SIMILAR PATTERNS OF AMINO ACIDS FOR 2VUF_A_FUAA2002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akm ORNITHINE
TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ILE A 228
ALA A 219
VAL A 222
GLU A 223
 None
 0.63A 2vufA-1akmA:
0.0		 2vufA-1akmA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 PHE A  63
ALA A  64
VAL A  67
GLU A  68
 None
 0.42A 2vufA-1bt2A:
0.5		 2vufA-1bt2A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf5 PROTEIN
(BETA-MOMORCHARIN)

(Momordica
charantia) 		PF00161
(RIP) 		4 ILE A 153
PHE A  83
ALA A  73
VAL A  71
 None
 0.79A 2vufA-1cf5A:
undetectable		 2vufA-1cf5A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		4 ILE A 150
ALA A 187
VAL A 190
GLU A 191
 None
 0.78A 2vufA-1ii0A:
0.0		 2vufA-1ii0A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		4 ILE A 225
ALA A 187
VAL A 190
GLU A 191
 None
 0.84A 2vufA-1ii0A:
0.0		 2vufA-1ii0A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ILE A  28
ALA A 281
VAL A 284
GLU A 285
 None
 0.72A 2vufA-1itzA:
0.0		 2vufA-1itzA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kae HISTIDINOL
DEHYDROGENASE

(Escherichia
coli) 		PF00815
(Histidinol_dh) 		4 ILE A 342
ALA A 314
VAL A 317
GLU A 318
 None
 0.65A 2vufA-1kaeA:
0.0		 2vufA-1kaeA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 PHE A 183
ALA A 184
VAL A 187
GLU A 188
 None
 0.21A 2vufA-1lamA:
0.0		 2vufA-1lamA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgy TRIACYLGLYCEROL
LIPASE

(Rhizopus niveus) 		PF01764
(Lipase_3) 		4 PHE A 185
ALA A 186
VAL A 189
GLU A 190
 None
 0.47A 2vufA-1lgyA:
undetectable		 2vufA-1lgyA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lr0 TOLA PROTEIN

(Pseudomonas
aeruginosa) 		PF13103
(TonB_2) 		4 ILE A  58
PHE A 116
ALA A  84
VAL A  88
 None
 0.87A 2vufA-1lr0A:
undetectable		 2vufA-1lr0A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p90 HYPOTHETICAL PROTEIN

(Azotobacter
vinelandii) 		PF02579
(Nitro_FeMo-Co) 		4 ILE A 187
ALA A 157
VAL A 160
GLU A 161
 None
 0.87A 2vufA-1p90A:
undetectable		 2vufA-1p90A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pex COLLAGENASE-3

(Homo sapiens) 		PF00045
(Hemopexin) 		4 ILE A 436
PHE A 392
ALA A 380
VAL A 429
 None
None
CL  A 501 ( 4.8A)
CA  A 503 ( 4.6A)
 0.63A 2vufA-1pexA:
undetectable		 2vufA-1pexA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE

(Acidaminococcus
fermentans) 		PF01144
(CoA_trans) 		4 ILE B  21
PHE B 105
ALA B 104
VAL B  27
 None
 0.80A 2vufA-1poiB:
undetectable		 2vufA-1poiB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 PHE A 227
ALA A 228
VAL A 231
GLU A 232
 None
 0.54A 2vufA-1ps9A:
undetectable		 2vufA-1ps9A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		4 ILE A  18
PHE A 298
VAL A 302
GLU A 303
 None
 0.78A 2vufA-1q8fA:
undetectable		 2vufA-1q8fA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		4 ILE A 261
PHE A 205
ALA A 206
VAL A 209
 None
 0.82A 2vufA-1qafA:
undetectable		 2vufA-1qafA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8n KUNITZ TRYPSIN
INHIBITOR

(Delonix regia) 		PF00197
(Kunitz_legume) 		4 ILE A  22
PHE A  83
VAL A  61
GLU A  19
 None
 0.81A 2vufA-1r8nA:
undetectable		 2vufA-1r8nA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Archaeoglobus
fulgidus) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 ILE A 135
PHE A 174
VAL A 152
GLU A 177
 None
 0.84A 2vufA-1txgA:
undetectable		 2vufA-1txgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf0 SERINE/THREONINE-PRO
TEIN KINASE DCAMKL1

