SIMILAR PATTERNS OF AMINO ACIDS FOR 2VZV_A_GCSA1900

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 GLU A 431
ASP A 469
MET A 512
TYR A 516
TRP A 781
 None
X05  A1900 (-3.2A)
X05  A1900 (-3.4A)
X05  A1900 (-3.5A)
None
 0.53A 2vzvA-2x05A:
69.1		 2vzvA-2x05A:
99.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		4 CYH A  34
GLU A  35
ASP A  37
TYR A  80
 None
 1.25A 2vzvA-4duuA:
0.0		 2vzvA-4duuA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3

(Homo sapiens) 		PF16953
(PRORP) 		4 GLU A 356
ASP A 546
TYR A 314
TRP A 576
 None
 1.45A 2vzvA-4xgmA:
0.5		 2vzvA-4xgmA:
16.18