SIMILAR PATTERNS OF AMINO ACIDS FOR 2WEK_A_DIFA1376_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 LEU A 230
LEU A 295
LYS A 298
ALA A 299
 None
 1.01A 2wekA-1ayeA:
undetectable		 2wekA-1ayeA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eih EOTAXIN-2

(Homo sapiens) 		PF00048
(IL8) 		4 TYR A  24
LEU A  63
LYS A  66
ALA A  65
 None
 1.08A 2wekA-1eihA:
undetectable		 2wekA-1eihA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1e HISTONE FOLD PROTEIN

(Methanopyrus
kandleri) 		PF00808
(CBFD_NFYB_HMF) 		4 TYR A 108
LEU A 107
LEU A  63
ALA A  67
 None
 0.96A 2wekA-1f1eA:
undetectable		 2wekA-1f1eA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II

(Saccharomyces
cerevisiae) 		PF00150
(Cellulase) 		4 TYR A 155
LEU A 156
LEU A  62
ALA A 138
 None
 0.97A 2wekA-1h4pA:
undetectable		 2wekA-1h4pA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k86 CASPASE-7

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 TYR A 111
LEU A 122
LYS A 125
ALA A 126
 None
 0.77A 2wekA-1k86A:
3.9		 2wekA-1k86A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3l TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR

(Agrobacterium
tumefaciens) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		4 TYR A 181
LEU A 182
LEU A 209
ALA A 212
 None
 1.00A 2wekA-1l3lA:
undetectable		 2wekA-1l3lA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np3 KETOL-ACID
REDUCTOISOMERASE

(Pseudomonas
aeruginosa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 TYR A 224
LEU A 320
ALA A 322
HIS A 229
 None
 0.94A 2wekA-1np3A:
6.4		 2wekA-1np3A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu9 STAPHYLOCOAGULASE

(Staphylococcus
aureus) 		PF08764
(Coagulase) 		4 LEU C 218
LEU C 164
LYS C 167
ALA C 168
 None
 0.96A 2wekA-1nu9C:
undetectable		 2wekA-1nu9C:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onf GLUTATHIONE
REDUCTASE

(Plasmodium
falciparum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 307
LEU A 145
LEU A 363
ALA A  20
 None
 1.04A 2wekA-1onfA:
2.9		 2wekA-1onfA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		4 TYR A 622
LEU A 103
LYS A 107
ALA A 105
 None
 1.00A 2wekA-1pemA:
undetectable		 2wekA-1pemA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpt PROSTATIC ACID
PHOSPHATASE

(Rattus
norvegicus) 		PF00328
(His_Phos_2) 		4 LEU A 231
ALA A 267
HIS A 282
MET A 284
 None
 1.08A 2wekA-1rptA:
undetectable		 2wekA-1rptA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		4 LEU A  29
LEU A  30
HIS A 409
MET A 411
 None
 0.82A 2wekA-1sqjA:
undetectable		 2wekA-1sqjA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		4 LEU A  30
ALA A  44
HIS A 409
MET A 411
 None
 1.05A 2wekA-1sqjA:
undetectable		 2wekA-1sqjA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 TYR A  89
LEU A  99
ALA A 182
HIS A  85
 None
 1.03A 2wekA-1v26A:
3.9		 2wekA-1v26A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN

(Thermus
thermophilus) 		PF02615
(Ldh_2) 		4 LEU A  46
LEU A  33
ALA A  36
HIS A 115
 None
 0.95A 2wekA-1x0aA:
undetectable		 2wekA-1x0aA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xho CHORISMATE MUTASE

(Ruminiclostridium
thermocellum) 		PF07736
(CM_1) 		4 LEU A  26
LEU A 107
LYS A 111
ALA A 110
 None
 1.06A 2wekA-1xhoA:
undetectable		 2wekA-1xhoA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		4 TYR A 272
LEU A 277
ALA A 282
HIS A 173
 None
 0.98A 2wekA-1z26A:
2.2		 2wekA-1z26A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6o FERRITIN HEAVY CHAIN

