SIMILAR PATTERNS OF AMINO ACIDS FOR 2W8Y_A_486A1000_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU B 103
LEU B 249
MET B  49
MET B  92
 None
 1.09A 2w8yA-1ffvB:
0.0		 2w8yA-1ffvB:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 LEU A 319
ASN A 320
LEU A 347
MET A 346
 None
 1.27A 2w8yA-1fuiA:
0.0		 2w8yA-1fuiA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6z CYTOCHROME C4

(Pseudomonas
stutzeri) 		PF00034
(Cytochrom_C) 		4 LEU A  32
GLU A  37
LEU A  41
MET A  66
 HEC  A 199 (-4.7A)
None
None
HEC  A 199 (-2.3A)
 1.18A 2w8yA-1m6zA:
0.0		 2w8yA-1m6zA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 LEU B 320
ASN B 321
GLU B 325
LEU B 328
 None
 0.68A 2w8yA-1mhyB:
0.0		 2w8yA-1mhyB:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 LEU A 331
ASN A 227
GLU A 229
TYR A 203
 None
ONL  A2511 (-3.9A)
ONL  A2511 (-3.4A)
None
 1.26A 2w8yA-1ofeA:
0.0		 2w8yA-1ofeA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oz9 HYPOTHETICAL PROTEIN
AQ_1354

(Aquifex
aeolicus) 		PF02130
(UPF0054) 		4 LEU A  38
ASN A   9
GLU A  30
LEU A  31
 None
 1.25A 2w8yA-1oz9A:
0.0		 2w8yA-1oz9A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		4 LEU A 387
ASN A 386
LEU A 210
TYR A 692
 None
 1.02A 2w8yA-1pemA:
0.0		 2w8yA-1pemA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 GLU A 501
LEU A 505
MET A 312
TYR A 464
 None
 1.03A 2w8yA-1pl0A:
undetectable		 2w8yA-1pl0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q32 TYROSYL-DNA
PHOSPHODIESTERASE

(Saccharomyces
cerevisiae) 		PF06087
(Tyr-DNA_phospho) 		4 LEU A 325
ASN A 324
LEU A 359
TYR A 436
 None
 1.26A 2w8yA-1q32A:
undetectable		 2w8yA-1q32A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qju PROTEIN VP1

(Rhinovirus A) 		PF00073
(Rhv) 		4 LEU 1  11
ASN 1  12
LEU 1  15
TYR 1   6
 None
 0.98A 2w8yA-1qju1:
undetectable		 2w8yA-1qju1:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		4 LEU 1 221
ASN 1 222
LEU 1 176
TYR 1 448
 None
 1.27A 2w8yA-1y791:
undetectable		 2w8yA-1y791:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 LEU X 520
LEU X 615
TYR X 534
MET X 492
 None
 1.22A 2w8yA-1z3iX:
undetectable		 2w8yA-1z3iX:
18.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 704
ASN A 705
GLU A 709
LEU A 712
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
None
None
 0.53A 2w8yA-2ax9A:
34.7		 2w8yA-2ax9A:
53.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1l RESTRICTION
ENDONUCLEASE

(Bacillus firmus) 		PF13091
(PLDc_2) 		4 LEU A  71
LEU A 161
TYR A 109
MET A 160
 None
 1.15A 2w8yA-2c1lA:
undetectable		 2w8yA-2c1lA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1) 		4 LEU A 174
GLU A 177
LEU A 179
TYR A 160
 None
 1.11A 2w8yA-2d5rA:
undetectable		 2w8yA-2d5rA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gm8 TENA HOMOLOG/THI-4
THIAMINASE

