SIMILAR PATTERNS OF AMINO ACIDS FOR 2WD9_B_IBPB1570_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF01261
(AP_endonuc_2) 		4 ILE A 175
VAL A 136
GLY A 181
GLY A 139
 None
 0.73A 2wd9B-1a0cA:
undetectable		 2wd9B-1a0cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		4 LEU A 126
VAL A 178
GLY A 135
GLY A 133
 None
 0.65A 2wd9B-1a27A:
4.1		 2wd9B-1a27A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aip ELONGATION FACTOR TS

(Thermus
thermophilus) 		PF00889
(EF_TS) 		4 ILE C   7
LEU C  10
GLY C  15
GLY C  17
 None
 0.65A 2wd9B-1aipC:
undetectable		 2wd9B-1aipC:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		4 ILE A 194
LEU A 193
VAL A 204
GLY A 256
 None
 0.66A 2wd9B-1eb3A:
2.1		 2wd9B-1eb3A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evl THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 LEU A 277
GLY A 516
GLN A 381
THR A 380
 None
TSB  A2002 (-3.3A)
TSB  A2002 (-3.2A)
None
 0.71A 2wd9B-1evlA:
undetectable		 2wd9B-1evlA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A 265
GLY A 292
GLN A 308
THR A 310
 None
 0.68A 2wd9B-1flgA:
undetectable		 2wd9B-1flgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j4a D-LACTATE
DEHYDROGENASE

(Lactobacillus
delbrueckii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A  66
VAL A  50
GLY A  49
GLN A  95
 None
 0.74A 2wd9B-1j4aA:
3.8		 2wd9B-1j4aA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		4 LEU A 158
GLY A  47
GLY A 185
THR A 180
 None
 0.75A 2wd9B-1kplA:
undetectable		 2wd9B-1kplA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmy PROTEASE

(Foot-and-mouth
disease virus) 		PF05408
(Peptidase_C28) 		4 ILE A  83
LEU A  86
VAL A 103
GLY A  98
 None
 0.64A 2wd9B-1qmyA:
undetectable		 2wd9B-1qmyA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 ILE A 366
VAL A 442
GLY A 443
GLN A 471
THR A 472
 AMP  A 720 (-4.9A)
AMP  A 720 ( 4.7A)
AMP  A 720 (-3.9A)
AMP  A 720 (-4.4A)
AMP  A 720 (-3.6A)
 0.75A 2wd9B-1ry2A:
41.8		 2wd9B-1ry2A:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sv6 2-KETO-4-PENTENOATE
HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 ILE A 108
VAL A 255
GLY A 167
GLY A 253
GLN A 171
 None
 0.89A 2wd9B-1sv6A:
undetectable		 2wd9B-1sv6A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te4 CONSERVED PROTEIN
MTH187

(Methanothermobacter
thermautotrophicus) 		PF13646
(HEAT_2) 		4 LEU A  62
GLY A  72
GLY A  67
ARG A  39
 None
 0.77A 2wd9B-1te4A:
undetectable		 2wd9B-1te4A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ust HISTONE H1

(Saccharomyces
cerevisiae) 		PF00538
(Linker_histone) 		4 ILE A  51
LEU A  50
VAL A  80
GLY A  81
 None
 0.67A 2wd9B-1ustA:
undetectable		 2wd9B-1ustA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpq HYPOTHETICAL PROTEIN
TM1631

(Thermotoga
maritima) 		PF01904
(DUF72) 		4 LEU A 251
VAL A  18
GLY A 244
GLN A 245
 None
 0.72A 2wd9B-1vpqA:
undetectable		 2wd9B-1vpqA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0m AMINOTRANSFERASE II
HOMOLOGUE

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		4 ILE A 270
GLY A 356
GLY A 240
ARG A 326
 None
 0.78A 2wd9B-1x0mA:
4.7		 2wd9B-1x0mA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkt FATTY ACID SYNTHASE

(Homo sapiens) 		PF00975
(Thioesterase) 		4 ILE A2404
LEU A2403
VAL A2383
GLN A2374
 None
 0.65A 2wd9B-1xktA:
3.3		 2wd9B-1xktA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y80 PREDICTED COBALAMIN
BINDING PROTEIN

