SIMILAR PATTERNS OF AMINO ACIDS FOR 2VQY_A_PARA1201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		5 GLY A 145
TYR A 275
VAL A 283
TYR A 218
SER A 222
 None
 1.35A 2vqyA-1a27A:
undetectable		 2vqyA-1a27A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		5 GLY A 266
TYR A 302
LEU A 286
TYR A 327
SER A 179
 COA  A 380 (-3.5A)
None
None
None
None
 1.35A 2vqyA-1a59A:
0.0		 2vqyA-1a59A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b43 PROTEIN (FEN-1)

(Pyrococcus
furiosus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 GLY A 239
GLU A 114
GLN A 121
ASP A 235
ASP A 174
 None
 1.44A 2vqyA-1b43A:
0.0		 2vqyA-1b43A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 GLY A  97
TYR A 208
LEU A 170
VAL A 167
SER A 119
 None
 1.50A 2vqyA-1dj2A:
0.0		 2vqyA-1dj2A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqs PROTEIN
(3-DEHYDROQUINATE
SYNTHASE)

(Aspergillus
nidulans) 		PF01761
(DHQ_synthase) 		5 GLY A 114
GLU A 278
VAL A 291
ASP A 146
ASP A 119
 NAD  A 400 (-3.0A)
NAD  A 400 ( 4.8A)
None
CRB  A 401 ( 2.9A)
NAD  A 400 (-3.1A)
 1.17A 2vqyA-1dqsA:
undetectable		 2vqyA-1dqsA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		5 GLY A 442
TYR A 196
LEU A 199
VAL A 280
SER A 282
 None
 1.35A 2vqyA-1e6zA:
0.0		 2vqyA-1e6zA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g2p ADENINE
PHOSPHORIBOSYLTRANSF
ERASE 1

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		5 GLY A 136
TYR A 155
LEU A 152
GLU A 146
VAL A 145
 SO4  A 301 (-3.8A)
None
None
None
None
 1.20A 2vqyA-1g2pA:
0.0		 2vqyA-1g2pA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		5 GLY S 212
TYR S 154
VAL S 197
SER S 199
ASP S 139
 None
 1.46A 2vqyA-1i84S:
undetectable		 2vqyA-1i84S:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 GLY A 999
TYR A1051
LEU A1006
GLU A1004
VAL A1005
 None
 1.42A 2vqyA-1jx2A:
0.0		 2vqyA-1jx2A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		5 GLY A 290
VAL A  55
SER A  63
ASP A 358
ASP A 261
 None
None
None
IMP  A 801 (-2.5A)
TAD  A 901 (-2.3A)
 1.42A 2vqyA-1lrtA:
0.1		 2vqyA-1lrtA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3f TRNA PSEUDOURIDINE
SYNTHASE B

(Escherichia
coli) 		PF01509
(TruB_N)
PF09157
(TruB-C_2)
PF16198
(TruB_C_2) 		5 GLY A 177
TYR A  76
LEU A 200
VAL A 197
SER A  89
 None
 1.29A 2vqyA-1r3fA:
undetectable		 2vqyA-1r3fA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		5 GLY A 382
TYR A  48
VAL A  44
ASP A 415
ASP A 413
 None
 1.45A 2vqyA-1uz4A:
0.0		 2vqyA-1uz4A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb4 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		5 GLY A 142
TYR A 145
LEU A 200
VAL A 197
SER A 122
 None
 1.37A 2vqyA-1vb4A:
undetectable		 2vqyA-1vb4A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xaj 3-DEHYDROQUINATE
SYNTHASE

(Staphylococcus
aureus) 		PF01761
(DHQ_synthase) 		5 GLY A  99
GLU A 249
VAL A 260
ASP A 130
ASP A 104
 NAD  A 400 (-3.5A)
NAD  A 400 ( 4.8A)
None
CRB  A 500 ( 3.2A)
NAD  A 400 (-2.9A)
 1.25A 2vqyA-1xajA:
undetectable		 2vqyA-1xajA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		5 TYR A 255
LEU A  51
GLU A  54
VAL A  56
GLN A 262
 None
 1.32A 2vqyA-2g37A:
undetectable		 2vqyA-2g37A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2)
no annotation 		5 GLY I 250
LEU I 127
VAL I  96
TYR A  48
SER A  52
 None
 1.08A 2vqyA-2gk1I:
undetectable		 2vqyA-2gk1I:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3g BIOSYNTHETIC PROTEIN

(Bacillus
anthracis) 		PF03309
(Pan_kinase) 		5 GLY X 222
LEU X  22
ASP X   6
ASP X 109
ASP X 129
 None
None
EDO  X 501 (-3.6A)
None
None
 1.34A 2vqyA-2h3gX:
undetectable		 2vqyA-2h3gX:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 LEU A 117
GLU A 114
GLN A 146
SER A 110
ASP A 142
 None
 1.46A 2vqyA-2jg5A:
undetectable		 2vqyA-2jg5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prv UNCHARACTERIZED
PROTEIN YOBK

(Bacillus
subtilis) 		PF14567
(SUKH_5) 		5 GLY A  53
TYR A  43
LEU A 100
VAL A 112
TYR A  98
 None
 1.50A 2vqyA-2prvA:
undetectable		 2vqyA-2prvA:
23.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qir AMINOGLYCOSIDE
6-N-ACETYLTRANSFERAS
E TYPE IB11

