SIMILAR PATTERNS OF AMINO ACIDS FOR 2WEK_B_DIFB1376_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs9 ACETYL XYLAN
ESTERASE

(Talaromyces
purpureogenus) 		PF01083
(Cutinase) 		4 VAL A  26
GLY A   9
ALA A  40
SER A  22
 None
 0.88A 2wekB-1bs9A:
undetectable		 2wekB-1bs9A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyd CARBONYL REDUCTASE

(Mus musculus) 		PF13561
(adh_short_C2) 		4 GLY A 154
ALA A 155
MET A 156
LEU A 159
 None
 0.86A 2wekB-1cydA:
9.1		 2wekB-1cydA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 VAL A 496
GLY A 473
ALA A 474
LEU A 191
 None
None
None
SF4  A 582 (-4.3A)
 0.92A 2wekB-1fehA:
2.4		 2wekB-1fehA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN

(Influenza C
virus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 TYR A 113
GLY A  42
ALA A  43
LEU A 367
 None
 0.89A 2wekB-1flcA:
undetectable		 2wekB-1flcA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqo HYPOTHETICAL PROTEIN
MTH1880

(Methanothermobacter) 		PF05370
(DUF749) 		4 TYR A  59
GLY A  73
ALA A  72
LEU A  54
 None
 0.79A 2wekB-1iqoA:
undetectable		 2wekB-1iqoA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE BETA
SUBUNIT

(Klebsiella
pneumoniae) 		PF02288
(Dehydratase_MU) 		4 TYR B  12
GLY B  20
ALA B  21
LEU B  25
 None
 0.84A 2wekB-1nbwB:
undetectable		 2wekB-1nbwB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qoz ACETYL XYLAN
ESTERASE

(Trichoderma
reesei) 		PF01083
(Cutinase) 		4 VAL A  26
GLY A   9
ALA A  40
SER A  22
 None
 0.89A 2wekB-1qozA:
3.1		 2wekB-1qozA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s16 TOPOISOMERASE IV
SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 VAL A1126
GLY A1144
ALA A1121
LEU A1122
 None
 0.86A 2wekB-1s16A:
undetectable		 2wekB-1s16A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcz GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		4 TYR A  88
VAL A 196
GLY A 182
LEU A  47
 None
 0.86A 2wekB-1wczA:
undetectable		 2wekB-1wczA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wly 2-HALOACRYLATE
REDUCTASE

(Burkholderia
sp. WS) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 302
GLY A 125
ALA A 124
SER A 300
 VAL  A 302 ( 0.6A)
GLY  A 125 ( 0.0A)
ALA  A 124 ( 0.0A)
SER  A 300 ( 0.0A)
 0.93A 2wekB-1wlyA:
32.3		 2wekB-1wlyA:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yna ENDO-1,4-BETA-XYLANA
SE

(Thermomyces
lanuginosus) 		PF00457
(Glyco_hydro_11) 		4 TYR A 180
GLY A  22
ALA A  23
LEU A  45
 None
 0.79A 2wekB-1ynaA:
undetectable		 2wekB-1ynaA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Streptococcus
pneumoniae) 		PF02390
(Methyltransf_4) 		5 TYR A  19
GLY A  50
ALA A  78
LEU A  75
SER A  54
 None
 1.45A 2wekB-1yzhA:
5.6		 2wekB-1yzhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Streptococcus
pneumoniae) 		PF03070
(TENA_THI-4) 		4 TYR A 127
GLY A  66
ALA A  67
MET A  64
 None
 0.87A 2wekB-1z72A:
undetectable		 2wekB-1z72A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE

(Escherichia
coli) 		PF02734
(Dak2) 		4 VAL A  76
GLY A  78
ALA A  79
LEU A  83
 None
ADP  A1211 (-3.5A)
ADP  A1211 (-3.5A)
ADP  A1211 (-4.5A)
 0.90A 2wekB-2btdA:
undetectable		 2wekB-2btdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1f THREONINE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		4 VAL A 325
GLY A 327
LEU A  62
SER A 299
 None
PLP  A 500 ( 3.8A)
None
PLP  A 500 ( 4.3A)
 0.74A 2wekB-2d1fA:
2.6		 2wekB-2d1fA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE

