SIMILAR PATTERNS OF AMINO ACIDS FOR 2VUF_B_FUAB2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxz MAJOR POLLEN
ALLERGEN JUN A 1

(Juniperus ashei) 		PF00544
(Pec_lyase_C) 		5 ARG A 229
PHE A 222
ILE A 261
ARG A 234
GLY A 236
 None
 1.35A 2vufB-1pxzA:
undetectable		 2vufB-1pxzA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qox BETA-GLUCOSIDASE

(Bacillus
circulans) 		PF00232
(Glyco_hydro_1) 		5 TYR A 255
ILE A 254
HIS A 201
TYR A 346
GLY A 218
 None
 1.34A 2vufB-1qoxA:
0.0		 2vufB-1qoxA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 ARG A 117
PHE A 134
TYR A 138
ILE A 142
TYR A 161
GLY A 189
 None
 1.00A 2vufB-1tf0A:
48.7		 2vufB-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 PRO A 118
PHE A 134
TYR A 138
ILE A 142
HIS A 146
TYR A 161
GLY A 189
 None
 0.59A 2vufB-1tf0A:
48.7		 2vufB-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE

(Thermotoga
maritima) 		PF02547
(Queuosine_synth) 		5 ARG A  96
PRO A  97
ILE A 109
ARG A  67
GLY A 142
 None
 1.38A 2vufB-1vkyA:
undetectable		 2vufB-1vkyA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE

(Agrobacterium
fabrum) 		PF03562
(MltA)
PF06725
(3D) 		5 PRO A 303
ILE A  86
HIS A 292
ARG A 332
GLY A 329
 None
 1.41A 2vufB-2pnwA:
0.0		 2vufB-2pnwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa2 TREHALOSE-SYNTHASE
TRET

(Pyrococcus
horikoshii) 		PF00534
(Glycos_transf_1) 		5 ARG A 116
PHE A 172
ILE A  78
TYR A 111
GLY A  80
 None
 1.36A 2vufB-2xa2A:
0.0		 2vufB-2xa2A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3l KETOHEXOKINASE

(Homo sapiens) 		PF00294
(PfkB) 		5 ARG A 176
PHE A 183
ILE A 138
ARG A 141
GLY A  10
 None
 1.16A 2vufB-3b3lA:
0.0		 2vufB-3b3lA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flb RIFR

(Amycolatopsis
mediterranei) 		PF00975
(Thioesterase) 		5 ARG A 186
ILE A  99
TYR A 180
ARG A 106
GLY A  71
 None
 1.48A 2vufB-3flbA:
undetectable		 2vufB-3flbA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE

(Homo sapiens) 		PF03747
(ADP_ribosyl_GH) 		5 PRO A 188
ILE A 277
HIS A 299
TYR A 230
ARG A 295
 None
 1.50A 2vufB-3hfwA:
0.7		 2vufB-3hfwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqg LIPOPOLYSACCHARIDES
BIOSYNTHESIS
ACETYLTRANSFERASE

(Bordetella
petrii) 		PF00132
(Hexapep) 		5 ARG A  49
PHE A  45
ILE A  34
ARG A  51
GLY A  53
 None
 1.15A 2vufB-3mqgA:
undetectable		 2vufB-3mqgA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qg5 RAD50

(Thermotoga
maritima) 		PF13476
(AAA_23)
PF13558
(SbcCD_C) 		5 ARG A   2
PHE A 795
ILE A 129
ARG A 790
GLY A 789
 None
 1.49A 2vufB-3qg5A:
2.2		 2vufB-3qg5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gax AMORPHA-4,11-DIENE
SYNTHASE

(Artemisia annua) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ARG A 153
PRO A 155
PHE A 116
TYR A 494
ILE A 509
 None
 1.41A 2vufB-4gaxA:
undetectable		 2vufB-4gaxA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcu 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
ISOMERASE

(Deinococcus
radiodurans) 		PF02962
(CHMI) 		5 ARG A  66
PHE A  62
TYR A   8
ILE A  17
ARG A  43
 None
 1.24A 2vufB-4jcuA:
1.2		 2vufB-4jcuA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1v D-3-PHOSPHOGLYCERATE
DEHYDROGENASE-RELATE
D PROTEIN

(Vibrio cholerae) 		no annotation 5 ILE D 151
HIS D 208
TYR D 189
ARG D 160
GLY D 155
 None
 1.32A 2vufB-4s1vD:
undetectable		 2vufB-4s1vD:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 ARG A 157
PRO A 158
ILE A 334
HIS A 335
GLY A 298
 None
 1.39A 2vufB-4ztxA:
1.7		 2vufB-4ztxA:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		5 PHE A 134
TYR A 138
ILE A 142
HIS A 146
TYR A 161
 None
 0.52A 2vufB-5ghkA:
46.0		 2vufB-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 PRO A 118
PHE A 134
TYR A 138
ILE A 142
HIS A 146
TYR A 161
 None
 0.48A 2vufB-5yxeA:
47.1		 2vufB-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 PRO A 118
PHE A 134
TYR A 138
ILE A 142
TYR A 161
ARG A 186
 None
 0.86A 2vufB-5yxeA:
47.1		 2vufB-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea NITROGENASE PROTEIN
ALPHA CHAIN

(Azotobacter
vinelandii) 		no annotation 5 PHE A 403
TYR A 425
ILE A 213
TYR A 430
GLY A 215
 None
 1.45A 2vufB-6feaA:
1.3		 2vufB-6feaA:
11.49