(Salmonella
enterica) 		PF13523
(Acetyltransf_8) 		8 TYR A  55
LEU A  60
GLU A  63
VAL A  65
GLN A  81
TYR A  83
SER A  88
ASP A 105
 None
None
9CS  A 501 (-4.6A)
None
9CS  A 501 (-4.0A)
9CS  A 501 (-3.4A)
9CS  A 501 (-3.0A)
9CS  A 501 (-2.9A)
 0.79A 2vqyA-2qirA:
32.8		 2vqyA-2qirA:
90.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qir AMINOGLYCOSIDE
6-N-ACETYLTRANSFERAS
E TYPE IB11

(Salmonella
enterica) 		PF13523
(Acetyltransf_8) 		10 TYR A  55
LEU A  60
VAL A  65
GLN A  81
TYR A  83
SER A  88
TRP A  92
ASP A 105
ASP A 142
ASP A 169
 None
None
None
9CS  A 501 (-4.0A)
9CS  A 501 (-3.4A)
9CS  A 501 (-3.0A)
9CS  A 501 (-4.1A)
9CS  A 501 (-2.9A)
9CS  A 501 (-2.5A)
None
 0.38A 2vqyA-2qirA:
32.8		 2vqyA-2qirA:
90.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A 151
LEU A 165
VAL A  72
TRP A 159
ASP A  50
 None
 0.85A 2vqyA-2qyvA:
undetectable		 2vqyA-2qyvA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A 154
LEU A 165
VAL A  72
TRP A 159
ASP A  50
 None
 1.22A 2vqyA-2qyvA:
undetectable		 2vqyA-2qyvA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq0 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		5 GLY A 142
TYR A 145
LEU A 200
VAL A 197
SER A 122
 None
 1.39A 2vqyA-2vq0A:
undetectable		 2vqyA-2vq0A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA

(Homo sapiens) 		PF01504
(PIP5K) 		5 GLY A 106
TYR A 142
LEU A 116
VAL A  45
ASP A 109
 None
 1.44A 2vqyA-2ybxA:
undetectable		 2vqyA-2ybxA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 GLY A 191
TYR A 307
LEU A 301
VAL A 297
ASP A 313
 None
 1.38A 2vqyA-3b9eA:
undetectable		 2vqyA-3b9eA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA

(Lactococcus
lactis) 		PF00496
(SBP_bac_5) 		5 GLY A 245
LEU A 102
GLU A 113
VAL A 114
SER A 112
 None
 1.34A 2vqyA-3drkA:
undetectable		 2vqyA-3drkA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g87 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Burkholderia
pseudomallei) 		PF00698
(Acyl_transf_1) 		5 GLY A 110
LEU A  88
VAL A 223
TYR A 232
SER A 225
 None
 1.25A 2vqyA-3g87A:
undetectable		 2vqyA-3g87A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs9 PROTEIN GP18

(Listeria
monocytogenes) 		PF06605
(Prophage_tail) 		5 GLY A 106
LEU A 152
GLN A 155
ASP A 159
ASP A 246
 None
 1.42A 2vqyA-3gs9A:
undetectable		 2vqyA-3gs9A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 GLY A 225
TYR A  56
LEU A  52
GLN A 147
TYR A 143
 EDO  A 608 (-3.4A)
EDO  A 609 (-4.0A)
None
None
None
 1.05A 2vqyA-3hdxA:
undetectable		 2vqyA-3hdxA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrx PROBABLE ENOYL-COA
HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		5 GLY A  52
LEU A  87
VAL A  83
TYR A  80
SER A 137
 None
 1.46A 2vqyA-3hrxA:
undetectable		 2vqyA-3hrxA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 TYR A  54
LEU A  58
SER A 124
ASP A  41
ASP A 153
 MPD  A 505 (-4.6A)
None
None
None
ZN  A 502 (-2.6A)
 1.29A 2vqyA-3jv7A:
undetectable		 2vqyA-3jv7A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvd LIPOPROTEIN

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		5 GLY D 229
LEU D 289
VAL D 299
SER D 169
ASP D 136
 None
 1.32A 2vqyA-3kvdD:
undetectable		 2vqyA-3kvdD:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nsj PERFORIN-1

(Mus musculus) 		PF00168
(C2)
PF01823
(MACPF) 		5 GLY A  56
TYR A 218
LEU A 214
GLU A 213
TYR A 366
 None
 1.47A 2vqyA-3nsjA:
undetectable		 2vqyA-3nsjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujp MN TRANSPORTER
SUBUNIT

(Synechocystis
sp. PCC 6803) 		PF01297
(ZnuA) 		5 GLY A 136
TYR A 165
LEU A  64
TYR A 109
SER A 130
 None
 1.42A 2vqyA-3ujpA:
undetectable		 2vqyA-3ujpA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w95 GENOME POLYPROTEIN

(Enterovirus A) 		PF00947
(Pico_P2A) 		5 GLY A 111
VAL A  84
GLN A  95
SER A  87
ASP A  39
 None
 1.34A 2vqyA-3w95A:
undetectable		 2vqyA-3w95A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkx XA4815

