SIMILAR PATTERNS OF AMINO ACIDS FOR 2WGJ_A_VGHA2346

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 202
ALA A 220
TYR A 268
MET A 269
GLY A 272
ASP A 332
 None
 0.75A 2wgjA-1k9aA:
31.4		 2wgjA-1k9aA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 202
VAL A 209
ALA A 220
TYR A 268
MET A 269
GLY A 272
 None
 0.74A 2wgjA-1k9aA:
31.4		 2wgjA-1k9aA:
27.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 588
ALA A 606
TYR A 656
MET A 657
GLY A 660
ALA A 741
ASP A 742
 None
 0.80A 2wgjA-1lufA:
34.9		 2wgjA-1lufA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 GLY A 212
VAL A 219
ALA A 230
LEU A 260
TYR A 282
GLY A 286
ALA A 350
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-4.2A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
PY1  A 700 ( 4.2A)
 0.74A 2wgjA-1py5A:
25.2		 2wgjA-1py5A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  16
VAL A  23
ALA A  36
LEU A  84
TYR A  86
GLY A  90
ASP A 148
 HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-3.9A)
 0.88A 2wgjA-1zltA:
21.1		 2wgjA-1zltA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  27
VAL A  34
ALA A  47
LEU A  78
LEU A  98
GLY A 104
ASP A 166
 STU  A1301 ( 3.8A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 ( 4.7A)
STU  A1301 ( 4.0A)
None
 0.71A 2wgjA-2bujA:
23.3		 2wgjA-2bujA:
26.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLY X  18
VAL X  25
ALA X  37
TYR X  84
MET X  85
GLY X  88
ALA X 147
ASP X 148
 STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-4.6A)
None
STU  X 902 (-3.5A)
STU  X 902 ( 4.1A)
STU  X 902 (-3.6A)
 0.78A 2wgjA-2dq7X:
25.1		 2wgjA-2dq7X:
36.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 GLY A  35
VAL A  42
ALA A  55
TYR A 107
GLY A 110
ASP A 169
 STU  A 400 (-3.3A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 (-4.5A)
STU  A 400 (-3.4A)
STU  A 400 (-3.6A)
 0.74A 2wgjA-2gcdA:
25.8		 2wgjA-2gcdA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 GLY A 274
VAL A 281
ALA A 293
TYR A 340
MET A 341
GLY A 344
ALA A 403
ASP A 404
 H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
None
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.0A)
H8H  A 534 (-4.2A)
 0.97A 2wgjA-2h8hA:
30.5		 2wgjA-2h8hA:
24.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 252
VAL A 259
ALA A 271
MET A 319
GLY A 322
ALA A 381
 None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
 0.75A 2wgjA-2hk5A:
31.1		 2wgjA-2hk5A:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 259
ALA A 271
MET A 319
GLY A 322
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.72A 2wgjA-2hk5A:
31.1		 2wgjA-2hk5A:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 259
ALA A 271
TYR A 318
MET A 319
GLY A 322
ALA A 381
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 3.3A)
 0.59A 2wgjA-2og8A:
30.0		 2wgjA-2og8A:
34.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 GLY A  26
VAL A  33
ALA A  46
MET A 106
GLY A 109
ASP A 167
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
MN  A 382 (-2.0A)
 0.73A 2wgjA-2phkA:
22.6		 2wgjA-2phkA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		7 GLY B  48
VAL B  55
ALA B  67
TYR B 116
MET B 117
GLY B 120
ASP B 182
 None
 0.76A 2wgjA-2qkwB:
19.9		 2wgjA-2qkwB:
29.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 GLY A 682
VAL A 689
ALA A 705
TYR A 755
MET A 756
GLY A 759
 None
 0.76A 2wgjA-2r2pA:
31.3		 2wgjA-2r2pA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 689
ALA A 705
TYR A 755
MET A 756
GLY A 759
ASP A 818
 None
