SIMILAR PATTERNS OF AMINO ACIDS FOR 2W26_A_RIVA1001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a0j TRYPSIN

(Salmo salar) 		PF00089
(Trypsin) 		8 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
None
BEN  A 246 ( 3.9A)
None
BEN  A 246 (-3.3A)
None
 0.35A 2w26A-1a0jA:
14.0		 2w26A-1a0jA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus) 		PF00089
(Trypsin) 		9 TYR A  99
ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 0GJ  A 245 (-3.9A)
0GJ  A 245 (-3.1A)
0GJ  A 245 (-3.4A)
0GJ  A 245 (-1.4A)
None
0GJ  A 245 (-3.5A)
0GJ  A 245 (-3.8A)
0GJ  A 245 ( 4.2A)
None
 0.47A 2w26A-1a5iA:
32.5		 2w26A-1a5iA:
35.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1afq BOVINE
GAMMA-CHYMOTRYPSIN

(Bos taurus) 		PF00089
(Trypsin) 		6 SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 226
TYR C 228
 0FG  C 301 ( 3.0A)
None
None
0FG  C 301 (-3.4A)
0FG  C 301 ( 4.4A)
None
 0.31A 2w26A-1afqC:
11.0		 2w26A-1afqC:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 217
TYR A 228
 0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
None
0GJ  A   1 (-3.5A)
0GJ  A   1 (-4.1A)
None
 0.86A 2w26A-1bqyA:
11.8		 2w26A-1bqyA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
None
 0.33A 2w26A-1bqyA:
11.8		 2w26A-1bqyA:
28.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dlk THROMBIN HEAVY CHAIN

(Bos taurus) 		PF00089
(Trypsin) 		6 SER B 195
VAL B 213
TRP B 215
GLY B 216
GLY B 226
TYR B 228
 None
 0.29A 2w26A-1dlkB:
35.5		 2w26A-1dlkB:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekb ENTEROPEPTIDASE

(Bos taurus) 		PF00089
(Trypsin) 		5 ASP B 189
SER B 195
GLY B 216
GLY B 226
TYR B 228
 None
 0.48A 2w26A-1ekbB:
36.6		 2w26A-1ekbB:
28.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elv COMPLEMENT C1S
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		7 ASP A 611
SER A 617
VAL A 638
TRP A 640
GLY A 641
GLY A 648
TYR A 650
 None
SO4  A2001 ( 2.7A)
None
None
None
None
None
 0.35A 2w26A-1elvA:
31.4		 2w26A-1elvA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ept PORCINE E-TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		8 ASP C 189
SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 219
GLY C 226
TYR C 228
 None
 0.46A 2w26A-1eptC:
12.7		 2w26A-1eptC:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eq9 CHYMOTRYPSIN

(Solenopsis
invicta) 		PF00089
(Trypsin) 		5 ALA A 190
SER A 195
VAL A 213
GLY A 216
TYR A 228
 PMS  A1201 (-3.6A)
PMS  A1201 (-1.5A)
None
PMS  A1201 ( 4.5A)
None
 0.37A 2w26A-1eq9A:
11.8		 2w26A-1eq9A:
34.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis aries) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-4.9A)
PBZ  A 305 (-3.3A)
None
 0.34A 2w26A-1fiwA:
35.4		 2w26A-1fiwA:
31.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
None
PBZ  A 308 (-3.6A)
None
PBZ  A 308 ( 3.7A)
None
 0.50A 2w26A-1fizA:
16.2		 2w26A-1fizA:
34.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
None
0G6  A   1 (-3.9A)
None
0G6  A   1 (-3.3A)
None
 0.41A 2w26A-1fxyA:
12.5		 2w26A-1fxyA:
65.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA

(Homo sapiens) 		PF00089
(Trypsin) 		8 TYR A  99
ASP A 189
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 0G6  A   1 (-4.0A)
0G6  A   1 (-2.8A)
None
None
0G6  A   1 (-3.9A)
None
0G6  A   1 (-3.3A)
None
 0.54A 2w26A-1fxyA:
12.5		 2w26A-1fxyA:
65.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g65 PROTEASOME COMPONENT
PUP3