(Pyrococcus
horikoshii) 		PF00390
(malic)
PF03949
(Malic_M) 		4 GLY A 195
ALA A 194
LEU A 202
SER A 139
 NAD  A2503 ( 3.3A)
None
None
NAD  A2503 ( 4.2A)
 0.79A 2wekB-2dvmA:
6.6		 2wekB-2dvmA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		4 VAL A 344
GLY A 342
ALA A 341
LEU A  31
 None
 0.81A 2wekB-2g04A:
5.7		 2wekB-2g04A:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 TYR A 208
VAL A 233
GLY A 235
MET A 237
 None
 0.53A 2wekB-2j3hA:
36.2		 2wekB-2j3hA:
30.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 VAL A 233
GLY A 235
MET A 237
SER A 258
 None
 0.48A 2wekB-2j3hA:
36.2		 2wekB-2j3hA:
30.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyt 2-DEHYDROPANTOATE
2-REDUCTASE

(Porphyromonas
gingivalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 GLY A  21
ALA A  22
MET A  23
LEU A  26
 None
 0.61A 2wekB-2qytA:
5.6		 2wekB-2qytA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rha TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Novosphingobium
aromaticivorans) 		PF14514
(TetR_C_9) 		4 TYR A  54
GLY A  15
ALA A  16
LEU A  20
 None
SO4  A 216 (-3.3A)
None
None
 0.63A 2wekB-2rhaA:
undetectable		 2wekB-2rhaA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A  52
GLY A  28
ALA A  98
LEU A  96
 None
 0.87A 2wekB-2v6bA:
5.9		 2wekB-2v6bA:
23.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 TYR A 193
VAL A 218
GLY A 220
SER A 243
 NAP  A 701 (-4.2A)
NAP  A 701 (-4.3A)
None
NAP  A 701 (-4.9A)
 0.49A 2wekB-2y05A:
35.7		 2wekB-2y05A:
30.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio) 		PF00514
(Arm) 		4 VAL A 616
GLY A 574
ALA A 575
LEU A 579
 None
 0.94A 2wekB-2z6gA:
undetectable		 2wekB-2z6gA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc0 ALANINE GLYOXYLATE
TRANSAMINASE

(Thermococcus
litoralis) 		PF00155
(Aminotran_1_2) 		4 TYR A 179
GLY A 109
ALA A 110
LEU A 114
 None
 0.78A 2wekB-2zc0A:
3.6		 2wekB-2zc0A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 VAL A 257
GLY A 253
ALA A 249
LEU A 250
 None
 0.82A 2wekB-3blwA:
undetectable		 2wekB-3blwA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm1 PROTEIN YDJA

(Escherichia
coli) 		PF00881
(Nitroreductase) 		4 VAL A 142
GLY A  65
ALA A  66
SER A 139
 None
 0.92A 2wekB-3bm1A:
undetectable		 2wekB-3bm1A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c28 RECOMBINASE CRE

(Escherichia
virus P1) 		PF00589
(Phage_integrase) 		4 GLY A 333
ALA A 334
MET A 335
LEU A 338
 None
 0.60A 2wekB-3c28A:
undetectable		 2wekB-3c28A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dme CONSERVED EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF01266
(DAO) 		4 VAL A   9
GLY A  11
ALA A  12
LEU A 167
 None
FAD  A 500 (-3.3A)
None
None
 0.94A 2wekB-3dmeA:
3.0		 2wekB-3dmeA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtt NADP OXIDOREDUCTASE

(Arthrobacter
sp. FB24) 		PF03807
(F420_oxidored) 		4 VAL A  26
GLY A  17
ALA A  18
LEU A  22
 None
 0.87A 2wekB-3dttA:
5.2		 2wekB-3dttA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egc PUTATIVE RIBOSE
OPERON REPRESSOR

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		4 GLY A 259
ALA A 260
MET A 261
LEU A 264
 None
 0.54A 2wekB-3egcA:
undetectable		 2wekB-3egcA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv5 DNA TOPOISOMERASE 4
SUBUNIT B