(Lama glama) 		PF07686
(V-set) 		5 GLY C 185
TYR C 257
LEU C 238
GLU C 165
SER C 166
 None
 1.43A 2vqyA-3zkxC:
undetectable		 2vqyA-3zkxC:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zok 3-DEHYDROQUINATE
SYNTHASE

(Actinidia
chinensis) 		PF01761
(DHQ_synthase) 		5 GLY A 118
GLU A 268
VAL A 282
ASP A 150
ASP A 123
 NAD  A1381 (-3.3A)
None
None
NAD  A1381 ( 3.2A)
NAD  A1381 (-3.0A)
 1.12A 2vqyA-3zokA:
undetectable		 2vqyA-3zokA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C

(Homo sapiens) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 GLU A 271
VAL A 270
GLN A 246
TRP A 249
ASP A 222
 None
 1.48A 2vqyA-3zyjA:
undetectable		 2vqyA-3zyjA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be3 ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		5 GLY A 153
TYR A 287
LEU A 254
GLU A 115
GLN A 292
 None
 1.35A 2vqyA-4be3A:
undetectable		 2vqyA-4be3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Escherichia
coli) 		PF04378
(RsmJ) 		5 GLY A  99
TYR A  38
LEU A 160
ASP A 164
ASP A  15
 EDO  A1283 ( 3.8A)
None
None
TRS  A1281 ( 3.0A)
EDO  A1283 ( 2.8A)
 1.47A 2vqyA-4bluA:
1.1		 2vqyA-4bluA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecp INORGANIC
PYROPHOSPHATASE

(Mycobacterium
leprae) 		PF00719
(Pyrophosphatase) 		5 GLY A  53
GLU A  18
TYR A  42
ASP A  57
ASP A  89
 None
None
None
EDO  A 201 (-3.0A)
EDO  A 201 (-3.1A)
 1.31A 2vqyA-4ecpA:
undetectable		 2vqyA-4ecpA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fiu HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 GLY A 318
TYR A  12
LEU A 330
ASP A 437
ASP A 433
 None
 1.40A 2vqyA-4fiuA:
undetectable		 2vqyA-4fiuA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 GLY A 514
SER A 493
ASP A 509
ASP A 746
ASP A 459
 None
None
ZN  A1003 (-2.2A)
ZN  A1003 (-2.4A)
None
 1.24A 2vqyA-4g9iA:
undetectable		 2vqyA-4g9iA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4icq AMINOPEPTIDASE PEPS

(Streptococcus
pneumoniae) 		PF02073
(Peptidase_M29) 		5 GLY A 318
LEU A 222
VAL A 267
SER A 269
ASP A 383
 None
None
None
None
ZN  A 501 (-2.2A)
 1.42A 2vqyA-4icqA:
undetectable		 2vqyA-4icqA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TYR A 326
VAL A  52
TYR A  56
SER A  24
ASP A 194
 None
4OP  A 416 ( 4.7A)
4OP  A 416 (-4.4A)
None
MG  A 414 ( 2.6A)
 1.47A 2vqyA-4izgA:
undetectable		 2vqyA-4izgA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TYR A 326
VAL A  52
TYR A  56
SER A  24
ASP A 242
 None
4OP  A 416 ( 4.7A)
4OP  A 416 (-4.4A)
None
MG  A 414 ( 3.1A)
 1.29A 2vqyA-4izgA:
undetectable		 2vqyA-4izgA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43

(Thermotoga
petrophila) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		5 GLY A 324
LEU A 440
VAL A 438
TYR A 421
ASP A 232
 None
 1.45A 2vqyA-4kc8A:
undetectable		 2vqyA-4kc8A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 GLY A 315
LEU A 369
VAL A 349
TYR A 324
SER A 347
 None
 1.24A 2vqyA-4om9A:
undetectable		 2vqyA-4om9A:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Alicyclobacillus
acidocaldarius) 		PF13416
(SBP_bac_8) 		5 TYR A 243
LEU A 247
VAL A 253
SER A 277
ASP A 205
 None
 1.31A 2vqyA-4ovjA:
undetectable		 2vqyA-4ovjA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qc6 BIFUNCTIONAL AAC/APH

(Staphylococcus
warneri) 		PF13523
(Acetyltransf_8) 		6 GLY A  35
TYR A  50
GLN A  74
TYR A  76
ASP A  99
ASP A 136
 FMT  A 203 ( 3.5A)
KAN  A 201 ( 3.9A)
KAN  A 201 (-3.1A)
None
KAN  A 201 ( 3.9A)
KAN  A 201 (-3.8A)
 0.87A 2vqyA-4qc6A:
20.1		 2vqyA-4qc6A:
28.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		5 GLY A 176
LEU A  76
GLN A 151
SER A 309
ASP A  60
 None
17E  A 501 (-4.9A)
17E  A 501 (-2.9A)
17E  A 501 (-3.2A)
None
 1.28A 2vqyA-4r85A:
0.2		 2vqyA-4r85A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		5 GLY A 177
LEU A  76
GLN A 151
SER A 309
ASP A  60
 None
17E  A 501 (-4.9A)
17E  A 501 (-2.9A)
17E  A 501 (-3.2A)
None
 1.43A 2vqyA-4r85A:
0.2		 2vqyA-4r85A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster) 		PF07034
(ORC3_N)
PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 GLY E  46
LEU E 249
TYR E 291
SER C 259
ASP E 243
 CL  E 501 (-3.9A)
None
None
None
None
 1.29A 2vqyA-4xgcE:
undetectable		 2vqyA-4xgcE:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE

(Bacillus cereus) 		PF05547
(Peptidase_M6) 		5 GLY A 257
LEU A  57
GLU A 321
ASP A 329
ASP A 259
 None
None
None
None
CA  A1004 (-3.3A)
 1.41A 2vqyA-4yu5A:
undetectable		 2vqyA-4yu5A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvn 3-DEHYDROQUINATE
SYNTHASE

(Francisella
tularensis) 		PF01761
(DHQ_synthase) 		5 GLY A 104
GLU A 254
VAL A 268
ASP A 136
ASP A 109
 NAD  A 401 (-3.4A)
None
None
NAD  A 401 (-3.6A)
NAD  A 401 (-3.3A)
 1.22A 2vqyA-5hvnA:
undetectable		 2vqyA-5hvnA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Paraburkholderia
xenovorans) 		PF00483
(NTP_transferase) 		5 GLY A 203
TYR A 208
LEU A 111
ASP A 134
ASP A 255
 None
 1.43A 2vqyA-5j49A:
undetectable		 2vqyA-5j49A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m42 PROLINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		5 TYR A 255
LEU A  51
GLU A  54
VAL A  56
GLN A 262
 None
 1.31A 2vqyA-5m42A:
undetectable		 2vqyA-5m42A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpr 3-DEHYDROQUINATE
SYNTHASE

(Trichormus
variabilis) 		PF01761
(DHQ_synthase) 		5 GLY A 118
GLU A 278
VAL A 291
ASP A 150
ASP A 123
 NAD  A 503 ( 3.2A)
NAD  A 503 ( 4.7A)
None
NAD  A 503 ( 2.3A)
NAD  A 503 (-2.1A)
 1.16A 2vqyA-5tprA:
undetectable		 2vqyA-5tprA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE

(Streptomyces
platensis) 		PF13714
(PEP_mutase) 		5 GLY A 102
TYR A 116
ASP A  98
ASP A  71
ASP A  73
 None
None
TLA  A 401 (-3.3A)
TLA  A 401 (-3.1A)
None
 1.38A 2vqyA-5uncA:
undetectable		 2vqyA-5uncA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE

(Homo sapiens) 		no annotation 5 GLY A  94
LEU A  24
VAL A  47
TYR A  81
ASP A  89
 None
 1.35A 2vqyA-5wy0A:
2.2		 2vqyA-5wy0A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE

(Escherichia
coli) 		no annotation 5 TYR A  49
GLN A  73
TYR A  75
ASP A  98
ASP A 135
 None
None
None
MG  A 201 (-2.8A)
MG  A 201 (-2.7A)
 0.81A 2vqyA-6bffA:
21.2		 2vqyA-6bffA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6c TOBACCO RINGSPOT
VIRUS CAPSID PROTEIN

(Tobacco
ringspot virus) 		PF03391
(Nepo_coat)
PF03688
(Nepo_coat_C)
PF03689
(Nepo_coat_N) 		3 TRP A 181
GLN A 184
TRP A 506
 None
 1.23A 2vqyA-1a6cA:
0.0		 2vqyA-1a6cA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgf STAT-4

(Mus musculus) 		PF02865
(STAT_int) 		3 TRP A   4
GLN A   6
TRP A  43
 None
 1.38A 2vqyA-1bgfA:
undetectable		 2vqyA-1bgfA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		3 TRP B 154
GLN B 169
TRP B 143
 None
 1.28A 2vqyA-1cp9B:
0.0		 2vqyA-1cp9B:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de6 L-RHAMNOSE ISOMERASE

(Escherichia
coli) 		PF06134
(RhaA) 		3 TRP A  17
GLN A  22
TRP A 392
 None
 0.87A 2vqyA-1de6A:
0.0		 2vqyA-1de6A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		3 TRP A  57
GLN A  59
TRP A 461
 None
 1.29A 2vqyA-1fwxA:
0.8		 2vqyA-1fwxA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir1 SMALL SUBUNIT OF
RUBISCO

(Spinacia
oleracea) 		PF00101
(RuBisCO_small) 		3 TRP S  67
GLN S 111
TRP S  70
 None
 1.30A 2vqyA-1ir1S:
0.0		 2vqyA-1ir1S:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I

(Escherichia
coli) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 TRP A 184
GLN A 450
TRP A 390
 None
 1.39A 2vqyA-1k0gA:
0.0		 2vqyA-1k0gA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4n PROTEIN EC4020

(Escherichia
coli) 		PF06185
(YecM) 		3 TRP A 115
GLN A   9
TRP A  95
 None
 1.31A 2vqyA-1k4nA:
undetectable		 2vqyA-1k4nA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5s PENICILLIN G ACYLASE
BETA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		3 TRP B 154
GLN B 169
TRP B 143
 None
 1.32A 2vqyA-1k5sB:
0.0		 2vqyA-1k5sB:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks8 ENDO-B-1,4-GLUCANASE

(Nasutitermes
takasagoensis) 		PF00759
(Glyco_hydro_9) 		3 TRP A 247
GLN A 261
TRP A 253
 None
 1.29A 2vqyA-1ks8A:
0.0		 2vqyA-1ks8A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 TRP A 240
GLN A 324
TRP A 393
 None
 0.95A 2vqyA-1ksiA:
undetectable		 2vqyA-1ksiA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odh MGCM1