(Trichoplusia ni) 		PF00210
(Ferritin) 		4 LEU M 113
LEU M 160
LYS M 163
ALA M 164
 None
 0.75A 2wekA-1z6oM:
undetectable		 2wekA-1z6oM:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		4 LEU A 150
LEU A 124
HIS A 112
MET A 115
 None
 1.04A 2wekA-2b3oA:
undetectable		 2wekA-2b3oA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwl MANGANESE-FREE
PSEUDOCATALASE

(Thermus
thermophilus) 		PF05067
(Mn_catalase) 		4 TYR A 192
LEU A  62
ALA A  64
HIS A 188
 None
 1.02A 2wekA-2cwlA:
undetectable		 2wekA-2cwlA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dk5 DNA-DIRECTED RNA
POLYMERASE III 39
KDA POLYPEPTIDE

(Homo sapiens) 		PF05158
(RNA_pol_Rpc34) 		4 TYR A  26
LEU A  60
LYS A  63
MET A  15
 None
 1.05A 2wekA-2dk5A:
undetectable		 2wekA-2dk5A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TYR A 728
LEU A 725
LEU A  25
ALA A  27
 None
 1.00A 2wekA-2ecfA:
undetectable		 2wekA-2ecfA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqm GLUTATHIONE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 330
LEU A 165
LEU A 352
ALA A  42
 None
 1.04A 2wekA-2hqmA:
3.0		 2wekA-2hqmA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mri 26S PROTEASOME
REGULATORY SUBUNIT
RPN9

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 LEU A 258
LEU A 255
ALA A 221
MET A 239
 None
 1.05A 2wekA-2mriA:
undetectable		 2wekA-2mriA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		4 TYR A 166
LEU A 167
LYS A 196
ALA A 225
 None
 0.97A 2wekA-2o1bA:
4.6		 2wekA-2o1bA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1w ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 TYR A 258
LEU A 259
LEU A 251
LYS A 252
 None
 1.08A 2wekA-2o1wA:
undetectable		 2wekA-2o1wA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 TYR A 700
LEU A 697
LEU A 732
ALA A 728
 None
 0.94A 2wekA-2qf7A:
4.5		 2wekA-2qf7A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 4 LEU A 497
LEU A 506
ALA A 487
HIS A 518
 None
 1.05A 2wekA-2quaA:
undetectable		 2wekA-2quaA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv6 GTP CYCLOHYDROLASE
III

(Methanocaldococcus
jannaschii) 		PF05165
(GCH_III) 		4 TYR A  35
LEU A  38
LEU A  57
ALA A  59
 None
 0.86A 2wekA-2qv6A:
undetectable		 2wekA-2qv6A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22)
PF01163
(RIO1) 		4 TYR A 226
LEU A 223
LEU A 202
ALA A 205
 None
 1.08A 2wekA-2vwbA:
undetectable		 2wekA-2vwbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w35 ENDONUCLEASE V

(Thermotoga
maritima) 		PF04493
(Endonuclease_5) 		4 LEU A  44
LEU A  92
LYS A  95
ALA A  96
 None
 0.93A 2wekA-2w35A:
undetectable		 2wekA-2w35A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071

(Thermus
thermophilus) 		PF01261
(AP_endonuc_2) 		4 TYR A 215
LEU A 212
LEU A 186
ALA A 163
 None
 0.92A 2wekA-3aytA:
undetectable		 2wekA-3aytA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 TYR A 723
LEU A 720
LEU A 755
ALA A 751
 None
 0.97A 2wekA-3bg9A:
undetectable		 2wekA-3bg9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8o REGULATOR OF
RIBONUCLEASE
ACTIVITY A

