SIMILAR PATTERNS OF AMINO ACIDS FOR 2WEY_B_EV1B1771_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		4 LEU A 280
VAL A 185
ILE A 227
PHE A 199
 None
 0.92A 2weyB-1a2oA:
undetectable		 2weyB-1a2oA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aok VIPOXIN COMPLEX

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 LEU B  13
ILE B  82
TYR B  75
PHE B  77
 None
 0.84A 2weyB-1aokB:
undetectable		 2weyB-1aokB:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bnl COLLAGEN XVIII

(Homo sapiens) 		PF06482
(Endostatin) 		4 LEU A  86
VAL A 119
ILE A 100
PHE A  49
 None
 0.83A 2weyB-1bnlA:
undetectable		 2weyB-1bnlA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 LEU A 362
PHE A 367
MET A 378
PHE A 398
 None
 0.98A 2weyB-1br2A:
undetectable		 2weyB-1br2A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbh PROTEIN (HUMAN SOS
1)

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 LEU A 324
ILE A 245
PHE A 246
PHE A 237
 None
 0.97A 2weyB-1dbhA:
undetectable		 2weyB-1dbhA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		4 ILE A 188
TYR A 208
GLN A 154
PHE A 157
 None
 0.98A 2weyB-1i5pA:
4.5		 2weyB-1i5pA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 LEU S 362
PHE S 367
MET S 378
PHE S 398
 None
 0.75A 2weyB-1i84S:
undetectable		 2weyB-1i84S:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00117
(GATase) 		4 LEU H  72
ILE H   8
TYR H  10
PHE H  59
 None
 0.94A 2weyB-1ka9H:
undetectable		 2weyB-1ka9H:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 LEU A 580
VAL A 765
TYR A 492
GLN A 646
 None
 0.96A 2weyB-1ofeA:
undetectable		 2weyB-1ofeA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Plasmodium
falciparum) 		PF00160
(Pro_isomerase) 		4 LEU A 105
ILE A 165
PHE A  60
MET A 149
 None
 0.96A 2weyB-1qnhA:
undetectable		 2weyB-1qnhA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)

(Salmonella
enterica) 		PF00268
(Ribonuc_red_sm) 		4 VAL A  36
ILE A 108
TYR A 105
PHE A  60
 None
 0.60A 2weyB-1r2fA:
undetectable		 2weyB-1r2fA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		4 LEU A  57
ILE A 130
PHE A 178
PHE A 161
 None
 0.73A 2weyB-1r4pA:
undetectable		 2weyB-1r4pA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 LEU A 519
ILE A  35
PHE A  39
PHE A  89
 None
 0.94A 2weyB-1r8wA:
2.4		 2weyB-1r8wA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 LEU A 895
ILE A 955
PHE A 959
GLN A 988
PHE A 991
 None
IBM  A2111 (-4.2A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.35A 2weyB-1sojA:
36.2		 2weyB-1sojA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		4 VAL A  41
ILE A 113
TYR A 110
PHE A  65
 None
 0.61A 2weyB-1uzrA:
undetectable		 2weyB-1uzrA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x77 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF03358
(FMN_red) 		5 LEU A  91
VAL A 139
ILE A  70
PHE A  66
PHE A  78
 None
 1.44A 2weyB-1x77A:
undetectable		 2weyB-1x77A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		4 LEU A 324
ILE A 245
PHE A 246
PHE A 237
 None
 0.98A 2weyB-1xdvA:
2.3		 2weyB-1xdvA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 LEU A 399
PHE A 587
MET A 583
PHE A 415
 None
 0.76A 2weyB-1xjeA:
undetectable		 2weyB-1xjeA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 LEU A 127
VAL A 185
ILE A 115
PHE A 108
 None
 0.94A 2weyB-1xvxA:
undetectable		 2weyB-1xvxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl0 HYPOTHETICAL PROTEIN
PA5198

(Pseudomonas
aeruginosa) 		PF02016
(Peptidase_S66) 		4 LEU A  98
VAL A  82
ILE A 117
PHE A 124
 None
 0.89A 2weyB-1zl0A:
undetectable		 2weyB-1zl0A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 LEU A1601
VAL A1539
TYR A1618
PHE A1582
 None
 0.98A 2weyB-2b39A:
undetectable		 2weyB-2b39A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5v HEPATOCYTE NUCLEAR
FACTOR 6