 0.53A 2wgjA-2r2pA:
31.3		 2wgjA-2r2pA:
34.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  83
VAL A  90
ALA A 103
TYR A 155
MET A 156
GLY A 159
ALA A 215
ASP A 216
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 ( 4.9A)
None
None
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 0.86A 2wgjA-2v55A:
14.7		 2wgjA-2v55A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  78
VAL A  85
ALA A  98
TYR A 150
ALA A 212
ASP A 213
 BI8  A1417 ( 3.9A)
BI8  A1417 ( 4.7A)
BI8  A1417 ( 3.8A)
BI8  A1417 (-4.8A)
BI8  A1417 ( 4.1A)
BI8  A1417 (-3.8A)
 0.48A 2wgjA-2vd5A:
20.3		 2wgjA-2vd5A:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 GLY A 628
VAL A 635
ALA A 651
TYR A 701
MET A 702
GLY A 705
 None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
None
Q9G  A1898 ( 3.8A)
 0.64A 2wgjA-2xyuA:
28.6		 2wgjA-2xyuA:
31.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 306
VAL A 313
ALA A 326
TYR A 378
GLY A 382
ASP A 463
 770  A 901 ( 4.6A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.2A)
770  A 901 (-3.4A)
770  A 901 (-3.8A)
 0.63A 2wgjA-2z2wA:
23.3		 2wgjA-2z2wA:
23.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A1003
VAL A1010
ALA A1028
MET A1079
GLY A1082
MET A1139
ASP A1150
 S91  A   1 ( 3.9A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
None
S91  A   1 (-3.3A)
S91  A   1 ( 3.7A)
None
 0.67A 2wgjA-2z8cA:
22.6		 2wgjA-2z8cA:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 261
ALA A 273
MET A 322
GLY A 325
ALA A 384
ASP A 385
 None
 0.72A 2wgjA-2zv7A:
31.0		 2wgjA-2zv7A:
36.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  98
VAL A 105
ALA A 121
LEU A 172
TYR A 174
GLY A 178
MET A 225
ASP A 236
 STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.1A)
STU  A 400 (-4.7A)
STU  A 400 ( 4.4A)
STU  A 400 (-3.6A)
STU  A 400 ( 3.8A)
 0.89A 2wgjA-3a62A:
21.8		 2wgjA-3a62A:
25.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 488
VAL A 495
ALA A 515
TYR A 566
GLY A 570
ALA A 643
 M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
None
 0.71A 2wgjA-3b2tA:
27.5		 2wgjA-3b2tA:
35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  20
VAL A  27
ALA A  40
LEU A  93
MET A 146
ASP A 161
 4RB  A 401 (-3.6A)
4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 4.1A)
4RB  A 401 (-2.8A)
GOL  A 503 ( 3.1A)
 0.74A 2wgjA-3bqrA:
20.9		 2wgjA-3bqrA:
25.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 GLY A1085
VAL A1092
ALA A1108
LEU A1140
LEU A1157
TYR A1159
MET A1160
GLY A1163
MET A1211
ALA A1221
 None
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-4.8A)
CKK  A1500 (-4.7A)
CKK  A1500 (-4.5A)
None
CKK  A1500 ( 4.5A)
CKK  A1500 (-3.6A)
CKK  A1500 (-3.4A)
 0.50A 2wgjA-3c1xA:
28.5		 2wgjA-3c1xA:
80.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 202
ALA A 220
TYR A 268
MET A 269
GLY A 272
ASP A 332
 None
 0.75A 2wgjA-3d7uA:
31.3		 2wgjA-3d7uA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 202
VAL A 209
ALA A 220
TYR A 268
MET A 269
GLY A 272
 None
 0.74A 2wgjA-3d7uA:
31.3		 2wgjA-3d7uA:
37.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 GLY A  60
VAL A  67
ALA A  80
TYR A 131
GLY A 135
ALA A 192
ASP A 193
 None
 0.69A 2wgjA-3iecA:
22.4		 2wgjA-3iecA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  40
VAL A  47
ALA A  60
LEU A 110
TYR A 112
GLY A 116
 None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
None
 0.72A 2wgjA-3lm5A:
8.4		 2wgjA-3lm5A:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A1006
VAL A1013
ALA A1031
