SIMILAR PATTERNS OF AMINO ACIDS FOR 2VZS_B_GCSB1903

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2vmf	BETA-MANNOSIDASE (Bacteroides thetaiotaomicron)	PF00703 (Glyco_hydro_2)	5	ASP A 199 CYH A 424 GLU A 555 TRP A 645 TRP A 656	MVL A1865 ( 2.9A) EDO A1876 (-3.3A) MVL A1865 (-2.6A) MVL A1865 (-3.7A) MVL A1865 (-3.7A)	1.18A	2vzsB-2vmfA: 30.2	2vzsB-2vmfA: 23.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2x05	EXO-BETA-D-GLUCOSAMI NIDASE (Amycolatopsis orientalis)	PF00703 (Glyco_hydro_2) PF02837 (Glyco_hydro_2_N)	11	ILE A 202 ASP A 203 GLU A 394 SER A 468 ASP A 469 MET A 512 TYR A 516 GLU A 541 TRP A 642 TRP A 653 TRP A 781	X05 A1900 (-3.5A) X05 A1900 (-2.7A) X05 A1900 (-2.6A) X05 A1900 (-3.6A) X05 A1900 (-3.2A) X05 A1900 (-3.4A) X05 A1900 (-3.5A) X05 A1900 (-2.5A) X05 A1900 (-4.3A) None None	0.35A	2vzsB-2x05A: 69.7	2vzsB-2x05A: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ecq	ENDO-ALPHA-N-ACETYLG ALACTOSAMINIDASE (Streptococcus pneumoniae)	PF12905 (Glyco_hydro_101) PF17451 (Glyco_hyd_101C)	5	GLU A 655 SER A 654 ASP A 666 GLU A1261 TRP A1284	None	1.35A	2vzsB-3ecqA: 2.0	2vzsB-3ecqA: 23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4cvu	BETA-MANNOSIDASE (Trichoderma harzianum)	PF00703 (Glyco_hydro_2)	5	ASP A 201 TYR A 573 GLU A 594 TRP A 706 TRP A 717	None	1.07A	2vzsB-4cvuA: 26.6	2vzsB-4cvuA: 24.42

[["2VZS_B_GCSB1903_1","2vmf","Bacteroides thetaiotaomicron","BETA-MANNOSIDASE","PF00703(Glyco_hydro_2)",5,"ASP A 199;CYH A 424;GLU A 555;TRP A 645;TRP A 656","MVL A1865 ( 2.9A);EDO A1876 (-3.3A);MVL A1865 (-2.6A);MVL A1865 (-3.7A);MVL A1865 (-3.7A)","1.18A","2vzsB-2vmfA:30.2","2vzsB-2vmfA:23.48"],["2VZS_B_GCSB1903_1","2x05","Amycolatopsis orientalis","EXO-BETA-D-GLUCOSAMINIDASE","PF00703(Glyco_hydro_2);PF02837(Glyco_hydro_2_N)",11,"ILE A 202;ASP A 203;GLU A 394;SER A 468;ASP A 469;MET A 512;TYR A 516;GLU A 541;TRP A 642;TRP A 653;TRP A 781","X05 A1900 (-3.5A);X05 A1900 (-2.7A);X05 A1900 (-2.6A);X05 A1900 (-3.6A);X05 A1900 (-3.2A);X05 A1900 (-3.4A);X05 A1900 (-3.5A);X05 A1900 (-2.5A);X05 A1900 (-4.3A);None;None","0.35A","2vzsB-2x05A:69.7","2vzsB-2x05A:100.00"],["2VZS_B_GCSB1903_1","3ecq","Streptococcus pneumoniae","ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE","PF12905(Glyco_hydro_101);PF17451(Glyco_hyd_101C)",5,"GLU A 655;SER A 654;ASP A 666;GLU A1261;TRP A1284","None","1.35A","2vzsB-3ecqA:2.0","2vzsB-3ecqA:23.09"],["2VZS_B_GCSB1903_1","4cvu","Trichoderma harzianum","BETA-MANNOSIDASE","PF00703(Glyco_hydro_2)",5,"ASP A 201;TYR A 573;GLU A 594;TRP A 706;TRP A 717","None","1.07A","2vzsB-4cvuA:26.6","2vzsB-4cvuA:24.42"]]