SIMILAR PATTERNS OF AMINO ACIDS FOR 2WA2_B_SAMB1267_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azz COLLAGENASE

(Leptuca
pugilator) 		PF00089
(Trypsin) 		3 SER A  45
HIS A  71
ASP A 153
 None
 0.76A 2wa2B-1azzA:
undetectable		 2wa2B-1azzA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cq3 VIRAL CHEMOKINE
INHIBITOR

(Cowpox virus) 		PF02250
(Orthopox_35kD) 		3 SER A 119
HIS A  16
ASP A 108
 None
 0.62A 2wa2B-1cq3A:
undetectable		 2wa2B-1cq3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dix EXTRACELLULAR
RIBONUCLEASE LE

(Solanum
lycopersicum) 		PF00445
(Ribonuclease_T2) 		3 SER A  87
HIS A 109
ASP A 117
 None
 0.76A 2wa2B-1dixA:
undetectable		 2wa2B-1dixA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5q GAMMA HERPESVIRUS
CYCLIN

(Murid
gammaherpesvirus
4) 		PF00134
(Cyclin_N) 		3 SER B 149
HIS B 201
ASP B 216
 None
 0.79A 2wa2B-1f5qB:
undetectable		 2wa2B-1f5qB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 SER A  79
HIS A 144
ASP A 502
 None
 0.61A 2wa2B-1h17A:
undetectable		 2wa2B-1h17A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03372
(Exo_endo_phos) 		3 SER A 640
HIS A 699
ASP A 816
 None
 0.70A 2wa2B-1i9zA:
undetectable		 2wa2B-1i9zA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibg IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  76
HIS H  35
ASP H  58
 None
OBN  H   1 (-4.1A)
None
 0.69A 2wa2B-1ibgH:
undetectable		 2wa2B-1ibgH:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyb RIBONUCLEASE

(Nicotiana
glutinosa) 		PF00445
(Ribonuclease_T2) 		3 SER A  87
HIS A 108
ASP A 116
 None
 0.71A 2wa2B-1iybA:
undetectable		 2wa2B-1iybA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		3 SER A 185
HIS A 227
ASP A  95
 None
None
G  D 915 ( 3.3A)
 0.74A 2wa2B-1j2bA:
undetectable		 2wa2B-1j2bA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j4a D-LACTATE
DEHYDROGENASE

(Lactobacillus
delbrueckii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 SER A 204
HIS A 215
ASP A 243
 None
 0.75A 2wa2B-1j4aA:
undetectable		 2wa2B-1j4aA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j89 HIGH AFFINITY
IMMUNOGLOBULIN
EPSILON RECEPTOR
ALPHA-SUBUNIT

(Homo sapiens) 		PF13895
(Ig_2)
PF13927
(Ig_3) 		3 SER A 137
HIS A 108
ASP A 114
 None
 0.80A 2wa2B-1j89A:
undetectable		 2wa2B-1j89A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd H57 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER E 208
HIS E 189
ASP E 157
 None
 0.76A 2wa2B-1nfdE:
undetectable		 2wa2B-1nfdE:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nld FAB1583

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  76
HIS H  35
ASP H  58
 None
 0.75A 2wa2B-1nldH:
undetectable		 2wa2B-1nldH:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw5 NAGD PROTEIN,
PUTATIVE

(Thermotoga
maritima) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 SER A  47
HIS A  80
ASP A 190
 None
 0.71A 2wa2B-1pw5A:
undetectable		 2wa2B-1pw5A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		3 SER A1079
HIS A1144
ASP A1502
 None
 0.63A 2wa2B-1qhmA:
undetectable		 2wa2B-1qhmA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		3 SER A 277
HIS A 232
ASP A 178
 None
ABD  A1200 ( 3.8A)
ABD  A1200 ( 4.9A)
 0.66A 2wa2B-1qhoA:
undetectable		 2wa2B-1qhoA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2q FAB NNA7 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  77
HIS H  36
ASP H  59
 None
 0.64A 2wa2B-1t2qH:
undetectable		 2wa2B-1t2qH:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5t ORC2

