SIMILAR PATTERNS OF AMINO ACIDS FOR 2WEK_B_DIFB1374_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ako EXONUCLEASE III

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		4 MET A 152
PRO A 111
ILE A 154
LEU A 190
 None
 1.07A 2wekB-1akoA:
undetectable		 2wekB-1akoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		4 PRO A 434
ILE A 459
ASN A 430
LEU A 396
 GOL  A 900 (-4.4A)
None
None
None
 1.28A 2wekB-1dl2A:
undetectable		 2wekB-1dl2A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtp DIPHTHERIA TOXIN

(Corynephage
beta) 		PF02763
(Diphtheria_C) 		4 PRO A  25
ILE A  31
ASN A 166
LEU A 163
 None
APU  A 200 ( 3.7A)
None
None
 1.00A 2wekB-1dtpA:
undetectable		 2wekB-1dtpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
SMALL SUBUNIT

(Desulfovibrio
desulfuricans) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 MET A 260
PRO A 262
ILE A 249
ASN A 266
 None
None
F3S  A 267 (-4.4A)
None
 1.29A 2wekB-1e3dA:
undetectable		 2wekB-1e3dA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 TYR A 448
ILE A  28
ASN A 272
LEU A 258
 None
 1.24A 2wekB-1gpeA:
undetectable		 2wekB-1gpeA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3d ATP-PHOSPHORIBOSYLTR
ANSFERASE

(Escherichia
coli) 		PF01634
(HisG)
PF08029
(HisG_C) 		4 MET A 265
PRO A 251
ILE A 229
LEU A 281
 None
 1.26A 2wekB-1h3dA:
undetectable		 2wekB-1h3dA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2

(Saccharomyces
cerevisiae) 		PF00268
(Ribonuc_red_sm) 		4 PRO B 238
ILE B 246
ASN B 291
LEU B 286
 None
 1.38A 2wekB-1jk0B:
undetectable		 2wekB-1jk0B:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp2 ARGININOSUCCINATE
SYNTHETASE

(Escherichia
coli) 		PF00764
(Arginosuc_synth) 		4 TYR A 291
PRO A 103
ILE A 282
ASN A  91
 None
PO4  A 456 (-4.1A)
None
None
 1.39A 2wekB-1kp2A:
6.5		 2wekB-1kp2A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 TYR A 604
PRO A 618
ILE A 696
LEU A 797
 None
 1.27A 2wekB-1n7rA:
undetectable		 2wekB-1n7rA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E

(Streptococcus
pyogenes) 		PF01515
(PTA_PTB) 		4 PRO A 294
ILE A 173
ASN A 277
LEU A 273
 None
 1.29A 2wekB-1r5jA:
3.3		 2wekB-1r5jA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 PRO A 435
ILE A 346
ASN A 603
LEU A 336
 None
 1.26A 2wekB-1ryyA:
2.2		 2wekB-1ryyA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT

(Thauera
aromatica) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 TYR B 159
PRO B 234
ASN B 115
LEU B  78
 None
None
FAD  B1900 (-3.2A)
FAD  B1900 (-4.7A)
 1.31A 2wekB-1sb3B:
undetectable		 2wekB-1sb3B:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tev UMP-CMP KINASE

(Homo sapiens) 		PF00406
(ADK) 		4 TYR A 166
PRO A  95
ILE A  69
ASN A 105
 None
 1.14A 2wekB-1tevA:
undetectable		 2wekB-1tevA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xs5 MEMBRANE LIPOPROTEIN
TPN32

(Treponema
pallidum) 		PF03180
(Lipoprotein_9) 		4 TYR A  44
ILE A 110
ASN A 175
LEU A  89
 MET  A 301 (-3.7A)
None
MET  A 301 (-3.8A)
None
 1.35A 2wekB-1xs5A:
undetectable		 2wekB-1xs5A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeg HYPOTHETICAL PROTEIN
AGR_PAT_140

