SIMILAR PATTERNS OF AMINO ACIDS FOR 2W1B_A_DXCA2034
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a25 | PROTEIN KINASE C(BETA) (Rattusnorvegicus) |
PF00168(C2) | 3 | PHE A 255SER A 241LEU A 259 | None | 0.83A | 2w1bA-1a25A:0.0 | 2w1bA-1a25A:9.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1epx | FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE (Leishmaniamexicana) |
PF00274(Glycolytic) | 3 | PHE A 154SER A 310LEU A 40 | None | 0.71A | 2w1bA-1epxA:0.0 | 2w1bA-1epxA:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f2j | FRUCTOSE-BISPHOSPHATE ALDOLASE,GLYCOSOMAL (Trypanosomabrucei) |
PF00274(Glycolytic) | 3 | PHE A 154SER A 310LEU A 40 | None | 0.78A | 2w1bA-1f2jA:0.0 | 2w1bA-1f2jA:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fba | FRUCTOSE1,6-BISPHOSPHATEALDOLASE (Drosophilamelanogaster) |
PF00274(Glycolytic) | 3 | PHE A 144SER A 300LEU A 30 | None | 0.75A | 2w1bA-1fbaA:0.0 | 2w1bA-1fbaA:16.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fdj | FRUCTOSE1,6-BISPHOSPHATEALDOLASE (Oryctolaguscuniculus) |
PF00274(Glycolytic) | 3 | PHE A1144SER A1300LEU A1030 | None | 0.60A | 2w1bA-1fdjA:0.0 | 2w1bA-1fdjA:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pu7 | 3-METHYLADENINE DNAGLYCOSYLASE (Helicobacterpylori) |
PF00633(HHH)PF00730(HhH-GPD) | 3 | PHE A 174SER A 210LEU A 155 | None | 0.80A | 2w1bA-1pu7A:undetectable | 2w1bA-1pu7A:12.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q40 | MRNA TRANSPORTREGULATOR MTR2 (Candidaalbicans) |
PF10429(Mtr2) | 3 | PHE A 71SER A 19LEU A 17 | None | 0.77A | 2w1bA-1q40A:0.0 | 2w1bA-1q40A:9.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v6t | HYPOTHETICAL UPF0271PROTEIN PH0986 (Pyrococcushorikoshii) |
PF03746(LamB_YcsF) | 3 | PHE A 253SER A 30LEU A 5 | None | 0.60A | 2w1bA-1v6tA:0.0 | 2w1bA-1v6tA:12.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wcd | MAJOR STRUCTURALPROTEIN VP2 (Infectiousbursal diseasevirus) |
PF01766(Birna_VP2) | 3 | PHE J 371SER J 43LEU J 87 | None | 0.79A | 2w1bA-1wcdJ:0.1 | 2w1bA-1wcdJ:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x9d | ENDOPLASMICRETICULUMMANNOSYL-OLIGOSACCHARIDE1,2-ALPHA-MANNOSIDASE (Homo sapiens) |
PF01532(Glyco_hydro_47) | 3 | PHE A 307SER A 341LEU A 339 | None | 0.80A | 2w1bA-1x9dA:0.0 | 2w1bA-1x9dA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xfb | ALDOLASE C (Homo sapiens) |
PF00274(Glycolytic) | 3 | PHE A 145SER A 301LEU A 31 | None | 0.73A | 2w1bA-1xfbA:undetectable | 2w1bA-1xfbA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xx4 | 3,2-TRANS-ENOYL-COAISOMERASE,MITOCHONDRIAL (Rattusnorvegicus) |
PF00378(ECH_1) | 3 | PHE A 267SER A 276LEU A 168 | BAM A 600 (-3.5A)NoneNone | 0.74A | 2w1bA-1xx4A:undetectable | 2w1bA-1xx4A:13.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yb1 | 17-BETA-HYDROXYSTEROID DEHYDROGENASETYPE XI (Homo sapiens) |
PF00106(adh_short) | 3 | PHE A 51SER A 110LEU A 112 | None | 0.82A | 2w1bA-1yb1A:undetectable | 2w1bA-1yb1A:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ypz | T-CELL RECEPTORGAMMA CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | PHE F 225SER F 193LEU F 153 | None | 0.80A | 2w1bA-1ypzF:undetectable | 2w1bA-1ypzF:12.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z5x | ECDYSONE RECEPTORLIGAND BINDINGDOMAIN (Bemisia tabaci) |