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		3 SER A 217
HIS A 241
ASP A 284
 None
 0.71A 2wa2B-1w5tA:
undetectable		 2wa2B-1w5tA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		3 SER A 227
HIS A 256
ASP A 317
 None
 0.80A 2wa2B-1wpwA:
undetectable		 2wa2B-1wpwA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		3 SER A 214
HIS A  34
ASP A 316
 None
 0.73A 2wa2B-1wraA:
undetectable		 2wa2B-1wraA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0l HOMOISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		3 SER A 231
HIS A 260
ASP A 313
 None
 0.78A 2wa2B-1x0lA:
undetectable		 2wa2B-1x0lA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqw PROLINE
IMINOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00561
(Abhydrolase_1) 		3 SER A 104
HIS A 264
ASP A 287
 LEU  A 301 (-3.3A)
None
None
 0.79A 2wa2B-1xqwA:
undetectable		 2wa2B-1xqwA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE

(Bacillus
thuringiensis) 		PF00753
(Lactamase_B) 		3 SER A 242
HIS A 235
ASP A  50
 None
ZN  A 251 (-3.3A)
None
 0.71A 2wa2B-2a7mA:
undetectable		 2wa2B-2a7mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		3 SER A 301
HIS A 330
ASP A 383
 None
 0.73A 2wa2B-2dhtA:
undetectable		 2wa2B-2dhtA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dld D-LACTATE
DEHYDROGENASE

(Lactobacillus
helveticus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 SER A 204
HIS A 215
ASP A 243
 None
 0.61A 2wa2B-2dldA:
4.7		 2wa2B-2dldA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		3 SER A 316
HIS A 339
ASP A 248
 XTS  A 502 (-2.5A)
None
None
 0.77A 2wa2B-2eg5A:
6.3		 2wa2B-2eg5A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eve HYPOTHETICAL PROTEIN
PSPTO5229

(Pseudomonas
syringae group
genomosp. 3) 		PF01878
(EVE) 		3 SER A  14
HIS A  81
ASP A  77
 None
 0.76A 2wa2B-2eveA:
undetectable		 2wa2B-2eveA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk6 RIBONUCLEASE Z

(Bacillus
subtilis) 		PF12706
(Lactamase_B_2) 		3 SER A 293
HIS A 269
ASP A  37
 None
ZN  A 401 (-3.6A)
None
 0.64A 2wa2B-2fk6A:
undetectable		 2wa2B-2fk6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsv NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Rhodospirillum
rubrum) 		PF02233
(PNTB) 		3 SER C 169
HIS C  85
ASP C 153
 None
 0.73A 2wa2B-2fsvC:
2.1		 2wa2B-2fsvC:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 SER A  97
HIS A  88
ASP A 306
 None
None
MG  A 901 (-2.1A)
 0.77A 2wa2B-2fuvA:
undetectable		 2wa2B-2fuvA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 SER A 437
HIS A  63
ASP A 540
 None
 0.78A 2wa2B-2g3nA:
undetectable		 2wa2B-2g3nA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 SER A 155
HIS A 129
ASP A 117
 BG6  A1002 ( 3.4A)
None
None
 0.73A 2wa2B-2nztA:
undetectable		 2wa2B-2nztA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oap TYPE II SECRETION
SYSTEM PROTEIN