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		6 PHE I  31
ASP I 166
ALA I 130
SER I 127
GLY I   1
GLY I  -1
 None
 1.26A 2w26A-1g65I:
undetectable		 2w26A-1g65I:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gvl KALLIKREIN 6

(Homo sapiens) 		PF00089
(Trypsin) 		5 SER A 195
VAL A 213
GLY A 216
GLY A 226
TYR A 228
 None
 0.71A 2w26A-1gvlA:
6.0		 2w26A-1gvlA:
34.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gvl KALLIKREIN 6

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.35A 2w26A-1gvlA:
6.0		 2w26A-1gvlA:
34.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4w TRYPSIN IVA

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 BEN  A 250 (-2.9A)
BEN  A 250 (-3.6A)
None
None
BEN  A 250 (-3.9A)
None
BEN  A 250 (-3.3A)
None
 0.37A 2w26A-1h4wA:
18.2		 2w26A-1h4wA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		8 ASP E 189
SER E 195
VAL E 213
TRP E 215
GLY E 216
GLY E 219
GLY E 226
TYR E 228
 None
 0.38A 2w26A-1h9hE:
12.7		 2w26A-1h9hE:
37.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1id5 THROMBIN

(Bos taurus) 		PF00089
(Trypsin) 		9 ASP H 189
ALA H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 219
GLY H 226
TYR H 228
 None
 0.44A 2w26A-1id5H:
35.1		 2w26A-1id5H:
40.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		11 TYR T  99
PHE T 174
ASP T 189
ALA T 190
SER T 195
VAL T 213
TRP T 215
GLY T 216
GLY T 219
GLY T 226
TYR T 228
 ZEN  T   1 (-3.8A)
ZEN  T   1 (-3.8A)
ZEN  T   1 ( 3.8A)
ZEN  T   1 (-3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.4A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-4.5A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.6A)
 0.40A 2w26A-1j17T:
14.3		 2w26A-1j17T:
39.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		11 TYR H  99
PHE H 174
ASP H 189
ALA H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 218
GLY H 226
TYR H 228
 None
 0.40A 2w26A-1kigH:
41.6		 2w26A-1kigH:
84.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mbq TRYPSIN

(Oncorhynchus
keta) 		PF00089
(Trypsin) 		8 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
None
BEN  A1222 (-3.9A)
None
BEN  A1222 (-3.4A)
None
 0.42A 2w26A-1mbqA:
14.4		 2w26A-1mbqA:
37.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mkx PRETHROMBIN-2

(Bos taurus) 		PF00089
(Trypsin)
PF09396
(Thrombin_light) 		5 SER K 195
VAL K 213
TRP K 215
GLY K 226
TYR K 228
 None
 0.45A 2w26A-1mkxK:
29.1		 2w26A-1mkxK:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1npm NEUROPSIN

(Mus musculus) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.33A 2w26A-1npmA:
13.4		 2w26A-1npmA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o5f SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin) 		9 ASP H 189
ALA H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 219
GLY H 226
TYR H 228
 CR9  H 256 (-2.4A)
CR9  H 256 (-2.9A)
CR9  H 256 (-1.5A)
CR9  H 256 (-4.3A)
None
CR9  H 256 ( 3.8A)
CR9  H 256 (-4.3A)
CR9  H 256 (-3.0A)
None
 0.28A 2w26A-1o5fH:
34.7		 2w26A-1o5fH:
36.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1op2 VENOM SERINE
PROTEINASE

(Deinagkistrodon
acutus) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
TYR A 228
 None
 0.23A 2w26A-1op2A:
10.9		 2w26A-1op2A:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
GLY A 216
GLY A 226
TYR A 228
 0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
None
 0.35A 2w26A-1orfA:
11.6		 2w26A-1orfA:
29.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pfx FACTOR IXA

