SIMILAR PATTERNS OF AMINO ACIDS FOR 2W9S_E_TOPE1160_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6t RIBONUCLEASE P

(Staphylococcus
aureus) 		PF00825
(Ribonuclease_P) 		4 ILE A  66
ALA A  86
LEU A  53
ILE A  98
 None
 0.78A 2w9sE-1d6tA:
undetectable		 2w9sE-1d6tA:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		5 ILE A   7
ALA A   9
LEU A  22
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
HBI  A 198 ( 4.5A)
 0.45A 2w9sE-1dr6A:
19.9		 2w9sE-1dr6A:
30.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 228
ALA A 115
LEU A 149
ILE A 129
 None
 0.71A 2w9sE-1ee0A:
undetectable		 2w9sE-1ee0A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekq HYDROXYETHYLTHIAZOLE
KINASE

(Bacillus
subtilis) 		PF02110
(HK) 		4 ILE A 219
ALA A 221
LEU A 200
ILE A 174
 None
 0.81A 2w9sE-1ekqA:
undetectable		 2w9sE-1ekqA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 ILE A 417
ALA A 419
LEU A 454
ILE A 160
 None
 0.82A 2w9sE-1ewkA:
2.7		 2w9sE-1ewkA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5m GAF

(Saccharomyces
cerevisiae) 		PF13185
(GAF_2) 		4 ILE A  64
ALA A  56
LEU A  25
ILE A 150
 None
 0.81A 2w9sE-1f5mA:
undetectable		 2w9sE-1f5mA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzy 4-CHLOROBENZOYL
COENZYME A
DEHALOGENASE

(Pseudomonas sp.
CBS3) 		PF00378
(ECH_1) 		4 ILE B  96
LEU B  27
ILE B  93
THR B  36
 None
 0.82A 2w9sE-1nzyB:
undetectable		 2w9sE-1nzyB:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u70 DIHYDROFOLATE
REDUCTASE

(Mus musculus) 		PF00186
(DHFR_1) 		4 ILE A   7
ALA A   9
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
None
MTX  A 187 (-4.4A)
 0.17A 2w9sE-1u70A:
19.9		 2w9sE-1u70A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u71 DIHYDROFOLATE
REDUCTASE

(Homo sapiens) 		PF00186
(DHFR_1) 		4 ILE A   7
ALA A   9
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
None
MXA  A 187 (-4.3A)
 0.29A 2w9sE-1u71A:
20.5		 2w9sE-1u71A:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5z MAJOR NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Aliivibrio
fischeri) 		PF00881
(Nitroreductase) 		4 ILE A  51
ALA A 188
ILE A  53
PHE A 176
 None
 0.84A 2w9sE-1v5zA:
undetectable		 2w9sE-1v5zA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ILE A 624
LEU A 491
ILE A 498
THR A 512
 None
 0.77A 2w9sE-1w99A:
undetectable		 2w9sE-1w99A:
13.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zdr DIHYDROFOLATE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00186
(DHFR_1) 		5 ILE A   5
ALA A   7
LEU A  20
ASP A  27
THR A 115
 None
 0.44A 2w9sE-1zdrA:
26.1		 2w9sE-1zdrA:
49.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2blb DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
vivax) 		PF00186
(DHFR_1) 		6 ILE A  13
ALA A  15
LEU A  45
ASP A  53
TYR A 179
THR A 194
 CP7  A1240 (-4.1A)
CP7  A1240 (-3.7A)
NDP  A1239 (-4.8A)
CP7  A1240 (-3.1A)
None
CP7  A1240 (-4.1A)
 0.52A 2w9sE-2blbA:
19.5		 2w9sE-2blbA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 ILE A 337
LEU A 265
ILE A 246
PHE A 329
 None
 0.79A 2w9sE-2eg5A:
undetectable		 2w9sE-2eg5A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekm HYPOTHETICAL PROTEIN
ST1511

