SIMILAR PATTERNS OF AMINO ACIDS FOR 2VUF_A_FUAA2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		5 LEU A 424
ILE A 467
HIS A 466
ARG A 426
GLY A 469
 None
 1.34A 2vufA-1js6A:
0.0		 2vufA-1js6A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxz MAJOR POLLEN
ALLERGEN JUN A 1

(Juniperus ashei) 		PF00544
(Pec_lyase_C) 		5 ARG A 229
PHE A 222
ILE A 261
ARG A 234
GLY A 236
 None
 1.24A 2vufA-1pxzA:
undetectable		 2vufA-1pxzA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qox BETA-GLUCOSIDASE

(Bacillus
circulans) 		PF00232
(Glyco_hydro_1) 		5 TYR A 255
ILE A 254
HIS A 201
TYR A 346
GLY A 218
 None
 1.36A 2vufA-1qoxA:
0.0		 2vufA-1qoxA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 ARG A 117
MET A 123
PHE A 134
TYR A 138
ILE A 142
TYR A 161
GLY A 189
 None
 0.87A 2vufA-1tf0A:
48.3		 2vufA-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 LEU A 115
PHE A 134
TYR A 138
ILE A 142
HIS A 146
TYR A 161
GLY A 189
 None
 0.77A 2vufA-1tf0A:
48.3		 2vufA-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 LEU A 115
PHE A 165
TYR A 138
ILE A 142
HIS A 146
TYR A 161
 None
 1.36A 2vufA-1tf0A:
48.3		 2vufA-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 MET A 123
PHE A 134
TYR A 138
ILE A 142
HIS A 146
TYR A 161
GLY A 189
 None
 0.60A 2vufA-1tf0A:
48.3		 2vufA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x37 ATP-DEPENDENT
PROTEASE LA 1

(Bacillus
subtilis) 		PF05362
(Lon_C) 		5 LEU A  54
PHE A  93
TYR A  45
ILE A  41
ARG A  56
 None
 1.50A 2vufA-1x37A:
undetectable		 2vufA-1x37A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a11 RIBONUCLEASE III

(Mycobacterium
tuberculosis) 		PF14622
(Ribonucleas_3_3) 		5 LEU A  20
ARG A   5
ILE A 129
HIS A 133
GLY A  13
 None
 1.48A 2vufA-2a11A:
0.0		 2vufA-2a11A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 LEU A 205
ARG A 237
PHE A 275
ILE A 321
GLY A 484
 None
 1.40A 2vufA-2e4uA:
0.0		 2vufA-2e4uA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm8 CELL INVASION
PROTEIN SIPA
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK

(Salmonella
enterica) 		PF03519
(Invas_SpaK)
PF09052
(SipA) 		5 LEU C  31
PHE A 115
ILE A  24
ARG C  35
GLY A  26
 None
 1.17A 2vufA-2fm8C:
4.3		 2vufA-2fm8C:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i00 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 ARG A 298
MET A 120
TYR A  89
ILE A  84
HIS A 191
 None
 1.48A 2vufA-2i00A:
undetectable		 2vufA-2i00A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kl1 YLBL PROTEIN

(Geobacillus
thermodenitrificans) 		PF13180
(PDZ_2) 		5 LEU A  70
ARG A  54
TYR A  45
ILE A  31
GLY A  33
 None
 1.47A 2vufA-2kl1A:
undetectable		 2vufA-2kl1A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa2 TREHALOSE-SYNTHASE
TRET

(Pyrococcus
horikoshii) 		PF00534
(Glycos_transf_1) 		5 ARG A 116
PHE A 172
ILE A  78
TYR A 111
GLY A  80
 None
 1.29A 2vufA-2xa2A:
0.3		 2vufA-2xa2A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqg LIPOPOLYSACCHARIDES
BIOSYNTHESIS
ACETYLTRANSFERASE

(Bordetella
petrii) 		PF00132
(Hexapep) 		5 ARG A  49
PHE A  45
ILE A  34
ARG A  51
GLY A  53
 None
 1.36A 2vufA-3mqgA:
undetectable		 2vufA-3mqgA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qg5 RAD50

