SIMILAR PATTERNS OF AMINO ACIDS FOR 2W03_A_ADNA1588

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)

(Salmonella
enterica) 		PF00180
(Iso_dh) 		5 HIS A  42
PRO A  11
ILE A  38
THR A  40
ARG A  31
 None
 1.17A 2w03A-1cnzA:
0.0		 2w03A-1cnzA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jax CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF03807
(F420_oxidored) 		5 LEU A  12
HIS A 133
PRO A  96
ILE A 195
THR A 192
 None
 1.41A 2w03A-1jaxA:
0.6		 2w03A-1jaxA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		5 LEU A 111
PRO A  41
ILE A  67
HIS A  74
GLN A 116
 None
 1.46A 2w03A-2cybA:
0.0		 2w03A-2cybA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Porphyromonas
gingivalis) 		PF00588
(SpoU_methylase) 		5 LEU A 131
PRO A 156
ILE A 199
THR A 102
LEU A 118
 None
 1.39A 2w03A-2i6dA:
0.0		 2w03A-2i6dA:
17.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		10 LEU A 166
HIS A 170
PRO A 171
ILE A 300
THR A 301
ARG A 305
HIS A 444
LEU A 445
GLN A 446
ASN A 509
 None
AMP  A1588 (-3.8A)
None
None
AMP  A1588 (-3.2A)
AMP  A1588 (-3.7A)
AMP  A1588 (-3.3A)
AMP  A1588 (-4.0A)
SO4  A1589 ( 2.8A)
AMP  A1588 (-3.1A)
 0.52A 2w03A-2x3kA:
60.2		 2w03A-2x3kA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		7 LEU A 166
PRO A 171
ILE A 280
HIS A 444
LEU A 445
GLN A 446
ASN A 509
 None
None
None
AMP  A1588 (-3.3A)
AMP  A1588 (-4.0A)
SO4  A1589 ( 2.8A)
AMP  A1588 (-3.1A)
 1.17A 2w03A-2x3kA:
60.2		 2w03A-2x3kA:
100.00