(Agrobacterium
fabrum) 		PF02586
(SRAP) 		4 PRO A 192
ILE A 233
ASN A 187
LEU A 231
 None
 1.36A 2wekB-2aegA:
undetectable		 2wekB-2aegA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 PRO A 276
ILE A 261
ASN A 319
LEU A 218
 None
 1.15A 2wekB-2bpqA:
2.2		 2wekB-2bpqA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		4 TYR A 811
PRO A 945
ILE A 999
LEU A1045
 None
 1.35A 2wekB-2ec5A:
undetectable		 2wekB-2ec5A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 PRO A 162
ILE A 250
ASN A 216
LEU A 229
 None
 1.27A 2wekB-2ep5A:
5.3		 2wekB-2ep5A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsj PUTATIVE PLATELET
ACTIVATING FACTOR

(Streptococcus
pneumoniae) 		PF13472
(Lipase_GDSL_2) 		4 TYR A  21
ILE A  34
ASN A  59
LEU A  47
 None
 1.36A 2wekB-2hsjA:
undetectable		 2wekB-2hsjA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rha TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Novosphingobium
aromaticivorans) 		PF14514
(TetR_C_9) 		4 TYR A 104
MET A 115
ILE A 129
LEU A 134
 None
None
None
GOL  A 229 ( 4.4A)
 1.15A 2wekB-2rhaA:
undetectable		 2wekB-2rhaA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 PRO B 559
ILE B 603
ASN B 679
LEU B 681
 None
 1.19A 2wekB-2rhqB:
undetectable		 2wekB-2rhqB:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq5 S-NORCOCLAURINE
SYNTHASE

(Thalictrum
flavum) 		PF00407
(Bet_v_1) 		4 TYR A 108
MET A 183
PRO A 179
LEU A  72
 None
HBA  A1203 (-2.9A)
None
None
 1.17A 2wekB-2vq5A:
undetectable		 2wekB-2vq5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9e MYOSIN-2

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 MET X 331
PRO X 220
ILE X 437
LEU X 433
 None
 1.29A 2wekB-2y9eX:
undetectable		 2wekB-2y9eX:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC9

(Schizosaccharomyces
pombe) 		PF03874
(RNA_pol_Rpb4)
PF03876
(SHS2_Rpb7-N)
PF08292
(RNA_pol_Rbc25) 		4 PRO B  79
ILE B 101
ASN A  13
LEU A  56
 None
 1.38A 2wekB-3ayhB:
undetectable		 2wekB-3ayhB:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE

(Desulfovibrio
alaskensis) 		PF09837
(DUF2064) 		4 PRO A 116
ILE A 112
ASN A 204
LEU A 200
 None
 0.97A 2wekB-3cgxA:
2.9		 2wekB-3cgxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE

(Exiguobacterium
sibiricum) 		PF13649
(Methyltransf_25) 		4 TYR A 205
MET A 142
PRO A 139
ASN A 107
 None
 1.26A 2wekB-3d2lA:
7.8		 2wekB-3d2lA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dme CONSERVED EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF01266
(DAO) 		4 TYR A 234
ILE A  51
ASN A  47
LEU A 353
 None
None
FAD  A 500 (-3.6A)
FAD  A 500 (-4.0A)
 1.24A 2wekB-3dmeA:
2.7		 2wekB-3dmeA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		4 PRO X 119
ILE X 141
ASN X 238
LEU X 240
 None
C8E  X 454 (-4.1A)
None
None
 1.27A 2wekB-3dwoX:
undetectable		 2wekB-3dwoX:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Clostridium
acetobutylicum) 		PF00155
(Aminotran_1_2) 		4 PRO A 153
ILE A 150
ASN A 157
LEU A 127
 None
 1.15A 2wekB-3ftbA:
4.8		 2wekB-3ftbA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PRO A 155
ILE A 113
ASN A 211
LEU A 216
 None
 1.25A 2wekB-3gyrA:
undetectable		 2wekB-3gyrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		4 PRO A 398
ILE A 243
ASN A  76
LEU A 422
 None
 1.19A 2wekB-3h5cA:
undetectable		 2wekB-3h5cA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzr TRYPTOPHANYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00579
(tRNA-synt_1b) 		4 TYR A  53
MET A 353
ILE A 357
LEU A  92
 None
 1.19A 2wekB-3hzrA:
undetectable		 2wekB-3hzrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T