(Sus scrofa) 		PF00089
(Trypsin) 		7 PHE C 174
ASP C 189
SER C 195
TRP C 215
GLY C 216
GLY C 226
TYR C 228
 0G6  C 301 (-4.6A)
0G6  C 301 (-3.0A)
0G6  C 301 (-1.4A)
None
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
None
 0.54A 2w26A-1pfxC:
37.4		 2w26A-1pfxC:
46.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pq5 TRYPSIN

(Fusarium
oxysporum) 		PF00089
(Trypsin) 		8 ASP A 189
SER A 195
VAL A 210
TRP A 212
GLY A 213
GLY A 215
GLY A 223
TYR A 225
 ARG  A 703 (-2.0A)
ARG  A 703 (-2.3A)
ARG  A 703 (-4.5A)
None
ARG  A 703 ( 3.7A)
ARG  A 703 (-4.3A)
ARG  A 703 (-2.6A)
None
 0.38A 2w26A-1pq5A:
15.3		 2w26A-1pq5A:
34.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		7 ASP A 627
SER A 633
VAL A 653
TRP A 655
GLY A 656
GLY A 667
TYR A 669
 NA  A 800 ( 4.6A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
None
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
None
 0.47A 2w26A-1q3xA:
34.1		 2w26A-1q3xA:
26.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sgf NERVE GROWTH FACTOR

(Mus musculus) 		PF00089
(Trypsin) 		6 ASP G 189
SER G 195
TRP G 215
GLY G 216
GLY G 226
TYR G 228
 None
 0.45A 2w26A-1sgfG:
17.6		 2w26A-1sgfG:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sgf NERVE GROWTH FACTOR

(Mus musculus) 		PF00089
(Trypsin) 		6 TYR G  99
ASP G 189
TRP G 215
GLY G 216
GLY G 226
TYR G 228
 None
 0.78A 2w26A-1sgfG:
17.6		 2w26A-1sgfG:
32.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		6 SER A  39
VAL A 327
TRP A 324
GLY A 346
GLY A  82
GLY A 366
 None
 1.25A 2w26A-1ur4A:
undetectable		 2w26A-1ur4A:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 592
ALA A 593
SER A 598
CYH A 622
TYR A 631
 None
 0.77A 2w26A-1ybwA:
31.8		 2w26A-1ybwA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 592
ALA A 593
SER A 598
GLY A 629
TYR A 631
 None
 0.68A 2w26A-1ybwA:
31.8		 2w26A-1ybwA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ym0 FIBRINOTIC ENZYME
COMPONENT B

(Eisenia fetida) 		PF00089
(Trypsin) 		8 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 None
 0.44A 2w26A-1ym0A:
36.5		 2w26A-1ym0A:
32.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 VAL A 653
TRP A 655
GLY A 656
GLY A 667
TYR A 669
 None
 0.23A 2w26A-1zjkA:
30.1		 2w26A-1zjkA:
26.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 218
GLY A 226
TYR A 228
 368  A 901 (-2.8A)
368  A 901 (-3.7A)
368  A 901 (-1.4A)
None
368  A 901 (-3.6A)
368  A 901 (-4.3A)
368  A 901 (-3.5A)
None
 0.43A 2w26A-1zlrA:
35.0		 2w26A-1zlrA:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aip PROTEIN C ACTIVATOR

(Agkistrodon
contortrix) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
GLY A 216
GLY A 226
TYR A 228
 None
SO4  A 301 (-2.8A)
None
None
None
 0.39A 2w26A-2aipA:
11.3		 2w26A-2aipA:
28.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eek TRYPSIN-1

(Gadus morhua) 		PF00089
(Trypsin) 		8 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 BEN  A 301 (-2.7A)
BEN  A 301 (-3.4A)
None
None
BEN  A 301 ( 3.8A)
None
BEN  A 301 (-3.2A)
None
 0.35A 2w26A-2eekA:
13.9		 2w26A-2eekA:
35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		11 TYR A  99
PHE A 174
ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 218
GLY A 226
TYR A 228
 DT8  A 700 (-3.4A)
DT8  A 700 (-3.4A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.6A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.9A)
DT8  A 700 (-3.5A)
DT8  A 700 (-4.1A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
 0.32A 2w26A-2ei8A:
46.6		 2w26A-2ei8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f91 HEPATOPANCREAS
TRYPSIN

