SIMILAR PATTERNS OF AMINO ACIDS FOR 2VOU_B_ACTB1391
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cv8 | STAPHOPAIN (Staphylococcusaureus) |
PF05543(Peptidase_C47) | 3 | PRO A 81GLY A 74TYR A 174 | None | 0.72A | 2vouB-1cv8A:undetectable | 2vouB-1cv8A:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dmu | BGLI RESTRICTIONENDONUCLEASE (Bacillussubtilis) |
PF14562(Endonuc_BglI) | 3 | PRO A 216GLY A 86TYR A 53 | None | 0.71A | 2vouB-1dmuA:undetectable | 2vouB-1dmuA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fc4 | 2-AMINO-3-KETOBUTYRATE CONENZYME ALIGASE (Escherichiacoli) |
PF00155(Aminotran_1_2) | 3 | PRO A 270GLY A 117TYR A 108 | None | 0.63A | 2vouB-1fc4A:0.0 | 2vouB-1fc4A:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hfu | LACCASE 1 (Coprinopsiscinerea) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 3 | PRO A 180GLY A 20TYR A 176 | None | 0.71A | 2vouB-1hfuA:0.0 | 2vouB-1hfuA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hkw | DIAMINOPIMELATEDECARBOXYLASE (Mycobacteriumtuberculosis) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 3 | PRO A 41GLY A 337TYR A 314 | None | 0.56A | 2vouB-1hkwA:0.2 | 2vouB-1hkwA:24.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jd5 | APOPTOSIS 1INHIBITOR (Drosophilamelanogaster) |
PF00653(BIR) | 3 | PRO A 237GLY A 258TYR A 254 | None | 0.69A | 2vouB-1jd5A:undetectable | 2vouB-1jd5A:13.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lv7 | FTSH (Escherichiacoli) |
PF00004(AAA) | 3 | PRO A 177GLY A 293TYR A 173 | None | 0.67A | 2vouB-1lv7A:0.0 | 2vouB-1lv7A:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ocm | MALONAMIDASE E2 (Bradyrhizobiumjaponicum) |
PF01425(Amidase) | 3 | PRO A 349GLY A 357TYR A 162 | None | 0.51A | 2vouB-1ocmA:0.0 | 2vouB-1ocmA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ot5 | KEXIN (Saccharomycescerevisiae) |
PF00082(Peptidase_S8)PF01483(P_proprotein) | 3 | PRO A 275GLY A 284TYR A 327 | None | 0.64A | 2vouB-1ot5A:0.0 | 2vouB-1ot5A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pvj | PYROGENIC EXOTOXIN B (Streptococcuspyogenes) |
PF01640(Peptidase_C10)PF13734(Inhibitor_I69) | 3 | PRO A 207GLY A 210TYR A 240 | None | 0.62A | 2vouB-1pvjA:undetectable | 2vouB-1pvjA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8r | CROSSOVER JUNCTIONENDODEOXYRIBONUCLEASE RUSA (Escherichiacoli) |
PF05866(RusA) | 3 | PRO A 12GLY A 31TYR A 17 | None | 0.69A | 2vouB-1q8rA:undetectable | 2vouB-1q8rA:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgc | PROTEIN (VIRUSCAPSID PROTEIN VP2) (Foot-and-mouthdisease virus) |
PF00073(Rhv) | 3 | PRO 2 176GLY 2 164TYR 2 162 | None | 0.55A | 2vouB-1qgc2:undetectable | 2vouB-1qgc2:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uyp | BETA-FRUCTOSIDASE (Thermotogamaritima) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 3 | PRO A 10GLY A 13TYR A 34 | None | 0.68A | 2vouB-1uypA:undetectable | 2vouB-1uypA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v0f | ENDO-ALPHA-SIALIDASE (Enterobacteriaphage K1F) |
PF12217(End_beta_propel)PF12218(End_N_terminal)PF12219(End_tail_spike) | 3 | PRO A 632GLY A 705TYR A 716 | PRO A 632 ( 1.1A)GLY A 705 ( 0.0A)TYR A 716 ( 1.3A) | 0.65A | 2vouB-1v0fA:undetectable | 2vouB-1v0fA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vcn | CTP SYNTHETASE (Thermusthermophilus) |
PF00117(GATase)PF06418(CTP_synth_N) | 3 | PRO A 362GLY A 307TYR A 316 | None | 0.69A | 2vouB-1vcnA:undetectable | 2vouB-1vcnA:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wcx | UROPORPHYRINOGEN IIISYNTHASE (Thermusthermophilus) |
