SIMILAR PATTERNS OF AMINO ACIDS FOR 2VZV_B_GCSB1899_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		10 ILE A 202
ASP A 203
TRP A 204
GLU A 394
ASP A 469
MET A 512
TYR A 516
TRP A 642
TRP A 653
TRP A 781
 X05  A1900 (-3.5A)
X05  A1900 (-2.7A)
X05  A1900 (-4.2A)
X05  A1900 (-2.6A)
X05  A1900 (-3.2A)
X05  A1900 (-3.4A)
X05  A1900 (-3.5A)
X05  A1900 (-4.3A)
None
None
 0.44A 2vzvB-2x05A:
69.4		 2vzvB-2x05A:
99.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		5 ASP A 201
TRP A 202
TYR A 573
TRP A 706
TRP A 717
 None
 1.17A 2vzvB-4cvuA:
26.6		 2vzvB-4cvuA:
24.42