(Mus musculus) 		PF03615
(GCM) 		3 TRP A 137
GLN A 147
TRP A  36
 None
 1.22A 2vqyA-1odhA:
undetectable		 2vqyA-1odhA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjz THIOPURINE
S-METHYLTRANSFERASE

(Pseudomonas
syringae) 		PF05724
(TPMT) 		3 TRP A 166
GLN A 155
TRP A  13
 None
 1.01A 2vqyA-1pjzA:
2.4		 2vqyA-1pjzA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		3 TRP M  75
GLN M  77
TRP L 266
 CRT  M 304 (-4.4A)
None
None
 1.19A 2vqyA-1pssM:
undetectable		 2vqyA-1pssM:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ql0 NUCLEASE

(Serratia
marcescens) 		PF01223
(Endonuclease_NS) 		3 TRP A 123
GLN A 192
TRP A  41
 None
 1.12A 2vqyA-1ql0A:
undetectable		 2vqyA-1ql0A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s6r BETA-LACTAMASE

(Enterobacter
cloacae) 		PF00144
(Beta-lactamase) 		3 TRP A 101
GLN A 102
TRP A 142
 None
 1.20A 2vqyA-1s6rA:
undetectable		 2vqyA-1s6rA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te5 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF13230
(GATase_4) 		3 TRP A 244
GLN A 239
TRP A 248
 None
 1.15A 2vqyA-1te5A:
undetectable		 2vqyA-1te5A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uas ALPHA-GALACTOSIDASE

(Oryza sativa) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		3 TRP A 237
GLN A 277
TRP A 334
 None
 1.36A 2vqyA-1uasA:
undetectable		 2vqyA-1uasA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 TRP A 243
GLN A 242
TRP A  89
 None
 1.37A 2vqyA-1w99A:
undetectable		 2vqyA-1w99A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfg REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2

(Homo sapiens) 		PF00595
(PDZ) 		3 TRP A  93
GLN A 118
TRP A  18
 None
 1.35A 2vqyA-1wfgA:
undetectable		 2vqyA-1wfgA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xyn ENDO-1,4-BETA-XYLANA
SE I

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		3 TRP A 146
GLN A 140
TRP A  68
 None
 1.32A 2vqyA-1xynA:
undetectable		 2vqyA-1xynA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		3 TRP A 144
GLN A 101
TRP A 155
 C  C   8 ( 4.1A)
None
None
 1.12A 2vqyA-1yvpA:
undetectable		 2vqyA-1yvpA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bod ENDOGLUCANASE E-2

(Thermobifida
fusca) 		PF01341
(Glyco_hydro_6) 		3 TRP X  97
GLN X  49
TRP X  41
 None
None
BGC  X1290 ( 3.5A)
 1.36A 2vqyA-2bodX:
0.0		 2vqyA-2bodX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dk7 TRANSCRIPTION
ELONGATION REGULATOR
1

(Homo sapiens) 		PF00397
(WW) 		3 TRP A  26
GLN A  61
TRP A  22
 None
 1.33A 2vqyA-2dk7A:
undetectable		 2vqyA-2dk7A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		3 TRP A 312
GLN A 311
TRP A  79
 UDP  A1424 (-3.6A)
None
ZIO  A1425 (-3.8A)
 1.28A 2vqyA-2iyaA:
undetectable		 2vqyA-2iyaA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nun AVIRULENCE B PROTEIN

(Pseudomonas
savastanoi) 		PF05394
(AvrB_AvrC) 		3 TRP A 257
GLN A 236
TRP A  92
 None
 1.39A 2vqyA-2nunA:
undetectable		 2vqyA-2nunA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 TRP A  39
GLN A 445
TRP A 414
 None
None
PRX  A 998 (-3.4A)
 1.00A 2vqyA-2p2mA:
undetectable		 2vqyA-2p2mA:
15.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qir AMINOGLYCOSIDE
6-N-ACETYLTRANSFERAS
E TYPE IB11

(Salmonella
enterica) 		PF13523
(Acetyltransf_8) 		3 TRP A  39
GLN A  54
TRP A  93
 9CS  A 501 (-4.1A)
None
9CS  A 501 (-4.3A)
 0.23A 2vqyA-2qirA:
32.8		 2vqyA-2qirA:
90.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB

(Salmonella
enterica) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		3 TRP A 203
GLN A 194
TRP A 269
 GOL  A1449 (-4.3A)
None
None
 1.18A 2vqyA-2wnwA:
undetectable		 2vqyA-2wnwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		3 TRP A 273
GLN A 306
TRP A 377
 CBI  A 459 (-3.9A)
CBI  A 459 (-3.4A)
None
 1.03A 2vqyA-3axxA:
undetectable		 2vqyA-3axxA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		3 TRP A 377
GLN A 359
TRP A 273
 None
None
CBI  A 459 (-3.9A)
 1.34A 2vqyA-3axxA:
undetectable		 2vqyA-3axxA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		3 TRP A 400
GLN A 422
TRP A 292
 GOL  A 440 (-4.5A)
None
None
 1.28A 2vqyA-3cc1A:
undetectable		 2vqyA-3cc1A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czp PUTATIVE
POLYPHOSPHATE KINASE
2