(Archaeoglobus
fulgidus) 		PF00437
(T2SSE) 		3 SER 1 207
HIS 1   5
ASP 1 128
 None
 0.77A 2wa2B-2oap1:
2.9		 2wa2B-2oap1:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oor NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Rhodospirillum
rubrum) 		PF02233
(PNTB) 		3 SER C 169
HIS C  85
ASP C 153
 None
 0.75A 2wa2B-2oorC:
undetectable		 2wa2B-2oorC:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		3 SER A 777
HIS A 758
ASP A 764
 None
 0.63A 2wa2B-2pggA:
undetectable		 2wa2B-2pggA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po3 4-DEHYDRASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		3 SER A1331
HIS A1350
ASP A1122
 None
 0.69A 2wa2B-2po3A:
undetectable		 2wa2B-2po3A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		3 SER A  38
HIS A 168
ASP A 310
 None
None
FAD  A 403 (-2.7A)
 0.72A 2wa2B-2rgjA:
3.6		 2wa2B-2rgjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22)
PF01163
(RIO1) 		3 SER A 455
HIS A 496
ASP A 500
 None
 0.74A 2wa2B-2vwbA:
undetectable		 2wa2B-2vwbA:
17.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wa2 NON-STRUCTURAL
PROTEIN 5

(Modoc virus) 		PF01728
(FtsJ) 		3 SER A  87
HIS A 111
ASP A 132
 SAM  A1248 (-3.9A)
SAM  A1248 (-3.8A)
SAM  A1248 (-3.6A)
 0.72A 2wa2B-2wa2A:
37.0		 2wa2B-2wa2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zds PUTATIVE DNA-BINDING
PROTEIN

(Streptomyces
coelicolor) 		PF01261
(AP_endonuc_2)
PF07582
(AP_endonuc_2_N) 		3 SER A 292
HIS A 212
ASP A 264
 None
 0.65A 2wa2B-2zdsA:
undetectable		 2wa2B-2zdsA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N)
PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		3 SER B 120
HIS B 112
ASP A 772
 None
None
MD1  A1245 (-2.7A)
 0.73A 2wa2B-3egwB:
undetectable		 2wa2B-3egwB:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 SER A 273
HIS A 230
ASP A 182
 None
 0.74A 2wa2B-3eh2A:
undetectable		 2wa2B-3eh2A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ila RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF08709
(Ins145_P3_rec) 		3 SER A 119
HIS A 113
ASP A  61
 None
 0.78A 2wa2B-3ilaA:
undetectable		 2wa2B-3ilaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 3 SER A 343
HIS A 333
ASP A 241
 None
 0.80A 2wa2B-3lg5A:
undetectable		 2wa2B-3lg5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		3 SER X 835
HIS X 922
ASP X 926
 None
 0.73A 2wa2B-3lxuX:
1.9		 2wa2B-3lxuX:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1l FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00551
(Formyl_trans_N) 		3 SER A  97
HIS A 108
ASP A 134
 None
 0.63A 2wa2B-3o1lA:
2.1		 2wa2B-3o1lA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa4 GLYOXALASE

(Bacillus
halodurans) 		PF13669
(Glyoxalase_4) 		3 SER A 125
HIS A  82
ASP A  10
 None
ZN  A 300 (-3.3A)
None
 0.73A 2wa2B-3oa4A:
undetectable		 2wa2B-3oa4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		3 SER A 352
HIS A 175
ASP A 288
 GDP  A 663 (-2.6A)
None
None
 0.80A 2wa2B-3p27A:
undetectable		 2wa2B-3p27A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		3 SER A 336
HIS A 169
ASP A 291
 None
 0.75A 2wa2B-3pm0A:
undetectable		 2wa2B-3pm0A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		3 SER A1300
HIS A1318
ASP A1275
 None
 0.78A 2wa2B-3pvlA:
undetectable		 2wa2B-3pvlA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvm OLEI00960

(Oleispira
antarctica) 		PF00561
(Abhydrolase_1) 		3 SER A 131
HIS A  34
ASP A  86
 None
 0.54A 2wa2B-3qvmA:
undetectable		 2wa2B-3qvmA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbn DNA MISMATCH REPAIR
PROTEIN MLH1