(Pyrobaculum
aerophilum) 		PF03070
(TENA_THI-4) 		4 LEU A 131
GLU A 122
LEU A 121
TYR A  46
 None
None
None
HMH  A 301 (-3.6A)
 1.21A 2w8yA-2gm8A:
undetectable		 2w8yA-2gm8A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 LEU A1089
ASN A1087
LEU A1116
MET A1076
 None
 1.26A 2w8yA-2nlkA:
undetectable		 2w8yA-2nlkA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 LEU A 221
ASN A 222
GLU A 226
LEU A 229
 None
 0.46A 2w8yA-2vl8A:
undetectable		 2w8yA-2vl8A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		4 LEU A 123
GLU A 126
LEU A 156
MET A 284
 None
 1.22A 2w8yA-2vy0A:
undetectable		 2w8yA-2vy0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		4 LEU A 879
ASN A 876
GLU A 363
TYR A 308
 None
 1.23A 2w8yA-2x6kA:
undetectable		 2w8yA-2x6kA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A A SUBUNIT

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		4 LEU A  29
ASN A  30
GLU A  19
LEU A  16
 None
 1.13A 2w8yA-3c5wA:
undetectable		 2w8yA-3c5wA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis) 		PF05163
(DinB) 		4 LEU A  54
ASN A  57
LEU A 121
TYR A  85
 None
 1.11A 2w8yA-3dkaA:
undetectable		 2w8yA-3dkaA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edy TRIPEPTIDYL-PEPTIDAS
E 1

(Homo sapiens) 		PF09286
(Pro-kuma_activ) 		4 ASN A 489
GLU A 490
LEU A 494
TYR A  79
 None
None
None
EDO  A 704 (-4.6A)
 1.22A 2w8yA-3edyA:
undetectable		 2w8yA-3edyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efv PUTATIVE
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Salmonella
enterica) 		PF00171
(Aldedh) 		4 GLU A 318
LEU A 315
MET A 297
TYR A 261
 None
 1.18A 2w8yA-3efvA:
undetectable		 2w8yA-3efvA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi7 LMO1076 PROTEIN

(Listeria
monocytogenes) 		PF01832
(Glucosaminidase) 		4 LEU A 180
ASN A 183
GLU A 122
LEU A 121
 None
 1.20A 2w8yA-3fi7A:
undetectable		 2w8yA-3fi7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 282
GLU A 141
LEU A 145
TYR A 415
 None
 1.26A 2w8yA-3ihvA:
undetectable		 2w8yA-3ihvA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 LEU A 261
ASN A 265
GLU A 217
LEU A 219
 None
MG  A 399 (-3.0A)
ANP  A   1 (-4.4A)
None
 1.21A 2w8yA-3is5A:
undetectable		 2w8yA-3is5A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu6 PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 LEU A 847
ASN A 850
GLU A 852
LEU A 854
 None
 1.24A 2w8yA-3iu6A:
undetectable		 2w8yA-3iu6A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS

(Escherichia
coli) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 LEU A 179
GLU A 182
LEU A 201
TYR A 145
 None
 1.25A 2w8yA-3k0sA:
undetectable		 2w8yA-3k0sA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN

(Escherichia
coli) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30) 		4 LEU D 454
ASN D 455
MET D 407
TYR D 415
 None
 1.25A 2w8yA-3k70D:
undetectable		 2w8yA-3k70D:
17.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 718
ASN A 719
GLU A 723
LEU A 726
MET A 801
TYR A 890
 WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
None
None
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
 0.33A 2w8yA-3kbaA:
40.3		 2w8yA-3kbaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 718
ASN A 719
LEU A 726
MET A 801
TYR A 890
MET A 909
 WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
None
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
None
 0.87A 2w8yA-3kbaA:
40.3		 2w8yA-3kbaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 206
ASN A 210
GLU A 166
LEU A 168
 None
 1.17A 2w8yA-3nuuA:
undetectable		 2w8yA-3nuuA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2p CELL DIVISION
CONTROL PROTEIN 53

(Saccharomyces
cerevisiae) 		PF10557
(Cullin_Nedd8) 		4 LEU E 743
ASN E 744
LEU E 751
MET E 788
 None
 1.18A 2w8yA-3o2pE:
undetectable		 2w8yA-3o2pE:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of5 DETHIOBIOTIN
SYNTHETASE