(Pseudomonas
aeruginosa) 		PF03737
(RraA-like) 		4 LEU A  74
LEU A  78
LYS A  81
ALA A  82
 None
EDO  A 166 (-4.2A)
EDO  A 170 ( 4.9A)
None
 0.91A 2wekA-3c8oA:
undetectable		 2wekA-3c8oA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9p UNCHARACTERIZED
PROTEIN SP1917

(Streptococcus
pneumoniae) 		PF09966
(DUF2200) 		4 TYR A  14
LEU A  50
ALA A  48
HIS A  32
 None
 1.05A 2wekA-3c9pA:
undetectable		 2wekA-3c9pA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		no annotation 4 TYR B1057
LEU B1055
LEU B1054
LYS B1050
 None
 1.01A 2wekA-3cqcB:
undetectable		 2wekA-3cqcB:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dez OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Streptococcus
mutans) 		PF00156
(Pribosyltran) 		4 LEU A 197
LEU A 194
LYS A 184
ALA A 183
 None
 1.06A 2wekA-3dezA:
3.7		 2wekA-3dezA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqv CULLIN-5

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 LEU C1531
ALA C1535
HIS C1574
MET C1577
 None
 1.05A 2wekA-3dqvC:
undetectable		 2wekA-3dqvC:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f11 IRON TRANSPORT
PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		4 TYR A 164
LEU A 193
ALA A 196
HIS A 274
 None
None
SO4  A 403 ( 3.7A)
None
 1.09A 2wekA-3f11A:
undetectable		 2wekA-3f11A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 TYR A 723
LEU A 720
LEU A 755
ALA A 751
 None
 0.88A 2wekA-3ho8A:
5.1		 2wekA-3ho8A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		4 LEU 3 355
LEU 3 664
ALA 3 660
HIS 3 613
 None
 1.08A 2wekA-3i9v3:
3.7		 2wekA-3i9v3:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 LEU A 466
LEU A 602
LYS A 601
ALA A 604
 None
 0.99A 2wekA-3ikmA:
undetectable		 2wekA-3ikmA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knz PUTATIVE SUGAR
BINDING PROTEIN

(Salmonella
enterica) 		PF01380
(SIS) 		4 LEU A  19
LEU A 152
ALA A 154
MET A 176
 None
 1.03A 2wekA-3knzA:
3.1		 2wekA-3knzA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A 110
LEU A 102
LEU A 101
ALA A  99
 None
None
None
JIM  A 193 ( 4.0A)
 0.81A 2wekA-3kq0A:
undetectable		 2wekA-3kq0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Mus musculus) 		PF00079
(Serpin) 		4 LEU A 165
LEU A  46
ALA A  44
MET A 295
 None
 0.98A 2wekA-3lw2A:
undetectable		 2wekA-3lw2A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		5 LEU A 150
LEU A 124
ALA A 126
HIS A 112
MET A 115
 None
 1.49A 2wekA-3ps5A:
undetectable		 2wekA-3ps5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtn UNCHARACTERIZED
PROTEIN C4B3.07

(Schizosaccharomyces
pombe) 		PF12753
(Nro1) 		4 LEU B 301
LEU B 311
LYS B 314
ALA B 315
 None
 1.04A 2wekA-3qtnB:
undetectable		 2wekA-3qtnB:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qye TBC1 DOMAIN FAMILY
MEMBER 1

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 TYR A 947
LEU A 944
LEU A1003
MET A1048
 None
 1.04A 2wekA-3qyeA:
undetectable		 2wekA-3qyeA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6a UNCHARACTERIZED
PROTEIN

(Methanosarcina
mazei) 		no annotation 4 TYR A  22
LEU A  19
LEU A  51
ALA A  53
 None
 0.95A 2wekA-3r6aA:
undetectable		 2wekA-3r6aA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN

(Leptographium
truncatum) 		PF00961
(LAGLIDADG_1) 		4 LEU A 143
LEU A 114
LYS A 117
ALA A 118
 None
 0.62A 2wekA-3r7pA:
undetectable		 2wekA-3r7pA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 1