(Pseudomonas
aeruginosa) 		PF03976
(PPK2) 		3 TRP A 444
GLN A 446
TRP A 438
 None
 1.30A 2vqyA-3czpA:
undetectable		 2vqyA-3czpA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora) 		PF06722
(DUF1205) 		3 TRP A 191
GLN A 300
TRP A 268
 None
 1.14A 2vqyA-3d0qA:
undetectable		 2vqyA-3d0qA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgt PUTATIVE
PHOSPHOLIPASE B-LIKE
2 28 KDA FORM
PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM

(Mus musculus) 		PF04916
(Phospholip_B) 		3 TRP A 170
GLN B 343
TRP B 351
 None
 1.04A 2vqyA-3fgtA:
undetectable		 2vqyA-3fgtA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2

(Mus musculus) 		PF04916
(Phospholip_B) 		3 TRP A 170
GLN A 343
TRP A 351
 None
 1.06A 2vqyA-3fgwA:
1.4		 2vqyA-3fgwA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxt NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 6

(Homo sapiens) 		no annotation 3 TRP A  85
GLN A  83
TRP A 128
 None
 0.81A 2vqyA-3fxtA:
5.5		 2vqyA-3fxtA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic8 UNCHARACTERIZED
GST-LIKE
PROTEINPROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 TRP A 156
GLN A 112
TRP A 190
 None
 1.38A 2vqyA-3ic8A:
undetectable		 2vqyA-3ic8A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijl MUCONATE
CYCLOISOMERASE

(Bacteroides
thetaiotaomicron) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TRP A 229
GLN A 227
TRP A 264
 None
 1.33A 2vqyA-3ijlA:
undetectable		 2vqyA-3ijlA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipo PUTATIVE THIOSULFATE
SULFURTRANSFERASE
YNJE

(Escherichia
coli) 		PF00581
(Rhodanese) 		3 TRP A 261
GLN A 259
TRP A  54
 None
 1.27A 2vqyA-3ipoA:
undetectable		 2vqyA-3ipoA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		3 TRP B2219
GLN B2222
TRP B2271
 None
 1.14A 2vqyA-3j2sB:
1.1		 2vqyA-3j2sB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kie CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 TRP A 279
GLN A 646
TRP A 247
 None
 1.28A 2vqyA-3kieA:
undetectable		 2vqyA-3kieA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw8 PUTATIVE COPPER
OXIDASE

(Streptomyces
coelicolor) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TRP A 240
GLN A 272
TRP A 284
 None
 1.02A 2vqyA-3kw8A:
undetectable		 2vqyA-3kw8A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12979
(DUF3863)
PF12980
(DUF3864) 		3 TRP A 281
GLN A 258
TRP A 314
 None
 1.22A 2vqyA-3lm3A:
undetectable		 2vqyA-3lm3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrh ANTI-HUNTINGTIN VL
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		3 TRP A  36
GLN A  38
TRP A  99
 None
 1.36A 2vqyA-3lrhA:
undetectable		 2vqyA-3lrhA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		3 TRP B 154
GLN B 169
TRP B 143
 None
 1.16A 2vqyA-3ml0B:
0.9		 2vqyA-3ml0B:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Escherichia
coli) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 TRP A 391
GLN A 326
TRP A 438
 None
 1.26A 2vqyA-3mogA:
undetectable		 2vqyA-3mogA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng9 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 TRP A 280
GLN A 646
TRP A 247
 None
 1.37A 2vqyA-3ng9A:
undetectable		 2vqyA-3ng9A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		3 TRP A 406
GLN A 577
TRP A 477
 None
 1.35A 2vqyA-3ob8A:
undetectable		 2vqyA-3ob8A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pay PUTATIVE ADHESIN

(Bacteroides
ovatus) 		PF08842
(Mfa2) 		3 TRP A 249
GLN A 214
TRP A 207
 None
 1.35A 2vqyA-3payA:
undetectable		 2vqyA-3payA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg5 UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF13614
(AAA_31) 		3 TRP A 199
GLN A 206
TRP A 140
 None
 1.36A 2vqyA-3pg5A:
undetectable		 2vqyA-3pg5A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 TRP A 282
GLN A 648
TRP A 248
 None
 1.36A 2vqyA-3ra2A:
undetectable		 2vqyA-3ra2A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 TRP A 280
GLN A 646
TRP A 247
 None
 1.29A 2vqyA-3shmA:
undetectable		 2vqyA-3shmA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TRP A 228
GLN A 260
TRP A 272
 None
 0.94A 2vqyA-3t9wA:
undetectable		 2vqyA-3t9wA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbb SMALL LACCASE,
OXIDOREDUCTASE

(Streptomyces
viridosporus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TRP A 235
GLN A 267
TRP A 279
 None
 1.06A 2vqyA-3tbbA:
undetectable		 2vqyA-3tbbA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u8e PAPAIN-LIKE CYSTEINE
PROTEASE