(Francisella
tularensis) 		PF13500
(AAA_26) 		4 LEU A 155
ASN A 159
GLU A 160
LEU A 119
 None
 1.24A 2w8yA-3of5A:
undetectable		 2w8yA-3of5A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		4 LEU A  76
ASN A  77
LEU A  73
TYR A 273
 None
 1.19A 2w8yA-3op1A:
undetectable		 2w8yA-3op1A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0u NUCLEAR RECEPTOR
SUBFAMILY 2 GROUP C
MEMBER 2

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 494
GLU A 444
LEU A 445
MET A 457
 None
 1.22A 2w8yA-3p0uA:
14.1		 2w8yA-3p0uA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 LEU A1089
ASN A1087
LEU A1116
MET A1076
 None
 1.25A 2w8yA-3qciA:
undetectable		 2w8yA-3qciA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 LEU A 313
ASN A 312
GLU A 310
TYR A 616
 None
 1.21A 2w8yA-3qr1A:
undetectable		 2w8yA-3qr1A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9j MEMBER OF DUF4221
FAMILY

(Bacteroides
vulgatus) 		PF13970
(DUF4221) 		4 LEU A 334
ASN A 335
GLU A  32
TYR A 259
 None
 1.21A 2w8yA-3s9jA:
undetectable		 2w8yA-3s9jA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 LEU A 501
GLU A 623
LEU A 703
MET A 680
 None
AMP  A 747 (-3.5A)
None
None
 1.24A 2w8yA-3ttfA:
undetectable		 2w8yA-3ttfA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE

(Escherichia
coli) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 LEU A 406
ASN A 410
LEU A 225
TYR A 426
 LEU  A 406 ( 0.6A)
ASN  A 410 ( 0.6A)
LEU  A 225 ( 0.6A)
TYR  A 426 ( 1.3A)
 1.23A 2w8yA-3ulkA:
undetectable		 2w8yA-3ulkA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v57 PHYCOERYTHRIN ALPHA
SUBUNIT

(Porphyridium
purpureum) 		PF00502
(Phycobilisome) 		4 LEU A 120
ASN A 121
GLU A  71
LEU A  66
 PEB  A 201 (-4.6A)
None
None
PEB  A 201 ( 3.8A)
 1.17A 2w8yA-3v57A:
undetectable		 2w8yA-3v57A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		4 LEU A  37
GLU A 141
MET A 427
MET A 143
 None
 1.24A 2w8yA-3vilA:
undetectable		 2w8yA-3vilA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3win HA3

(Clostridium
botulinum) 		PF03505
(Clenterotox) 		4 LEU E 473
ASN E 509
LEU E 504
TYR E 480
 None
 1.14A 2w8yA-3winE:
undetectable		 2w8yA-3winE:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxy PUTATIVE
UNCHARACTERIZED
PROTEIN CSYB

(Aspergillus
oryzae) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 LEU A  96
GLU A  91
LEU A  88
TYR A  64
 None
 1.24A 2w8yA-3wxyA:
undetectable		 2w8yA-3wxyA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 204
LEU A 273
TYR A 177
MET A 274
 None
 1.20A 2w8yA-4bgqA:
undetectable		 2w8yA-4bgqA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3e MATRIX M2-1

(Human
orthopneumovirus) 		PF06436
(Pneumovirus_M2) 		4 LEU A 114
ASN A 117
GLU A 119
LEU A 120
 None
 1.12A 2w8yA-4c3eA:
undetectable		 2w8yA-4c3eA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9y SPINDLE AND
KINETOCHORE-ASSOCIAT
ED PROTEIN 1

(Homo sapiens) 		PF07160
(SKA1) 		4 LEU A 101
ASN A 102
MET A   6
MET A  21
 None
 1.13A 2w8yA-4c9yA:
undetectable		 2w8yA-4c9yA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus) 		PF00480
(ROK) 		4 LEU A 232
GLU A 264
LEU A 260
TYR A 201
 None
 1.01A 2w8yA-4db3A:
undetectable		 2w8yA-4db3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei0 UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF14725
(DUF4466) 		4 LEU A 295
LEU A 178
MET A 255
TYR A 231
 None
 1.20A 2w8yA-4ei0A:
undetectable		 2w8yA-4ei0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		4 LEU M 346
GLU M 518
LEU M 520
TYR M 286
 None
 1.19A 2w8yA-4gq2M:
undetectable		 2w8yA-4gq2M:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1