(Sulfurisphaera
tokodaii) 		PF04008
(Adenosine_kin) 		4 ILE A  86
ALA A 112
ILE A 100
PHE A  84
 None
 0.73A 2w9sE-2ekmA:
undetectable		 2w9sE-2ekmA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 ALA A  28
ASP A  48
TYR A 160
THR A 178
 NAP  A 523 (-3.7A)
None
None
None
 0.18A 2w9sE-2h2qA:
19.3		 2w9sE-2h2qA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jb7 HYPOTHETICAL PROTEIN
PAE2307

(Pyrobaculum
aerophilum) 		PF04008
(Adenosine_kin) 		4 ILE A  89
ALA A 115
ILE A 103
PHE A  87
 None
 0.71A 2w9sE-2jb7A:
undetectable		 2w9sE-2jb7A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz4 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A

(Homo sapiens) 		PF00076
(RRM_1) 		5 ILE A  12
ALA A  55
LEU A  17
ILE A  84
PHE A  34
 None
 1.28A 2w9sE-2nz4A:
undetectable		 2w9sE-2nz4A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ALA A  11
LEU A  25
ASP A  32
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
None
MTX  A 605 ( 4.2A)
 0.41A 2w9sE-2oipA:
21.2		 2w9sE-2oipA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4g HYPOTHETICAL PROTEIN

(Corynebacterium
diphtheriae) 		PF01872
(RibD_C) 		4 ILE A  38
ASP A  61
TYR A 199
THR A 214
 EDO  A 278 (-4.7A)
EDO  A 278 (-3.2A)
EDO  A 280 (-4.3A)
None
 0.46A 2w9sE-2p4gA:
15.1		 2w9sE-2p4gA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qk8 DIHYDROFOLATE
REDUCTASE

(Bacillus
anthracis) 		PF00186
(DHFR_1) 		4 ALA A   8
PHE A  96
TYR A 102
THR A 115
 MTX  A 200 ( 3.4A)
MTX  A 200 ( 3.9A)
None
MTX  A 200 ( 4.4A)
 0.34A 2w9sE-2qk8A:
24.7		 2w9sE-2qk8A:
44.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ILE A  75
ALA A 233
ILE A  38
PHE A  65
 None
 0.77A 2w9sE-2r9vA:
undetectable		 2w9sE-2r9vA:
14.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w3w DIHYDROFOLATE
REDUCTASE

(Mycobacterium
avium) 		PF00186
(DHFR_1) 		4 ALA A  11
ASP A  31
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
None
VG9  A1168 ( 4.7A)
 0.14A 2w9sE-2w3wA:
22.5		 2w9sE-2w3wA:
32.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ILE A 207
LEU A 155
ILE A  67
PHE A 249
 None
 0.69A 2w9sE-2yd0A:
undetectable		 2w9sE-2yd0A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys1 DYNAMIN-2

(Homo sapiens) 		PF00169
(PH) 		4 ILE A  60
LEU A  14
ILE A  76
PHE A 108
 None
 0.79A 2w9sE-2ys1A:
undetectable		 2w9sE-2ys1A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13469
(Sulfotransfer_3) 		4 ALA A 246
LEU A 239
ILE A 306
PHE A 311
 None
 0.82A 2w9sE-2z6vA:
undetectable		 2w9sE-2z6vA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Huperzia
serrata) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 233
ALA A 120
LEU A 154
ILE A 134
 None
 0.68A 2w9sE-3awkA:
undetectable		 2w9sE-3awkA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cty THIOREDOXIN
REDUCTASE

(Thermoplasma
acidophilum) 		PF07992
(Pyr_redox_2) 		4 ILE A  97
LEU A 264
ILE A 120
PHE A 256
 None
None
None
FAD  A1000 (-3.9A)
 0.73A 2w9sE-3ctyA:
undetectable		 2w9sE-3ctyA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3f YVGN PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		4 ALA A 188
ASP A 222
ILE A 218
THR A 229
 None
 0.79A 2w9sE-3d3fA:
undetectable		 2w9sE-3d3fA:
17.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dfr DIHYDROFOLATE
REDUCTASE