MET A1082
GLY A1085
MET A1142
ASP A1153
 None
None
None
None
None
None
CCX  A   1 ( 4.3A)
 1.06A 2wgjA-3lw0A:
32.7		 2wgjA-3lw0A:
37.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 GLY A 211
ALA A 229
LEU A 259
TYR A 281
GLY A 285
ALA A 349
ASP A 350
 LDN  A   1 ( 4.7A)
LDN  A   1 (-3.6A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 ( 3.8A)
LDN  A   1 (-3.9A)
 0.87A 2wgjA-3mdyA:
24.5		 2wgjA-3mdyA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 GLY A 211
VAL A 218
ALA A 229
LEU A 259
TYR A 281
GLY A 285
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
 0.71A 2wgjA-3mdyA:
24.5		 2wgjA-3mdyA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 209
VAL A 216
ALA A 227
LEU A 257
TYR A 279
GLY A 283
ALA A 347
 None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 ( 3.8A)
 0.78A 2wgjA-3my0A:
24.5		 2wgjA-3my0A:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 216
ALA A 227
LEU A 257
TYR A 279
GLY A 283
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 ( 3.8A)
None
 0.85A 2wgjA-3my0A:
24.5		 2wgjA-3my0A:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 GLY A  30
VAL A  37
ALA A  49
MET A 101
ALA A 161
ASP A 162
 ADP  A 314 (-3.3A)
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
None
MG  A 312 ( 3.3A)
 0.74A 2wgjA-3nizA:
23.7		 2wgjA-3nizA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  89
VAL A  96
ALA A 109
LEU A 159
TYR A 161
GLY A 165
ASP A 223
 JOZ  A 361 ( 4.3A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
JOZ  A 361 (-4.0A)
None
None
SO4  A   5 ( 4.5A)
 0.64A 2wgjA-3nuuA:
23.7		 2wgjA-3nuuA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 GLY A 193
VAL A 200
ALA A 213
LEU A 263
MET A 266
GLY A 269
ASP A 329
 AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.7A)
None
None
AMP  A 577 (-4.0A)
 0.82A 2wgjA-3nyoA:
22.4		 2wgjA-3nyoA:
17.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 GLY A1089
VAL A1096
ALA A1112
LEU A1144
LEU A1161
TYR A1163
MET A1164
GLY A1167
MET A1215
ALA A1225
 ANP  A1358 ( 3.7A)
ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
None
ANP  A1358 ( 4.1A)
ANP  A1358 (-4.3A)
None
None
ANP  A1358 (-3.9A)
None
 0.55A 2wgjA-3plsA:
34.6		 2wgjA-3plsA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 GLY A 558
VAL A 565
ALA A 576
TYR A 627
GLY A 631
ASP A 694
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-3.5A)
 0.70A 2wgjA-3ppzA:
28.9		 2wgjA-3ppzA:
31.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 346
LEU A 397
TYR A 415
GLY A 419
ALA A 477
ASP A 478
 STU  A   1 (-3.4A)
STU  A   1 (-4.6A)
STU  A   1 (-4.7A)
STU  A   1 (-3.6A)
STU  A   1 ( 4.1A)
STU  A   1 ( 4.2A)
 0.75A 2wgjA-3s95A:
24.4		 2wgjA-3s95A:
30.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 485
VAL A 492
ALA A 512
TYR A 563
GLY A 567
ALA A 640
 07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.7A)
07J  A   1 (-3.7A)
07J  A   1 (-3.2A)
 0.65A 2wgjA-3tt0A:
31.7		 2wgjA-3tt0A:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 GLY A 296
VAL A 303
ALA A 315
LEU A 347
TYR A 365
MET A 366
GLY A 369
 None
 0.72A 2wgjA-3ulzA:
23.0		 2wgjA-3ulzA:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A 140
VAL A 147
ALA A 160
LEU A 194
LEU A 210
TYR A 212
GLY A 216
ALA A 273
 None
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-4.9A)
N13  A 501 ( 4.8A)
N13  A 501 (-4.4A)
N13  A 501 (-3.5A)
N13  A 501 ( 3.8A)
 0.86A 2wgjA-3w18A:
22.1		 2wgjA-3w18A:
26.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A1959
