SIMILAR PATTERNS OF AMINO ACIDS FOR 2WET_B_TRPB650_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		5 SER A 324
ILE A 318
HIS A 416
PHE A 350
GLU A 338
 None
 1.49A 2wetB-1lw3A:
0.7		 2wetB-1lw3A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158

(Thermotoga
maritima) 		PF00117
(GATase) 		5 SER A  91
ILE A   6
HIS A   8
GLN A 171
GLU A  70
 OCS  A  88 ( 2.6A)
None
None
OCS  A  88 ( 4.1A)
None
 1.46A 2wetB-1o1yA:
2.5		 2wetB-1o1yA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 SER A 517
THR A 352
GLN A 519
GLU A 605
TYR A 635
 None
 1.44A 2wetB-1r9jA:
3.4		 2wetB-1r9jA:
22.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2weu TRYPTOPHAN
5-HALOGENASE

(Streptomyces
rugosporus) 		PF04820
(Trp_halogenase) 		10 PHE A  49
SER A  50
THR A  51
ILE A  78
HIS A  92
PHE A  94
GLN A 160
GLN A 163
GLU A 354
TYR A 454
 TRP  A1512 (-3.5A)
TRP  A1512 (-2.5A)
TRP  A1512 (-3.8A)
TRP  A1512 ( 4.6A)
TRP  A1512 (-3.2A)
TRP  A1512 (-3.9A)
TRP  A1512 (-3.7A)
TRP  A1512 (-2.9A)
TRP  A1512 (-4.4A)
None
 0.16A 2wetB-2weuA:
62.0		 2wetB-2weuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		5 SER A 591
THR A 601
GLN A 589
GLN A 526
GLU A 953
 None
 1.16A 2wetB-5a42A:
0.0		 2wetB-5a42A:
16.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		6 PHE A  49
SER A  50
HIS A  92
PHE A  94
GLN A 167
TYR A 459
 None
 0.75A 2wetB-5lv9A:
53.8		 2wetB-5lv9A:
54.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY

(Brevundimonas
sp. BAL3) 		no annotation 5 THR A  59
ILE A  86
HIS A 100
PHE A 102
GLU A 349
 None
 0.58A 2wetB-6frlA:
45.6		 2wetB-6frlA:
undetectable