SIMILAR PATTERNS OF AMINO ACIDS FOR 2VTB_B_ACTB1500

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2j4d CRYPTOCHROME DASH

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ARG A 119
PHE A 134
VAL A 223
ASP A 224
 None
 0.26A 2vtbB-2j4dA:
61.5		 2vtbB-2j4dA:
99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A 264
PHE A 268
VAL A 289
ASP A 290
 None
 1.45A 2vtbB-3nv3A:
0.0		 2vtbB-3nv3A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		4 ARG A 110
PHE A 115
VAL A 220
ASP A 223
 None
 1.45A 2vtbB-3qanA:
0.3		 2vtbB-3qanA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsg NAD-BINDING
PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		4 ARG A 143
PHE A 148
VAL A  62
ASP A  61
 None
 1.22A 2vtbB-3qsgA:
2.1		 2vtbB-3qsgA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09272
(Hepsin-SRCR) 		4 ARG A  62
PHE A 117
VAL A 106
ASP A 105
 None
 1.23A 2vtbB-3t2nA:
0.0		 2vtbB-3t2nA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9d ACYL-COENZYME A
OXIDASE 1

(Yarrowia
lipolytica) 		no annotation 4 ARG A 305
PHE A 632
VAL A  56
ASP A 101
 None
 1.30A 2vtbB-5y9dA:
0.0		 2vtbB-5y9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 4 ARG M 251
PHE M 238
VAL M 236
ASP M 235
 None
 1.15A 2vtbB-6criM:
0.0		 2vtbB-6criM:
undetectable