SIMILAR PATTERNS OF AMINO ACIDS FOR 2W3B_B_FOLB401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		3 GLU A 690
GLN A 339
ARG A 471
 None
 0.90A 2w3bB-1e1cA:
undetectable		 2w3bB-1e1cA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee1 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Bacillus
subtilis) 		PF02540
(NAD_synthase) 		3 GLU A  67
GLN A  59
ARG A  56
 None
 0.78A 2w3bB-1ee1A:
1.5		 2w3bB-1ee1A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		3 GLU A 538
GLN A  59
ARG A  51
 None
 0.96A 2w3bB-1fwxA:
undetectable		 2w3bB-1fwxA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		3 GLU A 145
GLN A 229
ARG A 231
 None
 0.88A 2w3bB-1g1aA:
0.3		 2w3bB-1g1aA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl2 VESICLE TRANSPORT
V-SNARE PROTEIN
VTI1-LIKE 1

(Mus musculus) 		PF12352
(V-SNARE_C) 		3 GLU C 165
GLN C 173
ARG C 176
 None
 0.96A 2w3bB-1gl2C:
undetectable		 2w3bB-1gl2C:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl2 VESICLE TRANSPORT
V-SNARE PROTEIN
VTI1-LIKE 1
SYNTAXIN 8

(Mus musculus;
Rattus
norvegicus) 		PF12352
(V-SNARE_C)
no annotation 		3 GLU D 175
GLN C 173
ARG C 176
 None
 0.80A 2w3bB-1gl2D:
undetectable		 2w3bB-1gl2D:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLU A 441
GLN A 467
ARG A 468
 None
 0.81A 2w3bB-1k2pA:
undetectable		 2w3bB-1k2pA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p5q FK506-BINDING
PROTEIN 4

(Homo sapiens) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF07719
(TPR_2) 		3 GLU A 309
GLN A 315
ARG A 318
 None
 0.89A 2w3bB-1p5qA:
undetectable		 2w3bB-1p5qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryo SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 GLU A  13
GLN A  20
ARG A  23
 None
 0.77A 2w3bB-1ryoA:
undetectable		 2w3bB-1ryoA:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u70 DIHYDROFOLATE
REDUCTASE

(Mus musculus) 		PF00186
(DHFR_1) 		3 GLU A  30
GLN A  35
ARG A  70
 MTX  A 187 (-3.0A)
MTX  A 187 (-3.7A)
MTX  A 187 (-3.1A)
 0.27A 2w3bB-1u70A:
30.8		 2w3bB-1u70A:
89.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 GLU A 134
GLN A 323
ARG A 326
 None
ADP  A 550 (-3.9A)
None
 0.96A 2w3bB-1xtjA:
1.5		 2w3bB-1xtjA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5a GDP-MANNOSE-3',
5'-EPIMERASE

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		3 GLU A 279
GLN A 241
ARG A 304
 None
GDC  A1376 (-3.8A)
None
 0.98A 2w3bB-2c5aA:
undetectable		 2w3bB-2c5aA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhr FTSH

(Thermus
thermophilus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		3 GLU A 499
GLN A 468
ARG A 453
 None
 0.95A 2w3bB-2dhrA:
undetectable		 2w3bB-2dhrA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exh BETA-D-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43) 		3 GLU A 427
GLN A 404
ARG A 516
 None
 0.99A 2w3bB-2exhA:
undetectable		 2w3bB-2exhA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gxa REPLICATION PROTEIN
E1

(Deltapapillomavirus
4) 		PF00519
(PPV_E1_C) 		3 GLU A 529
GLN A 527
ARG A 543
 None
 0.76A 2w3bB-2gxaA:
undetectable		 2w3bB-2gxaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN

(Homo sapiens) 		PF01269
(Fibrillarin) 		3 GLU A 283
GLN A 240
ARG A 219
 None
MTA  A4001 (-4.0A)
MTA  A4001 (-3.9A)
 0.61A 2w3bB-2ipxA:
undetectable		 2w3bB-2ipxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k60 PROTEIN (STROMAL
INTERACTION MOLECULE
1)