(Homo sapiens) 		PF12026
(DUF3513) 		4 TYR B 747
LEU B 744
LEU B 799
ALA B 803
 None
 1.09A 2wekA-3t6gB:
undetectable		 2wekA-3t6gB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqh QUINONE
OXIDOREDUCTASE

(Coxiella
burnetii) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 LEU A  64
LEU A  60
LYS A  59
HIS A 101
 None
 1.07A 2wekA-3tqhA:
35.0		 2wekA-3tqhA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uoe DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02615
(Ldh_2) 		4 LEU A  46
LEU A  33
ALA A  36
HIS A 116
 None
 0.91A 2wekA-3uoeA:
undetectable		 2wekA-3uoeA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh7 BETA-GLUCOSIDASE

(metagenomes) 		PF00232
(Glyco_hydro_1) 		4 TYR A 260
LEU A 280
ALA A 284
HIS A 195
 None
 1.04A 2wekA-3wh7A:
undetectable		 2wekA-3wh7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ays AMYLOSUCRASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase) 		4 TYR A 258
LEU A 281
LEU A 174
ALA A 277
 None
 1.08A 2wekA-4aysA:
undetectable		 2wekA-4aysA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4co6 NUCLEOPROTEIN

(Nipah
henipavirus) 		PF00973
(Paramyxo_ncap) 		4 LEU A 221
LEU A 175
LYS A 178
ALA A 179
 None
 0.92A 2wekA-4co6A:
undetectable		 2wekA-4co6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE SUBUNIT
RPT4

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 LEU L 186
LEU L 230
LYS L 233
ALA L 234
 None
 1.06A 2wekA-4cr4L:
undetectable		 2wekA-4cr4L:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8e GLUTATHIONE
S-TRANSFERASE

(Bombyx mori) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 LEU A  27
LEU A  77
ALA A  80
MET A  60
 None
 1.07A 2wekA-4e8eA:
undetectable		 2wekA-4e8eA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eal 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF16579
(AdenylateSensor) 		4 TYR A 422
LEU A 542
ALA A 540
MET A 447
 None
 1.08A 2wekA-4ealA:
undetectable		 2wekA-4ealA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx6 PYRUVATE CARBOXYLASE

(Rhizobium etli) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 TYR A 700
LEU A 697
LEU A 732
ALA A 728
 None
 0.97A 2wekA-4jx6A:
undetectable		 2wekA-4jx6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kiw 3-DEHYDROQUINATE
DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF01220
(DHquinase_II) 		4 LEU A 137
LEU A  45
LYS A   3
HIS A 143
 None
 0.99A 2wekA-4kiwA:
undetectable		 2wekA-4kiwA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kyi VIPD

(Legionella
pneumophila) 		PF01734
(Patatin) 		4 TYR A 422
LEU A 421
LEU A 498
LYS A 501
 None
 0.97A 2wekA-4kyiA:
undetectable		 2wekA-4kyiA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0x CHLOROMUCONATE
CYCLOISOMERASE

(Rhodococcus
opacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 240
LEU A 210
ALA A 214
MET A 168
 None
 1.08A 2wekA-4m0xA:
undetectable		 2wekA-4m0xA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F

(Thermococcus
kodakarensis) 		PF00575
(S1)
PF03874
(RNA_pol_Rpb4)
PF03876
(SHS2_Rpb7-N) 		4 TYR E   2
LEU F  20
LEU E  75
ALA E  47
 None
 1.08A 2wekA-4qiwE:
undetectable		 2wekA-4qiwE:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rtb HYDG PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		4 TYR A  94
LEU A 234
ALA A 230
HIS A 200
 SAM  A 501 (-4.5A)
None
None
None
 1.08A 2wekA-4rtbA:
undetectable		 2wekA-4rtbA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 301
LEU A 319
LYS A 318
ALA A 277
 None
 1.05A 2wekA-4wz9A:
undetectable		 2wekA-4wz9A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN

(Gloeobacter
violaceus;
Homo sapiens) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 TYR A 129
LEU A 130
ALA A 167
HIS A 127
 None
 0.99A 2wekA-4x5tA:
undetectable		 2wekA-4x5tA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 TYR A  32
LEU A  33
LYS A  39
ALA A  41
 None
 1.04A 2wekA-4xdoA:
undetectable		 2wekA-4xdoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuu PHOSPHATIDYLINOSITID
E PHOSPHATASE SAC2

(Homo sapiens) 		PF12456
(hSac2) 		4 TYR A  58
LEU A  52
LEU A  51
ALA A  61
 None
 1.03A 2wekA-4xuuA:
undetectable		 2wekA-4xuuA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2

(Homo sapiens) 		PF02146
(SIR2) 		4 TYR A 165
LEU A 272
LYS A 275
ALA A 276
 None
 0.73A 2wekA-4y6oA:
undetectable		 2wekA-4y6oA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y99 TROPONIN I, CARDIAC
MUSCLE
TROPONIN T, CARDIAC
MUSCLE

(Homo sapiens) 		PF00992
(Troponin)
PF11636
(Troponin-I_N) 		4 LEU C  93
LEU B 229
LYS B 232
ALA B 233
 None
None
DMS  B 301 (-2.7A)
None
 1.05A 2wekA-4y99C:
undetectable		 2wekA-4y99C:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica) 		PF00961
(LAGLIDADG_1) 		4 LEU A 134
LEU A 105
LYS A 108
ALA A 109
 None
 0.77A 2wekA-4yisA:
undetectable		 2wekA-4yisA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		4 TYR A 363
LEU A 360
ALA A 419
MET A 435
 None
 1.06A 2wekA-5a29A:
undetectable		 2wekA-5a29A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 TYR A 337
LEU A 341
LEU A 346
ALA A 344
 None
 0.97A 2wekA-5a5gA:
undetectable		 2wekA-5a5gA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2

(Ascophyllum
nodosum) 		no annotation 4 TYR A 458
LEU A 459
LEU A 455
ALA A 545
 None
 0.94A 2wekA-5aa6A:
undetectable		 2wekA-5aa6A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxy RNA
METHYLTRANSFERASE

(Salinibacter
ruber) 		PF13847
(Methyltransf_31) 		4 TYR A   4
LEU A  58
LYS A  60
ALA A  62
 SAH  A 201 (-4.7A)
SAH  A 201 (-4.4A)
None
None
 0.97A 2wekA-5bxyA:
8.6		 2wekA-5bxyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU A 614
LEU A 558
ALA A 556
HIS A 670
 None
 1.03A 2wekA-5cioA:
undetectable		 2wekA-5cioA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egi UNCHARACTERIZED
PROTEIN Y57A10A.10

(Caenorhabditis
elegans) 		PF05197
(TRIC) 		4 LEU A  75
ALA A 164
HIS A  34
MET A  38
 None
PT5  A 301 (-4.0A)
None
PT5  A 301 ( 3.8A)
 1.07A 2wekA-5egiA:
undetectable		 2wekA-5egiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Bacillus
subtilis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 LEU A 296
LEU A 102
LYS A 285
ALA A 286
 LEU  A 296 ( 0.5A)
LEU  A 102 ( 0.6A)
LYS  A 285 ( 0.0A)
ALA  A 286 ( 0.0A)
 1.00A 2wekA-5ep8A:
undetectable		 2wekA-5ep8A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		4 TYR A  77
LEU A  80
ALA A 504
HIS A 488
 None
 0.89A 2wekA-5f15A:
2.4		 2wekA-5f15A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2

(Homo sapiens) 		PF02146
(SIR2) 		4 TYR A 165
LEU A 272
LYS A 275
ALA A 276
 None
 1.01A 2wekA-5fyqA:
5.8		 2wekA-5fyqA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		4 TYR A  59
LEU A 167
ALA A 114
HIS A 118
 None
 1.06A 2wekA-5hpjA:
undetectable		 2wekA-5hpjA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2