(Lactobacillus
casei) 		PF00186
(DHFR_1) 		4 ALA A   6
LEU A  19
ASP A  26
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.50A 2w9sE-3dfrA:
23.3		 2w9sE-3dfrA:
35.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg8 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1) 		6 ILE A  14
ALA A  16
LEU A  46
ASP A  54
TYR A 170
THR A 185
 RJ6  A 609 (-4.5A)
RJ6  A 609 (-3.7A)
RJ6  A 609 (-3.8A)
RJ6  A 609 (-3.0A)
NDP  A 610 ( 4.9A)
RJ6  A 609 ( 4.5A)
 0.53A 2w9sE-3dg8A:
20.1		 2w9sE-3dg8A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9c METHIONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF09334
(tRNA-synt_1g) 		4 ILE A  58
ALA A  62
ILE A  73
PHE A 238
 None
 0.79A 2w9sE-3h9cA:
undetectable		 2w9sE-3h9cA:
16.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i8a DIHYDROFOLATE
REDUCTASE

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		5 ALA X   7
ASP X  27
PHE X  92
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 ( 3.7A)
None
N22  X 219 (-4.4A)
 0.13A 2w9sE-3i8aX:
29.8		 2w9sE-3i8aX:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i8a DIHYDROFOLATE
REDUCTASE

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		5 LEU X  20
ASP X  27
PHE X  92
TYR X  98
THR X 111
 N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 ( 3.7A)
None
N22  X 219 (-4.4A)
 0.52A 2w9sE-3i8aX:
29.8		 2w9sE-3i8aX:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ia4 DIHYDROFOLATE
REDUCTASE

(Moritella
profunda) 		PF00186
(DHFR_1) 		4 ILE A   6
ALA A   8
TYR A 102
THR A 115
 MTX  A 164 (-4.0A)
MTX  A 164 ( 3.7A)
None
MTX  A 164 (-4.3A)
 0.16A 2w9sE-3ia4A:
25.3		 2w9sE-3ia4A:
41.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ix9 DIHYDROFOLATE
REDUCTASE

(Streptococcus
pneumoniae) 		PF00186
(DHFR_1) 		4 ILE A   8
ALA A  10
LEU A  23
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.5A)
 0.48A 2w9sE-3ix9A:
24.4		 2w9sE-3ix9A:
34.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens) 		PF01582
(TIR)
PF13855
(LRR_8) 		4 ALA A 205
LEU A 160
ILE A 175
PHE A 201
 None
 0.74A 2w9sE-3j0aA:
undetectable		 2w9sE-3j0aA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 ALA A  16
ASP A  37
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
 0.20A 2w9sE-3kjrA:
20.4		 2w9sE-3kjrA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis) 		PF00491
(Arginase) 		4 ILE A  61
ALA A 301
ILE A 285
THR A 298
 None
 0.78A 2w9sE-3m1rA:
undetectable		 2w9sE-3m1rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr1 PROBABLE GTP-BINDING
PROTEIN ENGB

(Thermotoga
maritima) 		PF01926
(MMR_HSR1) 		4 ALA A  27
LEU A 105
ILE A  61
PHE A  63
 None
 0.83A 2w9sE-3pr1A:
undetectable		 2w9sE-3pr1A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 ILE A 651
ILE A 524
PHE A 513
THR A 517
 None
 0.68A 2w9sE-3qcwA:
undetectable		 2w9sE-3qcwA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ILE A 185
ASP A 192
ILE A 164
PHE A 206
 None
 0.82A 2w9sE-3rg1A:
undetectable		 2w9sE-3rg1A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg9 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
brucei) 		PF00186
(DHFR_1) 		4 ALA A  34
ASP A  54
TYR A 166
THR A 184
 WRA  A 602 (-3.9A)
WRA  A 602 (-2.9A)
None
WRA  A 602 (-4.2A)
 0.25A 2w9sE-3rg9A:
19.5		 2w9sE-3rg9A:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5t DUF3298 FAMILY
PROTEIN