(Homo sapiens) 		PF03607
(DCX) 		4 ILE A  30
PHE A  15
VAL A  13
GLU A  81
 None
 0.83A 2vufA-1uf0A:
undetectable		 2vufA-1uf0A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3w PEPTIDE:N-GLYCANASE

(Saccharomyces
cerevisiae) 		PF03835
(Rad4) 		4 ILE A 259
PHE A  51
ALA A  52
VAL A  55
 None
 0.74A 2vufA-1x3wA:
undetectable		 2vufA-1x3wA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y11 HYPOTHETICAL PROTEIN
RV1264/MT1302

(Mycobacterium
tuberculosis) 		PF00211
(Guanylate_cyc)
PF16701
(Ad_Cy_reg) 		4 ILE A  45
ALA A  29
VAL A  32
GLU A  33
 None
 0.85A 2vufA-1y11A:
1.5		 2vufA-1y11A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zx3 HYPOTHETICAL PROTEIN
NE0241

(Nitrosomonas
europaea) 		no annotation 4 PHE A  53
ALA A  54
VAL A  57
GLU A  58
 PHE  A  53 ( 1.4A)
ALA  A  54 ( 0.0A)
VAL  A  57 ( 0.6A)
GLU  A  58 ( 0.5A)
 0.49A 2vufA-1zx3A:
undetectable		 2vufA-1zx3A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ab4 TRNA PSEUDOURIDINE
SYNTHASE B

(Thermotoga
maritima) 		PF01472
(PUA)
PF01509
(TruB_N)
PF16198
(TruB_C_2) 		4 ILE A 171
PHE A 161
VAL A  69
GLU A 190
 None
 0.86A 2vufA-2ab4A:
undetectable		 2vufA-2ab4A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		4 ILE A 335
ALA A 471
VAL A 475
GLU A 472
 None
 0.83A 2vufA-2cdqA:
3.0		 2vufA-2cdqA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 PHE A  71
ALA A  72
VAL A  75
GLU A  76
 None
 0.40A 2vufA-2cx9A:
2.1		 2vufA-2cx9A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ev2 HYPOTHETICAL PROTEIN
RV1264/MT1302

(Mycobacterium
tuberculosis) 		PF16701
(Ad_Cy_reg) 		4 ILE A  45
ALA A  29
VAL A  32
GLU A  33
 None
 0.79A 2vufA-2ev2A:
undetectable		 2vufA-2ev2A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fna CONSERVED
HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF01637
(ATPase_2) 		4 ILE A 140
PHE A 123
ALA A 124
GLU A 128
 None
 0.79A 2vufA-2fnaA:
undetectable		 2vufA-2fnaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fy2 CHOLINE
O-ACETYLTRANSFERASE

(Homo sapiens) 		PF00755
(Carn_acyltransf) 		4 PHE A 589
ALA A 590
VAL A 593
GLU A 594
 None
 0.72A 2vufA-2fy2A:
undetectable		 2vufA-2fy2A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		4 ILE A 260
ALA A 222
VAL A 225
GLU A 226
 None
SO4  A 609 ( 3.7A)
None
None
 0.83A 2vufA-2gwnA:
undetectable		 2vufA-2gwnA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE

(Escherichia
coli) 		PF01204
(Trehalase) 		4 PHE A 211
ALA A 212
VAL A 215
GLU A 216
 None
 0.42A 2vufA-2jf4A:
undetectable		 2vufA-2jf4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxp PUTATIVE LIPOPROTEIN
B

(Nitrosomonas
europaea) 		PF04390
(LptE) 		4 ILE A  35
ALA A  52
VAL A  17
GLU A  51
 None
 0.82A 2vufA-2jxpA:
undetectable		 2vufA-2jxpA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2f APOPTOSIS REGULATOR
BCL-2