(Saccharomyces
cerevisiae) 		PF00149
(Metallophos)
PF08321
(PPP5) 		4 PRO A 363
ILE A 430
ASN A 425
LEU A 427
 None
 1.29A 2wekB-3icfA:
undetectable		 2wekB-3icfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 4 PRO B 192
ILE B 189
ASN B 349
LEU B 327
 None
 1.37A 2wekB-3iz3B:
undetectable		 2wekB-3iz3B:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF17

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		4 PRO L 179
ILE L 221
ASN L 139
LEU L 272
 None
 1.39A 2wekB-3jb9L:
undetectable		 2wekB-3jb9L:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kom TRANSKETOLASE

(Francisella
tularensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 MET A  35
PRO A  32
ILE A 249
ASN A  66
 None
 1.12A 2wekB-3komA:
2.1		 2wekB-3komA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lub PUTATIVE CREATININE
AMIDOHYDROLASE

(Bacteroides
fragilis) 		PF02633
(Creatininase) 		4 MET A  68
PRO A  70
ILE A  24
LEU A 113
 None
 1.37A 2wekB-3lubA:
undetectable		 2wekB-3lubA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn8 LP15968P

(Drosophila
melanogaster) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 MET A 262
PRO A 260
ASN A 324
LEU A 306
 None
 1.22A 2wekB-3mn8A:
undetectable		 2wekB-3mn8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		4 PRO A 229
ILE A 233
ASN A 272
LEU A  80
 None
 1.23A 2wekB-3n0lA:
3.9		 2wekB-3n0lA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6x GLUTAMINE SYNTHETASE

(Bacteroides
fragilis) 		PF00120
(Gln-synt_C)
PF12437
(GSIII_N) 		4 PRO A 166
ILE A 168
ASN A 302
LEU A 184
 None
 1.00A 2wekB-3o6xA:
undetectable		 2wekB-3o6xA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poh ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F1

(Bacteroides
thetaiotaomicron) 		PF08522
(DUF1735) 		4 PRO A 346
ILE A 174
ASN A 100
LEU A  96
 None
IMD  A 500 ( 4.1A)
None
None
 1.15A 2wekB-3pohA:
undetectable		 2wekB-3pohA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		4 MET A 604
PRO A 602
ILE A 663
LEU A 546
 None
 1.02A 2wekB-3rdeA:
undetectable		 2wekB-3rdeA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 TYR A 180
ILE A 475
ASN A 454
LEU A 457
 None
 1.27A 2wekB-3tchA:
undetectable		 2wekB-3tchA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 PRO B  37
ILE B   3
ASN B  17
LEU B   7
 None
 1.34A 2wekB-3v0aB:
undetectable		 2wekB-3v0aB:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		4 MET A 148
PRO A 125
ILE A 122
LEU A  70
 None
 1.15A 2wekB-3wqyA:
undetectable		 2wekB-3wqyA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwp (S)-HYDROXYNITRILE
LYASE

(Baliospermum
montanum) 		PF00561
(Abhydrolase_1) 		4 TYR A  57
PRO A  60
ILE A   7
ASN A  85
 None
 1.36A 2wekB-3wwpA:
3.7		 2wekB-3wwpA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 PRO A 152
ILE A 175
ASN A 170
LEU A 194
 None
 1.16A 2wekB-3zynA:
undetectable		 2wekB-3zynA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae0 DIPHTHERIA TOXIN