ALA A1978
LEU A2010
LEU A2026
MET A2029
GLY A2032
ASP A2102
 None
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
VGH  A3000 ( 4.2A)
None
VGH  A3000 (-3.5A)
None
 0.47A 2wgjA-3zbfA:
30.4		 2wgjA-3zbfA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 626
VAL A 633
ALA A 649
MET A 700
GLY A 703
ASP A 762
 None
 0.76A 2wgjA-3zfxA:
31.6		 2wgjA-3zfxA:
35.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  84
VAL A  91
ALA A 104
LEU A 138
LEU A 154
TYR A 156
GLY A 160
ALA A 217
 VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
None
None
VX6  A 500 (-4.2A)
VX6  A 500 (-3.3A)
VX6  A 500 ( 4.2A)
 0.78A 2wgjA-4af3A:
15.2		 2wgjA-4af3A:
28.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 568
ALA A 586
TYR A 635
MET A 636
GLY A 639
ASP A 710
 None
LTI  A1839 (-3.3A)
LTI  A1839 (-4.7A)
None
LTI  A1839 (-3.4A)
None
 0.67A 2wgjA-4at3A:
32.4		 2wgjA-4at3A:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A  98
VAL A 105
ALA A 121
MET A 172
GLY A 175
ASP A 234
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.5A)
30K  A1365 (-3.3A)
 0.62A 2wgjA-4aw5A:
31.7		 2wgjA-4aw5A:
35.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 GLY A 215
VAL A 222
ALA A 233
LEU A 263
TYR A 285
GLY A 289
ALA A 353
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 ( 4.2A)
 0.77A 2wgjA-4c02A:
24.7		 2wgjA-4c02A:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		6 GLY A 247
VAL A 254
ALA A 267
LEU A 318
TYR A 320
ASP A 382
 None
 0.75A 2wgjA-4c0tA:
22.8		 2wgjA-4c0tA:
14.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 523
ALA A 541
TYR A 590
MET A 591
GLY A 594
ASP A 667
 None
 0.75A 2wgjA-4f0iA:
33.4		 2wgjA-4f0iA:
36.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 GLY A 515
VAL A 522
ALA A 538
LEU A 593
MET A 596
GLY A 599
MET A 652
ALA A 662
 0T8  A 901 ( 3.9A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 4.5A)
 0.81A 2wgjA-4feqA:
29.6		 2wgjA-4feqA:
41.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 GLY A 515
VAL A 522
ALA A 538
MET A 596
GLY A 599
MET A 652
ALA A 662
ASP A 663
 0T8  A 901 ( 3.9A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
 0.92A 2wgjA-4feqA:
29.6		 2wgjA-4feqA:
41.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1130
ALA A1148
LEU A1196
MET A1199
GLY A1202
ASP A1270
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 ( 4.2A)
 0.47A 2wgjA-4fodA:
30.4		 2wgjA-4fodA:
33.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A 157
VAL A 164
ALA A 177
TYR A 229
GLY A 233
MET A 281
 GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
0XZ  A 501 ( 4.9A)
None
0XZ  A 501 (-3.5A)
 0.63A 2wgjA-4gv1A:
21.5		 2wgjA-4gv1A:
24.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 829
ALA A 853
TYR A 904
GLY A 908
ALA A 966
ASP A 967
 19S  A1201 (-3.7A)
19S  A1201 (-3.3A)
19S  A1201 (-4.7A)
19S  A1201 ( 3.8A)
19S  A1201 ( 4.1A)
19S  A1201 ( 4.1A)
 0.64A 2wgjA-4hviA:
29.2		 2wgjA-4hviA:
33.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  26
ALA A  39
LEU A  73
LEU A  89
GLY A  95
ALA A 153
ASP A 154
 631  A 301 (-4.6A)
631  A 301 (-3.3A)
None
631  A 301 ( 4.5A)
631  A 301 ( 3.7A)
631  A 301 (-3.4A)
EDO  A 302 (-3.7A)
 0.76A 2wgjA-4jxfA:
13.1		 2wgjA-4jxfA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 GLY A 274
VAL A 281
ALA A 293
TYR A 340
MET A 341
GLY A 344
ALA A 403
 0J9  A 601 ( 4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 ( 4.1A)
0J9  A 601 (-3.5A)
 0.70A 2wgjA-4k11A:
30.0		 2wgjA-4k11A:
28.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 479