(Homo sapiens) 		PF07647
(SAM_2) 		3 GLU A 146
GLN A 188
ARG A 184
 None
 0.99A 2w3bB-2k60A:
undetectable		 2w3bB-2k60A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2msr PC4 AND
SFRS1-INTERACTING
PROTEIN

(Homo sapiens) 		PF11467
(LEDGF) 		3 GLU B 379
GLN B 353
ARG B 344
 None
 0.94A 2w3bB-2msrB:
undetectable		 2w3bB-2msrB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oud DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00782
(DSPc) 		3 GLU A 318
GLN A 409
ARG A 414
 None
None
CL  A   1 ( 4.1A)
 0.87A 2w3bB-2oudA:
undetectable		 2w3bB-2oudA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		3 GLU A 454
GLN A 591
ARG A 594
 None
 0.67A 2w3bB-2ozoA:
undetectable		 2w3bB-2ozoA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9q DNA REPLICATION
COMPLEX GINS PROTEIN
PSF1

(Homo sapiens) 		no annotation 3 GLU C  12
GLN C  31
ARG C  30
 None
 0.76A 2w3bB-2q9qC:
undetectable		 2w3bB-2q9qC:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		3 GLU A   9
GLN A  70
ARG A  73
 None
 0.91A 2w3bB-2vycA:
2.9		 2w3bB-2vycA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		3 GLU A 394
GLN A 358
ARG A 549
 None
None
SO4  A 989 (-4.2A)
 1.00A 2w3bB-2wjvA:
undetectable		 2w3bB-2wjvA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xse THYMINE DIOXYGENASE
JBP1

(Leishmania
tarentolae) 		no annotation 3 GLU A 481
GLN A 550
ARG A 551
 None
 0.88A 2w3bB-2xseA:
undetectable		 2w3bB-2xseA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		3 GLU A  46
GLN A  16
ARG A 101
 None
 0.93A 2w3bB-2ylkA:
undetectable		 2w3bB-2ylkA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		3 GLU A 210
GLN A  39
ARG A  68
 None
 0.99A 2w3bB-3aeuA:
1.1		 2w3bB-3aeuA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byv RHOPTRY KINASE

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		3 GLU A 560
GLN A 525
ARG A 528
 None
 0.97A 2w3bB-3byvA:
undetectable		 2w3bB-3byvA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A  16
GLN A 323
ARG A 337
 None
 1.00A 2w3bB-3eezA:
undetectable		 2w3bB-3eezA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epv NICKEL AND COBALT
RESISTANCE PROTEIN
CNRR

(Cupriavidus
metallidurans) 		PF13801
(Metal_resist) 		3 GLU A  33
GLN A  38
ARG A  41
 CU  A   1 (-2.3A)
None
None
 0.85A 2w3bB-3epvA:
undetectable		 2w3bB-3epvA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLU A  66
GLN A  62
ARG A 398
 None
 0.88A 2w3bB-3eyaA:
undetectable		 2w3bB-3eyaA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19

(Rhodobacter
sphaeroides) 		PF01244
(Peptidase_M19) 		3 GLU A 343
GLN A 324
ARG A 328
 None
 0.90A 2w3bB-3fdgA:
undetectable		 2w3bB-3fdgA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flu DIHYDRODIPICOLINATE
SYNTHASE

(Neisseria
meningitidis) 		PF00701
(DHDPS) 		3 GLU A 263
GLN A 278
ARG A 282
 None
 0.93A 2w3bB-3fluA:
undetectable		 2w3bB-3fluA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go9 INSULINASE FAMILY
PROTEASE

(Yersinia pestis) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 GLU A  58
GLN A 401
ARG A 404
 None
 0.91A 2w3bB-3go9A:
undetectable		 2w3bB-3go9A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j99 SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 25