(Homo sapiens) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 PHE A 127
ALA A 128
VAL A 131
GLU A 132
 None
 0.55A 2vufA-2o2fA:
3.0		 2vufA-2o2fA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qiw PEP PHOSPHONOMUTASE

(Corynebacterium
glutamicum) 		PF13714
(PEP_mutase) 		4 ILE A 208
ALA A 192
VAL A 195
GLU A 196
 None
 0.71A 2vufA-2qiwA:
undetectable		 2vufA-2qiwA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdg SUPERANTIGEN-LIKE
PROTEIN 11

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		4 ILE A  57
PHE A  38
VAL A  36
GLU A  32
 None
 0.79A 2vufA-2rdgA:
undetectable		 2vufA-2rdgA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 ILE A 361
PHE A 353
ALA A 354
VAL A 357
 None
 0.77A 2vufA-2v5dA:
2.6		 2vufA-2v5dA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		4 ILE A 350
PHE A 215
ALA A 216
VAL A 219
 None
 0.84A 2vufA-2we8A:
undetectable		 2vufA-2we8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr1 AGGLUTININ-1 CHAIN A

(Abrus
precatorius) 		PF00161
(RIP) 		4 ILE A 158
PHE A  86
ALA A  76
VAL A  74
 None
 0.77A 2vufA-2zr1A:
undetectable		 2vufA-2zr1A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		4 ILE A 512
PHE A 475
VAL A 481
GLU A 479
 None
 0.83A 2vufA-3av6A:
undetectable		 2vufA-3av6A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		4 ILE A 374
PHE A 518
ALA A 519
VAL A 522
 None
 0.52A 2vufA-3ayfA:
4.7		 2vufA-3ayfA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 PHE A 503
ALA A 504
VAL A 507
GLU A 508
 None
 0.33A 2vufA-3b96A:
undetectable		 2vufA-3b96A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boh CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 4 ILE A  73
ALA A 142
VAL A 145
GLU A 146
 None
 0.61A 2vufA-3bohA:
undetectable		 2vufA-3bohA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2q UNCHARACTERIZED
CONSERVED PROTEIN

(Methanococcus
maripaludis) 		no annotation 4 ILE A 309
ALA A 226
VAL A 229
GLU A 230
 None
 0.66A 2vufA-3c2qA:
undetectable		 2vufA-3c2qA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		4 ILE A  42
ALA A 381
VAL A 385
GLU A 382
 None
 0.80A 2vufA-3da1A:
undetectable		 2vufA-3da1A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 232
PHE A 191
VAL A 224
GLU A 223
 None
 0.87A 2vufA-3dfhA:
undetectable		 2vufA-3dfhA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 220
ALA A 221
VAL A 224
GLU A 225
 None
 0.57A 2vufA-3dfhA:
undetectable		 2vufA-3dfhA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9r PHOSPHOMANNOMUTASE

(Trypanosoma
brucei) 		PF03332
(PMM) 		4 PHE A  48
ALA A  49
VAL A  52
GLU A  53
 None
 0.75A 2vufA-3f9rA:
undetectable		 2vufA-3f9rA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ILE A 258
PHE A 284
ALA A 285
VAL A 288
 None
 0.84A 2vufA-3fhtA:
undetectable		 2vufA-3fhtA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtd FUMARATE HYDRATASE
CLASS II

(Rickettsia
prowazekii) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ILE A 150
PHE A 246
ALA A 247
VAL A 250
 None
 0.70A 2vufA-3gtdA:
2.0		 2vufA-3gtdA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbx GLUTAMATE
DECARBOXYLASE 1

(Arabidopsis
thaliana) 		PF00282
(Pyridoxal_deC) 		4 ILE A 204
PHE A 170
ALA A 171
VAL A 176
 None
 0.82A 2vufA-3hbxA:
undetectable		 2vufA-3hbxA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1a SPECTINOMYCIN
PHOSPHOTRANSFERASE

(Legionella
pneumophila) 		PF01636
(APH) 		4 ARG A 187
PHE A 317
VAL A 323
GLU A 324
 DMS  A 341 (-4.4A)
None
None
None
 0.86A 2vufA-3i1aA:
2.3		 2vufA-3i1aA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0t ENDORIBONUCLEASE
L-PSP, PUTATIVE

