SIMILAR PATTERNS OF AMINO ACIDS FOR 2VQY_A_PARA1201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6c TOBACCO RINGSPOT
VIRUS CAPSID PROTEIN

(Tobacco
ringspot virus) 		PF03391
(Nepo_coat)
PF03688
(Nepo_coat_C)
PF03689
(Nepo_coat_N) 		3 TRP A 181
GLN A 184
TRP A 506
 None
 1.23A 2vqyA-1a6cA:
0.0		 2vqyA-1a6cA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgf STAT-4

(Mus musculus) 		PF02865
(STAT_int) 		3 TRP A   4
GLN A   6
TRP A  43
 None
 1.38A 2vqyA-1bgfA:
undetectable		 2vqyA-1bgfA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		3 TRP B 154
GLN B 169
TRP B 143
 None
 1.28A 2vqyA-1cp9B:
0.0		 2vqyA-1cp9B:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de6 L-RHAMNOSE ISOMERASE

(Escherichia
coli) 		PF06134
(RhaA) 		3 TRP A  17
GLN A  22
TRP A 392
 None
 0.87A 2vqyA-1de6A:
0.0		 2vqyA-1de6A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		3 TRP A  57
GLN A  59
TRP A 461
 None
 1.29A 2vqyA-1fwxA:
0.8		 2vqyA-1fwxA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir1 SMALL SUBUNIT OF
RUBISCO

(Spinacia
oleracea) 		PF00101
(RuBisCO_small) 		3 TRP S  67
GLN S 111
TRP S  70
 None
 1.30A 2vqyA-1ir1S:
0.0		 2vqyA-1ir1S:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I

(Escherichia
coli) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 TRP A 184
GLN A 450
TRP A 390
 None
 1.39A 2vqyA-1k0gA:
0.0		 2vqyA-1k0gA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4n PROTEIN EC4020

(Escherichia
coli) 		PF06185
(YecM) 		3 TRP A 115
GLN A   9
TRP A  95
 None
 1.31A 2vqyA-1k4nA:
undetectable		 2vqyA-1k4nA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5s PENICILLIN G ACYLASE
BETA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		3 TRP B 154
GLN B 169
TRP B 143
 None
 1.32A 2vqyA-1k5sB:
0.0		 2vqyA-1k5sB:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks8 ENDO-B-1,4-GLUCANASE

(Nasutitermes
takasagoensis) 		PF00759
(Glyco_hydro_9) 		3 TRP A 247
GLN A 261
TRP A 253
 None
 1.29A 2vqyA-1ks8A:
0.0		 2vqyA-1ks8A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 TRP A 240
GLN A 324
TRP A 393
 None
 0.95A 2vqyA-1ksiA:
undetectable		 2vqyA-1ksiA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odh MGCM1

(Mus musculus) 		PF03615
(GCM) 		3 TRP A 137
GLN A 147
TRP A  36
 None
 1.22A 2vqyA-1odhA:
undetectable		 2vqyA-1odhA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjz THIOPURINE
S-METHYLTRANSFERASE

(Pseudomonas
syringae) 		PF05724
(TPMT) 		3 TRP A 166
GLN A 155
TRP A  13
 None
 1.01A 2vqyA-1pjzA:
2.4		 2vqyA-1pjzA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		3 TRP M  75
GLN M  77
TRP L 266
 CRT  M 304 (-4.4A)
None
None
 1.19A 2vqyA-1pssM:
undetectable		 2vqyA-1pssM:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ql0 NUCLEASE

(Serratia
marcescens) 		PF01223
(Endonuclease_NS) 		3 TRP A 123
GLN A 192
TRP A  41
 None
 1.12A 2vqyA-1ql0A:
undetectable		 2vqyA-1ql0A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s6r BETA-LACTAMASE