(Homo sapiens) 		PF13405
(EF-hand_6) 		4 LEU A 174
LEU A 171
LYS A 159
ALA A 160
 None
 1.04A 2wekA-5i2qA:
undetectable		 2wekA-5i2qA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A1050
LEU A1049
ALA A1056
MET A1007
 None
 1.03A 2wekA-5iudA:
undetectable		 2wekA-5iudA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgg ALPHA CHAIN

(Acipenser
persicus) 		PF00042
(Globin) 		4 TYR A 113
LEU A 110
LEU A  24
ALA A  28
 None
 1.00A 2wekA-5jggA:
undetectable		 2wekA-5jggA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C1,
MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2

(Bos taurus) 		PF00329
(Complex1_30kDa)
PF00346
(Complex1_49kDa) 		4 TYR d  73
LEU d  76
LEU d  31
HIS c  35
 None
 1.01A 2wekA-5lc5d:
undetectable		 2wekA-5lc5d:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 TYR A1202
LEU A1205
LEU A1213
MET A1195
 None
 1.08A 2wekA-5m59A:
undetectable		 2wekA-5m59A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria) 		no annotation 4 TYR A 168
LEU A 169
LEU A 161
ALA A 145
 None
 0.99A 2wekA-5o3wA:
undetectable		 2wekA-5o3wA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Gloeobacter
violaceus;
Mus musculus) 		no annotation 4 TYR A 128
LEU A 129
ALA A 166
HIS A 126
 None
 1.02A 2wekA-5osbA:
undetectable		 2wekA-5osbA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 4 TYR A  11
LEU A   8
LEU A   7
HIS A  74
 None
 0.92A 2wekA-5tvtA:
undetectable		 2wekA-5tvtA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1o GLUTATHIONE
REDUCTASE

(Vibrio
parahaemolyticus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 303
LEU A 140
LEU A 326
ALA A  27
 None
 1.07A 2wekA-5u1oA:
2.9		 2wekA-5u1oA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Burkholderia
multivorans) 		PF00155
(Aminotran_1_2) 		4 LEU A 261
LEU A 107
ALA A 115
HIS A  77
 None
 1.06A 2wekA-5vnxA:
4.8		 2wekA-5vnxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6v RAGULATOR COMPLEX
PROTEIN LAMTOR2

(Homo sapiens) 		no annotation 4 LEU B  73
LEU B 104
LYS B 107
ALA B 108
 None
 0.95A 2wekA-5x6vB:
undetectable		 2wekA-5x6vB:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 4 TYR A 732
LEU A 729
LEU A  27
ALA A  29
 None
 0.99A 2wekA-5yp3A:
2.1		 2wekA-5yp3A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4o GLUTATHIONE
REDUCTASE

(Enterococcus
faecalis) 		no annotation 4 TYR A 298
LEU A 135
LEU A 320
ALA A  22
 None
 1.09A 2wekA-6b4oA:
3.2		 2wekA-6b4oA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Saccharomyces
cerevisiae) 		no annotation 4 LEU O 627
LEU O 602
LYS O 605
ALA O 606
 None
 0.99A 2wekA-6eu2O:
undetectable		 2wekA-6eu2O:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 LEU A 843
LEU A 879
LYS A 882
ALA A 883
 None
 0.80A 2wekA-6ez8A:
undetectable		 2wekA-6ez8A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4f GLUTATHIONE
TRANSFERASE

(Trametes
versicolor) 		no annotation 4 TYR A 115
LEU A 114
LEU A 143
ALA A 139
 None
PEG  A 303 ( 4.2A)
None
None
 1.08A 2wekA-6f4fA:
undetectable		 2wekA-6f4fA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml INO80

(Chaetomium
thermophilum) 		no annotation 4 TYR G1646
LEU G1558
ALA G1556
MET G1585
 None
 1.02A 2wekA-6fmlG:
2.4		 2wekA-6fmlG:
12.35