PF00104(Hormone_recep) | 3 | PHE E 311SER E 378LEU E 376 | None | 0.77A | 2w1bA-1z5xE:undetectable | 2w1bA-1z5xE:14.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zap | SECRETED ASPARTICPROTEINASE (Candidaalbicans) |
PF00026(Asp) | 3 | PHE A 279SER A 313LEU A 311 | None | 0.79A | 2w1bA-1zapA:undetectable | 2w1bA-1zapA:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjy | R-SPECIFIC ALCOHOLDEHYDROGENASE (Lactobacillusbrevis) |
PF13561(adh_short_C2) | 3 | PHE A 26SER A 84LEU A 86 | None | 0.81A | 2w1bA-1zjyA:undetectable | 2w1bA-1zjyA:14.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zkd | DUF185 (Rhodopseudomonaspalustris) |
PF02636(Methyltransf_28) | 3 | PHE A 303SER A 71LEU A 67 | None | 0.66A | 2w1bA-1zkdA:undetectable | 2w1bA-1zkdA:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zrz | PROTEIN KINASE C,IOTA (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 3 | PHE A 513SER A 486LEU A 484 | None | 0.82A | 2w1bA-1zrzA:undetectable | 2w1bA-1zrzA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zxx | 6-PHOSPHOFRUCTOKINASE (Lactobacillusdelbrueckii) |
PF00365(PFK) | 3 | PHE A 41SER A 119LEU A 110 | None | 0.67A | 2w1bA-1zxxA:undetectable | 2w1bA-1zxxA:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bc0 | NADH OXIDASE (Streptococcuspyogenes) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 3 | PHE A 61SER A 148LEU A 144 | None | 0.55A | 2w1bA-2bc0A:undetectable | 2w1bA-2bc0A:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2btu | PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE (Bacillusanthracis) |
PF00586(AIRS)PF02769(AIRS_C) | 3 | PHE A 252SER A 183LEU A 181 | None | 0.74A | 2w1bA-2btuA:3.4 | 2w1bA-2btuA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bw3 | TRANSPOSASE (Musca domestica) |
PF05699(Dimer_Tnp_hAT)PF10683(DBD_Tnp_Hermes) | 3 | PHE A 235SER A 602LEU A 598 | None | 0.52A | 2w1bA-2bw3A:undetectable | 2w1bA-2bw3A:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eij | CYTOCHROME C OXIDASESUBUNIT 1 (Bos taurus) |
PF00115(COX1) | 3 | PHE A 22SER A 156LEU A 152 | None | 0.66A | 2w1bA-2eijA:undetectable | 2w1bA-2eijA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fia | ACETYLTRANSFERASE (Enterococcusfaecalis) |
PF00583(Acetyltransf_1) | 3 | PHE A 126SER A 63LEU A 95 | None | 0.66A | 2w1bA-2fiaA:undetectable | 2w1bA-2fiaA:9.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fuv | PHOSPHOGLUCOMUTASE (Salmonellaenterica) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 3 | PHE A 376SER A 351LEU A 349 | None | 0.66A | 2w1bA-2fuvA:undetectable | 2w1bA-2fuvA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fwr | DNA REPAIR PROTEINRAD25 (Archaeoglobusfulgidus) |
PF04851(ResIII)PF16203(ERCC3_RAD25_C) | 3 | PHE A 198SER A 216LEU A 189 | None | 0.75A | 2w1bA-2fwrA:undetectable | 2w1bA-2fwrA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hyt | TETR-FAMILYTRANSCRIPTIONALREGULATOR (Pectobacteriumatrosepticum) |
PF00440(TetR_N) | 3 | PHE A 88SER A 159LEU A 155 | None | 0.83A | 2w1bA-2hytA:undetectable | 2w1bA-2hytA:10.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2inp | PHENOL HYDROXYLASECOMPONENT PHN (Pseudomonasstutzeri) |
PF02332(Phenol_Hydrox)PF04945(YHS) | 3 | PHE A 408SER A 277LEU A 273 | None | 0.81A | 2w1bA-2inpA:1.9 | 2w1bA-2inpA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nxx | ECDYSONE RECEPTOR(ECR, NRH1) (Triboliumcastaneum) |