(Corynebacterium
diphtheriae) 		PF01324
(Diphtheria_R)
PF02763
(Diphtheria_C)
PF02764
(Diphtheria_T) 		4 PRO A  25
ILE A  31
ASN A 166
LEU A 163
 None
 1.14A 2wekB-4ae0A:
undetectable		 2wekB-4ae0A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		4 TYR B 281
ILE B 304
ASN B 269
LEU B 294
 None
 1.27A 2wekB-4cakB:
undetectable		 2wekB-4cakB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 PRO A 220
ILE A 217
ASN A 347
LEU A 213
 None
 1.37A 2wekB-4cnsA:
undetectable		 2wekB-4cnsA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 PRO A 220
ILE A 217
ASN A 347
LEU A 213
 None
 1.36A 2wekB-4cntA:
undetectable		 2wekB-4cntA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00701
(DHDPS) 		4 MET A 292
PRO A 290
ASN A 285
LEU A 275
 None
 1.05A 2wekB-4dppA:
2.1		 2wekB-4dppA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fm9 DNA TOPOISOMERASE
2-ALPHA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 TYR A 907
PRO A 865
ILE A1018
ASN A 905
 None
 1.25A 2wekB-4fm9A:
undetectable		 2wekB-4fm9A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsp PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 PRO A 115
ILE A 117
ASN A 145
LEU A 133
 None
 1.27A 2wekB-4fspA:
undetectable		 2wekB-4fspA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Zea mays) 		PF00145
(DNA_methylase)
PF00385
(Chromo)
PF01426
(BAH) 		4 TYR A 776
PRO A 788
ILE A 733
LEU A 772
 None
 1.38A 2wekB-4ft2A:
4.8		 2wekB-4ft2A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE

(Vitis vinifera) 		PF00701
(DHDPS) 		4 PRO A 252
ILE A 230
ASN A 247
LEU A 237
 None
 0.99A 2wekB-4hnnA:
2.1		 2wekB-4hnnA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Francisella
tularensis) 		PF06026
(Rib_5-P_isom_A) 		4 PRO A 208
ILE A 203
ASN A  93
LEU A 132
 None
 1.13A 2wekB-4io1A:
2.2		 2wekB-4io1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 4 TYR A 203
ILE A  98
ASN A 160
LEU A  70
 None
 1.37A 2wekB-4j0kA:
2.1		 2wekB-4j0kA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lut ALANINE RACEMASE

(Clostridioides
difficile) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 TYR A 356
MET A 212
ILE A  24
LEU A 244
 DCS  A 401 (-4.0A)
None
None
None
 1.31A 2wekB-4lutA:
undetectable		 2wekB-4lutA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		4 TYR A 477
PRO A 439
ILE A 432
LEU A 399
 None
 1.18A 2wekB-4mifA:
undetectable		 2wekB-4mifA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mve UNCHARACTERIZED
PROTEIN

(Thermomonospora
curvata) 		PF14231
(GXWXG)
PF14232
(DUF4334) 		4 TYR A  87
PRO A  74
ILE A 115
LEU A  52
 None
 1.29A 2wekB-4mveA:
undetectable		 2wekB-4mveA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 TYR A  10
PRO A 128
ILE A  94
LEU A 148
 None
 1.35A 2wekB-4nbqA:
undetectable		 2wekB-4nbqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt4 GILGAMESH, ISOFORM I

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 TYR A  90
PRO A 101
ILE A 186
LEU A 125
 None
 1.21A 2wekB-4nt4A:
undetectable		 2wekB-4nt4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		4 MET A 103
PRO A 105
ILE A 311
ASN A 170
 None
 0.88A 2wekB-4pfrA:
undetectable		 2wekB-4pfrA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 PRO A 494
ILE A 311
ASN A 318
LEU A 320
 None
 1.20A 2wekB-4qaxA:
3.7		 2wekB-4qaxA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04101
(Glyco_tran_28_C)
PF06925
(MGDG_synth) 		4 PRO A 461
ILE A 436
ASN A 466
LEU A 503
 None
 1.38A 2wekB-4wyiA:
5.1		 2wekB-4wyiA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xae FERULOYL COA
ORTHO-HYDROXYLASE 1