PF02602(HEM4) | 3 | PRO A 162GLY A 70TYR A 163 | None | 0.64A | 2vouB-1wcxA:3.7 | 2vouB-1wcxA:25.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wls | L-ASPARAGINASE (Pyrococcushorikoshii) |
PF00710(Asparaginase) | 3 | PRO A 100GLY A 137TYR A 188 | None | 0.72A | 2vouB-1wlsA:undetectable | 2vouB-1wlsA:24.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xc3 | PUTATIVEFRUCTOKINASE (Bacillussubtilis) |
PF00480(ROK) | 3 | PRO A 269GLY A 228TYR A 125 | None | 0.66A | 2vouB-1xc3A:undetectable | 2vouB-1xc3A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aaa | ALPHA-AMYLASE (Aspergillusniger) |
PF00128(Alpha-amylase)PF09260(DUF1966) | 3 | PRO A 341GLY A 33TYR A 342 | None | 0.65A | 2vouB-2aaaA:undetectable | 2vouB-2aaaA:25.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2akc | CLASS A NONSPECIFICACID PHOSPHATASEPHON (Salmonellaenterica) |
PF01569(PAP2) | 3 | PRO A 131GLY A 195TYR A 57 | None | 0.68A | 2vouB-2akcA:undetectable | 2vouB-2akcA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eid | GALACTOSE OXIDASE (Fusariumgraminearum) |
PF00754(F5_F8_type_C)PF01344(Kelch_1)PF09118(DUF1929) | 3 | PRO A 448GLY A 505TYR A 532 | None | 0.73A | 2vouB-2eidA:undetectable | 2vouB-2eidA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f6d | GLUCOAMYLASE GLU1 (Saccharomycopsisfibuligera) |
PF00723(Glyco_hydro_15) | 3 | PRO A 147GLY A 124TYR A 196 | None | 0.68A | 2vouB-2f6dA:undetectable | 2vouB-2f6dA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hpi | DNA POLYMERASE IIIALPHA SUBUNIT (Thermusaquaticus) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 3 | PRO A 125GLY A 48TYR A 74 | None | 0.64A | 2vouB-2hpiA:undetectable | 2vouB-2hpiA:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ji9 | OXALYL-COADECARBOXYLASE (Oxalobacterformigenes) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 3 | PRO A 100GLY A 71TYR A 226 | NoneNoneADP A1556 ( 4.8A) | 0.65A | 2vouB-2ji9A:undetectable | 2vouB-2ji9A:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2osy | ENDOGLYCOCERAMIDASEII (Rhodococcus sp.) |
PF00150(Cellulase) | 3 | PRO A 43GLY A 376TYR A 45 | None | 0.71A | 2vouB-2osyA:undetectable | 2vouB-2osyA:24.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2poi | BACULOVIRAL IAPREPEAT-CONTAININGPROTEIN 4 (Homo sapiens) |
PF00653(BIR) | 3 | PRO A 37GLY A 58TYR A 54 | None | 0.70A | 2vouB-2poiA:undetectable | 2vouB-2poiA:14.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pok | PEPTIDASE,M20/M25/M40 FAMILY (Streptococcuspneumoniae) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 3 | PRO A 341GLY A 367TYR A 364 | None | 0.72A | 2vouB-2pokA:2.0 | 2vouB-2pokA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q9t | DING (Pseudomonasfluorescens) |
PF12849(PBP_like_2) | 3 | PRO A 10GLY A 60TYR A 27 | None | 0.73A | 2vouB-2q9tA:undetectable | 2vouB-2q9tA:23.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vkt | CTP SYNTHASE 2 (Homo sapiens) |
PF00117(GATase) | 3 | PRO A 370GLY A 305TYR A 314 | None | 0.69A | 2vouB-2vktA:undetectable | 2vouB-2vktA:21.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2vou | 2,6-DIHYDROXYPYRIDINE HYDROXYLASE (Paenarthrobacternicotinovorans) |
PF00070(Pyr_redox) | 3 | PRO A 311GLY A 318TYR A 357 | ACT A1397 (-4.1A)FAD A1395 ( 3.3A)ACT A1397 (-4.5A) | 0.21A | 2vouB-2vouA:67.7 | 2vouB-2vouA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wdw | PUTATIVE HEXOSEOXIDASE (Nonomuraeagerenzanensis) |