(Rattus
norvegicus) 		PF00835
(SNAP-25) 		3 GLU M 170
GLN M  56
ARG M  59
 None
 0.65A 2w3bB-3j99M:
undetectable		 2w3bB-3j99M:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0a PUTATIVE EXONUCLEASE

([Eubacterium]
rectale) 		PF12684
(DUF3799) 		3 GLU A 221
GLN A 182
ARG A 181
 None
 0.93A 2w3bB-3l0aA:
undetectable		 2w3bB-3l0aA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		3 GLU A 814
GLN A 807
ARG A 588
 None
 0.77A 2w3bB-3l4kA:
undetectable		 2w3bB-3l4kA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		3 GLU A 816
GLN A 807
ARG A 588
 None
 0.94A 2w3bB-3l4kA:
undetectable		 2w3bB-3l4kA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 GLU A  36
GLN A  91
ARG A  94
 None
 0.67A 2w3bB-3l8kA:
undetectable		 2w3bB-3l8kA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzx FERREDOXIN--NADP
REDUCTASE 2

(Bacillus
subtilis) 		PF07992
(Pyr_redox_2) 		3 GLU A  75
GLN A  67
ARG A  65
 None
 0.87A 2w3bB-3lzxA:
1.7		 2w3bB-3lzxA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		3 GLU B 328
GLN B 375
ARG B 449
 None
 0.96A 2w3bB-3ml0B:
undetectable		 2w3bB-3ml0B:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrk LIC12922

(Leptospira
interrogans) 		PF13145
(Rotamase_2)
PF13624
(SurA_N_3) 		3 GLU A 322
GLN A 161
ARG A 127
 None
 0.86A 2w3bB-3nrkA:
undetectable		 2w3bB-3nrkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 GLU A 406
GLN A 422
ARG A 435
 None
 0.99A 2w3bB-3nyoA:
undetectable		 2w3bB-3nyoA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otd TRNA(HIS)
GUANYLYLTRANSFERASE

(Homo sapiens) 		PF04446
(Thg1)
PF14413
(Thg1C) 		3 GLU A  38
GLN A 119
ARG A  49
 None
 0.97A 2w3bB-3otdA:
undetectable		 2w3bB-3otdA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q41 GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
ZETA-1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 GLU A 277
GLN A  40
ARG A  43
 None
 0.94A 2w3bB-3q41A:
2.2		 2w3bB-3q41A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		3 GLU A 245
GLN A 215
ARG A 214
 None
 0.98A 2w3bB-3qfwA:
undetectable		 2w3bB-3qfwA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3riq TAILSPIKE PROTEIN

(Salmonella
virus 9NA) 		PF09251
(PhageP22-tail) 		3 GLU A 341
GLN A 404
ARG A 448
 None
 0.88A 2w3bB-3riqA:
undetectable		 2w3bB-3riqA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 3 GLU M 108
GLN M 361
ARG M 365
 None
 0.66A 2w3bB-3rkoM:
undetectable		 2w3bB-3rkoM:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrc DUFFY RECEPTOR

(Plasmodium
vivax) 		PF03011
(PFEMP)
PF05424
(Duffy_binding) 		3 GLU A 464
GLN A 388
ARG A 391
 None
 0.70A 2w3bB-3rrcA:
undetectable		 2w3bB-3rrcA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLU A 140
GLN A 279
ARG A 282
 None
 0.80A 2w3bB-3sheA:
undetectable		 2w3bB-3sheA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		3 GLU A 484
GLN A 671
ARG A 678
 None
 0.99A 2w3bB-3slkA:
2.1		 2w3bB-3slkA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Coxiella
burnetii) 		PF00698
(Acyl_transf_1) 		3 GLU A 266
GLN A   3
ARG A 310
 None
 0.94A 2w3bB-3tqeA:
undetectable		 2w3bB-3tqeA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3s TYPE-2 SERINE--TRNA
LIGASE

(Methanopyrus
kandleri) 		PF00587
(tRNA-synt_2b) 		3 GLU A 440
GLN A 493
ARG A 191
 None
 0.85A 2w3bB-3w3sA:
undetectable		 2w3bB-3w3sA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ani PROTEIN GRPE