(Pseudomonas
syringae group
genomosp. 3) 		PF01042
(Ribonuc_L-PSP) 		4 ILE A  51
ALA A 115
VAL A 117
GLU A 118
 None
None
None
BGC  A 127 (-3.5A)
 0.86A 2vufA-3k0tA:
undetectable		 2vufA-3k0tA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l1c KINESIN-14 NCD

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		4 ILE A 349
PHE A 663
ALA A 664
VAL A 667
 None
 0.78A 2vufA-3l1cA:
undetectable		 2vufA-3l1cA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK

(Methanothermobacter
thermautotrophicus) 		PF07885
(Ion_trans_2) 		4 PHE A  87
ALA A  88
VAL A  91
GLU A  92
 None
 0.83A 2vufA-3lddA:
3.7		 2vufA-3lddA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsz GLUTATHIONE
S-TRANSFERASE

(Rhodobacter
sphaeroides) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 PHE A 108
ALA A 109
VAL A 113
GLU A 114
 None
None
None
GSH  A 300 ( 4.7A)
 0.60A 2vufA-3lszA:
undetectable		 2vufA-3lszA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwu SERINE PROTEASE
HTRA1

(Homo sapiens) 		PF13365
(Trypsin_2) 		4 ILE A 282
ALA A 173
VAL A 176
GLU A 177
 None
 0.86A 2vufA-3nwuA:
undetectable		 2vufA-3nwuA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkx UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR HI_0893

(Haemophilus
influenzae) 		PF00440
(TetR_N) 		4 ILE A 101
PHE A  58
ALA A  59
VAL A  62
 None
 0.67A 2vufA-3qkxA:
undetectable		 2vufA-3qkxA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Clostridium
beijerinckii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 220
ALA A 221
VAL A 224
GLU A 225
 None
 0.54A 2vufA-3s47A:
undetectable		 2vufA-3s47A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3see HYPOTHETICAL SUGAR
BINDING PROTEIN

(Bacteroides
thetaiotaomicron) 		PF15425
(DUF4627) 		4 ILE A 214
PHE A  28
ALA A  73
GLU A 224
 None
 0.86A 2vufA-3seeA:
undetectable		 2vufA-3seeA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vom PUTATIVE
PHOSPHOSERINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		4 ILE A  96
PHE A 112
ALA A 113
VAL A 116
 None
 0.61A 2vufA-3vomA:
undetectable		 2vufA-3vomA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq1 ENDOGLUCANASE A

(Pyrococcus
furiosus) 		PF01670
(Glyco_hydro_12) 		4 ILE A 271
PHE A 246
VAL A 234
GLU A 216
 None
 0.74A 2vufA-3wq1A:
undetectable		 2vufA-3wq1A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A)
PF11934
(DUF3452) 		4 ILE A 214
PHE A 430
ALA A 431
VAL A 434
 None
 0.83A 2vufA-4eljA:
2.7		 2vufA-4eljA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus) 		PF09481
(CRISPR_Cse1) 		4 PHE A 441
ALA A 442
VAL A 444
GLU A 446
 None
 0.86A 2vufA-4f3eA:
2.4		 2vufA-4f3eA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvl COLLAGENASE 3

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		4 ILE A 441
PHE A 397
ALA A 385
VAL A 434
 None
None
CA  A 506 ( 4.8A)
CA  A 506 ( 4.6A)
 0.73A 2vufA-4fvlA:
undetectable		 2vufA-4fvlA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio cholerae) 		PF00496
(SBP_bac_5) 		4 ILE A 281
PHE A 248
ALA A 247
VAL A 482
 None
 0.87A 2vufA-4gf8A:
undetectable		 2vufA-4gf8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyv FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF00621
(RhoGEF) 		4 ILE A 622
PHE A 596
VAL A 600
GLU A 601
 None
 0.78A 2vufA-4gyvA:
2.1		 2vufA-4gyvA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4had PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF01408
(GFO_IDH_MocA) 		4 PHE A 289
ALA A 290
VAL A 293
GLU A 294
 None
 0.38A 2vufA-4hadA:
undetectable		 2vufA-4hadA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7h EVAA 2,3-DEHYDRATASE