VAL A 486
ALA A 506
TYR A 557
GLY A 561
ALA A 634
ASP A 635
 ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
None
ACP  A 801 ( 4.6A)
None
MG  A 802 ( 3.0A)
 0.92A 2wgjA-4k33A:
28.4		 2wgjA-4k33A:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  34
VAL A  41
ALA A  54
TYR A 101
GLY A 105
ALA A 163
 None
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 3.0A)
 0.68A 2wgjA-4lg4A:
20.8		 2wgjA-4lg4A:
26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 GLY A 274
VAL A 281
ALA A 293
TYR A 340
MET A 341
GLY A 344
ALA A 403
 VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.2A)
 0.77A 2wgjA-4lggA:
28.1		 2wgjA-4lggA:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 281
ALA A 293
TYR A 340
MET A 341
ALA A 403
ASP A 404
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
None
VGG  A 601 ( 4.2A)
VGG  A 601 ( 4.7A)
 0.71A 2wgjA-4lggA:
28.1		 2wgjA-4lggA:
36.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY A  29
VAL A  36
ALA A  49
LEU A  74
MET A  98
GLY A 101
 ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
None
None
 0.71A 2wgjA-4m69A:
25.2		 2wgjA-4m69A:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY B  31
VAL B  38
ALA B  51
TYR B 101
GLY B 105
ALA B 161
ASP B 162
 ADP  B 500 ( 3.8A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 ( 4.7A)
None
None
ADP  B 500 ( 3.4A)
 0.83A 2wgjA-4o27B:
20.7		 2wgjA-4o27B:
28.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 GLY A 620
VAL A 627
ALA A 644
TYR A 694
MET A 695
GLY A 698
 None
 0.69A 2wgjA-4p2kA:
31.4		 2wgjA-4p2kA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 627
ALA A 644
TYR A 694
MET A 695
GLY A 698
ASP A 757
 None
 0.74A 2wgjA-4p2kA:
31.4		 2wgjA-4p2kA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 GLY A  15
VAL A  22
ALA A  35
TYR A  83
MET A  84
GLY A  87
ALA A 146
 ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 ( 4.5A)
None
ACP  A1264 (-3.5A)
None
 0.64A 2wgjA-4ueuA:
31.1		 2wgjA-4ueuA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 VAL A  22
ALA A  35
TYR A  83
MET A  84
GLY A  87
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 ( 4.5A)
None
ACP  A1264 (-3.5A)
None
None
 0.65A 2wgjA-4ueuA:
31.1		 2wgjA-4ueuA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 131
VAL A 138
ALA A 149
LEU A 200
GLY A 206
ASP A 289
 AGS  A1438 ( 3.8A)
AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-3.6A)
None
AGS  A1438 (-2.7A)
 0.71A 2wgjA-4uyaA:
25.3		 2wgjA-4uyaA:
31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 GLY A 194
VAL A 201
ALA A 214
MET A 267
GLY A 270
ASP A 332
 None
None
ANW  A 601 (-3.4A)
None
ANW  A 601 ( 4.5A)
None
 0.61A 2wgjA-4wboA:
18.8		 2wgjA-4wboA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		6 GLY A 409
VAL A 416
ALA A 428
TYR A 476
MET A 477
GLY A 480
 746  A 702 ( 3.5A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-4.4A)
None
746  A 702 (-3.6A)
 0.77A 2wgjA-4y93A:
32.1		 2wgjA-4y93A:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 GLY A 194
VAL A 201
ALA A 214
LEU A 264
MET A 267
ASP A 330
 AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 4.8A)
None
AN2  A 601 (-3.0A)
 0.61A 2wgjA-4yhjA:
16.8		 2wgjA-4yhjA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY A  27
VAL A  34
ALA A  47
LEU A  80
LEU A  96
ALA A 159
 None
 0.72A 2wgjA-4ynzA:
20.7		 2wgjA-4ynzA:
25.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 485
VAL A 492
ALA A 512
TYR A 563
GLY A 567
ALA A 640