(Enterobacter
cloacae) 		PF00144
(Beta-lactamase) 		3 TRP A 101
GLN A 102
TRP A 142
 None
 1.20A 2vqyA-1s6rA:
undetectable		 2vqyA-1s6rA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te5 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF13230
(GATase_4) 		3 TRP A 244
GLN A 239
TRP A 248
 None
 1.15A 2vqyA-1te5A:
undetectable		 2vqyA-1te5A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uas ALPHA-GALACTOSIDASE

(Oryza sativa) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		3 TRP A 237
GLN A 277
TRP A 334
 None
 1.36A 2vqyA-1uasA:
undetectable		 2vqyA-1uasA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 TRP A 243
GLN A 242
TRP A  89
 None
 1.37A 2vqyA-1w99A:
undetectable		 2vqyA-1w99A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfg REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2

(Homo sapiens) 		PF00595
(PDZ) 		3 TRP A  93
GLN A 118
TRP A  18
 None
 1.35A 2vqyA-1wfgA:
undetectable		 2vqyA-1wfgA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xyn ENDO-1,4-BETA-XYLANA
SE I

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		3 TRP A 146
GLN A 140
TRP A  68
 None
 1.32A 2vqyA-1xynA:
undetectable		 2vqyA-1xynA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		3 TRP A 144
GLN A 101
TRP A 155
 C  C   8 ( 4.1A)
None
None
 1.12A 2vqyA-1yvpA:
undetectable		 2vqyA-1yvpA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bod ENDOGLUCANASE E-2

(Thermobifida
fusca) 		PF01341
(Glyco_hydro_6) 		3 TRP X  97
GLN X  49
TRP X  41
 None
None
BGC  X1290 ( 3.5A)
 1.36A 2vqyA-2bodX:
0.0		 2vqyA-2bodX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dk7 TRANSCRIPTION
ELONGATION REGULATOR
1

(Homo sapiens) 		PF00397
(WW) 		3 TRP A  26
GLN A  61
TRP A  22
 None
 1.33A 2vqyA-2dk7A:
undetectable		 2vqyA-2dk7A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		3 TRP A 312
GLN A 311
TRP A  79
 UDP  A1424 (-3.6A)
None
ZIO  A1425 (-3.8A)
 1.28A 2vqyA-2iyaA:
undetectable		 2vqyA-2iyaA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nun AVIRULENCE B PROTEIN

(Pseudomonas
savastanoi) 		PF05394
(AvrB_AvrC) 		3 TRP A 257
GLN A 236
TRP A  92
 None
 1.39A 2vqyA-2nunA:
undetectable		 2vqyA-2nunA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 TRP A  39
GLN A 445
TRP A 414
 None
None
PRX  A 998 (-3.4A)
 1.00A 2vqyA-2p2mA:
undetectable		 2vqyA-2p2mA:
15.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qir AMINOGLYCOSIDE
6-N-ACETYLTRANSFERAS
E TYPE IB11

(Salmonella
enterica) 		PF13523
(Acetyltransf_8) 		3 TRP A  39
GLN A  54
TRP A  93
 9CS  A 501 (-4.1A)
None
9CS  A 501 (-4.3A)
 0.23A 2vqyA-2qirA:
32.8		 2vqyA-2qirA:
90.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB

(Salmonella
enterica) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		3 TRP A 203
GLN A 194
TRP A 269
 GOL  A1449 (-4.3A)
None
None
 1.18A 2vqyA-2wnwA:
undetectable		 2vqyA-2wnwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		3 TRP A 273
GLN A 306
TRP A 377
 CBI  A 459 (-3.9A)
CBI  A 459 (-3.4A)
None
 1.03A 2vqyA-3axxA:
undetectable		 2vqyA-3axxA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		3 TRP A 377
GLN A 359
TRP A 273
 None
None
CBI  A 459 (-3.9A)
 1.34A 2vqyA-3axxA:
undetectable		 2vqyA-3axxA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		3 TRP A 400
GLN A 422
TRP A 292
 GOL  A 440 (-4.5A)
None
None
 1.28A 2vqyA-3cc1A:
undetectable		 2vqyA-3cc1A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czp PUTATIVE
POLYPHOSPHATE KINASE
2