(Homo sapiens) 		PF13181
(TPR_8)
PF13424
(TPR_12) 		4 ASN A  68
LEU A  75
MET A  32
MET A 104
 None
 1.17A 2w8yA-4houA:
undetectable		 2w8yA-4houA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASN A 345
LEU A 165
MET A  84
MET A 349
 None
 1.14A 2w8yA-4jlwA:
undetectable		 2w8yA-4jlwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx2 HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		no annotation 4 LEU A 397
GLU A 391
MET A 148
TYR A 247
 None
 1.24A 2w8yA-4jx2A:
undetectable		 2w8yA-4jx2A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A3339
ASN A3484
GLU A3375
LEU A3379
 None
 1.26A 2w8yA-4kc5A:
undetectable		 2w8yA-4kc5A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kha SPT16M-HISTONE H2B
1.1 CHIMERA

(Chaetomium
thermophilum;
Xenopus laevis) 		PF00125
(Histone)
PF08512
(Rtt106)
PF08644
(SPT16) 		4 LEU A 940
GLU A 910
LEU A 860
MET A 921
 None
 1.24A 2w8yA-4khaA:
undetectable		 2w8yA-4khaA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mct ANTIDOTE PROTEIN
KILLER PROTEIN

(Proteus
vulgaris) 		PF01381
(HTH_3)
PF05015
(HigB-like_toxin) 		4 LEU A  60
GLU B  45
LEU B  46
MET A  20
 None
 1.15A 2w8yA-4mctA:
undetectable		 2w8yA-4mctA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9j SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		no annotation 4 LEU A 637
GLU A 618
LEU A 614
TYR A 650
 None
 1.15A 2w8yA-4n9jA:
undetectable		 2w8yA-4n9jA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqj E3 UBIQUITIN-PROTEIN
LIGASE TRIM69

(Homo sapiens) 		no annotation 4 LEU A 240
ASN A 239
GLU A 235
LEU A 232
 None
 0.90A 2w8yA-4nqjA:
undetectable		 2w8yA-4nqjA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE

(Bacteroides
fragilis) 		PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 LEU A  71
ASN A  70
GLU A 110
LEU A 112
 None
 1.07A 2w8yA-4ogzA:
undetectable		 2w8yA-4ogzA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7k HYPOTHETICAL PROTEIN
JHP0584

(Helicobacter
pylori) 		no annotation 4 LEU A 111
ASN A 103
GLU A  82
MET A 151
 None
None
CME  A  73 ( 3.5A)
None
 1.15A 2w8yA-4r7kA:
undetectable		 2w8yA-4r7kA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		4 LEU A 359
GLU A 353
LEU A 351
TYR A 329
 None
 1.21A 2w8yA-4raeA:
undetectable		 2w8yA-4raeA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tt1 DENEDDYLASE

(Human
alphaherpesvirus
1) 		no annotation 4 LEU A1636
ASN A1635
GLU A1631
LEU A1628
 None
 1.04A 2w8yA-4tt1A:
undetectable		 2w8yA-4tt1A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urp FATTY ACID
REPRESSION MUTANT
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00881
(Nitroreductase) 		4 LEU A 145
ASN A 144
LEU A 136
TYR A 148
 None
 1.15A 2w8yA-4urpA:
undetectable		 2w8yA-4urpA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y82 PROTEASOME SUBUNIT
BETA TYPE-7

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 LEU M  27
GLU M  40
LEU M  42
TYR M 185
 None
 0.98A 2w8yA-4y82M:
undetectable		 2w8yA-4y82M:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE

(Helicobacter
pylori) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 LEU A 174
LEU A 120
TYR A 166
MET A   1
 None
 1.18A 2w8yA-4zi6A:
undetectable		 2w8yA-4zi6A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eef HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 LEU A 208
ASN A 206
LEU A 120
TYR A 249
 None
 1.13A 2w8yA-5eefA:
undetectable		 2w8yA-5eefA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7v LMO0181 PROTEIN

(Listeria
monocytogenes) 		PF01547
(SBP_bac_1) 		4 ASN A 387
GLU A 391
LEU A 394
TYR A 201
 None
 1.24A 2w8yA-5f7vA:
undetectable		 2w8yA-5f7vA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC98

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		4 LEU B 185
GLU B 217
LEU B 221
TYR B 190
 None
 1.04A 2w8yA-5flzB:
undetectable		 2w8yA-5flzB:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gri ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		PF00180
(Iso_dh) 		4 LEU A 227
ASN A 226
GLU A 123
LEU A 143
 None
 1.23A 2w8yA-5griA:
undetectable		 2w8yA-5griA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		4 LEU A 468
ASN A 469
GLU A 475
MET A 445
 None
 1.00A 2w8yA-5gslA:
undetectable		 2w8yA-5gslA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4e BETA 1-3 GLUCANASE

(Clostridium
beijerinckii) 		no annotation 4 LEU A 263
ASN A 264
LEU A 267
TYR A 304
 None
 1.12A 2w8yA-5h4eA:
undetectable		 2w8yA-5h4eA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		4 LEU A1642
LEU A1596
MET A1529
MET A1595
 None
 1.18A 2w8yA-5h64A:
undetectable		 2w8yA-5h64A:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00180
(Iso_dh) 		4 LEU A 215
ASN A 214
GLU A 115
LEU A 134
 None
 1.17A 2w8yA-5hn4A:
undetectable		 2w8yA-5hn4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikf CHROMATIN REMODELING
FACTOR MIT1
CRYPTIC LOCI
REGULATOR PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 4 LEU B 422
ASN B 419
GLU A1281
LEU A1325
 None
 1.21A 2w8yA-5ikfB:
undetectable		 2w8yA-5ikfB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikf CRYPTIC LOCI
REGULATOR PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 4 LEU B 398
ASN B 399
GLU B 390
LEU B 391
 None
 1.13A 2w8yA-5ikfB:
undetectable		 2w8yA-5ikfB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LEU A 296
ASN A 294
GLU A 316
MET A 280
 None
 1.16A 2w8yA-5ixqA:
undetectable		 2w8yA-5ixqA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf2 PREDICTED
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00583
(Acetyltransf_1) 		4 LEU A 212
ASN A 171
GLU A 271
LEU A 267
 None
 1.15A 2w8yA-5kf2A:
undetectable		 2w8yA-5kf2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Acidaminococcus
sp. BV3L6) 		no annotation 4 ASN A 547
GLU A 549
MET A 604
TYR A 687
 None
 1.14A 2w8yA-5kk5A:
undetectable		 2w8yA-5kk5A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2

(Sus scrofa) 		no annotation 4 LEU A 425
ASN A 469
GLU A 466
LEU A 462
 None
 1.26A 2w8yA-5mpmA:
undetectable		 2w8yA-5mpmA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE

(Meiothermus
ruber) 		no annotation 4 LEU A 104
GLU A  98
LEU A  99
TYR A 125
 None
 1.23A 2w8yA-5o6kA:
undetectable		 2w8yA-5o6kA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 4 LEU A 527
LEU A 486
MET A 507
TYR A 514
 None
 1.20A 2w8yA-5oglA:
undetectable		 2w8yA-5oglA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sui RIBOSOME BIOGENESIS
PROTEIN NSA1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 271
ASN A 272
GLU A 201
LEU A 200
 None
 1.20A 2w8yA-5suiA:
undetectable		 2w8yA-5suiA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv2 ELONGATION FACTOR G