 38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
EDO  A1766 ( 4.4A)
 0.61A 2wgjA-5a46A:
31.3		 2wgjA-5a46A:
34.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  23
VAL A  30
ALA A  44
TYR A  94
GLY A  98
ALA A 164
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
None
 0.70A 2wgjA-5ci7A:
23.1		 2wgjA-5ci7A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 251
VAL A 258
ALA A 275
LEU A 305
GLY A 331
ASP A 397
 STU  A 601 (-2.9A)
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 ( 3.8A)
STU  A 601 (-3.5A)
STU  A 601 (-3.0A)
 0.70A 2wgjA-5e8yA:
24.1		 2wgjA-5e8yA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 GLY A  63
VAL A  70
ALA A  83
TYR A 134
GLY A 138
ASP A 196
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.3A)
5RC  A4000 (-3.6A)
 0.74A 2wgjA-5es1A:
9.3		 2wgjA-5es1A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 GLY A 100
VAL A 107
ALA A 120
LEU A 154
LEU A 170
GLY A 176
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.8A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.4A)
None
 0.73A 2wgjA-5eykA:
12.1		 2wgjA-5eykA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 VAL A 107
ALA A 120
LEU A 154
LEU A 170
GLY A 176
ALA A 233
ASP A 234
 5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.8A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.4A)
None
None
 0.93A 2wgjA-5eykA:
12.1		 2wgjA-5eykA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 GLY A  87
VAL A  94
ALA A 105
TYR A 150
GLY A 154
ASP A 226
 None
 0.61A 2wgjA-5gz8A:
18.2		 2wgjA-5gz8A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gza PROTEIN O-MANNOSE
KINASE

(Danio rerio) 		PF07714
(Pkinase_Tyr) 		6 GLY A  86
VAL A  93
ALA A 104
TYR A 149
GLY A 153
ASP A 225
 ADP  A 401 (-3.6A)
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
MG  A 402 ( 1.8A)
 0.77A 2wgjA-5gzaA:
18.0		 2wgjA-5gzaA:
26.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A1092
ALA A1108
LEU A1140
LEU A1157
TYR A1159
MET A1160
GLY A1163
MET A1211
ALA A1221
ASP A1222
 63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
None
63K  A1401 (-4.2A)
63K  A1401 (-3.5A)
None
63K  A1401 (-3.6A)
63K  A1401 (-4.0A)
63K  A1401 (-3.3A)
None
 0.43A 2wgjA-5horA:
33.2		 2wgjA-5horA:
96.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  28
VAL A  35
ALA A  50
TYR A  99
ALA A 172
ASP A 173
 6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-4.9A)
6A7  A 401 ( 4.1A)
FMT  A 403 ( 3.3A)
 0.64A 2wgjA-5idnA:
15.4		 2wgjA-5idnA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 GLY A 890
VAL A 897
ALA A 909
MET A 959
GLY A 962
ASP A1027
 ADP  A1200 ( 4.0A)
ADP  A1200 (-4.4A)
ADP  A1200 (-3.5A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-3.4A)
 0.67A 2wgjA-5lpzA:
24.0		 2wgjA-5lpzA:
29.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 GLY A 594
VAL A 601
ALA A 617
LEU A 671
MET A 674
GLY A 677
MET A 730
ALA A 740
ASP A 741
 7AE  A1000 ( 4.2A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.7A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-3.6A)
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
 0.49A 2wgjA-5td2A:
30.9		 2wgjA-5td2A:
43.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 6 GLY A  18
VAL A  25
ALA A  38
LEU A  86
TYR A  88
ASP A 150
 7LV  A 401 ( 3.9A)
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 ( 4.2A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.2A)
 0.52A 2wgjA-5tvtA:
22.6		 2wgjA-5tvtA:
23.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 543