(Escherichia
coli) 		PF02518
(HATPase_c) 		4 VAL A 126
GLY A 144
ALA A 121
LEU A 122
 None
 0.91A 2wekB-3fv5A:
undetectable		 2wekB-3fv5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION

(Saccharomyces
cerevisiae) 		PF10291
(muHD) 		4 TYR A 701
GLY A 697
ALA A 698
LEU A 671
 None
 0.76A 2wekB-3g9hA:
undetectable		 2wekB-3g9hA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 VAL A  77
ALA A  69
MET A  70
LEU A  73
 None
 0.77A 2wekB-3gd5A:
8.1		 2wekB-3gd5A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05193
(Peptidase_M16_C) 		4 GLY A 373
ALA A 374
MET A 375
LEU A 380
 None
 0.89A 2wekB-3gwbA:
undetectable		 2wekB-3gwbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 GLY A 344
ALA A 345
MET A 346
LEU A 349
 None
 0.31A 2wekB-3hjrA:
undetectable		 2wekB-3hjrA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hug PROBABLE CONSERVED
MEMBRANE PROTEIN

(Mycobacterium
tuberculosis) 		PF13490
(zf-HC2) 		4 TYR B  34
GLY B  59
ALA B  60
LEU B  64
 None
 0.82A 2wekB-3hugB:
undetectable		 2wekB-3hugB:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1j OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF00106
(adh_short) 		4 TYR A  33
GLY A  20
ALA A  21
LEU A  42
 None
EDO  A 252 (-3.3A)
None
None
 0.91A 2wekB-3i1jA:
8.2		 2wekB-3i1jA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iah SHORT CHAIN
DEHYDROGENASE YCIK

(Salmonella
enterica) 		PF00106
(adh_short) 		4 TYR A  32
GLY A  19
ALA A  20
LEU A  41
 None
NAP  A 254 (-3.2A)
None
None
 0.94A 2wekB-3iahA:
8.2		 2wekB-3iahA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j93 NEUTRALIZING
ANTIBODY 22A12,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H 143
GLY H 140
ALA H 139
SER H 191
 None
 0.92A 2wekB-3j93H:
undetectable		 2wekB-3j93H:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 GASTRIC INTRINSIC
FACTOR

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		4 GLY A 173
ALA A 174
MET A 175
LEU A 178
 None
 0.52A 2wekB-3kq4A:
undetectable		 2wekB-3kq4A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A

(Homo sapiens) 		PF13419
(HAD_2) 		4 GLY A  94
ALA A  95
LEU A  91
SER A 213
 None
 0.87A 2wekB-3l5kA:
4.0		 2wekB-3l5kA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6d PUTATIVE
OXIDOREDUCTASE

(Pseudomonas
putida) 		PF03446
(NAD_binding_2) 		4 VAL A  72
GLY A  18
ALA A  19
MET A  20
 None
 0.86A 2wekB-3l6dA:
5.6		 2wekB-3l6dA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 VAL A 414
GLY A 380
ALA A 381
LEU A 405
 None
 0.92A 2wekB-3lkdA:
8.5		 2wekB-3lkdA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lps TOPOISOMERASE IV
SUBUNIT B

(Xanthomonas
oryzae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 VAL A 170
GLY A 188
ALA A 165
LEU A 166
 None
 0.90A 2wekB-3lpsA:
undetectable		 2wekB-3lpsA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my9 MUCONATE
CYCLOISOMERASE

(Azorhizobium
caulinodans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 205
ALA A 206
MET A 207
LEU A 210
 None
 0.64A 2wekB-3my9A:
undetectable		 2wekB-3my9A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		4 VAL A 218
GLY A 249
ALA A 250
LEU A 254
 None
 0.72A 2wekB-3o82A:
2.3		 2wekB-3o82A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		4 GLY A 396
ALA A 397
MET A 398
LEU A 401
 None
 0.65A 2wekB-3odmA:
undetectable		 2wekB-3odmA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on3 KETO/OXOACID
FERREDOXIN
OXIDOREDUCTASE,
GAMMA SUBUNIT