(Moorella
thermoacetica) 		PF02310
(B12-binding) 		4 ILE A 164
LEU A 163
VAL A 174
GLY A 190
 None
 0.70A 2wd9B-1y80A:
6.9		 2wd9B-1y80A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybf AMP NUCLEOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01048
(PNP_UDP_1) 		4 LEU A 206
VAL A 158
GLY A 183
GLY A 156
 None
 0.77A 2wd9B-1ybfA:
2.2		 2wd9B-1ybfA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		4 LEU A 591
GLY A 661
GLN A 660
THR A 549
 None
 0.76A 2wd9B-1z45A:
3.7		 2wd9B-1z45A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bma GLUTAMATE
DEHYDROGENASE
(NADP+)

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A 100
VAL A  79
GLY A 107
ARG A  93
 None
 0.71A 2wd9B-2bmaA:
2.8		 2wd9B-2bmaA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb3 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LE

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 ILE A 222
LEU A 221
GLY A 277
GLY A 245
 None
None
GOL  A1344 (-3.6A)
None
 0.75A 2wd9B-2cb3A:
undetectable		 2wd9B-2cb3A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddw PYRIDOXINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		4 LEU A 150
GLY A 155
GLN A 154
THR A 188
 None
 0.75A 2wd9B-2ddwA:
2.9		 2wd9B-2ddwA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejx STK_08120

(Sulfurisphaera
tokodaii) 		PF11485
(DUF3211) 		4 ILE A  96
LEU A  97
GLY A  81
ARG A  71
 None
 0.71A 2wd9B-2ejxA:
undetectable		 2wd9B-2ejxA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjn HYPOTHETICAL PROTEIN
PA1024

(Pseudomonas
aeruginosa) 		PF03060
(NMO) 		4 ILE A 296
LEU A 295
GLY A 180
GLY A 290
 None
None
FMN  A1904 (-3.7A)
FMN  A1904 ( 4.1A)
 0.77A 2wd9B-2gjnA:
2.5		 2wd9B-2gjnA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izw RYEGRASS MOTTLE
VIRUS COAT PROTEIN

(Ryegrass mottle
virus) 		PF00729
(Viral_coat) 		4 LEU A 209
VAL A 124
GLY A 215
THR A  75
 None
 0.76A 2wd9B-2izwA:
undetectable		 2wd9B-2izwA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 VAL A 386
GLY A 387
GLN A 415
THR A 416
ARG A 526
 None
PRX  A 998 (-3.4A)
PRX  A 998 (-3.9A)
PRX  A 998 (-3.7A)
PRX  A 998 (-3.9A)
 0.52A 2wd9B-2p2mA:
41.0		 2wd9B-2p2mA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		4 VAL B 157
GLY B 269
GLN B 495
THR B 493
 None
 0.68A 2wd9B-2pffB:
2.7		 2wd9B-2pffB:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rh0 NUDC
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF04969
(CS) 		4 ILE A  61
LEU A  62
GLY A  19
GLN A  33
 None
 0.74A 2wd9B-2rh0A:
undetectable		 2wd9B-2rh0A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		4 ILE A 464
LEU A 465
GLY A  43
GLY A  48
 None
None
None
ADP  A1843 (-3.2A)
 0.64A 2wd9B-2vf8A:
2.3		 2wd9B-2vf8A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlt L-ASPARAGINASE

(Helicobacter
pylori) 		PF00710
(Asparaginase) 		4 LEU A  46
VAL A 139
GLN A  53
ARG A  51
 None
 0.68A 2wd9B-2wltA:
2.9		 2wd9B-2wltA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0i MALATE DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A 274
LEU A 275
VAL A 289
GLY A 288
 None
 0.74A 2wd9B-2x0iA:
2.8		 2wd9B-2x0iA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfh GLUTAMATE
DEHYDROGENASE,
NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE,
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli;
[Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A 101
VAL A  80
GLY A 108
ARG A  94
 None
 0.75A 2wd9B-2yfhA:
3.9		 2wd9B-2yfhA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahu PROTEIN HFQ

(Bacillus
subtilis) 		PF17209
(Hfq) 		5 ILE A  14
VAL A  23
GLY A  33
GLN A  34
THR A  19
 None
 1.33A 2wd9B-3ahuA:
undetectable		 2wd9B-3ahuA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		4 LEU A 223
VAL A 177
GLY A 178
GLN A 219
 None
 0.76A 2wd9B-3ddhA:
3.4		 2wd9B-3ddhA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE

(Bacillus cereus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 198
GLY A 270
GLY A 295
THR A 297
 DAL  A 701 ( 4.1A)
DAL  A 701 ( 3.1A)
AMP  A 711 ( 4.7A)
AMP  A 711 (-3.9A)
 0.61A 2wd9B-3dhvA:
37.2		 2wd9B-3dhvA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 197
GLY A 294
THR A 296
ARG A 407
 None
AMP  A 513 (-4.9A)
AMP  A 513 (-4.0A)
AMP  A 513 (-3.8A)
 0.68A 2wd9B-3e7wA:
40.4		 2wd9B-3e7wA:
25.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3etc AMP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLY A 327
GLY A 351
GLN A 352
THR A 353
 1PE  A 994 (-3.6A)
1PE  A 994 (-4.4A)
None
GOL  A1005 ( 2.7A)
 0.57A 2wd9B-3etcA:
49.6		 2wd9B-3etcA:
37.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 462
VAL A 433
GLY A 434
ARG A 469
 None
 0.71A 2wd9B-3fg4A:
undetectable		 2wd9B-3fg4A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjy PROBABLE MUTT1
PROTEIN

(Bifidobacterium
adolescentis) 		PF00293
(NUDIX)
PF00300
(His_Phos_1) 		4 ILE A 326
LEU A 325
GLY A 306
ARG A 195
 None
 0.72A 2wd9B-3fjyA:
undetectable		 2wd9B-3fjyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 ILE A 302
VAL A 253
GLY A 252
GLN A 249
 None
 0.77A 2wd9B-3h7lA:
undetectable		 2wd9B-3h7lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 214
GLY A 281
GLY A 304
THR A 306
 None
 0.63A 2wd9B-3iplA:
38.4		 2wd9B-3iplA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izk CHAPERONIN

(Methanococcus
maripaludis) 		PF00118
(Cpn60_TCP1) 		4 ILE A  73
LEU A  72
VAL A  91
GLY A  55
 None
 0.77A 2wd9B-3izkA:
2.3		 2wd9B-3izkA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S11,
MITOCHONDRIAL

(Bos taurus) 		PF00411
(Ribosomal_S11) 		4 GLY K 171
GLY K 167
GLN K 132
THR K 133
 None
 0.62A 2wd9B-3jd5K:
undetectable		 2wd9B-3jd5K:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Streptococcus
pyogenes) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 196
GLY A 268
GLY A 293
THR A 295
 None
ATP  A 600 (-3.4A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-3.6A)
 0.67A 2wd9B-3lgxA:
40.1		 2wd9B-3lgxA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkc GERANYL DIPHOSPHATE
SYNTHASE SMALL
SUBUNIT

(Antirrhinum
majus) 		no annotation 4 ILE B 230
LEU B 233
GLY B 213
GLY B 217
 None
 0.77A 2wd9B-3qkcB:
undetectable		 2wd9B-3qkcB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3j GLUTAMATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A 164
VAL A 143
GLY A 171
ARG A 157
 None
 0.75A 2wd9B-3r3jA:
undetectable		 2wd9B-3r3jA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE

(Maricaulis
maris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		4 GLY A 153
GLY A 179
THR A 185
ARG A 151
 None
 0.67A 2wd9B-3s6hA:
undetectable		 2wd9B-3s6hA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp. PCC 7002) 		PF00933
(Glyco_hydro_3) 		4 ILE A 315
GLY A  56
GLY A  54
GLN A  16
 EDO  A 545 (-3.8A)
None
None
None
 0.77A 2wd9B-3sqlA:
undetectable		 2wd9B-3sqlA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4g APNAA1

(Planktothrix
agardhii) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLY A 274
GLY A 300
THR A 302
ARG A 420
 ANP  A1489 ( 3.3A)
GOL  A1490 (-3.9A)
ANP  A1489 ( 3.6A)
ANP  A1489 (-3.8A)
 0.34A 2wd9B-4d4gA:
43.3		 2wd9B-4d4gA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg8 PA1221

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		4 GLY A 283
GLY A 308
THR A 310
ARG A 426
 BU3  A 702 ( 3.1A)
BU3  A 702 (-4.6A)
AMP  A 701 (-3.8A)
AMP  A 701 (-3.1A)
 0.64A 2wd9B-4dg8A:
37.3		 2wd9B-4dg8A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex9 ALNA