(Homo sapiens) 		PF16413
(Mlh1_C) 		3 SER A 210
HIS A 260
ASP A 177
 None
 0.77A 2wa2B-3rbnA:
undetectable		 2wa2B-3rbnA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		3 SER A 925
HIS A 658
ASP A 615
 None
 0.71A 2wa2B-3tsyA:
undetectable		 2wa2B-3tsyA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		3 SER A 926
HIS A 658
ASP A 615
 None
 0.77A 2wa2B-3tsyA:
undetectable		 2wa2B-3tsyA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9x MULTICOPPER OXIDASE

(uncultured
bacterium) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 SER A1232
HIS A1204
ASP A1209
 None
CU  A1404 ( 3.0A)
None
 0.61A 2wa2B-4e9xA:
undetectable		 2wa2B-4e9xA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN

(Idiomarina
loihiensis) 		PF05299
(Peptidase_M61)
PF13180
(PDZ_2) 		3 SER A  93
HIS A 277
ASP A 314
 None
ZN  A 602 ( 3.2A)
None
 0.77A 2wa2B-4fgmA:
undetectable		 2wa2B-4fgmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Yersinia pestis) 		PF01513
(NAD_kinase) 		3 SER A 173
HIS A 158
ASP A 239
 None
 0.81A 2wa2B-4haoA:
3.5		 2wa2B-4haoA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3f SERINE HYDROLASE
CCSP0084

(Cycloclasticus
sp. P1) 		PF12697
(Abhydrolase_6) 		3 SER A  32
HIS A  68
ASP A  88
 CL  A 302 (-3.1A)
None
None
 0.63A 2wa2B-4i3fA:
undetectable		 2wa2B-4i3fA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7i RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		3 SER A 119
HIS A 113
ASP A  61
 None
 0.74A 2wa2B-4i7iA:
undetectable		 2wa2B-4i7iA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itm TETRAACYLDISACCHARID
E 4'-KINASE

(Aquifex
aeolicus) 		PF02606
(LpxK) 		3 SER A 131
HIS A 110
ASP A  60
 None
 0.78A 2wa2B-4itmA:
undetectable		 2wa2B-4itmA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE

(Lactobacillus
rhamnosus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		3 SER A 482
HIS A 497
ASP A 127
 None
 0.73A 2wa2B-4iuwA:
undetectable		 2wa2B-4iuwA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		3 SER A 510
HIS A 517
ASP A 460
 None
 0.68A 2wa2B-4k17A:
undetectable		 2wa2B-4k17A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE

(Oryza sativa) 		PF03098
(An_peroxidase) 		3 SER A 101
HIS A 205
ASP A 165
 None
 0.75A 2wa2B-4kvlA:
undetectable		 2wa2B-4kvlA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		3 SER A 380
HIS A 372
ASP A 356
 None
 0.48A 2wa2B-4l22A:
undetectable		 2wa2B-4l22A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		3 SER A 138
HIS A  71
ASP A  78
 None
None
MG  A 302 (-2.5A)
 0.74A 2wa2B-4lfeA:
undetectable		 2wa2B-4lfeA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt4 CMEC

(Campylobacter
jejuni) 		PF02321
(OEP) 		3 SER A 278
HIS A  66
ASP A  59
 None
 0.69A 2wa2B-4mt4A:
undetectable		 2wa2B-4mt4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		3 SER A 335
HIS A 121
ASP A 471
 None
NI  A 604 (-3.7A)
None
 0.81A 2wa2B-4n0rA:
undetectable		 2wa2B-4n0rA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2

(Streptococcus
pyogenes) 		no annotation 3 SER A 708
HIS A 701
ASP A 697
 None
 0.67A 2wa2B-4nuzA:
undetectable		 2wa2B-4nuzA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		3 SER A 177
HIS A 461
ASP A 237
 None
None
NI  A1001 ( 2.7A)
 0.74A 2wa2B-4q2cA:
undetectable		 2wa2B-4q2cA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r84 SIALYLTRANSFERASE
0160