(Rattus
norvegicus) 		PF00046
(Homeobox)
PF02376
(CUT) 		4 LEU A  43
VAL A  31
ILE A  22
TYR A  20
 None
 0.95A 2weyB-2d5vA:
undetectable		 2weyB-2d5vA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		4 LEU A 176
VAL A 241
ILE A 221
PHE A 216
 None
 0.79A 2weyB-2d7dA:
2.4		 2weyB-2d7dA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		4 LEU A 168
MET A 303
GLN A 299
PHE A 296
 None
 0.97A 2weyB-2dh4A:
undetectable		 2weyB-2dh4A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fdo HYPOTHETICAL PROTEIN
AF2331

(Archaeoglobus
fulgidus) 		no annotation 4 LEU B  19
VAL B  27
ILE B  75
PHE B  11
 None
 0.97A 2weyB-2fdoB:
undetectable		 2weyB-2fdoB:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs0 RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF08567
(PH_TFIIH) 		4 LEU A  48
VAL A  40
ILE A  16
PHE A  91
 None
 0.95A 2weyB-2gs0A:
undetectable		 2weyB-2gs0A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy4 NON-HEME
IRON-CONTAINING
FERRITIN

(Listeria
monocytogenes) 		PF00210
(Ferritin) 		4 LEU A 102
ILE A 139
TYR A 113
GLN A  56
 None
 0.90A 2weyB-2iy4A:
2.4		 2weyB-2iy4A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j85 STIV B116

(Sulfolobus
turreted
icosahedral
virus 1) 		PF08960
(DUF1874) 		4 VAL A  58
ILE A 110
TYR A 105
PHE A  32
 None
 0.93A 2weyB-2j85A:
undetectable		 2weyB-2j85A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqm NEUROPILIN-1

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 LEU A 551
VAL A 495
ILE A 517
PHE A 515
 None
 0.98A 2weyB-2qqmA:
undetectable		 2weyB-2qqmA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL

(Trichormus
variabilis) 		PF01261
(AP_endonuc_2) 		4 LEU A  39
ILE A  31
TYR A  28
PHE A  17
 None
 0.88A 2weyB-2qw5A:
undetectable		 2weyB-2qw5A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 270
VAL A 319
ILE A 291
PHE A 294
 None
 0.96A 2weyB-2qygA:
undetectable		 2weyB-2qygA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ILE A 548
PHE A 552
MET A 569
GLN A 581
PHE A 584
 NPV  A   3 (-3.8A)
NPV  A   3 (-4.8A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
 0.87A 2weyB-2qykA:
37.7		 2weyB-2qykA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		4 PHE A 857
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.59A 2weyB-2r8qA:
39.1		 2weyB-2r8qA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		4 VAL A 839
PHE A 857
MET A 874
PHE A 890
 None
IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.6A)
 0.63A 2weyB-2r8qA:
39.1		 2weyB-2r8qA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcy PYRROLINE
CARBOXYLATE
REDUCTASE

(Plasmodium
falciparum) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 LEU A  19
VAL A 110
ILE A  61
PHE A 145
 None
 0.93A 2weyB-2rcyA:
undetectable		 2weyB-2rcyA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wf7 BETA-PHOSPHOGLUCOMUT
ASE

(Lactococcus
lactis) 		PF13419
(HAD_2) 		4 VAL A 199
ILE A 166
PHE A   2
MET A   1
 None
 0.82A 2weyB-2wf7A:
undetectable		 2weyB-2wf7A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 591
ILE A 535
TYR A 612
PHE A 569
 None
 0.96A 2weyB-2yd0A:
undetectable		 2weyB-2yd0A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z13 EF-HAND
DOMAIN-CONTAINING
FAMILY MEMBER C2

(Homo sapiens) 		PF06565
(DUF1126) 		4 VAL A  52
ILE A  73
TYR A  84
PHE A 102
 None
 0.94A 2weyB-2z13A:
undetectable		 2weyB-2z13A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU A 498
VAL A 464
ILE A 455
PHE A 472
 None
 0.92A 2weyB-2z7xA:
undetectable		 2weyB-2z7xA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zam VACUOLAR PROTEIN
SORTING-ASSOCIATING
PROTEIN 4B

(Mus musculus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 LEU A 172
VAL A 150
ILE A 230
PHE A 196
 None
 0.96A 2weyB-2zamA:
undetectable		 2weyB-2zamA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zam VACUOLAR PROTEIN
SORTING-ASSOCIATING
PROTEIN 4B