(Astacus
leptodactylus) 		PF00089
(Trypsin) 		8 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 218
GLY A 227
TYR A 229
 None
 0.41A 2w26A-2f91A:
36.4		 2w26A-2f91A:
37.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jet CHYMOTRYPSINOGEN B
CHAIN C

(Rattus
norvegicus) 		PF00089
(Trypsin) 		6 SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 226
TYR C 228
 None
 0.60A 2w26A-2jetC:
9.2		 2w26A-2jetC:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		5 TYR A 538
SER A 659
VAL A 677
TRP A 679
GLY A 680
 None
 0.45A 2w26A-2odpA:
23.3		 2w26A-2odpA:
18.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 BEN  A 245 (-3.0A)
BEN  A 245 (-3.9A)
BEN  A 245 (-3.3A)
None
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
None
 0.35A 2w26A-2oq5A:
35.7		 2w26A-2oq5A:
34.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pka KALLIKREIN A

(Sus scrofa) 		PF00089
(Trypsin) 		5 ASP B 189
SER B 195
TRP B 215
GLY B 216
TYR B 228
 BEN  B   1 (-3.0A)
BEN  B   1 ( 4.0A)
None
BEN  B   1 (-3.5A)
None
 0.50A 2w26A-2pkaB:
14.8		 2w26A-2pkaB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pka KALLIKREIN A

(Sus scrofa) 		PF00089
(Trypsin) 		5 TYR B  99
ASP B 189
TRP B 215
GLY B 216
TYR B 228
 None
BEN  B   1 (-3.0A)
None
BEN  B   1 (-3.5A)
None
 0.51A 2w26A-2pkaB:
14.8		 2w26A-2pkaB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pks THROMBIN HEAVY CHAIN
FRAGMENT

(Homo sapiens) 		PF00089
(Trypsin) 		9 ASP C 229
ALA C 230
SER C 235
VAL C 255
TRP C 257
GLY C 258
GLY C 260
GLY C 268
TYR C 270
 G44  C 101 (-2.6A)
G44  C 101 (-3.8A)
G44  C 101 (-3.5A)
None
G44  C 101 (-4.1A)
G44  C 101 (-3.3A)
None
G44  C 101 (-3.0A)
None
 0.37A 2w26A-2pksC:
12.7		 2w26A-2pksC:
23.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psy KALLIKREIN-5

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.33A 2w26A-2psyA:
11.7		 2w26A-2psyA:
31.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qy0 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		PF00089
(Trypsin) 		9 ASP B 631
ALA B 632
SER B 637
VAL B 657
TRP B 659
GLY B 660
GLY B 662
GLY B 668
TYR B 670
 None
 0.48A 2w26A-2qy0B:
32.2		 2w26A-2qy0B:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 None
 0.47A 2w26A-2r0lA:
34.3		 2w26A-2r0lA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP U 189
VAL U 213
TRP U 215
GLY U 216
GLY U 219
GLY U 226
TYR U 228
 4PG  U 300 (-2.8A)
None
None
4PG  U 300 (-3.3A)
None
4PG  U 300 (-3.2A)
None
 0.39A 2w26A-2r2wU:
33.5		 2w26A-2r2wU:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		8 TYR S  99
PHE S 174
ASP S 189
SER S 195
TRP S 215
GLY S 216
GLY S 226
TYR S 228
 None
 0.44A 2w26A-2wpmS:
38.9		 2w26A-2wpmS:
46.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrc HUMAN COMPLEMENT
FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00089
(Trypsin)
PF00530
(SRCR) 		5 TYR A 408
VAL A 526
TRP A 528
GLY A 539
TYR A 541
 None
 0.39A 2w26A-2xrcA:
22.2		 2w26A-2xrcA:
16.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP A 203
SER A 209
VAL A 227
TRP A 229
GLY A 230
GLY A 232
GLY A 240
TYR A 242
 11N  A   1 (-2.6A)
11N  A   1 (-3.3A)
None
None
11N  A   1 (-3.9A)
11N  A   1 (-3.8A)
11N  A   1 (-3.6A)
None
 0.47A 2w26A-2zecA:
32.9		 2w26A-2zecA:
34.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		6 TYR A  37
ALA A  21
VAL A   7
GLY A  10
GLY A  16
GLY A 130
 None
 1.32A 2w26A-2zvbA:
undetectable		 2w26A-2zvbA:
23.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3beu TRYPSIN