(Pseudomonas
aeruginosa) 		PF03976
(PPK2) 		3 TRP A 444
GLN A 446
TRP A 438
 None
 1.30A 2vqyA-3czpA:
undetectable		 2vqyA-3czpA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora) 		PF06722
(DUF1205) 		3 TRP A 191
GLN A 300
TRP A 268
 None
 1.14A 2vqyA-3d0qA:
undetectable		 2vqyA-3d0qA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgt PUTATIVE
PHOSPHOLIPASE B-LIKE
2 28 KDA FORM
PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM

(Mus musculus) 		PF04916
(Phospholip_B) 		3 TRP A 170
GLN B 343
TRP B 351
 None
 1.04A 2vqyA-3fgtA:
undetectable		 2vqyA-3fgtA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2

(Mus musculus) 		PF04916
(Phospholip_B) 		3 TRP A 170
GLN A 343
TRP A 351
 None
 1.06A 2vqyA-3fgwA:
1.4		 2vqyA-3fgwA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxt NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 6

(Homo sapiens) 		no annotation 3 TRP A  85
GLN A  83
TRP A 128
 None
 0.81A 2vqyA-3fxtA:
5.5		 2vqyA-3fxtA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic8 UNCHARACTERIZED
GST-LIKE
PROTEINPROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 TRP A 156
GLN A 112
TRP A 190
 None
 1.38A 2vqyA-3ic8A:
undetectable		 2vqyA-3ic8A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijl MUCONATE
CYCLOISOMERASE

(Bacteroides
thetaiotaomicron) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TRP A 229
GLN A 227
TRP A 264
 None
 1.33A 2vqyA-3ijlA:
undetectable		 2vqyA-3ijlA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipo PUTATIVE THIOSULFATE
SULFURTRANSFERASE
YNJE

(Escherichia
coli) 		PF00581
(Rhodanese) 		3 TRP A 261
GLN A 259
TRP A  54
 None
 1.27A 2vqyA-3ipoA:
undetectable		 2vqyA-3ipoA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		3 TRP B2219
GLN B2222
TRP B2271
 None
 1.14A 2vqyA-3j2sB:
1.1		 2vqyA-3j2sB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kie CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 TRP A 279
GLN A 646
TRP A 247
 None
 1.28A 2vqyA-3kieA:
undetectable		 2vqyA-3kieA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw8 PUTATIVE COPPER
OXIDASE

(Streptomyces
coelicolor) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TRP A 240
GLN A 272
TRP A 284
 None
 1.02A 2vqyA-3kw8A:
undetectable		 2vqyA-3kw8A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12979
(DUF3863)
PF12980
(DUF3864) 		3 TRP A 281
GLN A 258
TRP A 314
 None
 1.22A 2vqyA-3lm3A:
undetectable		 2vqyA-3lm3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrh ANTI-HUNTINGTIN VL
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		3 TRP A  36
GLN A  38
TRP A  99
 None
 1.36A 2vqyA-3lrhA:
undetectable		 2vqyA-3lrhA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		3 TRP B 154
GLN B 169
TRP B 143
 None
 1.16A 2vqyA-3ml0B:
0.9		 2vqyA-3ml0B:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Escherichia
coli) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 TRP A 391
GLN A 326
TRP A 438
 None
 1.26A 2vqyA-3mogA:
undetectable		 2vqyA-3mogA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng9 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 TRP A 280
GLN A 646
TRP A 247
 None
 1.37A 2vqyA-3ng9A:
undetectable		 2vqyA-3ng9A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		3 TRP A 406
GLN A 577
TRP A 477
 None
 1.35A 2vqyA-3ob8A:
undetectable		 2vqyA-3ob8A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pay PUTATIVE ADHESIN