PF00104(Hormone_recep) | 3 | PHE E 442SER E 509LEU E 507 | None | 0.76A | 2w1bA-2nxxE:undetectable | 2w1bA-2nxxE:12.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pjz | HYPOTHETICAL PROTEINST1066 (Sulfurisphaeratokodaii) |
PF00005(ABC_tran) | 3 | PHE A 198SER A 216LEU A 214 | None | 0.83A | 2w1bA-2pjzA:undetectable | 2w1bA-2pjzA:15.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2py6 | METHYLTRANSFERASEFKBM (Methylobacillusflagellatus) |
PF05050(Methyltransf_21) | 3 | PHE A 337SER A 218LEU A 214 | None | 0.71A | 2w1bA-2py6A:undetectable | 2w1bA-2py6A:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzw | CANDIDAPEPSIN-1 (Candidaalbicans) |
PF00026(Asp) | 3 | PHE A 279SER A 313LEU A 311 | None | 0.83A | 2w1bA-2qzwA:undetectable | 2w1bA-2qzwA:16.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ri6 | 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE (Paraburkholderiaxenovorans) |
PF12697(Abhydrolase_6) | 3 | PHE A 74SER A 207LEU A 205 | None | 0.77A | 2w1bA-2ri6A:undetectable | 2w1bA-2ri6A:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v7b | BENZOATE-COENZYME ALIGASE (Paraburkholderiaxenovorans) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 3 | PHE A 403SER A 334LEU A 338 | None | 0.75A | 2w1bA-2v7bA:3.0 | 2w1bA-2v7bA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v8j | PECTATE LYASE (Yersiniaenterocolitica) |
PF06917(Pectate_lyase_2) | 3 | PHE A 344SER A 384LEU A 382 | None | 0.83A | 2w1bA-2v8jA:undetectable | 2w1bA-2v8jA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bv4 | FRUCTOSE-BISPHOSPHATE ALDOLASE A (Oryctolaguscuniculus) |
PF00274(Glycolytic) | 3 | PHE A 144SER A 300LEU A 30 | None | 0.71A | 2w1bA-3bv4A:undetectable | 2w1bA-3bv4A:16.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bxw | CHITINASEDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
no annotation | 3 | PHE B 279SER B 340LEU B 338 | None | 0.81A | 2w1bA-3bxwB:undetectable | 2w1bA-3bxwB:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3csk | PROBABLEDIPEPTIDYL-PEPTIDASE3 (Saccharomycescerevisiae) |
PF03571(Peptidase_M49) | 3 | PHE A 109SER A 55LEU A 98 | None | 0.79A | 2w1bA-3cskA:2.3 | 2w1bA-3cskA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3guv | SITE-SPECIFICRECOMBINASE,RESOLVASE FAMILYPROTEIN (Streptococcuspneumoniae) |
PF00239(Resolvase) | 3 | PHE A 63SER A 97LEU A 99 | None | 0.81A | 2w1bA-3guvA:undetectable | 2w1bA-3guvA:10.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3if8 | PROTEIN ZWILCHHOMOLOG (Homo sapiens) |
PF09817(Zwilch) | 3 | PHE B 348SER B 376LEU B 372 | None | 0.83A | 2w1bA-3if8B:undetectable | 2w1bA-3if8B:12.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ivu | HOMOCITRATESYNTHASE,MITOCHONDRIAL (Schizosaccharomycespombe) |
PF00682(HMGL-like) | 3 | PHE A 53SER A 250LEU A 252 | None | 0.82A | 2w1bA-3ivuA:undetectable | 2w1bA-3ivuA:17.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lkl | ANTISIGMA-FACTORANTAGONIST STAS (Rhodobactersphaeroides) |
PF01740(STAS) | 3 | PHE A 1SER A 57LEU A 61 | None | 0.81A | 2w1bA-3lklA:undetectable | 2w1bA-3lklA:5.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lwd | 6-PHOSPHOGLUCONOLACTONASE (Chromohalobactersalexigens) |