(Geobacillus
kaustophilus) 		PF01025
(GrpE) 		3 GLU A 191
GLN A 194
ARG A 124
 None
 0.97A 2w3bB-4aniA:
undetectable		 2w3bB-4aniA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CO
DEHYDROGENASE/ACETYL
-COA SYNTHASE,
IRON-SULFUR PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD) 		3 GLU B 275
GLN B 248
ARG B  94
 None
 0.69A 2w3bB-4c1nB:
undetectable		 2w3bB-4c1nB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ciu CHAPERONE PROTEIN
CLPB

(Escherichia
coli) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 GLU A 480
GLN A 488
ARG A 491
 None
 0.91A 2w3bB-4ciuA:
undetectable		 2w3bB-4ciuA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di4 TATP(T) (TP0957)

(Treponema
pallidum) 		PF03480
(DctP) 		3 GLU B  34
GLN B 257
ARG B 256
 None
 0.96A 2w3bB-4di4B:
undetectable		 2w3bB-4di4B:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gct NUCLEOID OCCLUSION
FACTOR SLMA

(Vibrio cholerae) 		PF00440
(TetR_N) 		3 GLU A 128
GLN A 136
ARG A 139
 None
 0.91A 2w3bB-4gctA:
undetectable		 2w3bB-4gctA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8a UREIDOGLYCOLATE
DEHYDROGENASE

(Escherichia
coli) 		PF02615
(Ldh_2) 		3 GLU A 277
GLN A 285
ARG A 288
 None
 0.84A 2w3bB-4h8aA:
undetectable		 2w3bB-4h8aA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lws UNCHARACTERIZED
PROTEIN

(Thermomonospora
curvata) 		PF06013
(WXG100) 		3 GLU A  88
GLN A  93
ARG A  97
 None
 0.94A 2w3bB-4lwsA:
undetectable		 2w3bB-4lwsA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtn TRANSCRIPTION
TERMINATION FACTOR
NUSA

(Planctopirus
limnophila) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5)
PF14520
(HHH_5) 		3 GLU A 381
GLN A 389
ARG A 392
 None
 0.86A 2w3bB-4mtnA:
undetectable		 2w3bB-4mtnA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nr2 SERINE/THREONINE-PRO
TEIN KINASE 4

(Homo sapiens) 		PF11629
(Mst1_SARAH) 		3 GLU A 460
GLN A 467
ARG A 470
 None
None
EDO  A 503 (-3.7A)
 0.98A 2w3bB-4nr2A:
undetectable		 2w3bB-4nr2A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Xanthobacter
autotrophicus) 		PF03480
(DctP) 		3 GLU A 274
GLN A  34
ARG A  88
 None
GTR  A 403 (-4.1A)
GTR  A 403 (-2.6A)
 0.90A 2w3bB-4ovrA:
undetectable		 2w3bB-4ovrA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qkw MUSCLE-RELATED
COILED-COIL PROTEIN

(Danio rerio) 		PF15237
(PTRF_SDPR) 		3 GLU A  93
GLN A 101
ARG A 104
 None
 0.62A 2w3bB-4qkwA:
undetectable		 2w3bB-4qkwA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 GLU A 241
GLN A 237
ARG A 234
 None
 0.97A 2w3bB-4rcnA:
undetectable		 2w3bB-4rcnA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT II,
CHLOROPLASTIC

(Pisum sativum;
Pisum sativum) 		PF00223
(PsaA_PsaB)
PF02531
(PsaD) 		3 GLU D 136
GLN B 672
ARG B 668
 None
 0.92A 2w3bB-4rkuD:
undetectable		 2w3bB-4rkuD:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzi TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF00017
(SH2) 		3 GLU A 159
GLN A 142
ARG A 141
 None
 0.81A 2w3bB-4tziA:
undetectable		 2w3bB-4tziA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2