(Mus musculus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 LEU A 183
VAL A 150
ILE A 230
PHE A 196
 None
 0.94A 2weyB-2zamA:
undetectable		 2weyB-2zamA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1e BETAC-S LYASE

(Streptococcus
anginosus) 		PF00155
(Aminotran_1_2) 		4 LEU A 366
TYR A 331
PHE A 328
PHE A 306
 None
 0.98A 2weyB-3b1eA:
undetectable		 2weyB-3b1eA:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 725
PHE A 786
GLN A 817
PHE A 820
 None
None
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.52A 2weyB-3b2rA:
36.2		 2weyB-3b2rA:
38.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb8 CDP-4-KETO-6-DEOXY-D
-GLUCOSE-3-DEHYDRASE

(Yersinia
pseudotuberculosis) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A  75
VAL A 310
ILE A 222
PHE A 216
 None
 0.97A 2weyB-3bb8A:
undetectable		 2weyB-3bb8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 725
PHE A 786
GLN A 817
PHE A 820
 None
WAN  A 901 (-4.8A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.39A 2weyB-3bjcA:
38.6		 2weyB-3bjcA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpn GEOBACILLUS
STEAROTHERMOPHILUS
UVRB INTERACTION
DOMAIN

(Geobacillus
stearothermophilus) 		no annotation 4 LEU B 176
VAL B 241
ILE B 221
PHE B 216
 None
 0.78A 2weyB-3fpnB:
undetectable		 2weyB-3fpnB:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw8 RETICULINE OXIDASE

(Eschscholzia
californica) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 VAL A 281
ILE A 387
TYR A 418
MET A 444
 None
 0.99A 2weyB-3fw8A:
undetectable		 2weyB-3fw8A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ILE A 502
PHE A 506
GLN A 535
PHE A 538
 D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.84A 2weyB-3g4gA:
37.3		 2weyB-3g4gA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF01030
(Recep_L_domain) 		4 LEU A 118
VAL A  80
ILE A  55
TYR A  28
 None
 0.92A 2weyB-3h3bA:
undetectable		 2weyB-3h3bA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiw VACUOLAR SAPORIN

(Saponaria
officinalis) 		PF00161
(RIP) 		4 LEU A  65
ILE A 126
TYR A 119
PHE A  91
 None
None
None
C2X  A 260 ( 4.6A)
 0.99A 2weyB-3hiwA:
undetectable		 2weyB-3hiwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3a ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Leptospira
interrogans) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 VAL A 118
ILE A  63
PHE A  57
PHE A 112
 None
 0.96A 2weyB-3i3aA:
undetectable		 2weyB-3i3aA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		4 LEU A 623
VAL A 646
PHE A 746
MET A 757
 None
 0.93A 2weyB-3ibjA:
36.4		 2weyB-3ibjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 LEU A 770
ILE A 826
TYR A 827
GLN A 859
PHE A 862
 None
 0.78A 2weyB-3ibjA:
36.4		 2weyB-3ibjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT

(Bacteroides
thetaiotaomicron) 		PF01012
(ETF) 		5 VAL A 107
ILE A  79
TYR A 193
PHE A  63
PHE A  84
 None
None
MLA  A 216 (-3.7A)
None
None
 1.33A 2weyB-3ih5A:
undetectable		 2weyB-3ih5A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 LEU A 362
PHE A 367
MET A 378
PHE A 398
 None
 0.77A 2weyB-3j04A:
undetectable		 2weyB-3j04A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jx8 PUTATIVE LIPOPROTEIN

(Parabacteroides
distasonis) 		PF10988
(DUF2807) 		5 VAL A 155
ILE A 130
TYR A  55
PHE A 128
GLN A  57
 None
 1.50A 2weyB-3jx8A:
undetectable		 2weyB-3jx8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus) 		PF01048
(PNP_UDP_1) 		5 LEU A 103
ILE A  50
TYR A  47
PHE A  53
PHE A  67
 None
 1.37A 2weyB-3khsA:
undetectable		 2weyB-3khsA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrh ANTI-HUNTINGTIN VL
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		4 LEU A  40
VAL A 109
ILE A  76
PHE A  63
 None
 0.97A 2weyB-3lrhA:
undetectable		 2weyB-3lrhA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muo PROLYL ENDOPEPTIDASE