PF01182(Glucosamine_iso) | 3 | PHE A 97SER A 78LEU A 82 | None | 0.83A | 2w1bA-3lwdA:undetectable | 2w1bA-3lwdA:13.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mbf | FRUCTOSE-BISPHOSPHATE ALDOLASE (Encephalitozooncuniculi) |
PF00274(Glycolytic) | 3 | PHE A 136SER A 292LEU A 25 | None2FP A 345 (-4.4A)None | 0.69A | 2w1bA-3mbfA:undetectable | 2w1bA-3mbfA:15.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mfq | HIGH-AFFINITY ZINCUPTAKE SYSTEMPROTEIN ZNUA (Streptococcussuis) |
PF01297(ZnuA) | 3 | PHE A 42SER A 247LEU A 278 | None | 0.68A | 2w1bA-3mfqA:undetectable | 2w1bA-3mfqA:14.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mmt | FRUCTOSE-BISPHOSPHATE ALDOLASE (Bartonellahenselae) |
PF00274(Glycolytic) | 3 | PHE A 134SER A 292LEU A 20 | None2FP A 350 ( 4.7A)None | 0.72A | 2w1bA-3mmtA:undetectable | 2w1bA-3mmtA:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3naw | SECRETED EFFECTORPROTEIN (Escherichiacoli) |
PF00805(Pentapeptide)PF13979(SopA_C)PF13981(SopA) | 3 | PHE A 433SER A 411LEU A 406 | None | 0.70A | 2w1bA-3nawA:undetectable | 2w1bA-3nawA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oks | 4-AMINOBUTYRATETRANSAMINASE (Mycolicibacteriumsmegmatis) |
PF00202(Aminotran_3) | 3 | PHE A 238SER A 64LEU A 62 | None | 0.76A | 2w1bA-3oksA:undetectable | 2w1bA-3oksA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pfq | PROTEIN KINASE CBETA TYPE (Rattusnorvegicus) |
PF00069(Pkinase)PF00130(C1_1)PF00168(C2)PF00433(Pkinase_C) | 3 | PHE A 255SER A 241LEU A 259 | None | 0.72A | 2w1bA-3pfqA:undetectable | 2w1bA-3pfqA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r4t | 4-AMINOBUTYRATEAMINOTRANSFERASEGABT (Mycobacteriummarinum) |
PF00202(Aminotran_3) | 3 | PHE A 237SER A 63LEU A 61 | None | 0.83A | 2w1bA-3r4tA:undetectable | 2w1bA-3r4tA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sgz | HYDROXYACID OXIDASE2 (Rattusnorvegicus) |
PF01070(FMN_dh) | 3 | PHE A 199SER A 105LEU A 128 | HO6 A 402 ( 4.8A)FMN A 401 (-2.8A)None | 0.77A | 2w1bA-3sgzA:undetectable | 2w1bA-3sgzA:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sig | POLY(ADP-RIBOSE)GLYCOHYDROLASE (Thermomonosporacurvata) |
PF10021(DUF2263) | 3 | PHE A 238SER A 177LEU A 175 | None | 0.76A | 2w1bA-3sigA:undetectable | 2w1bA-3sigA:14.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v0a | NTNH (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07953(Toxin_R_bind_N)PF08470(NTNH_C) | 3 | PHE B 358SER B 258LEU B 248 | None | 0.39A | 2w1bA-3v0aB:undetectable | 2w1bA-3v0aB:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vkg | DYNEIN HEAVY CHAIN,CYTOPLASMIC (Dictyosteliumdiscoideum) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 3 | PHE A1904SER A4340LEU A4338 | None | 0.82A | 2w1bA-3vkgA:undetectable | 2w1bA-3vkgA:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vuo | NTNHA (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07953(Toxin_R_bind_N)PF08470(NTNH_C) | 3 | PHE A 358SER A 258LEU A 248 | None | 0.37A | 2w1bA-3vuoA:undetectable | 2w1bA-3vuoA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3woz | CLIP-ASSOCIATINGPROTEIN 2 (Mus musculus) |
no annotation | 3 | PHE A 766SER A 839LEU A 837 | None | 0.82A | 2w1bA-3wozA:undetectable | 2w1bA-3wozA:12.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zx9 | CAPSID PROTEIN (Turnip crinklevirus) |