(Homo sapiens) 		PF06470
(SMC_hinge) 		3 GLU A 476
GLN A 484
ARG A 487
 None
 0.84A 2w3bB-4u4pA:
undetectable		 2w3bB-4u4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubs PENTALENIC ACID
SYNTHASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		3 GLU A  83
GLN A 187
ARG A 190
 PEG  A 516 (-4.1A)
PEG  A 513 ( 4.6A)
DIF  A 502 ( 4.7A)
 0.97A 2w3bB-4ubsA:
undetectable		 2w3bB-4ubsA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvr DOWN SYNDROME CELL
ADHESION MOLECULE,
ISOFORM AK

(Drosophila
melanogaster) 		PF13927
(Ig_3) 		3 GLU A  24
GLN A  76
ARG A  79
 None
 0.99A 2w3bB-4wvrA:
undetectable		 2w3bB-4wvrA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT E

(Oryctolagus
cuniculus) 		PF01399
(PCI)
PF09440
(eIF3_N) 		3 GLU E  96
GLN E 103
ARG E 102
 None
 1.00A 2w3bB-5a5tE:
undetectable		 2w3bB-5a5tE:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anc RIBOSOME MATURATION
PROTEIN SBDS

(Homo sapiens) 		PF01172
(SBDS)
PF09377
(SBDS_C) 		3 GLU J  99
GLN J 106
ARG J 109
 None
 0.94A 2w3bB-5ancJ:
undetectable		 2w3bB-5ancJ:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo sapiens) 		PF00083
(Sugar_tr) 		3 GLU A 252
GLN A 395
ARG A 398
 None
 0.97A 2w3bB-5c65A:
undetectable		 2w3bB-5c65A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw9 DE NOVO DESIGNED
FERREDOXIN-FERREDOXI
N DOMAIN INSERTION
PROTEIN

(synthetic
construct) 		no annotation 3 GLU A 101
GLN A  59
ARG A  58
 None
 0.89A 2w3bB-5cw9A:
undetectable		 2w3bB-5cw9A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d19 TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		3 GLU A 200
GLN A  89
ARG A  93
 None
 0.99A 2w3bB-5d19A:
undetectable		 2w3bB-5d19A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		3 GLU A 393
GLN A 401
ARG A 404
 None
 0.75A 2w3bB-5ddsA:
2.1		 2w3bB-5ddsA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 GLU A 482
GLN A 520
ARG A 523
 None
 0.71A 2w3bB-5dfaA:
undetectable		 2w3bB-5dfaA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1r 7S VICILIN

(Carya
illinoinensis) 		PF00190
(Cupin_1) 		3 GLU A 405
GLN A 501
ARG A 503
 None
 0.76A 2w3bB-5e1rA:
undetectable		 2w3bB-5e1rA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT SKI6
EXOSOME COMPLEX
COMPONENT RRP42

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		3 GLU B 125
GLN E  85
ARG E  86
 None
 0.92A 2w3bB-5g06B:
undetectable		 2w3bB-5g06B:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		3 GLU A 580
GLN A 602
ARG A 646
 None
 0.94A 2w3bB-5gz4A:
2.5		 2w3bB-5gz4A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 GLU A 861
GLN A 867
ARG A 572
 None
 0.80A 2w3bB-5im3A:
undetectable		 2w3bB-5im3A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Yersinia pestis) 		PF04390
(LptE) 		3 GLU B 129
GLN B 134
ARG B 137
 None
 0.93A 2w3bB-5ixmB:
undetectable		 2w3bB-5ixmB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens) 		PF02275
(CBAH) 		3 GLU A  71
GLN A 103
ARG A  38
 None
 0.99A 2w3bB-5j9rA:
undetectable		 2w3bB-5j9rA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5juf TRANSCRIPTIONAL
REGULATOR

(Streptococcus
thermophilus) 		PF01381
(HTH_3) 		3 GLU A  23
GLN A  36
ARG A  39
 None
 0.79A 2w3bB-5jufA:
undetectable		 2w3bB-5jufA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm2 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23