(Photobacterium
damselae) 		PF11477
(PM0188) 		3 SER A 147
HIS A 131
ASP A 285
 None
 0.81A 2wa2B-4r84A:
3.5		 2wa2B-4r84A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9v SIALYLTRANSFERASE
0160

(Photobacterium
damselae) 		PF11477
(PM0188) 		3 SER A 147
HIS A 131
ASP A 285
 None
 0.80A 2wa2B-4r9vA:
3.1		 2wa2B-4r9vA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urn DNA TOPOISOMERASE
IV, B SUBUNIT

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		3 SER A 123
HIS A  41
ASP A  35
 None
 0.80A 2wa2B-4urnA:
undetectable		 2wa2B-4urnA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w2q ANTI-MARBURGVIRUS
NUCLEOPROTEIN SINGLE
DOMAIN ANTIBODY C
NUCLEOPROTEIN

(Lama glama;
Marburg
marburgvirus) 		no annotation
no annotation 		3 SER B 658
HIS B 690
ASP A  98
 None
 0.80A 2wa2B-4w2qB:
undetectable		 2wa2B-4w2qB:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yvd PLEIOTROPIC
REGULATOR 1

(Homo sapiens) 		PF00400
(WD40) 		3 SER A 404
HIS A 381
ASP A 440
 CL  A 606 (-2.9A)
UNX  A 607 ( 4.6A)
None
 0.53A 2wa2B-4yvdA:
undetectable		 2wa2B-4yvdA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4za3 RRNA N-GLYCOSIDASE

(Momordica
charantia) 		PF00652
(Ricin_B_lectin) 		3 SER B  71
HIS B 101
ASP B  85
 None
 0.69A 2wa2B-4za3B:
undetectable		 2wa2B-4za3B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aoy ENDONUCLEASE V

(Mus musculus) 		PF04493
(Endonuclease_5) 		3 SER A 216
HIS A 225
ASP A 181
 None
 0.79A 2wa2B-5aoyA:
undetectable		 2wa2B-5aoyA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		3 SER A 695
HIS A 179
ASP A 535
 None
None
MTT  A2001 (-3.0A)
 0.78A 2wa2B-5d0fA:
undetectable		 2wa2B-5d0fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		3 SER A 138
HIS A 149
ASP A  44
 None
 0.71A 2wa2B-5du9A:
undetectable		 2wa2B-5du9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf DNA REPAIR HELICASE
RAD25, SSL2

(Saccharomyces
cerevisiae) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		3 SER 1 294
HIS 1 314
ASP 1 334
 None
 0.66A 2wa2B-5fmf1:
2.1		 2wa2B-5fmf1:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqe BETA-N-ACETYLGALACTO
SAMINIDASE

(Clostridium
perfringens) 		PF13320
(DUF4091) 		3 SER A 342
HIS A 329
ASP A 255
 None
None
BR  A1638 (-4.5A)
 0.54A 2wa2B-5fqeA:
undetectable		 2wa2B-5fqeA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		3 SER A 112
HIS A 253
ASP A 237
 None
 0.74A 2wa2B-5g5zA:
undetectable		 2wa2B-5g5zA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai PORTAL PROTEIN

(Salmonella
virus P22) 		PF16510
(P22_portal) 		3 SER A 279
HIS A 297
ASP A 166
 None
 0.72A 2wa2B-5gaiA:
undetectable		 2wa2B-5gaiA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF03071
(GNT-I)
PF15711
(ILEI) 		3 SER A 226
HIS A 132
ASP A 150
 None
 0.72A 2wa2B-5gggA:
undetectable		 2wa2B-5gggA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7

(synthetic
construct) 		PF12796
(Ank_2) 		3 SER A  33
HIS A  75
ASP A  95
 None
 0.72A 2wa2B-5hs0A:
undetectable		 2wa2B-5hs0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ji5 BUPHA.10154.A.B1

(Paraburkholderia
phymatum) 		PF00850
(Hist_deacetyl) 		3 SER A 119
HIS A 246
ASP A 259
 None
 0.57A 2wa2B-5ji5A:
3.0		 2wa2B-5ji5A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kba DESIGNED PROTEIN
ANK1C2

