SIMILAR PATTERNS OF AMINO ACIDS FOR 2WEK_A_DIFA1374_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9x M32 CARBOXYPEPTIDASE

(Pyrococcus
furiosus) 		PF02074
(Peptidase_M32) 		4 TYR A 255
PRO A 239
ASN A 216
LEU A 220
 None
 1.22A 2wekA-1k9xA:
0.0		 2wekA-1k9xA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT

(Thauera
aromatica) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 TYR B 159
PRO B 234
ASN B 115
LEU B  78
 None
None
FAD  B1900 (-3.2A)
FAD  B1900 (-4.7A)
 1.36A 2wekA-1sb3B:
0.0		 2wekA-1sb3B:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq5 S-NORCOCLAURINE
SYNTHASE

(Thalictrum
flavum) 		PF00407
(Bet_v_1) 		4 TYR A 108
MET A 183
PRO A 179
LEU A  72
 None
HBA  A1203 (-2.9A)
None
None
 1.19A 2wekA-2vq5A:
0.0		 2wekA-2vq5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE

(Exiguobacterium
sibiricum) 		PF13649
(Methyltransf_25) 		4 TYR A 205
MET A 142
PRO A 139
ASN A 107
 None
 1.28A 2wekA-3d2lA:
7.5		 2wekA-3d2lA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		4 TYR B 650
MET B 191
PRO B 218
LEU B 185
 None
 1.45A 2wekA-3jb9B:
1.7		 2wekA-3jb9B:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn8 LP15968P

(Drosophila
melanogaster) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 MET A 262
PRO A 260
ASN A 324
LEU A 306
 None
 1.26A 2wekA-3mn8A:
0.0		 2wekA-3mn8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00701
(DHDPS) 		4 MET A 292
PRO A 290
ASN A 285
LEU A 275
 None
 1.01A 2wekA-4dppA:
0.8		 2wekA-4dppA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avo HOMOSERINE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 MET A   1
PRO A  66
ASN A  96
LEU A 299
 None
 1.16A 2wekA-5avoA:
3.1		 2wekA-5avoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 TYR A 144
PRO A 328
ASN A 284
LEU A 597
 None
 1.45A 2wekA-5lq3A:
undetectable		 2wekA-5lq3A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5non S-NORCOCLAURINE
SYNTHASE

(Thalictrum
flavum) 		PF00407
(Bet_v_1) 		4 TYR A 108
MET A 183
PRO A 179
LEU A  72
 None
93H  A 501 (-3.4A)
93H  A 501 (-4.5A)
93H  A 501 (-4.3A)
 1.25A 2wekA-5nonA:
undetectable		 2wekA-5nonA:
19.88