(Homo sapiens) 		PF13949
(ALIX_LYPXL_bnd) 		3 GLU A 306
GLN A 313
ARG A 316
 None
 0.90A 2w3bB-5lm2A:
undetectable		 2w3bB-5lm2A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		3 GLU A 813
GLN A 781
ARG A 822
 None
 0.94A 2w3bB-5me3A:
undetectable		 2w3bB-5me3A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01409
(tRNA-synt_2d)
PF03147
(FDX-ACB) 		3 GLU A 204
GLN A 192
ARG A 187
 None
 0.78A 2w3bB-5mgvA:
undetectable		 2w3bB-5mgvA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN
MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 GLU A 236
GLN A 227
ARG B 411
 None
 0.91A 2w3bB-5mkkA:
undetectable		 2w3bB-5mkkA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN10

(Saccharomyces
cerevisiae) 		PF13519
(VWA_2) 		3 GLU W 166
GLN W 108
ARG W 101
 None
 0.85A 2w3bB-5mpdW:
undetectable		 2w3bB-5mpdW:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1

(Chlamydomonas
reinhardtii) 		PF00400
(WD40) 		3 GLU A  44
GLN A  49
ARG A  52
 SO4  A 501 (-4.5A)
None
None
 0.95A 2w3bB-5mzhA:
undetectable		 2w3bB-5mzhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2u NUCLEOPROTEIN

(Influenza D
virus) 		no annotation 3 GLU A 287
GLN A  25
ARG A  29
 None
 0.88A 2w3bB-5n2uA:
undetectable		 2w3bB-5n2uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhb XYLOSE ISOMERASE

(Piromyces sp.
E2) 		no annotation 3 GLU A 193
GLN A 170
ARG A 166
 None
 0.95A 2w3bB-5nhbA:
undetectable		 2w3bB-5nhbA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		3 GLU T2383
GLN T2418
ARG T2415
 None
 0.99A 2w3bB-5ojsT:
undetectable		 2w3bB-5ojsT:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twx BROMODOMAIN-CONTAINI
NG PROTEIN 9

(Homo sapiens) 		PF00439
(Bromodomain) 		3 GLU A 146
GLN A 151
ARG A 154
 None
 0.82A 2w3bB-5twxA:
undetectable		 2w3bB-5twxA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s DNA REPLICATION
LICENSING FACTOR
MCM4

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 GLU 4 799
GLN 4 652
ARG 4 557
 None
 0.99A 2w3bB-5u8s4:
undetectable		 2w3bB-5u8s4:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		3 GLU A 466
GLN A 151
ARG A 365
 None
 0.98A 2w3bB-5vocA:
undetectable		 2w3bB-5vocA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		3 GLU A 249
GLN A 305
ARG A 304
 GLU  A 249 ( 0.6A)
GLN  A 305 ( 0.6A)
ARG  A 304 ( 0.6A)
 0.79A 2w3bB-5wo6A:
undetectable		 2w3bB-5wo6A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnr ALYQ

(Persicobacter
sp. CCB-QB2) 		no annotation 3 GLU A 549
GLN A 543
ARG A 452
 None
None
PO4  A 604 (-3.3A)
 0.81A 2w3bB-5xnrA:
undetectable		 2w3bB-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzh PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Mus musculus) 		no annotation 3 GLU A  37
GLN A  65
ARG A   6
 None
 0.97A 2w3bB-6bzhA:
undetectable		 2w3bB-6bzhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE GAMMA
SUBUNIT
ATP SYNTHASE DELTA
SUBUNIT

(Trypanosoma
brucei;
Trypanosoma
brucei) 		no annotation
no annotation 		3 GLU G 233
GLN H  40
ARG H  39
 None
 0.91A 2w3bB-6f5dG:
undetectable		 2w3bB-6f5dG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g74 QUINOLINATE SYNTHASE
A

(Thermotoga
maritima) 		no annotation 3 GLU A 218
GLN A  38
ARG A  41
 None
 0.94A 2w3bB-6g74A:
undetectable		 2w3bB-6g74A:
undetectable