(Amycolatopsis
orientalis) 		PF03559
(Hexose_dehydrat) 		4 ILE A  86
PHE A 303
VAL A 305
GLU A 294
 None
 0.84A 2vufA-4j7hA:
undetectable		 2vufA-4j7hA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		4 ILE A 138
PHE A 157
ALA A 158
VAL A 161
 None
 0.70A 2vufA-4kpnA:
undetectable		 2vufA-4kpnA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nle ADENYLOSUCCINATE
LYASE

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 ILE A 259
ARG A 161
ALA A 354
VAL A 268
 None
 0.86A 2vufA-4nleA:
undetectable		 2vufA-4nleA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Verminephrobacter
eiseniae) 		PF03480
(DctP) 		4 PHE A  57
ALA A  58
VAL A  61
GLU A  62
 None
 0.47A 2vufA-4p9kA:
undetectable		 2vufA-4p9kA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		4 PHE A  57
ALA A  58
VAL A  61
GLU A  62
 None
 0.52A 2vufA-4pdhA:
undetectable		 2vufA-4pdhA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO

(Escherichia
coli) 		PF02624
(YcaO) 		4 ILE A 385
ARG A 193
PHE A 363
VAL A 370
 None
 0.86A 2vufA-4q85A:
undetectable		 2vufA-4q85A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 PHE A 379
ALA A 380
VAL A 383
GLU A 384
 None
 0.50A 2vufA-4rbnA:
undetectable		 2vufA-4rbnA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvs PROBABLE QUINONE
REDUCTASE QOR
(NADPH:QUINONE
REDUCTASE)
(ZETA-CRYSTALLIN
HOMOLOG PROTEIN)

(Mycobacterium
tuberculosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 171
PHE A 201
ALA A 202
VAL A 205
 None
 0.70A 2vufA-4rvsA:
undetectable		 2vufA-4rvsA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		4 PHE A 351
ALA A 352
VAL A 355
GLU A 356
 None
 0.47A 2vufA-4rxeA:
undetectable		 2vufA-4rxeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		5 ILE A 145
PHE A 155
ALA A 154
VAL A 150
GLU A 151
 None
 1.21A 2vufA-4v2dA:
undetectable		 2vufA-4v2dA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w9z CYTOCHROME C OXIDASE
SUBUNIT 2

(Bradyrhizobium
diazoefficiens) 		PF00116
(COX2) 		4 PHE A 252
ALA A 253
VAL A 256
GLU A 257
 None
 0.53A 2vufA-4w9zA:
undetectable		 2vufA-4w9zA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wql 2''-AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE

(Klebsiella
pneumoniae) 		PF10706
(Aminoglyc_resit) 		4 ILE A 129
ALA A 161
VAL A 164
GLU A 165
 None
 0.74A 2vufA-4wqlA:
undetectable		 2vufA-4wqlA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjc DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE

(Bacillus
halodurans) 		PF00692
(dUTPase) 		4 ILE A 122
ALA A 111
VAL A  95
GLU A  96
 TTP  A 201 (-4.1A)
None
TTP  A 201 ( 4.6A)
None
 0.73A 2vufA-4xjcA:
undetectable		 2vufA-4xjcA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338

(Methanocaldococcus
jannaschii) 		PF03201
(HMD) 		4 ILE A 264
ALA A 256
VAL A 259
GLU A 260
 None
 0.70A 2vufA-4yt2A:
3.1		 2vufA-4yt2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 ILE A 361
PHE A 353
ALA A 354
VAL A 357
 None
 0.70A 2vufA-4zxlA:
2.8		 2vufA-4zxlA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		4 PHE B 351
ALA B 352
VAL B 355
GLU B 356
 None
 0.42A 2vufA-5ahuB:
2.9		 2vufA-5ahuB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Cryptococcus
neoformans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ILE A 334
PHE A 278
ALA A 277
VAL A 274
 None
 0.86A 2vufA-5cefA:
undetectable		 2vufA-5cefA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcp FILAMIN-B