VAL A 550
ALA A 565
LEU A 620
MET A 623
GLY A 626
MET A 679
 7YS  A9001 ( 4.2A)
7YS  A9001 (-4.2A)
7YS  A9001 (-3.3A)
7YS  A9001 (-4.2A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
7YS  A9001 (-3.5A)
 0.73A 2wgjA-5u6bA:
32.6		 2wgjA-5u6bA:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 550
ALA A 565
LEU A 620
MET A 623
GLY A 626
MET A 679
ALA A 689
ASP A 690
 7YS  A9001 (-4.2A)
7YS  A9001 (-3.3A)
7YS  A9001 (-4.2A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
7YS  A9001 (-3.5A)
7YS  A9001 (-3.4A)
None
 0.64A 2wgjA-5u6bA:
32.6		 2wgjA-5u6bA:
41.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  99
VAL A 106
ALA A 119
TYR A 171
MET A 172
GLY A 175
ALA A 231
ASP A 232
 None
 0.77A 2wgjA-5u7qA:
20.2		 2wgjA-5u7qA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 219
VAL A 226
ALA A 239
TYR A 291
GLY A 295
ASP A 380
 8X7  A 501 ( 3.8A)
8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-4.2A)
8X7  A 501 (-3.6A)
8X7  A 501 (-4.8A)
 0.55A 2wgjA-5vdkA:
22.5		 2wgjA-5vdkA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 6 ALA A  45
LEU A  79
TYR A  97
MET A  98
GLY A 101
ALA A 163
 9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
None
None
9WS  A 401 ( 4.3A)
9WS  A 401 ( 4.0A)
 0.57A 2wgjA-5w5jA:
23.6		 2wgjA-5w5jA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 6 VAL A  32
ALA A  45
LEU A  79
TYR A  97
MET A  98
GLY A 101
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
None
None
9WS  A 401 ( 4.3A)
 0.64A 2wgjA-5w5jA:
23.6		 2wgjA-5w5jA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 8 GLY A  29
VAL A  36
ALA A  49
LEU A  82
TYR A  98
MET A  99
GLY A 102
ASP A 161
 VX6  A 402 ( 4.2A)
VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
VX6  A 402 ( 4.8A)
VX6  A 402 (-4.3A)
None
VX6  A 402 (-3.5A)
VX6  A 402 (-4.3A)
 0.68A 2wgjA-5wnmA:
27.3		 2wgjA-5wnmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 GLY A 892
VAL A 899
ALA A 917
LEU A 947
TYR A 965
GLY A 969
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
 0.57A 2wgjA-5wnoA:
28.9		 2wgjA-5wnoA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 6 GLY A  76
VAL A  83
ALA A  95
TYR A 143
GLY A 147
ALA A 216
 ANP  A1000 ( 3.8A)
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-4.3A)
None
MG  A1001 ( 4.4A)
 0.75A 2wgjA-5xd6A:
23.6		 2wgjA-5xd6A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 7 GLY A 734
VAL A 741
ALA A 754
TYR A 815
MET A 816
ALA A 876
ASP A 877
 CJM  A1102 (-3.4A)
None
CJM  A1102 (-3.1A)
CJM  A1102 (-4.1A)
None
CJM  A1102 (-3.6A)
MG  A1101 (-2.5A)
 0.71A 2wgjA-6b3eA:
23.8		 2wgjA-6b3eA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 6 GLY A 135
VAL A 142
ALA A 155
GLY A 236
ALA A 292
ASP A 293
 H1N  A 501 ( 3.8A)
H1N  A 501 (-4.4A)
H1N  A 501 (-3.4A)
H1N  A 501 (-3.6A)
H1N  A 501 ( 3.9A)
H1N  A 501 (-3.5A)
 0.47A 2wgjA-6ccfA:
23.3		 2wgjA-6ccfA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 7 GLY A 276
VAL A 283
ALA A 296
MET A 346
GLY A 349
MET A 400
ASP A 411
 FE7  A 601 ( 3.7A)
FE7  A 601 ( 4.3A)
FE7  A 601 (-3.3A)
FE7  A 601 (-4.7A)
FE7  A 601 ( 3.7A)
FE7  A 601 (-3.8A)
MG  A 602 ( 2.6A)
 0.85A 2wgjA-6cthA:
22.1		 2wgjA-6cthA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 7 GLY A 193
VAL A 200
ALA A 211
TYR A 264
MET A 265
GLY A 268
ASP A 329
 CJT  A 502 ( 3.9A)
CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
CJT  A 502 (-4.5A)
CJT  A 502 (-4.9A)
CJT  A 502 ( 4.3A)
CJT  A 502 ( 4.0A)
 0.80A 2wgjA-6f3dA:
24.6		 2wgjA-6f3dA:
15.94