(Crocus sativus) 		PF00112
(Peptidase_C1) 		3 TRP A  26
GLN A  19
TRP A 213
 None
 1.12A 2vqyA-3u8eA:
undetectable		 2vqyA-3u8eA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux1 CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 TRP A 281
GLN A 646
TRP A 247
 None
 1.31A 2vqyA-3ux1A:
undetectable		 2vqyA-3ux1A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwa CYTOPLASMIC EXPORT
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 TRP A 239
GLN A 249
TRP A 148
 None
 1.15A 2vqyA-3vwaA:
undetectable		 2vqyA-3vwaA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w94 ENTEROPEPTIDASE-1

(Oryzias latipes) 		PF00089
(Trypsin) 		3 TRP A 902
GLN A 863
TRP A 926
 None
 1.31A 2vqyA-3w94A:
undetectable		 2vqyA-3w94A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		3 TRP A  43
GLN A 277
TRP A 243
 None
 1.33A 2vqyA-3wrcA:
undetectable		 2vqyA-3wrcA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK

(Streptococcus
pneumoniae) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 TRP A  47
GLN A 134
TRP A 255
 None
 0.98A 2vqyA-4c23A:
undetectable		 2vqyA-4c23A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		3 TRP A 373
GLN A 700
TRP A 706
 None
 1.28A 2vqyA-4cvuA:
undetectable		 2vqyA-4cvuA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA

(Brucella
abortus) 		PF00677
(Lum_binding) 		3 TRP A  80
GLN A 110
TRP A  68
 None
 0.92A 2vqyA-4e0fA:
undetectable		 2vqyA-4e0fA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyb COPPER OXIDASE

(Streptomyces
lividans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TRP A 240
GLN A 272
TRP A 284
 None
 1.00A 2vqyA-4gybA:
undetectable		 2vqyA-4gybA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		3 TRP A 621
GLN A 325
TRP A 269
 None
None
HEM  A 701 (-4.8A)
 1.30A 2vqyA-4hhrA:
undetectable		 2vqyA-4hhrA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzy CRYPTOCHROME-1

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 TRP A 420
GLN A 402
TRP A 394
 FAD  A 601 (-3.6A)
None
None
 1.02A 2vqyA-4jzyA:
undetectable		 2vqyA-4jzyA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0r CRYPTOCHROME-1

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 TRP A 320
GLN A 317
TRP A 399
 None
 1.00A 2vqyA-4k0rA:
undetectable		 2vqyA-4k0rA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8g TUMOR SUPPRESSOR
CANDIDATE 3

(Homo sapiens) 		PF04756
(OST3_OST6) 		3 TRP A 140
GLN A 136
TRP A  75
 None
 1.02A 2vqyA-4m8gA:
undetectable		 2vqyA-4m8gA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME

(Bacillus
licheniformis) 		PF01547
(SBP_bac_1) 		3 TRP A 224
GLN A 409
TRP A 383
 None
None
GLA  A 503 ( 4.0A)
 1.25A 2vqyA-4rk9A:
undetectable		 2vqyA-4rk9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rso CAPSID PROTEIN VP1

(Non-human
primate
Adeno-associated
virus) 		PF00740
(Parvo_coat) 		3 TRP A 281
GLN A 646
TRP A 247
 None
 1.34A 2vqyA-4rsoA:
undetectable		 2vqyA-4rsoA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME

(Bacillus cereus) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		3 TRP A 328
GLN A 334
TRP A 285
 None
 1.40A 2vqyA-4s3jA:
undetectable		 2vqyA-4s3jA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3k SPORE GERMINATION
PROTEIN YAAH

(Bacillus
megaterium) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		3 TRP A 417
GLN A 345
TRP A 407
 None
 1.38A 2vqyA-4s3kA:
undetectable		 2vqyA-4s3kA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8h CRYPTOCHROME-2

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 TRP A 338
GLN A 335
TRP A 417
 None
 0.99A 2vqyA-4u8hA:
undetectable		 2vqyA-4u8hA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1t COPPER OXIDASE

(Streptomyces
sviceus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TRP A 237
GLN A 269
TRP A 281
 None
 1.06A 2vqyA-4w1tA:
undetectable		 2vqyA-4w1tA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcj POLYSACCHARIDE
DEACETYLASE

(Ammonifex
degensii) 		PF01522
(Polysacc_deac_1) 		3 TRP A 156
GLN A 158
TRP A 148
 None
 1.30A 2vqyA-4wcjA:
0.3		 2vqyA-4wcjA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrl MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF00047
(ig) 		3 TRP A  58
GLN A  77
TRP A 159
 None
FUC  A 402 (-4.0A)
None
 1.08A 2vqyA-4wrlA:
undetectable		 2vqyA-4wrlA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF00047
(ig)
PF13927
(Ig_3) 		3 TRP A  58
GLN A  77
TRP A 159
 None
 0.94A 2vqyA-4wrmA:
undetectable		 2vqyA-4wrmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xac EVDO2

(Micromonospora
carbonacea) 		PF05721
(PhyH) 		3 TRP A 147
GLN A  74
TRP A 128
 AKG  A 303 (-4.0A)
None
None
 1.16A 2vqyA-4xacA:
undetectable		 2vqyA-4xacA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuo ENDO-1,4-BETA-XYLANA
SE C

(Paenibacillus
barcinonensis) 		PF02018
(CBM_4_9) 		3 TRP A 118
GLN A  41
TRP A  24
 None
 1.18A 2vqyA-4xuoA:
undetectable		 2vqyA-4xuoA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xup ENDO-1,4-BETA-XYLANA
SE C

