SIMILAR PATTERNS OF AMINO ACIDS FOR 2W3B_A_FOLA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u71 DIHYDROFOLATE
REDUCTASE

(Homo sapiens) 		PF00186
(DHFR_1) 		4 GLU A  30
GLN A  35
ASN A  64
ARG A  70
 MXA  A 187 (-2.9A)
None
MXA  A 187 (-4.5A)
None
 0.39A 2w3bA-1u71A:
32.2		 2w3bA-1u71A:
99.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Homo sapiens) 		PF00149
(Metallophos)
PF08321
(PPP5) 		4 GLU A 329
GLN A 374
ASN A 308
ARG A 301
 None
 1.47A 2w3bA-3h68A:
0.0		 2w3bA-3h68A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35

(Homo sapiens) 		PF03635
(Vps35) 		4 GLU A  78
GLN A 155
ASN A 151
ARG A 226
 None
 1.28A 2w3bA-5f0kA:
0.0		 2w3bA-5f0kA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLU A  17
GLN A  47
ASN A 580
ARG A 668
 None
 1.48A 2w3bA-5fp1A:
0.0		 2w3bA-5fp1A:
13.39