(Aeromonas
caviae) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 LEU A 263
VAL A 222
ILE A 247
PHE A 186
 None
 0.96A 2weyB-3muoA:
undetectable		 2weyB-3muoA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 4 VAL B  36
ILE B 108
TYR B 105
PHE B  60
 None
 0.81A 2weyB-3n3bB:
undetectable		 2weyB-3n3bB:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ILE A 410
PHE A 414
GLN A 443
PHE A 446
 ZG2  A 506 (-4.4A)
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
 0.47A 2weyB-3o57A:
37.8		 2weyB-3o57A:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		4 TYR A 111
PHE A  88
GLN A 336
PHE A 333
 None
 0.98A 2weyB-3oqbA:
undetectable		 2weyB-3oqbA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oru DUF1989 FAMILY
PROTEIN

(Ruegeria sp.
TM1040) 		PF09347
(DUF1989) 		4 LEU A 108
VAL A  56
ILE A  46
PHE A  67
 None
 0.95A 2weyB-3oruA:
undetectable		 2weyB-3oruA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qjg EPIDERMIN
BIOSYNTHESIS PROTEIN
EPID

(Staphylococcus
aureus) 		PF02441
(Flavoprotein) 		4 LEU A 169
VAL A  32
ILE A  78
PHE A 113
 None
 0.98A 2weyB-3qjgA:
undetectable		 2weyB-3qjgA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnw CASPASE-6

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 LEU B 232
VAL A 115
ILE A  49
PHE A  78
 None
 0.98A 2weyB-3qnwB:
undetectable		 2weyB-3qnwB:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ILE A 336
MET A 357
GLN A 369
PHE A 372
 ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.86A 2weyB-3sl5A:
37.4		 2weyB-3sl5A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ILE A 336
PHE A 340
GLN A 369
PHE A 372
 ILE  A 336 ( 0.4A)
PHE  A 340 (-1.3A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.54A 2weyB-3sl5A:
37.4		 2weyB-3sl5A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqu NON-CANONICAL PURINE
NTP PYROPHOSPHATASE

(Coxiella
burnetii) 		PF01725
(Ham1p_like) 		4 LEU A 134
ILE A  26
PHE A  28
MET A  17
 None
 0.80A 2weyB-3tquA:
undetectable		 2weyB-3tquA:
21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		8 LEU A 635
VAL A 678
ILE A 692
TYR A 693
PHE A 696
MET A 713
GLN A 726
PHE A 729
 None
C1L  A   1 (-4.9A)
C1L  A   1 (-4.3A)
None
C1L  A   1 ( 4.7A)
C1L  A   1 (-3.7A)
C1L  A   1 (-2.9A)
C1L  A   1 (-3.5A)
 0.45A 2weyB-3ui7A:
49.6		 2weyB-3ui7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw0 PECTINESTERASE

(Yersinia
enterocolitica) 		PF01095
(Pectinesterase) 		4 LEU A 158
VAL A 170
ILE A 194
PHE A 189
 None
 0.92A 2weyB-3uw0A:
undetectable		 2weyB-3uw0A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v39 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		4 LEU A  68
ILE A 273
TYR A 272
PHE A 269
 None
 0.97A 2weyB-3v39A:
undetectable		 2weyB-3v39A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		4 ILE A 538
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.74A 2weyB-3v94A:
37.6		 2weyB-3v94A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A2711
ILE A2786
PHE A2788
PHE A2772
 None
 0.91A 2weyB-3vkgA:
undetectable		 2weyB-3vkgA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zl4 A17 ANTIBODY FAB
FRAGMENT LAMBDA
LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L  40
VAL L 108
ILE L  76
PHE L  63
 None
 0.95A 2weyB-3zl4L:
undetectable		 2weyB-3zl4L:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)

(Trypanosoma
brucei) 		PF00025
(Arf) 		4 VAL A  57
ILE A  77
TYR A  74
MET A 102
 None
 0.91A 2weyB-4basA:
undetectable		 2weyB-4basA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		4 LEU A 684
ILE A 619
TYR A 614
PHE A 702
 None
 0.95A 2weyB-4e93A:
undetectable		 2weyB-4e93A:
23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 623
VAL A 646
PHE A 746
MET A 757
 None
 0.89A 2weyB-4htzA:
40.9		 2weyB-4htzA:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		7 LEU A 770
ILE A 826
TYR A 827
PHE A 830
MET A 847
GLN A 859
PHE A 862
 None
 0.68A 2weyB-4htzA:
40.9		 2weyB-4htzA:
35.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hva CASPASE-6