(Bacteroides
fragilis) 		PF11738
(DUF3298)
PF13739
(DUF4163) 		4 ILE A 242
LEU A 151
ILE A 189
PHE A 235
 None
 0.70A 2w9sE-3s5tA:
undetectable		 2w9sE-3s5tA:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tq9 DIHYDROFOLATE
REDUCTASE

(Coxiella
burnetii) 		PF00186
(DHFR_1) 		5 ILE A   6
ALA A   8
LEU A  21
ASP A  28
THR A 115
 MTX  A2001 (-4.0A)
MTX  A2001 ( 3.4A)
MTX  A2001 (-4.4A)
MTX  A2001 (-2.7A)
MTX  A2001 (-4.3A)
 0.54A 2w9sE-3tq9A:
24.9		 2w9sE-3tq9A:
42.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		4 ILE A 810
ALA A 697
LEU A 731
ILE A 711
 None
 0.73A 2w9sE-3tsyA:
undetectable		 2w9sE-3tsyA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt9 PLAKOPHILIN-2

(Homo sapiens) 		PF00514
(Arm) 		4 ALA A 559
ASP A 557
PHE A 491
THR A 560
 None
 0.84A 2w9sE-3tt9A:
undetectable		 2w9sE-3tt9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ILE A  14
LEU A  46
ASP A  54
TYR A 170
THR A 185
 1CY  A 609 (-4.3A)
NDP  A 610 (-4.4A)
1CY  A 609 (-2.9A)
None
1CY  A 609 (-4.3A)
 0.52A 2w9sE-3um6A:
20.2		 2w9sE-3um6A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vco DIHYDROFOLATE
REDUCTASE

(Schistosoma
mansoni) 		PF00186
(DHFR_1) 		4 ALA A   8
ASP A  28
TYR A 117
THR A 133
 None
 0.50A 2w9sE-3vcoA:
17.4		 2w9sE-3vcoA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvj OVALBUMIN

(Dromaius
novaehollandiae) 		PF00079
(Serpin) 		4 ILE A  63
LEU A 125
ILE A   4
PHE A  60
 None
 0.70A 2w9sE-3vvjA:
undetectable		 2w9sE-3vvjA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx6 E1

(Kluyveromyces
marxianus) 		PF16420
(ATG7_N) 		4 ILE A 173
LEU A  46
ILE A 117
PHE A 197
 None
 0.82A 2w9sE-3vx6A:
undetectable		 2w9sE-3vx6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 223
ALA A 110
LEU A 144
ILE A 124
 ILE  A 223 ( 0.7A)
ALA  A 110 ( 0.0A)
LEU  A 144 ( 0.5A)
ILE  A 124 ( 0.7A)
 0.73A 2w9sE-3wd7A:
undetectable		 2w9sE-3wd7A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 166
ALA A 372
LEU A 370
PHE A 190
 None
 0.80A 2w9sE-3wd8A:
undetectable		 2w9sE-3wd8A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 223
ALA A 110
LEU A 144
ILE A 124
 None
 0.80A 2w9sE-3wd8A:
undetectable		 2w9sE-3wd8A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		4 ILE A 164
ALA A 176
ILE A  94
PHE A 152
 None
 0.79A 2w9sE-3welA:
undetectable		 2w9sE-3welA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awe ENDO-BETA-D-1,4-MANN
ANASE

(Neurospora
sitophila) 		PF00150
(Cellulase) 		4 ALA A 110
LEU A 117
ILE A  39
THR A 113
 None
 0.78A 2w9sE-4aweA:
undetectable		 2w9sE-4aweA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA
F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF00037
(Fer4)
PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6) 		4 ALA B  61
LEU B  87
ILE A 108
THR B  58
 None
 0.76A 2w9sE-4ci0B:
undetectable		 2w9sE-4ci0B:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dm4 CELL DIVISION
CONTROL PROTEIN 73