(Bacteroides
ovatus) 		PF08842
(Mfa2) 		3 TRP A 249
GLN A 214
TRP A 207
 None
 1.35A 2vqyA-3payA:
undetectable		 2vqyA-3payA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg5 UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF13614
(AAA_31) 		3 TRP A 199
GLN A 206
TRP A 140
 None
 1.36A 2vqyA-3pg5A:
undetectable		 2vqyA-3pg5A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 TRP A 282
GLN A 648
TRP A 248
 None
 1.36A 2vqyA-3ra2A:
undetectable		 2vqyA-3ra2A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 TRP A 280
GLN A 646
TRP A 247
 None
 1.29A 2vqyA-3shmA:
undetectable		 2vqyA-3shmA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TRP A 228
GLN A 260
TRP A 272
 None
 0.94A 2vqyA-3t9wA:
undetectable		 2vqyA-3t9wA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbb SMALL LACCASE,
OXIDOREDUCTASE

(Streptomyces
viridosporus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TRP A 235
GLN A 267
TRP A 279
 None
 1.06A 2vqyA-3tbbA:
undetectable		 2vqyA-3tbbA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u8e PAPAIN-LIKE CYSTEINE
PROTEASE

(Crocus sativus) 		PF00112
(Peptidase_C1) 		3 TRP A  26
GLN A  19
TRP A 213
 None
 1.12A 2vqyA-3u8eA:
undetectable		 2vqyA-3u8eA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux1 CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 TRP A 281
GLN A 646
TRP A 247
 None
 1.31A 2vqyA-3ux1A:
undetectable		 2vqyA-3ux1A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwa CYTOPLASMIC EXPORT
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 TRP A 239
GLN A 249
TRP A 148
 None
 1.15A 2vqyA-3vwaA:
undetectable		 2vqyA-3vwaA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w94 ENTEROPEPTIDASE-1

(Oryzias latipes) 		PF00089
(Trypsin) 		3 TRP A 902
GLN A 863
TRP A 926
 None
 1.31A 2vqyA-3w94A:
undetectable		 2vqyA-3w94A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		3 TRP A  43
GLN A 277
TRP A 243
 None
 1.33A 2vqyA-3wrcA:
undetectable		 2vqyA-3wrcA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK

(Streptococcus
pneumoniae) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 TRP A  47
GLN A 134
TRP A 255
 None
 0.98A 2vqyA-4c23A:
undetectable		 2vqyA-4c23A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		3 TRP A 373
GLN A 700
TRP A 706
 None
 1.28A 2vqyA-4cvuA:
undetectable		 2vqyA-4cvuA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA

(Brucella
abortus) 		PF00677
(Lum_binding) 		3 TRP A  80
GLN A 110
TRP A  68
 None
 0.92A 2vqyA-4e0fA:
undetectable		 2vqyA-4e0fA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyb COPPER OXIDASE

(Streptomyces
lividans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TRP A 240
GLN A 272
TRP A 284
 None
 1.00A 2vqyA-4gybA:
undetectable		 2vqyA-4gybA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		3 TRP A 621
GLN A 325
TRP A 269
 None
None
HEM  A 701 (-4.8A)
 1.30A 2vqyA-4hhrA:
undetectable		 2vqyA-4hhrA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzy CRYPTOCHROME-1

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 TRP A 420
GLN A 402
TRP A 394
 FAD  A 601 (-3.6A)
None
None
 1.02A 2vqyA-4jzyA:
undetectable		 2vqyA-4jzyA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0r CRYPTOCHROME-1

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 TRP A 320
GLN A 317
TRP A 399
 None
 1.00A 2vqyA-4k0rA:
undetectable		 2vqyA-4k0rA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8g TUMOR SUPPRESSOR
CANDIDATE 3

(Homo sapiens) 		PF04756
(OST3_OST6) 		3 TRP A 140
GLN A 136
TRP A  75
 None
 1.02A 2vqyA-4m8gA:
undetectable		 2vqyA-4m8gA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME

(Bacillus
licheniformis) 		PF01547
(SBP_bac_1) 		3 TRP A 224
GLN A 409
TRP A 383
 None
None
GLA  A 503 ( 4.0A)
 1.25A 2vqyA-4rk9A:
undetectable		 2vqyA-4rk9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rso CAPSID PROTEIN VP1

(Non-human
primate
Adeno-associated
virus) 		PF00740
(Parvo_coat) 		3 TRP A 281
GLN A 646
TRP A 247
 None
 1.34A 2vqyA-4rsoA:
undetectable		 2vqyA-4rsoA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME

(Bacillus cereus) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		3 TRP A 328
GLN A 334
TRP A 285
 None
 1.40A 2vqyA-4s3jA:
undetectable		 2vqyA-4s3jA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3k SPORE GERMINATION
PROTEIN YAAH

(Bacillus
megaterium) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		3 TRP A 417
GLN A 345
TRP A 407
 None
 1.38A 2vqyA-4s3kA:
undetectable		 2vqyA-4s3kA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8h CRYPTOCHROME-2

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 TRP A 338
GLN A 335
TRP A 417
 None
 0.99A 2vqyA-4u8hA:
undetectable		 2vqyA-4u8hA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1t COPPER OXIDASE

(Streptomyces
sviceus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TRP A 237
GLN A 269
TRP A 281
 None
 1.06A 2vqyA-4w1tA:
undetectable		 2vqyA-4w1tA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcj POLYSACCHARIDE
DEACETYLASE

(Ammonifex
degensii) 		PF01522
(Polysacc_deac_1) 		3 TRP A 156
GLN A 158
TRP A 148
 None
 1.30A 2vqyA-4wcjA:
0.3		 2vqyA-4wcjA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrl MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF00047
(ig) 		3 TRP A  58
GLN A  77
TRP A 159
 None
FUC  A 402 (-4.0A)
None
 1.08A 2vqyA-4wrlA:
undetectable		 2vqyA-4wrlA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF00047
(ig)
PF13927
(Ig_3) 		3 TRP A  58
GLN A  77
TRP A 159
 None
 0.94A 2vqyA-4wrmA:
undetectable		 2vqyA-4wrmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xac EVDO2

(Micromonospora
carbonacea) 		PF05721
(PhyH) 		3 TRP A 147
GLN A  74
TRP A 128
 AKG  A 303 (-4.0A)
None
None
 1.16A 2vqyA-4xacA:
undetectable		 2vqyA-4xacA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuo ENDO-1,4-BETA-XYLANA
SE C

(Paenibacillus
barcinonensis) 		PF02018
(CBM_4_9) 		3 TRP A 118
GLN A  41
TRP A  24
 None
 1.18A 2vqyA-4xuoA:
undetectable		 2vqyA-4xuoA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xup ENDO-1,4-BETA-XYLANA
SE C

(Paenibacillus
barcinonensis) 		PF02018
(CBM_4_9) 		3 TRP A 118
GLN A  41
TRP A  24
 None
 1.17A 2vqyA-4xupA:
undetectable		 2vqyA-4xupA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis) 		PF01977
(UbiD) 		3 TRP A 163
GLN A 196
TRP A 205
 None
4LU  A 603 (-3.4A)
None
 1.09A 2vqyA-4zadA:
undetectable		 2vqyA-4zadA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zid CYTOCHROME C-552

(Hydrogenobacter
thermophilus) 		PF00034
(Cytochrom_C) 		3 TRP A  75
GLN A  74
TRP A  54
 None
 1.38A 2vqyA-4zidA:
undetectable		 2vqyA-4zidA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu2 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		3 TRP A 336
GLN A 350
TRP A 422
 None
 1.35A 2vqyA-5bu2A:
undetectable		 2vqyA-5bu2A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		3 TRP A 150
GLN A 177
TRP A 185
 ACT  A 814 (-2.8A)
None
None
 1.21A 2vqyA-5bv9A:
undetectable		 2vqyA-5bv9A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5h 2-SUCCINYLBENZOATE--
COA LIGASE