(synthetic
construct) 		PF12796
(Ank_2) 		3 SER A  32
HIS A  74
ASP A  94
 None
 0.78A 2wa2B-5kbaA:
undetectable		 2wa2B-5kbaA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT
ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N)
PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		3 SER b 128
HIS B 257
ASP B  71
 None
 0.60A 2wa2B-5l9wb:
undetectable		 2wa2B-5l9wb:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mbm DARPIN 8H6

(synthetic
construct) 		no annotation 3 SER C  75
HIS C 117
ASP C 137
 None
 0.81A 2wa2B-5mbmC:
undetectable		 2wa2B-5mbmC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp7 RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Mycolicibacterium
smegmatis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		3 SER A  66
HIS A 138
ASP A 140
 None
 0.77A 2wa2B-5mp7A:
2.8		 2wa2B-5mp7A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndx GLYCOSYL HYDROLASE

(Rhizobium
leguminosarum) 		no annotation 3 SER A 368
HIS A 413
ASP A 513
 None
 0.80A 2wa2B-5ndxA:
undetectable		 2wa2B-5ndxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v ENVELOPE PROTEIN

(Tick-borne
encephalitis
virus) 		no annotation 3 SER A 397
HIS A 323
ASP A  10
 None
 0.55A 2wa2B-5o6vA:
undetectable		 2wa2B-5o6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oom 39S RIBOSOMAL
PROTEIN L22,
MITOCHONDRIAL

(Homo sapiens) 		PF00237
(Ribosomal_L22) 		3 SER T  98
HIS T  75
ASP T 131
 None
 0.77A 2wa2B-5oomT:
undetectable		 2wa2B-5oomT:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqm RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 3 SER 3  41
HIS 3  36
ASP 3  60
 ZN  3 401 ( 4.7A)
ZN  3 402 (-3.3A)
None
 0.73A 2wa2B-5oqm3:
undetectable		 2wa2B-5oqm3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unl 3-KETOACYL-ACP
REDUCTASE

(Burkholderia
multivorans) 		PF13561
(adh_short_C2) 		3 SER A   4
HIS A 249
ASP A  89
 None
 0.81A 2wa2B-5unlA:
5.5		 2wa2B-5unlA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL

(Aspergillus
fumigatus) 		no annotation 3 SER A 131
HIS A  95
ASP A 268
 None
 0.80A 2wa2B-5uqrA:
undetectable		 2wa2B-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 SER A 288
HIS A  98
ASP A 124
 None
 0.75A 2wa2B-5xfmA:
undetectable		 2wa2B-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsx CHITINASE

(Thermococcus
chitonophagus) 		no annotation 3 SER A 326
HIS A 417
ASP A 412
 None
PO4  A1007 (-3.8A)
None
 0.75A 2wa2B-5xsxA:
undetectable		 2wa2B-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elu SERUM RESISTANCE
ASSOCIATED
VSG PROTEIN

(Trypanosoma
brucei) 		no annotation 3 SER A  66
HIS A 129
ASP A 135
 None
 0.73A 2wa2B-6eluA:
undetectable		 2wa2B-6eluA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en3 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE
F2,MULTIFUNCTIONAL-A
UTOPROCESSING
REPEATS-IN-TOXIN

(Vibrio
cholerae;
Streptococcus
pyogenes) 		no annotation 3 SER A 708
HIS A 701
ASP A 697
 None
 0.77A 2wa2B-6en3A:
undetectable		 2wa2B-6en3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eub ANGIOPOIETIN-RELATED
PROTEIN 4

(Homo sapiens) 		no annotation 3 SER A 357
HIS A 333
ASP A 330
 1PE  A 501 ( 4.0A)
None
None
 0.60A 2wa2B-6eubA:
undetectable		 2wa2B-6eubA:
undetectable