(Saccharomyces
cerevisiae) 		PF05179
(CDC73_C) 		4 ILE A   9
ALA A  80
LEU A 150
ILE A  62
 None
 0.84A 2w9sE-4dm4A:
undetectable		 2w9sE-4dm4A:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g8z DIHYDROFOLATE
REDUCTASE

(Pneumocystis
jirovecii) 		PF00186
(DHFR_1) 		5 ILE X  10
ALA X  12
LEU X  25
TYR X 129
THR X 144
 TOP  X 301 (-4.2A)
NDP  X 302 ( 3.8A)
TOP  X 301 ( 4.0A)
None
TOP  X 301 (-4.5A)
 0.46A 2w9sE-4g8zX:
19.6		 2w9sE-4g8zX:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h96 DIHYDROFOLATE
REDUCTASE

(Candida
albicans) 		PF00186
(DHFR_1) 		4 ILE A   9
ALA A  11
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.6A)
 0.22A 2w9sE-4h96A:
17.8		 2w9sE-4h96A:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h98 DIHYDROFOLATE
REDUCTASE

([Candida]
glabrata) 		PF00186
(DHFR_1) 		5 ILE A   9
ALA A  11
LEU A  25
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
None
14Q  A 302 (-4.2A)
 0.61A 2w9sE-4h98A:
18.8		 2w9sE-4h98A:
31.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgg ESTERASE TESA

(Pseudomonas
aeruginosa) 		PF13472
(Lipase_GDSL_2) 		4 ILE A 109
ASP A   8
ILE A  10
PHE A 142
 None
 0.82A 2w9sE-4jggA:
undetectable		 2w9sE-4jggA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A 256
LEU A  10
ILE A 170
PHE A 407
 None
GOL  A 503 ( 4.7A)
None
None
 0.84A 2w9sE-4ls5A:
undetectable		 2w9sE-4ls5A:
17.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m2x DIHYDROFOLATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF00186
(DHFR_1) 		5 ILE A   5
ALA A   7
ASP A  27
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 (-4.2A)
 0.28A 2w9sE-4m2xA:
22.8		 2w9sE-4m2xA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m7v DIHYDROFOLATE
REDUCTASE

(Enterococcus
faecalis) 		PF00186
(DHFR_1) 		5 ILE A   5
ALA A   7
LEU A  20
ASP A  27
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.4A)
 0.41A 2w9sE-4m7vA:
25.4		 2w9sE-4m7vA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p68 DIHYDROFOLATE
REDUCTASE

(Escherichia
coli) 		PF00186
(DHFR_1) 		5 ILE A   5
ALA A   7
ASP A  27
TYR A 100
THR A 113
 MTX  A 201 (-4.1A)
MTX  A 201 ( 4.0A)
MTX  A 201 (-3.0A)
None
MTX  A 201 ( 4.5A)
 0.12A 2w9sE-4p68A:
25.5		 2w9sE-4p68A:
37.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkd U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
A,U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN 70
KDA

(Homo sapiens;
Sus scrofa) 		PF00076
(RRM_1)
PF12220
(U1snRNP70_N) 		5 ILE B  12
ALA B  55
LEU B  17
ILE B  84
PHE B  34
 None
 1.28A 2w9sE-4pkdB:
undetectable		 2w9sE-4pkdB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		4 ILE A 346
ALA A 349
ILE A 448
PHE A 257
 None
 0.83A 2w9sE-4r12A:
undetectable		 2w9sE-4r12A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA

(Escherichia
virus T4;
Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		4 ILE A 109
ALA A 113
LEU A 212
PHE A 106
 None
 0.70A 2w9sE-4wtvA:
undetectable		 2w9sE-4wtvA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 223
ALA A 110
LEU A 144
ILE A 124
 None
 0.74A 2w9sE-4wumA:
undetectable		 2w9sE-4wumA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjy CHALCONE SYNTHASE 1