(Streptomyces
sp. CM020) 		PF04227
(Indigoidine_A) 		4 ILE A  75
LEU A  74
VAL A  67
GLY A  60
 None
 0.72A 2wd9B-4ex9A:
undetectable		 2wd9B-4ex9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Bacillus
subtilis) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		4 ILE A 218
LEU A 219
VAL A 295
GLY A 291
 None
None
None
AI9  A 402 ( 4.0A)
 0.68A 2wd9B-4g3mA:
undetectable		 2wd9B-4g3mA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Ustilago maydis) 		PF01336
(tRNA_anti-codon)
PF08646
(Rep_fac-A_C)
PF16900
(REPA_OB_2) 		4 ILE C 549
LEU C 548
VAL C 477
ARG C 573
 None
 0.59A 2wd9B-4gnxC:
undetectable		 2wd9B-4gnxC:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ILE A 797
GLY A 801
GLY A 750
GLN A 748
 None
None
CD  A1103 ( 4.8A)
None
 0.77A 2wd9B-4iugA:
2.1		 2wd9B-4iugA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC

(Rattus
norvegicus) 		no annotation 5 ILE E  18
LEU E 158
GLY E  23
GLY E  20
THR E 161
 FAD  E 505 (-4.9A)
None
FAD  E 505 (-3.6A)
FAD  E 505 ( 4.8A)
FAD  E 505 (-3.9A)
 1.35A 2wd9B-4kprE:
undetectable		 2wd9B-4kprE:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2g L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
lavendulae) 		PF02668
(TauD) 		5 LEU A 106
VAL A 293
GLY A 170
GLY A 291
GLN A 290
 None
 1.09A 2wd9B-4m2gA:
undetectable		 2wd9B-4m2gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		4 ILE A 157
LEU A 156
VAL A 145
GLY A 144
 None
 0.71A 2wd9B-4otkA:
2.6		 2wd9B-4otkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN

(Vibrio cholerae) 		PF00501
(AMP-binding) 		4 GLY A 317
GLY A 341
THR A 343
ARG A 457
 GAP  A 601 (-3.2A)
GAP  A 601 (-4.9A)
GAP  A 601 (-4.0A)
GAP  A 601 (-3.7A)
 0.36A 2wd9B-4oxiA:
35.7		 2wd9B-4oxiA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p53 CYCLASE

(Streptomyces
hygroscopicus) 		PF01761
(DHQ_synthase) 		4 ILE A 214
LEU A 215
VAL A 332
GLY A 233
 None
 0.66A 2wd9B-4p53A:
4.2		 2wd9B-4p53A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN

(Lactococcus
phage 1358) 		no annotation 5 ILE A 167
LEU A 150
VAL A  32
GLY A  31
ARG A 132
 None
 0.97A 2wd9B-4rggA:
undetectable		 2wd9B-4rggA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		4 ILE A 240
LEU A 239
GLY A 137
GLY A 233
 None
 0.75A 2wd9B-4rncA:
3.4		 2wd9B-4rncA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		4 LEU A  31
VAL A 119
GLY A 118
GLY A  34
 None
 0.76A 2wd9B-4y9wA:
undetectable		 2wd9B-4y9wA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Burkholderia
multivorans) 		PF13407
(Peripla_BP_4) 		4 ILE A 169
VAL A 254
GLY A 255
THR A 183
 None
 0.78A 2wd9B-4yleA:
6.3		 2wd9B-4yleA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		4 LEU A 174
GLY A  12
GLY A  36
THR A 178
 None
FAD  A 401 ( 4.8A)
None
None
 0.76A 2wd9B-4yshA:
undetectable		 2wd9B-4yshA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zox 60S RIBOSOMAL
PROTEIN L10
RIBOSOME ASSEMBLY
PROTEIN SQT1

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A 113
GLY A 109
GLY A 131
ARG B   3
 None
 0.67A 2wd9B-4zoxA:
undetectable		 2wd9B-4zoxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN

(Photobacterium
profundum) 		PF00759
(Glyco_hydro_9) 		4 ILE A 310
VAL A 252
GLY A 251
GLN A 248
 None
None
None
NA  A 601 (-3.0A)
 0.75A 2wd9B-5dgqA:
undetectable		 2wd9B-5dgqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5di0 NATTERIN-LIKE
PROTEIN