(Streptomyces
griseus) 		PF00089
(Trypsin) 		9 PHE A 174
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 None
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
None
BEN  A 247 (-3.7A)
None
BEN  A 247 (-3.5A)
None
 0.37A 2w26A-3beuA:
33.0		 2w26A-3beuA:
41.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		9 ASP H 189
ALA H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 219
GLY H 226
TYR H 228
 0G6  H   1 (-2.8A)
0G6  H   1 (-3.4A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
None
0G6  H   1 ( 3.9A)
None
 0.51A 2w26A-3f6uH:
37.3		 2w26A-3f6uH:
37.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gov MASP-1

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP B 640
ALA B 641
SER B 646
VAL B 666
TRP B 668
GLY B 669
GLY B 679
TYR B 681
 None
 0.42A 2w26A-3govB:
34.1		 2w26A-3govB:
32.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gym PROSTASIN

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.36A 2w26A-3gymA:
34.5		 2w26A-3gymA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		9 ASP B 189
ALA B 190
SER B 195
VAL B 213
TRP B 215
GLY B 216
GLY B 219
GLY B 226
TYR B 228
 None
 0.38A 2w26A-3r3gB:
34.9		 2w26A-3r3gB:
40.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE

(Gloydius
saxatilis) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 195
VAL A 209
GLY A 212
GLY A 223
TYR A 225
 None
 0.32A 2w26A-3s69A:
11.0		 2w26A-3s69A:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9b VIPERA RUSSELLI
PROTEINASE RVV-V
GAMMA

(Daboia
siamensis) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
VAL A 213
GLY A 216
TYR A 228
 None
 0.43A 2w26A-3s9bA:
10.7		 2w26A-3s9bA:
29.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w94 ENTEROPEPTIDASE-1

(Oryzias latipes) 		PF00089
(Trypsin) 		6 ASP A 973
SER A 979
GLY A1000
GLY A1002
GLY A1010
TYR A1012
 None
 0.37A 2w26A-3w94A:
36.5		 2w26A-3w94A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bxw FACTOR XA

(Pseudonaja
textilis) 		PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		9 TYR A 262
ASP A 356
ALA A 357
SER A 362
VAL A 380
GLY A 383
GLY A 385
GLY A 393
TYR A 395
 0GJ  A1411 ( 3.5A)
0GJ  A1411 (-2.7A)
0GJ  A1411 (-3.4A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
None
0GJ  A1411 (-3.3A)
None
 0.39A 2w26A-4bxwA:
38.8		 2w26A-4bxwA:
55.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d9r COMPLEMENT FACTOR D

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
VAL A 213
GLY A 226
TYR A 228
 None
 0.25A 2w26A-4d9rA:
14.1		 2w26A-4d9rA:
32.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius halys) 		PF00089
(Trypsin) 		6 PHE A 173
ASP A 189
SER A 195
TRP A 215
GLY A 216
TYR A 228
 None
 0.72A 2w26A-4e7nA:
10.6		 2w26A-4e7nA:
30.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP H 627
VAL H 653
TRP H 655
GLY H 656
GLY H 667
TYR H 669
 None
 0.35A 2w26A-4fxgH:
34.0		 2w26A-4fxgH:
34.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1