(Homo sapiens) 		PF00630
(Filamin) 		4 ILE A1800
PHE A1747
VAL A1786
GLU A1775
 None
 0.87A 2vufA-5dcpA:
undetectable		 2vufA-5dcpA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		4 PHE A 324
ALA A 325
VAL A 328
GLU A 329
 None
 0.68A 2vufA-5du9A:
undetectable		 2vufA-5du9A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ILE A 541
ARG A 524
ALA A 591
VAL A 606
 None
 0.60A 2vufA-5i2tA:
undetectable		 2vufA-5i2tA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in8 ARISTOLOCHENE
SYNTHASE

(Aspergillus
terreus) 		no annotation 4 ILE A 201
ALA A 286
VAL A 289
GLU A 290
 None
 0.81A 2vufA-5in8A:
1.7		 2vufA-5in8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 PHE A 174
ALA A 175
VAL A 178
GLU A 179
 None
 0.47A 2vufA-5ja1A:
undetectable		 2vufA-5ja1A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		4 ILE A  50
PHE A 268
ALA A 659
GLU A 662
 None
 0.64A 2vufA-5jxkA:
3.2		 2vufA-5jxkA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE

(Bradyrhizobium
sp.) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ILE A 276
ALA A 244
VAL A 247
GLU A 248
 None
 0.59A 2vufA-5k8oA:
undetectable		 2vufA-5k8oA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE

(Brucella
melitensis) 		PF00551
(Formyl_trans_N) 		4 ILE A  35
ALA A  18
VAL A  22
GLU A  19
 None
 0.83A 2vufA-5vysA:
undetectable		 2vufA-5vysA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE

(Streptomyces
ribosidificus) 		PF01041
(DegT_DnrJ_EryC1) 		4 PHE A 219
ALA A 220
VAL A 223
GLU A 224
 None
 0.57A 2vufA-5w70A:
undetectable		 2vufA-5w70A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdh KINESIN-LIKE PROTEIN
KIFC1

(Homo sapiens) 		PF00225
(Kinesin) 		4 ILE A 603
PHE A 656
ALA A 657
VAL A 660
 None
 0.87A 2vufA-5wdhA:
undetectable		 2vufA-5wdhA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm9 RV0078

(Mycobacterium
tuberculosis) 		no annotation 4 ILE A 113
PHE A  62
VAL A  66
GLU A  67
 ILE  A 113 ( 0.7A)
PHE  A  62 ( 1.3A)
VAL  A  66 ( 0.6A)
GLU  A  67 ( 0.6A)
 0.82A 2vufA-5wm9A:
4.0		 2vufA-5wm9A:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtq PROTEASOME ASSEMBLY
CHAPERONE 4

(Homo sapiens) 		PF16093
(PAC4) 		4 PHE A 104
ALA A 105
VAL A 108
GLU A 109
 None
 0.49A 2vufA-5wtqA:
undetectable		 2vufA-5wtqA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 ILE A 168
PHE A 182
VAL A 152
GLU A 154
 None
 0.77A 2vufA-5x7hA:
undetectable		 2vufA-5x7hA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio harveyi) 		no annotation 4 ILE A 282
PHE A 249
ALA A 248
VAL A 483
 None
 0.74A 2vufA-5yqwA:
undetectable		 2vufA-5yqwA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 4 PHE A 408
ALA A 409
VAL A 412
GLU A 413
 None
ZN  A1035 ( 4.0A)
None
None
 0.68A 2vufA-6bv2A:
undetectable		 2vufA-6bv2A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus) 		no annotation 4 ILE A 310
PHE A 236
ALA A 237
GLU A 241
 None
 0.72A 2vufA-6d0nA:
undetectable		 2vufA-6d0nA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fel 14-3-3 PROTEIN GAMMA

(Homo sapiens) 		no annotation 4 ILE A 186
ALA A 144
VAL A 147
GLU A 148
 None
 0.51A 2vufA-6felA:
3.5		 2vufA-6felA:
11.43