(Geobacter
sulfurreducens) 		PF01558
(POR) 		4 GLY A 136
ALA A 137
MET A 138
LEU A 141
 None
 0.61A 2wekB-3on3A:
3.3		 2wekB-3on3A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7k PROBABLE ACYL COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 181
ALA A 230
LEU A 219
SER A 143
 None
 0.84A 2wekB-3r7kA:
undetectable		 2wekB-3r7kA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 VAL A1042
GLY A1050
ALA A1066
LEU A1064
 None
 0.92A 2wekB-3s5kA:
undetectable		 2wekB-3s5kA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3soe MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		no annotation 4 GLY A 589
ALA A 590
MET A 591
LEU A 594
 None
 0.74A 2wekB-3soeA:
undetectable		 2wekB-3soeA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am6 ACTIN-LIKE PROTEIN
ARP8

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		4 GLY A 734
ALA A 839
LEU A 840
SER A 737
 None
SO4  A1883 (-3.5A)
None
None
 0.89A 2wekB-4am6A:
undetectable		 2wekB-4am6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atg TAF6

(Antonospora
locustae) 		PF07571
(TAF6_C) 		4 TYR A 335
GLY A 311
ALA A 312
LEU A 316
 None
 0.61A 2wekB-4atgA:
undetectable		 2wekB-4atgA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 TYR A 289
GLY A 358
ALA A 359
LEU A 347
 None
 0.92A 2wekB-4av6A:
undetectable		 2wekB-4av6A:
19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b7x PROBABLE
OXIDOREDUCTASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 TYR A 200
VAL A 224
GLY A 226
SER A 249
 NAP  A 400 (-4.8A)
NAP  A 400 (-4.6A)
None
NAP  A 400 (-4.9A)
 0.49A 2wekB-4b7xA:
37.7		 2wekB-4b7xA:
30.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4co6 PHOSPHOPROTEIN

(Nipah
henipavirus) 		PF14313
(Soyouz_module) 		4 GLY D  -1
ALA D   0
MET D   1
LEU D   4
 None
 0.52A 2wekB-4co6D:
undetectable		 2wekB-4co6D:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee9 ENDOGLUCANASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		4 VAL A   9
GLY A  11
ALA A  12
LEU A  50
 None
 0.88A 2wekB-4ee9A:
undetectable		 2wekB-4ee9A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqo LMO0859 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		4 VAL A 119
ALA A 335
MET A 336
LEU A 339
 None
 0.92A 2wekB-4gqoA:
undetectable		 2wekB-4gqoA:
22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hfn ALLYL ALCOHOL
DEHYDROGENASE

(Nicotiana
tabacum) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 TYR A 206
VAL A 231
GLY A 233
MET A 235
 NAP  A 400 (-4.4A)
NAP  A 400 ( 4.5A)
None
None
 0.51A 2wekB-4hfnA:
36.4		 2wekB-4hfnA:
31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hfn ALLYL ALCOHOL
DEHYDROGENASE

(Nicotiana
tabacum) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 VAL A 231
GLY A 233
MET A 235
SER A 256
 NAP  A 400 ( 4.5A)
None
None
NAP  A 400 (-4.9A)
 0.36A 2wekB-4hfnA:
36.4		 2wekB-4hfnA:
31.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 TYR A3750
ALA A3716
MET A3717
LEU A3720
 None
 0.94A 2wekB-4kc5A:
undetectable		 2wekB-4kc5A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkj TRANSCOBALAMIN-1

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		4 GLY A 165
ALA A 166
MET A 167
LEU A 170
 None
 0.33A 2wekB-4kkjA:
undetectable		 2wekB-4kkjA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA) 		4 VAL A  73
GLY A  11
ALA A  12
MET A  13
 NAI  A 401 (-4.6A)
NAI  A 401 (-3.3A)
NAI  A 401 (-3.6A)
NAI  A 401 (-4.2A)
 0.89A 2wekB-4mioA:
6.6		 2wekB-4mioA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)