(Escherichia
coli) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 TRP A  30
GLN A  27
TRP A 178
 None
 1.02A 2vqyA-5c5hA:
undetectable		 2vqyA-5c5hA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9l PLL LECTIN

(Photorhabdus
luminescens) 		PF03984
(DUF346) 		3 TRP A 294
GLN A 342
TRP A 291
 None
None
EDO  A 409 (-3.7A)
 1.20A 2vqyA-5c9lA:
undetectable		 2vqyA-5c9lA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iu0 RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN 1B,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 3 TRP J  67
GLN J 111
TRP J  70
 None
 1.23A 2vqyA-5iu0J:
undetectable		 2vqyA-5iu0J:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m62 C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER K

(Mus musculus) 		PF00059
(Lectin_C) 		3 TRP A 269
GLN A 272
TRP A 255
 None
 1.33A 2vqyA-5m62A:
undetectable		 2vqyA-5m62A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		3 TRP A 389
GLN A 315
TRP A 400
 None
 1.38A 2vqyA-5mqsA:
undetectable		 2vqyA-5mqsA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swn FLUOROACETATE
DEHALOGENASE

(Rhodopseudomonas
palustris) 		PF00561
(Abhydrolase_1) 		3 TRP A 185
GLN A 255
TRP A 142
 None
 0.80A 2vqyA-5swnA:
undetectable		 2vqyA-5swnA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1

(Alicyclobacillus
acidoterrestris) 		no annotation 3 TRP A 733
GLN A 644
TRP A 723
 None
None
C  B  47 ( 4.5A)
 0.81A 2vqyA-5u30A:
undetectable		 2vqyA-5u30A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		3 TRP A 164
GLN A 166
TRP A 103
 None
 1.27A 2vqyA-5ujuA:
undetectable		 2vqyA-5ujuA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uro PREDICTED PROTEIN

(Trichoderma
reesei) 		PF00561
(Abhydrolase_1) 		3 TRP A 251
GLN A 240
TRP A  53
 None
 1.34A 2vqyA-5uroA:
1.7		 2vqyA-5uroA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3l C5 ANTIBODY VARIABLE
HEAVY DOMAIN
VIRAL PROTEIN 3

(Mus musculus;
Rhinovirus B) 		PF00073
(Rhv)
PF07686
(V-set) 		3 TRP B 190
GLN B 192
TRP E  52
 None
 1.22A 2vqyA-5w3lB:
undetectable		 2vqyA-5w3lB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5we1 PROTECTION OF
TELOMERES PROTEIN
POZ1,PROTECTION OF
TELOMERES PROTEIN
POZ1

(Schizosaccharomyces
pombe) 		no annotation 3 TRP A  91
GLN A 159
TRP A 174
 None
 1.13A 2vqyA-5we1A:
undetectable		 2vqyA-5we1A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsk RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN

(Triticum
aestivum) 		no annotation 3 TRP E 113
GLN E 157
TRP E 116
 None
 1.14A 2vqyA-5wskE:
undetectable		 2vqyA-5wskE:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxf PROTECTION OF
TELOMERES PROTEIN
POZ1

(Schizosaccharomyces
pombe) 		no annotation 3 TRP A  91
GLN A 159
TRP A 174
 None
 1.29A 2vqyA-5xxfA:
undetectable		 2vqyA-5xxfA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 3 TRP A1064
GLN A 892
TRP A1079
 None
 1.29A 2vqyA-6b3rA:
undetectable		 2vqyA-6b3rA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4c ALPHA-GALACTOSIDASE

(Nicotiana
benthamiana) 		no annotation 3 TRP B 288
GLN B 328
TRP B 385
 None
 1.33A 2vqyA-6f4cB:
undetectable		 2vqyA-6f4cB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea NITROGENASE PROTEIN
ALPHA CHAIN

(Azotobacter
vinelandii) 		no annotation 3 TRP A 282
GLN A 214
TRP A 224
 None
 1.09A 2vqyA-6feaA:
undetectable		 2vqyA-6feaA:
19.69