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 MET A 280
PRO A 312
ILE A 282
LEU A 321
 None
 1.21A 2wekB-4xaeA:
undetectable		 2wekB-4xaeA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF13458
(Peripla_BP_6) 		4 TYR A 238
PRO A 136
ILE A 166
LEU A 194
 ACT  A 500 (-4.4A)
None
None
None
 1.12A 2wekB-4xfkA:
4.3		 2wekB-4xfkA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 2

(Drosophila
melanogaster) 		PF04084
(ORC2) 		4 MET B 344
PRO B 341
ILE B 346
LEU B 463
 None
 1.33A 2wekB-4xgcB:
2.3		 2wekB-4xgcB:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yx8 DSBA-LIKE PROTEIN

(Proteus
mirabilis) 		PF13462
(Thioredoxin_4) 		4 TYR A  82
MET A 159
ILE A 167
LEU A 169
 None
 1.31A 2wekB-4yx8A:
undetectable		 2wekB-4yx8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 211
ILE A 116
ASN A 155
LEU A  91
 None
 1.33A 2wekB-5a7mA:
3.2		 2wekB-5a7mA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahv ANTH DOMAIN OF
ENDOCYTIC ADAPTOR
SLA2

(Saccharomyces
cerevisiae) 		PF07651
(ANTH) 		4 PRO F 223
ILE F 152
ASN F 268
LEU F 205
 None
 1.29A 2wekB-5ahvF:
undetectable		 2wekB-5ahvF:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avo HOMOSERINE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 MET A   1
PRO A  66
ASN A  96
LEU A 299
 None
 1.19A 2wekB-5avoA:
5.3		 2wekB-5avoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN

(Thauera
aromatica) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 TYR A 330
PRO A 202
ILE A 592
LEU A 208
 None
 1.14A 2wekB-5bwdA:
undetectable		 2wekB-5bwdA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxw PENICILLIN-BINDING
PROTEIN 1A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		4 PRO A 625
ILE A 391
ASN A 513
LEU A 356
 None
 1.32A 2wekB-5cxwA:
undetectable		 2wekB-5cxwA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6a PREDICTED ATPASE OF
THE ABC CLASS

(Vibrio
vulnificus) 		PF09818
(ABC_ATPase) 		4 MET A 536
PRO A 532
ILE A 488
LEU A 495
 None
 1.23A 2wekB-5d6aA:
undetectable		 2wekB-5d6aA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9n B-1,4-ENDOGLUCANASE

(Prevotella
bryantii) 		PF00150
(Cellulase) 		4 PRO A 275
ILE A 277
ASN A 204
LEU A 156
 None
 1.28A 2wekB-5d9nA:
undetectable		 2wekB-5d9nA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH) 		4 TYR A1034
PRO A 994
ILE A 997
ASN A1029
 None
 1.35A 2wekB-5gutA:
5.4		 2wekB-5gutA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwj DNA TOPOISOMERASE
2-BETA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 TYR A 923
PRO A 881
ILE A1034
ASN A 921
 None
 1.26A 2wekB-5gwjA:
undetectable		 2wekB-5gwjA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho9 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 PRO A 172
ILE A  72
ASN A 104
LEU A 105
 None
 1.23A 2wekB-5ho9A:
undetectable		 2wekB-5ho9A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho9 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 PRO A 172
ILE A 148
ASN A 104
LEU A 105
 None
 1.29A 2wekB-5ho9A:
undetectable		 2wekB-5ho9A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp6 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF13385
(Laminin_G_3)
PF16369
(GH43_C) 		4 PRO A 172
ILE A 148
ASN A 104
LEU A 105
 None
 1.31A 2wekB-5hp6A:
undetectable		 2wekB-5hp6A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imt INTERMEDILYSIN

(Streptococcus
intermedius) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 TYR A  67
PRO A 292
ILE A  78
ASN A 287
 None
 1.34A 2wekB-5imtA:
undetectable		 2wekB-5imtA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imw INTERMEDILYSIN

(Streptococcus
intermedius) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 TYR A  67
PRO A 292
ILE A  78
ASN A 287
 None
 1.31A 2wekB-5imwA:
undetectable		 2wekB-5imwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkn PROTEIN FAM63A