(Danio rerio) 		PF03318
(ETX_MTX2) 		4 LEU A 150
VAL A 153
GLY A 216
THR A 236
 None
 0.70A 2wd9B-5di0A:
undetectable		 2wd9B-5di0A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwd ESTERASE

(Pelagibacterium
halotolerans) 		PF02230
(Abhydrolase_2) 		4 LEU A 125
GLY A 143
GLY A 120
GLN A 119
 None
 0.77A 2wd9B-5dwdA:
3.3		 2wd9B-5dwdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 216
GLY A 312
GLN A 313
THR A 314
 None
 0.26A 2wd9B-5e7qA:
25.8		 2wd9B-5e7qA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		4 ILE A 491
LEU A 487
GLY A 386
GLN A 389
 None
 0.77A 2wd9B-5ej1A:
3.3		 2wd9B-5ej1A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eum LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Haemophilus
influenzae) 		PF00005
(ABC_tran) 		4 ILE A 412
LEU A 407
VAL A 506
ARG A 421
 None
 0.77A 2wd9B-5eumA:
undetectable		 2wd9B-5eumA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gri ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		PF00180
(Iso_dh) 		4 LEU A 318
VAL A 245
GLY A 244
GLY A 241
 None
 0.77A 2wd9B-5griA:
undetectable		 2wd9B-5griA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]

(Thermotoga
maritima) 		PF03060
(NMO) 		4 ILE A 284
LEU A 283
GLY A 172
GLY A 278
 None
None
FMN  A 402 (-3.7A)
FMN  A 402 ( 4.0A)
 0.77A 2wd9B-5gvhA:
undetectable		 2wd9B-5gvhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxd AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Dinoroseobacter
shibae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 GLY A 365
GLN A 390
THR A 391
ARG A 504
 AMP  A 701 ( 3.3A)
AMP  A 701 (-4.3A)
AMP  A 701 (-3.6A)
AMP  A 701 ( 3.9A)
 0.31A 2wd9B-5gxdA:
41.6		 2wd9B-5gxdA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ILE A 797
GLY A 801
GLY A 750
GLN A 748
 None
 0.72A 2wd9B-5ihrA:
undetectable		 2wd9B-5ihrA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5l UNCHARACTERIZED
PROTEIN

(Aspergillus
fumigatus) 		PF12296
(HsbA) 		4 LEU A  55
VAL A 123
GLY A 122
GLN A 117
 None
 0.75A 2wd9B-5j5lA:
undetectable		 2wd9B-5j5lA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 GLY A 723
GLY A 747
THR A 749
ARG A 866
 75C  A1301 (-3.4A)
75C  A1301 (-4.7A)
75C  A1301 (-4.5A)
75C  A1301 (-4.0A)
 0.30A 2wd9B-5ja1A:
41.3		 2wd9B-5ja1A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Streptomyces
sp. ML694-90F3) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLY A 290
GLY A 315
THR A 317
ARG A 434
 6L1  A 601 (-3.3A)
6L1  A 601 (-4.7A)
6L1  A 601 (-3.5A)
6L1  A 601 (-3.6A)
 0.38A 2wd9B-5jjqA:
33.7		 2wd9B-5jjqA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 ILE A 335
VAL A 411
GLY A 412
THR A 441
 None
ATP  A 703 (-4.8A)
ATP  A 703 ( 3.4A)
ATP  A 703 ( 3.7A)
 0.55A 2wd9B-5k8fA:
35.8		 2wd9B-5k8fA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh0 SMALL GTP-BINDING
PROTEIN

(Thermosipho
melanesiensis) 		PF01926
(MMR_HSR1) 		4 ILE A 164
LEU A 165
VAL A  56
GLY A 158
 None
 0.76A 2wd9B-5kh0A:
4.6		 2wd9B-5kh0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 LEU B 323
GLY B 474
GLY B 316
ARG B 343
 None
 0.77A 2wd9B-5kohB:
undetectable		 2wd9B-5kohB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 LEU A 551
GLY A 589
GLY A 544
GLN A 545
 None
 0.77A 2wd9B-5l46A:
undetectable		 2wd9B-5l46A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lad PUTATIVE GTP-BINDING
PROTEIN