(Bradyrhizobium
sp. BTAi1) 		PF03480
(DctP) 		4 VAL A 241
GLY A  79
ALA A  80
SER A 238
 None
 0.84A 2wekB-4n8yA:
undetectable		 2wekB-4n8yA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkj HEMAGGLUTININ HA2

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		4 GLY A  38
ALA A  39
MET A  40
LEU A  43
 None
 0.47A 2wekB-4nkjA:
undetectable		 2wekB-4nkjA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TYR A 365
VAL A 371
GLY A 369
ALA A 368
 None
 0.88A 2wekB-4q1vA:
2.6		 2wekB-4q1vA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3o MGS-MT1

(unidentified) 		PF07859
(Abhydrolase_3) 		4 TYR A  71
GLY A 252
ALA A 253
LEU A 257
 None
 0.83A 2wekB-4q3oA:
2.6		 2wekB-4q3oA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 GLY A 824
ALA A 821
MET A 822
LEU B 458
 None
 0.81A 2wekB-4qiwA:
undetectable		 2wekB-4qiwA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnh MOTILITY REGULATOR

(Pseudomonas
aeruginosa) 		PF00563
(EAL)
PF00990
(GGDEF) 		4 TYR A1321
ALA A1293
MET A1294
LEU A1297
 None
 0.87A 2wekB-4rnhA:
undetectable		 2wekB-4rnhA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Yersinia
enterocolitica) 		PF01380
(SIS) 		4 GLY A 211
ALA A 212
MET A 213
LEU A 216
 None
 0.57A 2wekB-4s12A:
3.6		 2wekB-4s12A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnm IMPORTIN SUBUNIT
ALPHA

(Arabidopsis
thaliana) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		4 GLY A 203
ALA A 204
MET A 205
LEU A 208
 None
 0.66A 2wekB-4tnmA:
undetectable		 2wekB-4tnmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzj NOTUM

(Drosophila
melanogaster) 		PF03283
(PAE) 		4 TYR A 317
GLY A 239
ALA A 238
MET A 241
 None
 0.89A 2wekB-4uzjA:
2.6		 2wekB-4uzjA:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wgg DOUBLE BOND
REDUCTASE

(Zingiber
officinale) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 TYR A 213
VAL A 238
GLY A 240
MET A 242
 NAP  A 400 (-4.5A)
NAP  A 400 ( 4.5A)
None
None
 0.50A 2wekB-4wggA:
36.9		 2wekB-4wggA:
30.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wgg DOUBLE BOND
REDUCTASE

(Zingiber
officinale) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 VAL A 238
GLY A 240
MET A 242
SER A 263
 NAP  A 400 ( 4.5A)
None
None
NAP  A 400 (-4.8A)
 0.41A 2wekB-4wggA:
36.9		 2wekB-4wggA:
30.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmo XEEL PROTEIN

(Xenopus laevis) 		no annotation 4 GLY F 310
ALA F 313
LEU F 315
SER F 130
 CA  F 403 ( 4.6A)
None
None
None
 0.88A 2wekB-4wmoF:
undetectable		 2wekB-4wmoF:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwh ABC TRANSPORTER

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 GLY A 187
ALA A 188
MET A 189
LEU A 192
 None
 0.59A 2wekB-4wwhA:
undetectable		 2wekB-4wwhA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ys6 PUTATIVE
SOLUTE-BINDING
COMPONENT OF ABC
TRANSPORTER

(Lachnoclostridium
phytofermentans) 		PF13407
(Peripla_BP_4) 		4 GLY A 164
ALA A 165
MET A 166
LEU A 169
 None
 0.64A 2wekB-4ys6A:
undetectable		 2wekB-4ys6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79

(Burkholderia
pseudomallei) 		PF12891
(Glyco_hydro_44) 		4 TYR A 192
GLY A 242
ALA A 243
LEU A 210
 None
 0.64A 2wekB-5bwiA:
undetectable		 2wekB-5bwiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy0 GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		4 GLY A 277
ALA A 278
MET A 279
LEU A 282
 None
 0.62A 2wekB-5gy0A:
undetectable		 2wekB-5gy0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 GLY A 820
ALA A 817
MET A 818
LEU B 514
 None
 0.92A 2wekB-5ip9A:
undetectable		 2wekB-5ip9A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Paraburkholderia
xenovorans) 		PF00155
(Aminotran_1_2) 		4 GLY A 112
ALA A 115
MET A 114
SER A 139
 None
 0.93A 2wekB-5jayA:
5.1		 2wekB-5jayA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh1 ALDOSE REDUCTASE,
AKR4C7