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 226
ALA A 113
LEU A 147
ILE A 127
 None
 0.66A 2w9sE-4yjyA:
undetectable		 2w9sE-4yjyA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 ILE A 301
ALA A 517
ILE A 531
PHE A 354
 None
 0.75A 2w9sE-4ztxA:
undetectable		 2w9sE-4ztxA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cee NAD-DEPENDENT MALIC
ENZYME

(Aster yellows
witches'-broom
phytoplasma) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ILE A 279
ALA A 304
LEU A 283
ILE A 171
 None
None
NAD  A 401 (-4.2A)
None
 0.82A 2w9sE-5ceeA:
undetectable		 2w9sE-5ceeA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm5 HYDROXYETHYLTHIAZOLE
KINASE

(Staphylococcus
aureus) 		PF02110
(HK) 		4 ILE A 212
ALA A 214
LEU A 192
ILE A 166
 None
 0.78A 2w9sE-5cm5A:
undetectable		 2w9sE-5cm5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dku PREX DNA POLYMERASE

(Plasmodium
falciparum) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 ILE A 465
ALA A 482
ILE A 461
PHE A 498
 None
 0.82A 2w9sE-5dkuA:
undetectable		 2w9sE-5dkuA:
14.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dxv RETHREADED DHFR

(synthetic
construct) 		PF00186
(DHFR_1) 		4 ILE A   5
ALA A   7
TYR A 117
THR A 130
 None
NAP  A 201 (-3.7A)
None
CME  A 140 ( 4.5A)
 0.37A 2w9sE-5dxvA:
13.8		 2w9sE-5dxvA:
31.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fda DIHYDROFOLATE
REDUCTASE

(Yersinia pestis) 		PF00186
(DHFR_1) 		4 ILE A   6
ALA A   8
TYR A 101
THR A 114
 None
 0.26A 2w9sE-5fdaA:
17.6		 2w9sE-5fdaA:
40.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 TOLL-LIKE RECEPTOR 3

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ILE A 367
LEU A 360
ILE A 346
PHE A 333
 None
 0.76A 2w9sE-5gs0A:
undetectable		 2w9sE-5gs0A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 4 ILE A 492
ALA A 592
LEU A 557
ILE A 610
 None
 0.84A 2w9sE-5h7jA:
undetectable		 2w9sE-5h7jA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4a ARGONAUTE PROTEIN

(Marinitoga
piezophila) 		no annotation 4 ILE A  92
LEU A 250
ILE A 132
PHE A  96
 None
 0.68A 2w9sE-5i4aA:
undetectable		 2w9sE-5i4aA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szm PCDHGA8 OR
PROTOCADHERIN GAMMA
A8

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 ILE A  77
LEU A  66
ILE A  92
PHE A  46
 None
 0.67A 2w9sE-5szmA:
undetectable		 2w9sE-5szmA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ALA A  10
LEU A  23
ASP A  31
TYR A 157
THR A 172
 73X  A 704 (-4.0A)
None
73X  A 704 (-2.8A)
None
73X  A 704 (-4.2A)
 0.50A 2w9sE-5t0lA:
20.3		 2w9sE-5t0lA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubu PUTATIVE
ACETAMIDASE/FORMAMID
ASE

(Yersinia
enterocolitica) 		PF03069
(FmdA_AmdA) 		4 ILE A 103
LEU A 213
ILE A 167
THR A 202
 None
 0.59A 2w9sE-5ubuA:
undetectable		 2w9sE-5ubuA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc5 CHS2 CHALCONE
SYNTHASE

(Malus domestica) 		no annotation 4 ILE A 223
ALA A 110
LEU A 144
ILE A 124
 None
 0.65A 2w9sE-5uc5A:
undetectable		 2w9sE-5uc5A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5urb METHIONINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 ILE A  55
ALA A  59
ILE A  70
PHE A 236
 None
 0.80A 2w9sE-5urbA:
undetectable		 2w9sE-5urbA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8q BIS3 BIPHENYL
SYNTHASE