(Thermotoga
maritima) 		PF01926
(MMR_HSR1) 		4 ILE A 168
LEU A 169
VAL A  57
GLY A 162
 None
 0.74A 2wd9B-5ladA:
4.3		 2wd9B-5ladA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 350
GLY A 356
GLY A 374
GLN A 377
 None
 0.76A 2wd9B-5nccA:
undetectable		 2wd9B-5nccA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o30 PUTATIVE
OXIDOREDUCTASE

(Ilumatobacter
coccineus) 		PF13561
(adh_short_C2) 		4 LEU A 136
VAL A 188
GLY A 145
GLY A 143
 None
 0.70A 2wd9B-5o30A:
3.1		 2wd9B-5o30A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS

(Erwinia
amylovora) 		no annotation 4 LEU A  20
VAL A 153
GLY A  10
GLY A 155
 None
 0.73A 2wd9B-5o8rA:
undetectable		 2wd9B-5o8rA:
10.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Brucella canis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLY A 323
GLY A 347
GLN A 348
THR A 349
 None
 0.57A 2wd9B-5u2aA:
44.2		 2wd9B-5u2aA:
34.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM6

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 ILE 6 661
LEU 6 672
GLY 6 392
GLY 6 626
 None
 0.63A 2wd9B-5udb6:
undetectable		 2wd9B-5udb6:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 LEU A 792
VAL A 751
GLY A 752
GLY A 763
 None
 0.76A 2wd9B-5ux5A:
undetectable		 2wd9B-5ux5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 GLY A 265
GLY A 297
GLN A 296
THR A 295
 None
 0.75A 2wd9B-5vniA:
undetectable		 2wd9B-5vniA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5b HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CMR

(Mycobacterium
tuberculosis) 		no annotation 4 ILE A 101
LEU A 102
VAL A  81
GLY A  84
 None
 0.71A 2wd9B-5w5bA:
undetectable		 2wd9B-5w5bA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1) 		no annotation 4 GLY A 282
GLY A 307
THR A 309
ARG A 424
 B6G  A1001 (-3.4A)
B6G  A1001 (-4.8A)
B6G  A1001 (-3.8A)
B6G  A1001 (-4.0A)
 0.31A 2wd9B-5wmmA:
40.6		 2wd9B-5wmmA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8g 2-SUCCINYLBENZOATE--
COA LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 197
GLY A 264
GLY A 287
THR A 289
 CA  A 505 ( 4.5A)
S0N  A 501 (-4.1A)
S0N  A 501 (-4.5A)
CA  A 505 (-3.3A)
 0.53A 2wd9B-5x8gA:
42.3		 2wd9B-5x8gA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvi GLUTAMATE
DEHYDROGENASE

(Aspergillus
niger) 		no annotation 4 LEU A  89
VAL A  68
GLY A  96
ARG A  82
 None
 0.70A 2wd9B-5xviA:
2.2		 2wd9B-5xviA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S16,
PUTATIVE

(Trichomonas
vaginalis) 		PF00380
(Ribosomal_S9) 		4 ILE Q  26
LEU Q  25
GLY Q  22
GLY Q  58
 None
 0.60A 2wd9B-5xyiQ:
undetectable		 2wd9B-5xyiQ:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A 260
LEU A 259
GLY A 203
GLY A 198
 None
None
None
PLP  A 401 (-3.3A)
 0.75A 2wd9B-6c2hA:
undetectable		 2wd9B-6c2hA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP

(Streptomyces
wadayamensis) 		no annotation 4 LEU A 373
VAL A 298
GLY A 297
GLY A 294
 None
 0.70A 2wd9B-6c9bA:
undetectable		 2wd9B-6c9bA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 5 ILE A  11
LEU A 143
GLY A  16
GLY A  13
THR A 146
 FAD  A 502 ( 4.9A)
None
FAD  A 502 (-3.7A)
FAD  A 502 ( 4.8A)
FAD  A 502 (-4.2A)
 1.39A 2wd9B-6cmzA:
undetectable		 2wd9B-6cmzA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwf NITRIC-OXIDE
REDUCTASE

(Neisseria
meningitidis) 		no annotation 4 GLY A 416
GLY A 409
GLN A  62
THR A  63
 None
 0.72A 2wd9B-6fwfA:
undetectable		 2wd9B-6fwfA:
9.31