PF00729(Viral_coat) | 3 | PHE A 286SER A 246LEU A 281 | None | 0.76A | 2w1bA-3zx9A:undetectable | 2w1bA-3zx9A:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a8j | ELONGATOR COMPLEXPROTEIN 4 (Saccharomycescerevisiae) |
PF05625(PAXNEB) | 3 | PHE A 160SER A 330LEU A 122 | None | 0.57A | 2w1bA-4a8jA:undetectable | 2w1bA-4a8jA:15.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bzk | PROTEIN TRANSPORTPROTEIN SEC31 (Saccharomycescerevisiae) |
PF00400(WD40)PF12931(Sec16_C) | 3 | PHE A 595SER A 575LEU A 573 | None | 0.83A | 2w1bA-4bzkA:undetectable | 2w1bA-4bzkA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c8y | CAS6A (Thermusthermophilus) |
PF10040(CRISPR_Cas6) | 3 | PHE A 122SER A 146LEU A 142 | None G C 26 ( 3.8A) G C 25 ( 4.5A) | 0.69A | 2w1bA-4c8yA:3.2 | 2w1bA-4c8yA:13.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c98 | CAS6B (Thermusthermophilus) |
PF10040(CRISPR_Cas6) | 3 | PHE A 138SER A 167LEU A 163 | None | 0.72A | 2w1bA-4c98A:undetectable | 2w1bA-4c98A:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4z | DNA POLYMERASE IV (Sulfolobusacidocaldarius;Sulfolobussolfataricus) |
no annotation | 3 | PHE B 150SER B 227LEU B 225 | None | 0.81A | 2w1bA-4f4zB:3.6 | 2w1bA-4f4zB:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4glk | ABIQ (Lactococcuslactis) |
PF13958(ToxN_toxin) | 3 | PHE A 5SER A 52LEU A 84 | None | 0.55A | 2w1bA-4glkA:undetectable | 2w1bA-4glkA:10.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hl7 | NICOTINATEPHOSPHORIBOSYLTRANSFERASE (Vibrio cholerae) |
PF04095(NAPRTase) | 3 | PHE A 402SER A 247LEU A 241 | None | 0.83A | 2w1bA-4hl7A:2.3 | 2w1bA-4hl7A:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jre | NITRITE EXTRUSIONPROTEIN 1 (Escherichiacoli) |
PF07690(MFS_1) | 3 | PHE A 325SER A 269LEU A 264 | NoneGYP A 502 ( 4.8A)GYP A 502 (-4.3A) | 0.82A | 2w1bA-4jreA:undetectable | 2w1bA-4jreA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k1x | NADPH:FERREDOXINREDUCTASE (Rhodobactercapsulatus) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 3 | PHE A 214SER A 247LEU A 245 | None | 0.82A | 2w1bA-4k1xA:undetectable | 2w1bA-4k1xA:13.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l9o | SEC16,PROTEINTRANSPORT PROTEINSEC13 (Komagataellapastoris;Komagataellaphaffii) |
PF00400(WD40) | 3 | PHE A2256SER A2294LEU A2283 | None | 0.81A | 2w1bA-4l9oA:undetectable | 2w1bA-4l9oA:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lhu | 9C2 TCR GAMMA CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 3 | PHE G 229SER G 197LEU G 157 | None | 0.79A | 2w1bA-4lhuG:undetectable | 2w1bA-4lhuG:12.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nlh | TAX1-BINDING PROTEIN1 (Homo sapiens) |
PF07888(CALCOCO1) | 3 | PHE A 19SER A 69LEU A 67 | None | 0.78A | 2w1bA-4nlhA:undetectable | 2w1bA-4nlhA:9.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oiy | PROTEIN TRANSPORTPROTEIN SEC7 (Saccharomycescerevisiae) |
PF01369(Sec7) | 3 | PHE A 896SER A 913LEU A 915 | None | 0.83A | 2w1bA-4oiyA:undetectable | 2w1bA-4oiyA:11.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pii | N-GLYCOSYLASE/DNALYASE (Pyrococcusfuriosus) |
PF09171(AGOG) | 3 | PHE A 164SER A 211LEU A 207 | None | 0.76A | 2w1bA-4piiA:1.8 | 2w1bA-4piiA:13.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ppu | CHORISMATE MUTASE 1,CHLOROPLASTIC (Arabidopsisthaliana) |