(Bothrops
jararacussu) 		PF00089
(Trypsin) 		6 ASP A 172
SER A 178
VAL A 192
GLY A 195
GLY A 206
TYR A 208
 None
 0.34A 2w26A-4gsoA:
undetectable		 2w26A-4gsoA:
29.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h4f CHYMOTRYPSIN-C

(Homo sapiens) 		PF00089
(Trypsin) 		5 ALA A 190
SER A 195
VAL A 213
GLY A 216
TYR A 228
 None
 0.30A 2w26A-4h4fA:
35.8		 2w26A-4h4fA:
34.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		6 SER A 646
VAL A 666
TRP A 668
GLY A 673
GLY A 679
TYR A 681
 None
None
GOL  A 702 (-3.9A)
None
None
None
 0.75A 2w26A-4igdA:
28.9		 2w26A-4igdA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP E 639
SER E 645
VAL E 665
TRP E 667
GLY E 668
GLY E 669
GLY E 680
TYR E 682
 None
 0.75A 2w26A-4iw4E:
32.0		 2w26A-4iw4E:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo sapiens) 		PF00089
(Trypsin) 		8 TYR E 531
ASP E 639
VAL E 665
TRP E 667
GLY E 668
GLY E 669
GLY E 680
TYR E 682
 None
 0.94A 2w26A-4iw4E:
32.0		 2w26A-4iw4E:
35.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k8y KALLIKREIN-4

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
TYR A 228
 None
 0.43A 2w26A-4k8yA:
12.5		 2w26A-4k8yA:
29.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		6 TYR A 550
VAL A 684
GLY A 687
GLY A 688
GLY A 699
TYR A 701
 None
 1.02A 2w26A-4kkdA:
28.3		 2w26A-4kkdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		6 TYR A 550
VAL A 684
TRP A 686
GLY A 687
GLY A 699
TYR A 701
 None
 0.61A 2w26A-4kkdA:
28.3		 2w26A-4kkdA:
23.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lk4 VESB PROTEASE

(Vibrio cholerae) 		PF00089
(Trypsin) 		5 VAL A 237
TRP A 239
GLY A 240
GLY A 251
TYR A 253
 None
 0.42A 2w26A-4lk4A:
27.6		 2w26A-4lk4A:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m7g TRYPSIN-LIKE
PROTEASE

(Saccharopolyspora
erythraea) 		PF00089
(Trypsin) 		7 ASP A 173
SER A 179
TRP A 195
GLY A 196
GLY A 198
GLY A 206
TYR A 208
 None
 0.47A 2w26A-4m7gA:
13.1		 2w26A-4m7gA:
34.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nff KALLIKREIN-2

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
TRP A 215
GLY A 216
TYR A 228
 0G6  A 301 (-3.0A)
0G6  A 301 (-1.4A)
0G6  A 301 (-3.7A)
0G6  A 301 (-3.4A)
None
 0.37A 2w26A-4nffA:
12.1		 2w26A-4nffA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 3KM  A 900 (-2.9A)
3KM  A 900 (-3.6A)
None
None
3KM  A 900 (-3.4A)
3KM  A 900 (-3.9A)
3KM  A 900 (-3.2A)
None
 0.32A 2w26A-4r0iA:
36.9		 2w26A-4r0iA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wwy TRYPSIN-1

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 None
 0.37A 2w26A-4wwyA:
13.9		 2w26A-4wwyA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ylq COAGULATION FACTOR
VII

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 218
GLY H 226
TYR H 228
 0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.5A)
0Z7  H 501 (-3.0A)
None
 0.32A 2w26A-4ylqH:
38.8		 2w26A-4ylqH:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		7 TYR E  99
ASP E 189
ALA E 190
TRP E 215
GLY E 216
GLY E 226
TYR E 228
 None
 0.44A 2w26A-5brrE:
34.3		 2w26A-5brrE:
38.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI

(Homo sapiens) 		PF00024
(PAN_1)
PF00089
(Trypsin) 		5 SER A 557
TRP A 577
GLY A 578
GLY A 588
TYR A 590
 None
 0.74A 2w26A-5eodA:
27.5		 2w26A-5eodA:
15.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP A 189
ALA A 190
SER A 195
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 None
 0.50A 2w26A-5f8zA:
35.3		 2w26A-5f8zA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP A 189
ALA A 190
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 None
 0.34A 2w26A-5f8zA:
35.3		 2w26A-5f8zA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fah KALLIKREIN-7

(Homo sapiens) 		PF00089
(Trypsin) 		6 ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 226
TYR A 228
 5VT  A 302 (-3.8A)
5VT  A 302 (-4.0A)
None
None
5VT  A 302 ( 4.3A)
None
 0.78A 2w26A-5fahA:
12.6		 2w26A-5fahA:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fah KALLIKREIN-7

(Homo sapiens) 		PF00089
(Trypsin) 		6 ALA A 190
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 5VT  A 302 (-3.8A)
None
None
5VT  A 302 (-3.4A)
5VT  A 302 ( 4.3A)
None
 0.45A 2w26A-5fahA:
12.6		 2w26A-5fahA:
33.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcr COMPLEMENT FACTOR D

(Mus musculus) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
VAL A 213
GLY A 226
TYR A 228
 None
 0.67A 2w26A-5fcrA:
11.2		 2w26A-5fcrA:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvt PLASMA KALLIKREIN

(Mus musculus) 		no annotation 7 ASP A 189
ALA A 190
SER A 195
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 None
 0.71A 2w26A-5gvtA:
35.3		 2w26A-5gvtA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvt PLASMA KALLIKREIN

(Mus musculus) 		no annotation 6 ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 226
TYR A 228
 None
 1.16A 2w26A-5gvtA:
35.3		 2w26A-5gvtA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms3 KALLIKREIN-8

(Homo sapiens) 		no annotation 6 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.33A 2w26A-5ms3A:
17.0		 2w26A-5ms3A:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o32 COMPLEMENT FACTOR I

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP I 519
ALA I 520
VAL I 544
TRP I 546
GLY I 547
GLY I 557
TYR I 559
 None
 0.79A 2w26A-5o32I:
10.9		 2w26A-5o32I:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o32 COMPLEMENT FACTOR I

(Homo sapiens) 		PF00089
(Trypsin) 		7 TYR I 426
ASP I 519
VAL I 544
TRP I 546
GLY I 547
GLY I 557
TYR I 559
 None
 0.78A 2w26A-5o32I:
10.9		 2w26A-5o32I:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		8 ASP B 214
ALA B 215
SER B 220
VAL B 240
GLY B 243
GLY B 245
GLY B 253
TYR B 255
 0G6  B 501 (-2.9A)
0G6  B 501 (-3.4A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
None
0G6  B 501 (-3.6A)
None
 0.36A 2w26A-5to3B:
35.5		 2w26A-5to3B:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ubm COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		no annotation 7 ASP A 626
SER A 632
VAL A 653
TRP A 655
GLY A 656
GLY A 663
TYR A 665
 None
 0.51A 2w26A-5ubmA:
31.5		 2w26A-5ubmA:
33.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus) 		no annotation 6 ASP A 200
SER A 206
VAL A 220
GLY A 223
GLY A 234
TYR A 236
 None
 0.57A 2w26A-5xrfA:
10.9		 2w26A-5xrfA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zfh KALLIKREIN-7

(Mus musculus) 		no annotation 6 SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.39A 2w26A-5zfhA:
11.7		 2w26A-5zfhA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b74 COAGULATION FACTOR
XII

(Homo sapiens) 		no annotation 9 TYR B  99
ASP B 189
ALA B 190
SER B 195
TRP B 215
GLY B 216
GLY B 219
GLY B 226
TYR B 228
 None
BEN  B 301 (-2.7A)
BEN  B 301 (-4.1A)
SO4  B 304 ( 2.5A)
None
BEN  B 301 (-3.3A)
SO4  B 307 ( 3.4A)
BEN  B 301 (-3.1A)
None
 0.58A 2w26A-6b74B:
34.1		 2w26A-6b74B:
17.87