(Paenibacillus
barcinonensis) 		PF02018
(CBM_4_9) 		3 TRP A 118
GLN A  41
TRP A  24
 None
 1.17A 2vqyA-4xupA:
undetectable		 2vqyA-4xupA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis) 		PF01977
(UbiD) 		3 TRP A 163
GLN A 196
TRP A 205
 None
4LU  A 603 (-3.4A)
None
 1.09A 2vqyA-4zadA:
undetectable		 2vqyA-4zadA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zid CYTOCHROME C-552

(Hydrogenobacter
thermophilus) 		PF00034
(Cytochrom_C) 		3 TRP A  75
GLN A  74
TRP A  54
 None
 1.38A 2vqyA-4zidA:
undetectable		 2vqyA-4zidA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu2 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		3 TRP A 336
GLN A 350
TRP A 422
 None
 1.35A 2vqyA-5bu2A:
undetectable		 2vqyA-5bu2A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		3 TRP A 150
GLN A 177
TRP A 185
 ACT  A 814 (-2.8A)
None
None
 1.21A 2vqyA-5bv9A:
undetectable		 2vqyA-5bv9A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5h 2-SUCCINYLBENZOATE--
COA LIGASE

(Escherichia
coli) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 TRP A  30
GLN A  27
TRP A 178
 None
 1.02A 2vqyA-5c5hA:
undetectable		 2vqyA-5c5hA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9l PLL LECTIN

(Photorhabdus
luminescens) 		PF03984
(DUF346) 		3 TRP A 294
GLN A 342
TRP A 291
 None
None
EDO  A 409 (-3.7A)
 1.20A 2vqyA-5c9lA:
undetectable		 2vqyA-5c9lA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iu0 RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN 1B,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 3 TRP J  67
GLN J 111
TRP J  70
 None
 1.23A 2vqyA-5iu0J:
undetectable		 2vqyA-5iu0J:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m62 C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER K

(Mus musculus) 		PF00059
(Lectin_C) 		3 TRP A 269
GLN A 272
TRP A 255
 None
 1.33A 2vqyA-5m62A:
undetectable		 2vqyA-5m62A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		3 TRP A 389
GLN A 315
TRP A 400
 None
 1.38A 2vqyA-5mqsA:
undetectable		 2vqyA-5mqsA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swn FLUOROACETATE
DEHALOGENASE

(Rhodopseudomonas
palustris) 		PF00561
(Abhydrolase_1) 		3 TRP A 185
GLN A 255
TRP A 142
 None
 0.80A 2vqyA-5swnA:
undetectable		 2vqyA-5swnA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1

(Alicyclobacillus
acidoterrestris) 		no annotation 3 TRP A 733
GLN A 644
TRP A 723
 None
None
C  B  47 ( 4.5A)
 0.81A 2vqyA-5u30A:
undetectable		 2vqyA-5u30A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		3 TRP A 164
GLN A 166
TRP A 103
 None
 1.27A 2vqyA-5ujuA:
undetectable		 2vqyA-5ujuA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uro PREDICTED PROTEIN

(Trichoderma
reesei) 		PF00561
(Abhydrolase_1) 		3 TRP A 251
GLN A 240
TRP A  53
 None
 1.34A 2vqyA-5uroA:
1.7		 2vqyA-5uroA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3l C5 ANTIBODY VARIABLE
HEAVY DOMAIN
VIRAL PROTEIN 3

(Mus musculus;
Rhinovirus B) 		PF00073
(Rhv)
PF07686
(V-set) 		3 TRP B 190
GLN B 192
TRP E  52
 None
 1.22A 2vqyA-5w3lB:
undetectable		 2vqyA-5w3lB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5we1 PROTECTION OF
TELOMERES PROTEIN
POZ1,PROTECTION OF
TELOMERES PROTEIN
POZ1

(Schizosaccharomyces
pombe) 		no annotation 3 TRP A  91
GLN A 159
TRP A 174
 None
 1.13A 2vqyA-5we1A:
undetectable		 2vqyA-5we1A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsk RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN

(Triticum
aestivum) 		no annotation 3 TRP E 113
GLN E 157
TRP E 116
 None
 1.14A 2vqyA-5wskE:
undetectable		 2vqyA-5wskE:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxf PROTECTION OF
TELOMERES PROTEIN
POZ1

(Schizosaccharomyces
pombe) 		no annotation 3 TRP A  91
GLN A 159
TRP A 174
 None
 1.29A 2vqyA-5xxfA:
undetectable		 2vqyA-5xxfA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 3 TRP A1064
GLN A 892
TRP A1079
 None
 1.29A 2vqyA-6b3rA:
undetectable		 2vqyA-6b3rA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4c ALPHA-GALACTOSIDASE

(Nicotiana
benthamiana) 		no annotation 3 TRP B 288
GLN B 328
TRP B 385
 None
 1.33A 2vqyA-6f4cB:
undetectable		 2vqyA-6f4cB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea NITROGENASE PROTEIN
ALPHA CHAIN

(Azotobacter
vinelandii) 		no annotation 3 TRP A 282
GLN A 214
TRP A 224
 None
 1.09A 2vqyA-6feaA:
undetectable		 2vqyA-6feaA:
19.69