(Homo sapiens) 		PF04424
(MINDY_DUB) 		4 PRO A 127
ILE A 161
ASN A 144
LEU A 140
 None
 1.36A 2wekB-5jknA:
undetectable		 2wekB-5jknA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpq ES1

(Chaetomium
thermophilum) 		no annotation 4 PRO o  39
ILE o 187
ASN o 193
LEU o 185
 None
 1.38A 2wekB-5jpqo:
undetectable		 2wekB-5jpqo:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kws GALACTOSE-BINDING
PROTEIN

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		4 TYR A  12
ILE A   5
ASN A  39
LEU A  55
 None
None
GOL  A 403 (-2.9A)
None
 1.27A 2wekB-5kwsA:
2.5		 2wekB-5kwsA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4

(Homo sapiens) 		no annotation 4 PRO A 220
ILE A 217
ASN A 347
LEU A 213
 PRO  A 220 ( 1.1A)
ILE  A 217 ( 0.7A)
ASN  A 347 ( 0.6A)
LEU  A 213 ( 0.5A)
 1.37A 2wekB-5nksA:
undetectable		 2wekB-5nksA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5non S-NORCOCLAURINE
SYNTHASE

(Thalictrum
flavum) 		PF00407
(Bet_v_1) 		4 TYR A 108
MET A 183
PRO A 179
LEU A  72
 None
93H  A 501 (-3.4A)
93H  A 501 (-4.5A)
93H  A 501 (-4.3A)
 1.24A 2wekB-5nonA:
undetectable		 2wekB-5nonA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B

(Methanothermobacter
sp. CaT2) 		PF00384
(Molybdopterin) 		4 MET B 339
PRO B  84
ILE B  77
LEU B 421
 None
 1.35A 2wekB-5t5iB:
3.0		 2wekB-5t5iB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti8 AMINOTRANSFERASE

(Pseudomonas sp.
M1) 		PF00202
(Aminotran_3) 		4 MET A 414
PRO A 425
ILE A 422
LEU A 383
 None
 1.19A 2wekB-5ti8A:
undetectable		 2wekB-5ti8A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tro PENICILLIN-BINDING
PROTEIN 1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 PRO A 431
ILE A 280
ASN A 303
LEU A 180
 None
 1.34A 2wekB-5troA:
undetectable		 2wekB-5troA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc2 SERINE
HYDROXYMETHYLTRANSFE
RASE

(Helicobacter
pylori) 		PF00464
(SHMT) 		4 PRO A 231
ILE A 235
ASN A 274
LEU A  82
 None
 1.30A 2wekB-5vc2A:
undetectable		 2wekB-5vc2A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgu RIBONUCLEASE R

(Escherichia
coli) 		no annotation 4 MET B 246
PRO B 248
ILE B 484
LEU B 490
 None
 1.09A 2wekB-5xguB:
undetectable		 2wekB-5xguB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvf -

(-) 		no annotation 4 TYR A 208
ILE A 137
ASN A  69
LEU A 107
 None
 1.29A 2wekB-5yvfA:
undetectable		 2wekB-5yvfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c14 -

(-) 		no annotation 4 TYR A1350
ILE A1359
ASN A1343
LEU A1339
 None
 1.35A 2wekB-6c14A:
undetectable		 2wekB-6c14A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 4 TYR A 477
PRO A 537
ILE A 545
LEU A 533
 None
None
C  B  46 ( 3.9A)
None
 1.31A 2wekB-6d6vA:
undetectable		 2wekB-6d6vA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza B
virus) 		no annotation 4 PRO B 341
ILE B 248
ASN B 346
LEU B 222
 None
 1.33A 2wekB-6f5oB:
undetectable		 2wekB-6f5oB:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae ADP-RIBOSYLATION
FACTOR 1
IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		no annotation 4 TYR B  81
ILE A 532
ASN A 563
LEU A 564
 None
EDO  B 201 ( 3.6A)
None
None
 1.28A 2wekB-6faeB:
undetectable		 2wekB-6faeB:
12.06