(Vibrio
vulnificus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		4 LEU A 222
ASN A 221
GLU A 217
LEU A 214
 None
 0.95A 2w8yA-5tv2A:
undetectable		 2w8yA-5tv2A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		4 LEU A 363
GLU A 407
LEU A 404
TYR A 317
 None
 1.17A 2w8yA-5u1sA:
undetectable		 2w8yA-5u1sA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Homo sapiens) 		PF07034
(ORC3_N) 		4 LEU A  69
ASN A  68
GLU A  64
LEU A  61
 None
 1.15A 2w8yA-5uj8A:
undetectable		 2w8yA-5uj8A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5un1 IONOTROPIC GLUTAMATE
RECEPTOR SUBUNIT
NR2B

(Xenopus laevis) 		no annotation 4 LEU B 780
GLU B 774
TYR B 745
MET B 772
 None
 1.27A 2w8yA-5un1B:
undetectable		 2w8yA-5un1B:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v88 LYSOZYME,DCN1-LIKE
PROTEIN 1

(Escherichia
virus T4;
Homo sapiens) 		PF00959
(Phage_lysozyme)
PF03556
(Cullin_binding) 		4 LEU A1093
LEU A1103
MET A1126
TYR A1072
 None
 1.13A 2w8yA-5v88A:
undetectable		 2w8yA-5v88A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Homo sapiens) 		PF03770
(IPK) 		4 LEU A 296
GLU A 173
LEU A 170
MET A 143
 None
 1.14A 2w8yA-5w2hA:
undetectable		 2w8yA-5w2hA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		no annotation 4 LEU A 329
GLU A 324
LEU A 200
TYR A 205
 None
 1.25A 2w8yA-5wm0A:
undetectable		 2w8yA-5wm0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2

(Leptotrichia
shahii) 		no annotation 4 LEU A 435
GLU A 440
LEU A 443
TYR A 408
 None
G  B  17 ( 4.8A)
None
U  B  12 ( 4.2A)
 0.83A 2w8yA-5wtkA:
undetectable		 2w8yA-5wtkA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x33 LTB4
RECEPTOR,LYSOZYME,LT
B4 RECEPTOR

(Cavia
porcellus;
Escherichia
virus T4) 		no annotation 4 LEU A1133
ASN A1132
GLU A1128
MET A1102
 None
 1.18A 2w8yA-5x33A:
undetectable		 2w8yA-5x33A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT

(Desulfovibrio
gigas) 		no annotation 4 ASN B 143
GLU B 144
LEU B 148
TYR A 151
 None
 1.22A 2w8yA-5xmjB:
undetectable		 2w8yA-5xmjB:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5q DCN1-LIKE PROTEIN 1

(Homo sapiens) 		no annotation 4 LEU A  93
LEU A 103
MET A 126
TYR A  72
 None
 1.07A 2w8yA-6b5qA:
undetectable		 2w8yA-6b5qA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 4 LEU A 366
ASN A 367
GLU A 340
LEU A 372
 None
 1.26A 2w8yA-6b6lA:
undetectable		 2w8yA-6b6lA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 4 LEU B 628
ASN B 629
LEU B 625
TYR B 634
 None
 1.26A 2w8yA-6bywB:
undetectable		 2w8yA-6bywB:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en3 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE
F2,MULTIFUNCTIONAL-A
UTOPROCESSING
REPEATS-IN-TOXIN

(Streptococcus
pyogenes;
Vibrio cholerae) 		no annotation 4 LEU A 570
ASN A 597
GLU A 576
MET A 614
 None
 1.21A 2w8yA-6en3A:
undetectable		 2w8yA-6en3A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN

(Escherichia
virus T4;
Homo sapiens) 		no annotation 4 LEU A1133
ASN A1132
GLU A1128
MET A1102
 None
 1.23A 2w8yA-6ffhA:
undetectable		 2w8yA-6ffhA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Mus musculus) 		no annotation 4 LEU N 202
LEU N 191
MET N  21
MET N 187
 None
 1.25A 2w8yA-6g72N:
undetectable		 2w8yA-6g72N:
15.38