ( 3.4A)
HQE  A 303 ( 3.0A)
None
ZN  A 302 (-3.1A)
 1.02A 2wkoF-5i3aA:
undetectable		 2wkoF-5i3aA:
16.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5in2 EXTRACELLULAR
SUPEROXIDE DISMUTASE
[CU-ZN]

(Onchocerca
volvulus) 		PF00080
(Sod_Cu) 		5 HIS A  46
HIS A  48
HIS A  63
VAL A 118
HIS A 120
 CU  A 203 ( 3.1A)
CU  A 203 ( 3.2A)
ZN  A 202 (-3.1A)
None
CU  A 203 ( 3.1A)
 0.18A 2wkoF-5in2A:
30.6		 2wkoF-5in2A:
57.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5

(Candida
albicans) 		PF00080
(Sod_Cu) 		5 HIS A  75
HIS A  77
HIS A  93
VAL A 151
HIS A 153
 CU1  A 201 (-3.0A)
CU1  A 201 (-3.1A)
CU1  A 201 (-4.2A)
CU1  A 201 ( 4.4A)
CU1  A 201 (-3.2A)
 0.22A 2wkoF-5kbmA:
16.4		 2wkoF-5kbmA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 108
HIS A 154
VAL A 123
HIS A 453
 CU  A 603 ( 3.1A)
CU  A 602 ( 3.4A)
None
CU  A 602 (-3.1A)
 0.82A 2wkoF-5lm8A:
undetectable		 2wkoF-5lm8A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  65
HIS A 112
HIS A 110
HIS A 402
 CU  A 503 (-3.1A)
CU  A 501 (-3.1A)
CU  A 502 (-3.1A)
CU  A 501 (-3.2A)
 1.04A 2wkoF-5mewA:
undetectable		 2wkoF-5mewA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3m ZINC FINGER PROTEIN
568

(Mus musculus) 		no annotation 4 HIS C 410
HIS C 409
VAL C 412
HIS C 413
 None
ZN  C1002 (-3.3A)
None
ZN  C1002 (-3.1A)
 0.91A 2wkoF-5v3mC:
undetectable		 2wkoF-5v3mC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		4 HIS A 257
HIS A 254
VAL A 275
HIS A 271
 None
ZN  A 401 (-3.4A)
None
ZN  A 401 ( 3.4A)
 1.04A 2wkoF-5xn8A:
undetectable		 2wkoF-5xn8A:
17.53