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 LEU A 232
VAL A 115
ILE A  49
PHE A  78
 None
 0.95A 2weyB-4hvaA:
undetectable		 2weyB-4hvaA:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		4 VAL A 826
PHE A 844
MET A 861
PHE A 877
 None
 0.71A 2weyB-4i15A:
38.4		 2weyB-4i15A:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 LEU A 493
VAL A 258
ILE A 464
PHE A 329
 None
 0.94A 2weyB-4ig9A:
undetectable		 2weyB-4ig9A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE

(Rhizomucor
miehei) 		PF03639
(Glyco_hydro_81) 		4 LEU A 225
VAL A 247
ILE A 205
PHE A 175
 None
 0.89A 2weyB-4k35A:
2.7		 2weyB-4k35A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		4 LEU A 129
VAL A 218
TYR A 485
GLN A 164
 None
 0.64A 2weyB-4kwgA:
undetectable		 2weyB-4kwgA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9f TRANSCRIPTIONAL
REGULATOR, PPSR

(Rhodobacter
sphaeroides) 		PF00989
(PAS) 		4 LEU A 234
ILE A 195
PHE A 207
MET A 211
 None
 0.89A 2weyB-4l9fA:
undetectable		 2weyB-4l9fA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		4 LEU A 202
VAL A 295
ILE A 216
PHE A 282
 None
 0.95A 2weyB-4mr0A:
undetectable		 2weyB-4mr0A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 333
VAL A 441
ILE A 308
PHE A 402
 None
 0.98A 2weyB-4na3A:
undetectable		 2weyB-4na3A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 LEU A 503
VAL A 277
ILE A 449
PHE A 450
 None
 0.95A 2weyB-4pfwA:
undetectable		 2weyB-4pfwA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 LEU A 241
ILE A 234
PHE A 221
MET A 220
 None
 0.98A 2weyB-4phcA:
undetectable		 2weyB-4phcA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb9 ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycolicibacterium
smegmatis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 LEU A 356
VAL A 314
ILE A 333
PHE A 386
 None
 0.97A 2weyB-4qb9A:
undetectable		 2weyB-4qb9A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qc6 BIFUNCTIONAL AAC/APH

(Staphylococcus
warneri) 		PF13523
(Acetyltransf_8) 		5 LEU A 124
ILE A 117
TYR A 148
PHE A 153
GLN A 100
 None
None
30N  A 202 (-4.5A)
None
None
 1.28A 2weyB-4qc6A:
undetectable		 2weyB-4qc6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		4 LEU A 264
ILE A  62
TYR A  72
PHE A  69
 None
 0.99A 2weyB-4rwfA:
2.1		 2weyB-4rwfA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 LEU E 179
VAL E 248
ILE E 215
PHE E 202
 None
 0.89A 2weyB-4v1dE:
undetectable		 2weyB-4v1dE:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrr PUTATIVE
DIACYLGLYCEROL
KINASE

(Bacillus
anthracis) 		PF00781
(DAGK_cat) 		4 LEU A 144
ILE A 239
TYR A 238
PHE A 235
 None
 0.79A 2weyB-4wrrA:
undetectable		 2weyB-4wrrA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ILE A 582
PHE A 586
GLN A 615
PHE A 618
 None
 0.56A 2weyB-4wziA:
37.6		 2weyB-4wziA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5x DIABODY 310 VH
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		4 LEU B  40
VAL B 109
ILE B  76
PHE B  63
 None
None
None
PEG  B 201 (-4.7A)
 0.97A 2weyB-4y5xB:
undetectable		 2weyB-4y5xB:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yam BETA-ETHERASE

(Sphingobium sp.
SYK-6) 		PF13417
(GST_N_3) 		4 LEU A 143
ILE A 119
TYR A 122
PHE A 115
 None
 0.99A 2weyB-4yamA:
undetectable		 2weyB-4yamA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF00497
(SBP_bac_3) 		4 LEU A 197
ILE A 128
PHE A 144
MET A 149
 None
 0.98A 2weyB-4z9nA:
undetectable		 2weyB-4z9nA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 LEU A 493
VAL A 258
ILE A 464
PHE A 329
 None
 0.93A 2weyB-4zzhA:
undetectable		 2weyB-4zzhA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		4 LEU A 129
VAL A 218
TYR A 485
GLN A 164
 None
 0.57A 2weyB-5abmA:
undetectable		 2weyB-5abmA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Arabidopsis
thaliana) 		PF02446
(Glyco_hydro_77) 		4 LEU A  88
VAL A 279
ILE A 290
TYR A 367
 None
 0.94A 2weyB-5csuA:
undetectable		 2weyB-5csuA:
21.68