SIMILAR PATTERNS OF AMINO ACIDS FOR 2W03_B_ADNB1588

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 HIS A 162
PRO A 163
SER A 284
ARG A 312
HIS A 449
 ATP  A1607 (-4.4A)
None
ATP  A1607 (-2.8A)
ATP  A1607 (-3.6A)
ATP  A1607 (-3.6A)
 0.73A 2w03B-2x0qA:
31.3		 2w03B-2x0qA:
23.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		10 LEU A 166
HIS A 170
PRO A 171
SER A 279
THR A 301
ARG A 305
HIS A 444
LEU A 445
GLN A 446
ASN A 509
 None
AMP  A1588 (-3.8A)
None
SO4  A1589 (-3.0A)
AMP  A1588 (-3.2A)
AMP  A1588 (-3.7A)
AMP  A1588 (-3.3A)
AMP  A1588 (-4.0A)
SO4  A1589 ( 2.8A)
AMP  A1588 (-3.1A)
 0.57A 2w03B-2x3kA:
62.2		 2w03B-2x3kA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Candida
albicans) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 LEU A 306
HIS A 399
ARG A 379
LEU A 401
ASN A 372
 None
 1.37A 2w03B-3qo7A:
0.0		 2w03B-3qo7A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		5 HIS A  35
PRO A  10
SER A 238
LEU A  32
GLN A  34
 None
 1.40A 2w03B-3rhyA:
0.0		 2w03B-3rhyA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 LEU A 558
HIS A 535
LEU A 544
GLN A 562
ASN A 515
 None
 1.16A 2w03B-3szeA:
0.0		 2w03B-3szeA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster) 		no annotation 5 LEU A 757
SER A 759
ARG A 760
LEU A 716
ASN A 696
 None
 1.25A 2w03B-4bwpA:
6.6		 2w03B-4bwpA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zs7 LLAMA FAB FRAGMENT
68F2 HEAVY CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU H  82
SER H  72
THR H  59
LEU H  84
GLN H  83
 None
 1.40A 2w03B-4zs7H:
0.0		 2w03B-4zs7H:
16.15