(Malus domestica) 		no annotation 4 ILE A 218
ALA A 105
LEU A 139
ILE A 119
 None
 0.69A 2w9sE-5w8qA:
undetectable		 2w9sE-5w8qA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx4 ALKYLQUINOLONE
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 228
ALA A 116
LEU A 150
ILE A 130
 None
 0.81A 2w9sE-5wx4A:
undetectable		 2w9sE-5wx4A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zcy PROTEIN TRANSLATION
FACTOR SUI1 HOMOLOG

(Pyrococcus
horikoshii) 		no annotation 4 ILE A  24
LEU A  57
ILE A  43
PHE A  91
 None
 0.67A 2w9sE-5zcyA:
undetectable		 2w9sE-5zcyA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co0 STYRYLPYRONE
SYNTHASE 1

(Piper
methysticum) 		no annotation 4 ILE A 224
ALA A 110
LEU A 144
ILE A 124
 None
 0.65A 2w9sE-6co0A:
undetectable		 2w9sE-6co0A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cqb CHALCONE SYNTHASE

(Piper
methysticum) 		no annotation 4 ILE A 224
ALA A 111
LEU A 145
ILE A 125
 None
 0.78A 2w9sE-6cqbA:
undetectable		 2w9sE-6cqbA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxm DIHYDROFOLATE
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 5 ILE A   6
ALA A   8
ASP A  28
TYR A  98
THR A 111
 MMV  A 202 (-4.0A)
NAP  A 201 (-3.9A)
MMV  A 202 (-2.9A)
None
MMV  A 202 (-4.4A)
 0.22A 2w9sE-6cxmA:
21.9		 2w9sE-6cxmA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e4e -

(-) 		no annotation 5 ALA A   7
LEU A  20
ASP A  27
PHE A  92
THR A 111
 MMV  A 202 ( 3.5A)
MMV  A 202 (-4.3A)
MMV  A 202 (-2.9A)
MMV  A 202 ( 3.5A)
MMV  A 202 (-4.3A)
 0.44A 2w9sE-6e4eA:
29.8		 2w9sE-6e4eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egt GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		no annotation 4 ILE A 721
ALA A 723
LEU A 859
ILE A 747
 None
 0.80A 2w9sE-6egtA:
undetectable		 2w9sE-6egtA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehi NUCLEASE NUCT

(Helicobacter
pylori) 		no annotation 4 ALA A 104
LEU A  17
ILE A  44
PHE A  35
 None
 0.80A 2w9sE-6ehiA:
undetectable		 2w9sE-6ehiA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehi NUCLEASE NUCT

(Helicobacter
pylori) 		no annotation 4 ILE A  56
LEU A  17
ILE A  44
PHE A  35
 None
 0.76A 2w9sE-6ehiA:
undetectable		 2w9sE-6ehiA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6el1 YAXB

(Yersinia
enterocolitica) 		no annotation 4 ILE O  17
ALA O 298
LEU O  57
PHE O  19
 None
 0.80A 2w9sE-6el1O:
undetectable		 2w9sE-6el1O:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4j U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A

(Drosophila
melanogaster) 		no annotation 5 ILE C   9
ALA C  52
LEU C  14
ILE C  81
PHE C  31
 None
 1.27A 2w9sE-6f4jC:
undetectable		 2w9sE-6f4jC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ILE A 696
ILE A 664
PHE A 724
THR A 613
 None
 0.77A 2w9sE-6f8zA:
undetectable		 2w9sE-6f8zA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g7x -

(-) 		no annotation 4 ILE A 146
ALA A 137
LEU A  86
ILE A 103
 None
 0.76A 2w9sE-6g7xA:
undetectable		 2w9sE-6g7xA:
undetectable