no annotation | 3 | PHE A 151SER A 227LEU A 223 | None | 0.83A | 2w1bA-4ppuA:3.5 | 2w1bA-4ppuA:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q1v | PUTATIVE DIPEPTIDYLAMINOPEPTIDASE IV (Bacteroidesovatus) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 3 | PHE A 420SER A 426LEU A 402 | None | 0.71A | 2w1bA-4q1vA:undetectable | 2w1bA-4q1vA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rl6 | SACCHAROPINEDEHYDROGENASE (Streptococcuspneumoniae) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 3 | PHE A 136SER A 216LEU A 248 | None | 0.71A | 2w1bA-4rl6A:undetectable | 2w1bA-4rl6A:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rlq | BENZOATE-COENZYME ALIGASE (Rhodopseudomonaspalustris) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 3 | PHE A 397SER A 328LEU A 332 | None | 0.73A | 2w1bA-4rlqA:3.8 | 2w1bA-4rlqA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rt6 | HEME/HEMOPEXIN-BINDING PROTEIN (Haemophilusinfluenzae) |
PF05860(Haemagg_act) | 3 | PHE A 182SER A 175LEU A 153 | None | 0.81A | 2w1bA-4rt6A:undetectable | 2w1bA-4rt6A:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tps | SPORULATIONINHIBITOR OFREPLICATION PROTEINSIRACHROMOSOMALREPLICATIONINITIATOR PROTEINDNAA (Bacillussubtilis;Bacillussubtilis) |
PF10747(SirA)PF11638(DnaA_N) | 3 | PHE A 14SER B 56LEU B 54 | None | 0.79A | 2w1bA-4tpsA:undetectable | 2w1bA-4tpsA:9.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uqm | URACIL-DNAGLYCOSYLASE (Deinococcusradiodurans) |
PF03167(UDG) | 3 | PHE A 96SER A 204LEU A 182 | None | 0.67A | 2w1bA-4uqmA:undetectable | 2w1bA-4uqmA:12.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5apm | VP0 (Parechovirus A) |
PF00073(Rhv) | 3 | PHE C 169SER C 144LEU C 141 | None | 0.51A | 2w1bA-5apmC:undetectable | 2w1bA-5apmC:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5df0 | AC-CHIA (Autographacalifornicamultiplenucleopolyhedrovirus) |
PF00704(Glyco_hydro_18)PF08329(ChitinaseA_N) | 3 | PHE A 377SER A 175LEU A 177 | None | 0.68A | 2w1bA-5df0A:undetectable | 2w1bA-5df0A:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dmy | BETA-GALACTOSIDASE (Bifidobacteriumbifidum) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 3 | PHE A 841SER A 560LEU A 558 | None | 0.50A | 2w1bA-5dmyA:undetectable | 2w1bA-5dmyA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gtm | INTERFERON-INDUCEDGTP-BINDING PROTEINMX1 (Homo sapiens) |
PF00350(Dynamin_N)PF01031(Dynamin_M)PF02212(GED) | 3 | PHE A 302SER A 219LEU A 251 | None | 0.62A | 2w1bA-5gtmA:2.5 | 2w1bA-5gtmA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gw7 | GLUCOSIDASE YGJK (Escherichiacoli) |
PF01204(Trehalase) | 3 | PHE A 348SER A 398LEU A 394 | None | 0.78A | 2w1bA-5gw7A:undetectable | 2w1bA-5gw7A:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nur | ABC TRANSPORTERPERMEASE (Klebsiellapneumoniae) |
no annotation | 3 | PHE D 29SER D 191LEU D 187 | None | 0.80A | 2w1bA-5nurD:undetectable | 2w1bA-5nurD:12.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tcv | 1-AMINOCYCLOPROPANE-1-CARBOXYLATEOXIDASE 1 (Petunia xhybrida) |