(Zea mays) 		PF00248
(Aldo_ket_red) 		4 GLY A 137
ALA A 138
MET A 139
LEU A 142
 None
 0.61A 2wekB-5jh1A:
2.0		 2wekB-5jh1A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjc CYSTEINE SYNTHASE

(Brucella
abortus) 		PF00291
(PALP) 		4 TYR A 218
VAL A 182
GLY A 235
ALA A 212
 None
LLP  A  42 ( 4.0A)
None
None
 0.93A 2wekB-5jjcA:
2.6		 2wekB-5jjcA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngj TAIL TUBE PROTEIN

(Escherichia
virus T5) 		no annotation 4 GLY A 111
ALA A 112
LEU A 106
SER A 100
 CL  A 502 (-3.4A)
None
None
CL  A 502 (-4.2A)
 0.84A 2wekB-5ngjA:
undetectable		 2wekB-5ngjA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj5 V-TYPE PROTON ATPASE
SUBUNIT A
V-TYPE PROTON ATPASE
SUBUNIT E

(Saccharomyces
cerevisiae) 		PF01496
(V_ATPase_I)
PF05493
(ATP_synt_H) 		4 TYR A 550
ALA L  42
MET L  43
LEU L  46
 None
 0.87A 2wekB-5tj5A:
undetectable		 2wekB-5tj5A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION

(Mycobacterium
tuberculosis) 		no annotation 4 TYR A 142
GLY A 227
ALA A 228
LEU A 232
 1PE  A 401 (-4.6A)
None
1PE  A 401 ( 4.0A)
1PE  A 401 ( 4.9A)
 0.88A 2wekB-5w95A:
3.4		 2wekB-5w95A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 GLY A 405
ALA A 406
LEU A 385
SER A 236
 None
 0.91A 2wekB-5xbpA:
undetectable		 2wekB-5xbpA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 4 TYR A 246
GLY A 336
ALA A 335
LEU A 252
 None
 0.89A 2wekB-5yimA:
undetectable		 2wekB-5yimA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		no annotation 4 GLY A 109
ALA A 111
MET A 112
LEU A 115
 None
 0.88A 2wekB-5zbqA:
undetectable		 2wekB-5zbqA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLY A  34
ALA A  37
MET A  36
SER A 368
 None
 0.94A 2wekB-6aphA:
9.5		 2wekB-6aphA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7p SDED

(Legionella
pneumophila) 		no annotation 4 TYR A  15
GLY A 122
ALA A 121
LEU A  21
 None
 0.83A 2wekB-6b7pA:
undetectable		 2wekB-6b7pA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 1

(Saccharomyces
cerevisiae) 		no annotation 4 GLY 1 386
ALA 1 387
LEU 1 383
SER 1 445
 None
 0.88A 2wekB-6c261:
undetectable		 2wekB-6c261:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 4 VAL A 111
GLY A  25
ALA A  24
LEU A   8
 None
 0.92A 2wekB-6cmzA:
2.8		 2wekB-6cmzA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 4 GLY A 100
ALA A 101
MET A 102
LEU A 105
 None
 0.71A 2wekB-6dk2A:
undetectable		 2wekB-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 TYR A 292
GLY A 236
ALA A 235
LEU A 246
 None
 0.83A 2wekB-6etzA:
undetectable		 2wekB-6etzA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila) 		no annotation 4 TYR A 246
GLY A 336
ALA A 335
LEU A 252
 None
 0.92A 2wekB-6g0cA:
undetectable		 2wekB-6g0cA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
11

(Mus musculus) 		no annotation 4 GLY Y  66
ALA Y  67
MET Y  68
LEU Y  71
 None
 0.60A 2wekB-6g72Y:
undetectable		 2wekB-6g72Y:
14.60