(Thermotoga
maritima) 		PF13476
(AAA_23)
PF13558
(SbcCD_C) 		5 ARG A   2
PHE A 795
ILE A 129
ARG A 790
GLY A 789
 None
 1.44A 2vufA-3qg5A:
1.1		 2vufA-3qg5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		5 LEU A 206
ARG A 181
HIS A 262
ARG A 235
GLY A 237
 None
 1.09A 2vufA-4hy3A:
undetectable		 2vufA-4hy3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		5 LEU A 206
ILE A 263
HIS A 262
ARG A 235
GLY A 237
 None
 1.13A 2vufA-4hy3A:
undetectable		 2vufA-4hy3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikh GLUTATHIONE
S-TRANSFERASE

(Pseudomonas
protegens) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 MET A  37
ILE A 174
HIS A 167
TYR A 179
GLY A 176
 None
 1.47A 2vufA-4ikhA:
2.7		 2vufA-4ikhA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1v D-3-PHOSPHOGLYCERATE
DEHYDROGENASE-RELATE
D PROTEIN

(Vibrio cholerae) 		no annotation 5 ILE D 151
HIS D 208
TYR D 189
ARG D 160
GLY D 155
 None
 1.38A 2vufA-4s1vD:
undetectable		 2vufA-4s1vD:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cws NUCLEOPORIN NIC96
NUCLEOPORIN NUP49
NUCLEOPORIN NUP57

(Chaetomium
thermophilum) 		PF13874
(Nup54)
no annotation 		5 LEU D 434
ARG F 174
TYR E 290
ILE E 286
ARG D 439
 None
 1.08A 2vufA-5cwsD:
undetectable		 2vufA-5cwsD:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghf AMINOTRANSFERASE
CLASS-III

(Ochrobactrum
anthropi) 		PF00202
(Aminotran_3) 		5 ARG A 375
PHE A 276
TYR A 240
ARG A 149
GLY A 182
 None
 1.47A 2vufA-5ghfA:
undetectable		 2vufA-5ghfA:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		5 PHE A 134
TYR A 138
ILE A 142
HIS A 146
TYR A 161
 None
 0.56A 2vufA-5ghkA:
45.7		 2vufA-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpy TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA

(Homo sapiens) 		no annotation 5 LEU B 151
ARG B 153
TYR B 143
ILE B 166
GLY B 164
 None
 1.15A 2vufA-5gpyB:
undetectable		 2vufA-5gpyB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7l ELP3 FAMILY, ELP3
FAMILY

(Dehalococcoides
mccartyi) 		PF04055
(Radical_SAM)
PF16199
(Radical_SAM_C) 		5 LEU A 361
TYR A 429
ILE A 419
TYR A 428
GLY A 422
 None
 1.48A 2vufA-5l7lA:
undetectable		 2vufA-5l7lA:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 5 LEU A 115
PHE A 133
TYR A 137
HIS A 145
TYR A 160
 None
 0.82A 2vufA-5oriA:
45.1		 2vufA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4f TAR DNA-BINDING
PROTEIN 43

(Homo sapiens) 		no annotation 5 LEU A  41
ARG A  52
ILE A   5
ARG A  55
GLY A  24
 None
 1.43A 2vufA-5x4fA:
undetectable		 2vufA-5x4fA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 7 LEU A 115
MET A 123
PHE A 134
TYR A 138
ILE A 142
HIS A 146
TYR A 161
 None
 0.85A 2vufA-5yxeA:
46.7		 2vufA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 MET A 123
PHE A 134
TYR A 138
ILE A 142
TYR A 161
ARG A 186
 None
 0.91A 2vufA-5yxeA:
46.7		 2vufA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea NITROGENASE PROTEIN
ALPHA CHAIN

(Azotobacter
vinelandii) 		no annotation 5 PHE A 403
TYR A 425
ILE A 213
TYR A 430
GLY A 215
 None
 1.49A 2vufA-6feaA:
undetectable		 2vufA-6feaA:
11.49