PF03171(2OG-FeII_Oxy)PF14226(DIOX_N) | 3 | PHE A 4SER A 212LEU A 186 | NoneNone1AC A 402 ( 3.8A) | 0.78A | 2w1bA-5tcvA:undetectable | 2w1bA-5tcvA:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u09 | CANNABINOID RECEPTOR1,GLGA GLYCOGENSYNTHASE (Homo sapiens;Pyrococcusabyssi) |
PF00001(7tm_1)PF00534(Glycos_transf_1) | 3 | PHE A 102SER A 383LEU A 387 | None7DY A1210 (-3.0A)7DY A1210 (-4.6A) | 0.79A | 2w1bA-5u09A:undetectable | 2w1bA-5u09A:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u1s | SEPARIN (Saccharomycescerevisiae) |
PF03568(Peptidase_C50) | 3 | PHE A1584SER A1477LEU A1479 | None | 0.77A | 2w1bA-5u1sA:undetectable | 2w1bA-5u1sA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uz5 | U1 SMALL NUCLEARRIBONUCLEOPROTEINCOMPONENT PRP42PROTEIN NAM8 (Saccharomycescerevisiae;Saccharomycescerevisiae) |
no annotationno annotation | 3 | PHE D 488SER F 517LEU F 513 | None | 0.81A | 2w1bA-5uz5D:undetectable | 2w1bA-5uz5D:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vha | DEAH(ASP-GLU-ALA-HIS)BOX POLYPEPTIDE 36 (Bos taurus) |
no annotation | 3 | PHE A 883SER A 875LEU A 901 | None | 0.78A | 2w1bA-5vhaA:undetectable | 2w1bA-5vhaA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vlj | NUCLEAR DISTRIBUTIONPROTEIN PAC1 (Saccharomycescerevisiae) |
PF00400(WD40) | 3 | PHE B 182SER B 149LEU B 151 | None | 0.66A | 2w1bA-5vljB:undetectable | 2w1bA-5vljB:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xjn | CYTOCHROME P450 (Corynebacteriumglutamicum) |
PF00067(p450) | 3 | PHE A 127SER A 261LEU A 259 | HEM A 502 (-3.7A)88L A 501 ( 2.7A)None | 0.63A | 2w1bA-5xjnA:2.7 | 2w1bA-5xjnA:18.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zbh | NEUROPEPTIDE YRECEPTOR TYPE 1,T4LYSOZYME,NEUROPEPTIDE Y RECEPTOR TYPE 1 (Homo sapiens;Escherichiavirus T4) |
no annotation | 3 | PHE A 327SER A 83LEU A 59 | None | 0.75A | 2w1bA-5zbhA:undetectable | 2w1bA-5zbhA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d46 | BETA SLIDING CLAMP (Rickettsiatyphi) |
no annotation | 3 | PHE A 116SER A 55LEU A 45 | None | 0.75A | 2w1bA-6d46A:undetectable | 2w1bA-6d46A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6er3 | BNR/ASP-BOX REPEATPROTEIN ([Ruminococcus]gnavus) |
no annotation | 3 | PHE A 144SER A 148LEU A 37 | None | 0.77A | 2w1bA-6er3A:undetectable | 2w1bA-6er3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6et0 | PQSB (Pseudomonasaeruginosa) |
no annotation | 3 | PHE B 241SER B 130LEU B 64 | None | 0.59A | 2w1bA-6et0B:undetectable | 2w1bA-6et0B:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fay | ODZ3 PROTEIN (Mus musculus) |
no annotation | 3 | PHE A 983SER A1692LEU A1694 | None | 0.81A | 2w1bA-6fayA:undetectable | 2w1bA-6fayA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fv5 | QUEUINETRNA-RIBOSYLTRANSFERASE ACCESSORYSUBUNIT 2 (Mus musculus) |
no annotation | 3 | PHE A 141SER A 181LEU A 177 | None | 0.53A | 2w1bA-6fv5A:undetectable | 2w1bA-6fv5A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g1k | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY CMEMBER 4A (Danio rerio) |
no annotation | 3 | PHE A 251SER A 213LEU A 211 | None | 0.83A | 2w1bA-6g1kA:undetectable | 2w1bA-6g1kA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g2j | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN5 (Mus musculus) |
no annotation | 3 | PHE L 32SER L 24LEU L 20 | None | 0.78A | 2w1bA-6g2jL:undetectable | 2w1bA-6g2jL:undetectable |