PF01565(FAD_binding_4)PF08031(BBE) | 3 | PRO A 147GLY A 173TYR A 178 | None | 0.71A | 2vouB-2wdwA:undetectable | 2vouB-2wdwA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ww8 | CELL WALL SURFACEANCHOR FAMILYPROTEIN (Streptococcuspneumoniae) |
PF13519(VWA_2) | 3 | PRO A 390GLY A 516TYR A 448 | None | 0.51A | 2vouB-2ww8A:3.6 | 2vouB-2ww8A:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zzr | UNSATURATEDGLUCURONYL HYDROLASE (Streptococcusagalactiae) |
PF07470(Glyco_hydro_88) | 3 | PRO A 357GLY A 375TYR A 61 | None | 0.72A | 2vouB-2zzrA:undetectable | 2vouB-2zzrA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3anw | PUTATIVEUNCHARACTERIZEDPROTEIN (Thermococcuskodakarensis) |
no annotation | 3 | PRO A 168GLY A 150TYR A 156 | None | 0.65A | 2vouB-3anwA:undetectable | 2vouB-3anwA:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b42 | METHYL-ACCEPTINGCHEMOTAXIS PROTEIN,PUTATIVE (Geobactersulfurreducens) |
no annotation | 3 | PRO A 133GLY A 113TYR A 150 | None | 0.70A | 2vouB-3b42A:undetectable | 2vouB-3b42A:15.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9t | TWIN-ARGININETRANSLOCATIONPATHWAY SIGNALPROTEIN (Methylobacillusflagellatus) |
PF03069(FmdA_AmdA) | 3 | PRO A 385GLY A 312TYR A 328 | None | 0.73A | 2vouB-3b9tA:undetectable | 2vouB-3b9tA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bb7 | INTERPAIN A (Prevotellaintermedia) |
PF01640(Peptidase_C10)PF13734(Inhibitor_I69) | 3 | PRO A 169GLY A 172TYR A 199 | None | 0.52A | 2vouB-3bb7A:undetectable | 2vouB-3bb7A:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bba | INTERPAIN A (Prevotellaintermedia) |
PF01640(Peptidase_C10) | 3 | PRO A 169GLY A 172TYR A 199 | None | 0.52A | 2vouB-3bbaA:undetectable | 2vouB-3bbaA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3beo | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Bacillusanthracis) |
PF02350(Epimerase_2) | 3 | PRO A 294GLY A 312TYR A 352 | None | 0.64A | 2vouB-3beoA:3.2 | 2vouB-3beoA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c8c | METHYL-ACCEPTINGCHEMOTAXIS PROTEIN (Vibrio cholerae) |
PF02743(dCache_1) | 3 | PRO A 149GLY A 127TYR A 155 | None | 0.58A | 2vouB-3c8cA:undetectable | 2vouB-3c8cA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f67 | PUTATIVEDIENELACTONEHYDROLASE (Klebsiellapneumoniae) |
PF01738(DLH) | 3 | PRO A 71GLY A 40TYR A 65 | None | 0.69A | 2vouB-3f67A:undetectable | 2vouB-3f67A:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fmc | PUTATIVESUCCINYLGLUTAMATEDESUCCINYLASE /ASPARTOACYLASE (Shewanellaamazonensis) |
PF04952(AstE_AspA) | 3 | PRO A 342GLY A 304TYR A 358 | None | 0.58A | 2vouB-3fmcA:undetectable | 2vouB-3fmcA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kf3 | INVERTASE (Schwanniomycesoccidentalis) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 3 | PRO A 43GLY A 46TYR A 69 | None | 0.69A | 2vouB-3kf3A:undetectable | 2vouB-3kf3A:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l22 | SUSD SUPERFAMILYPROTEIN (Bacteroidesfragilis) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 3 | PRO A 161GLY A 426TYR A 447 | None | 0.56A | 2vouB-3l22A:undetectable | 2vouB-3l22A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lxu | TRIPEPTIDYL-PEPTIDASE 2 (Drosophilamelanogaster) |
PF00082(Peptidase_S8)PF12580(TPPII)PF12583(TPPII_N) | 3 | PRO X 488GLY X 365TYR X 571 | None | 0.73A | 2vouB-3lxuX:2.5 | 2vouB-3lxuX:15.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qgu | LL-DIAMINOPIMELATEAMINOTRANSFERASE (Chlamydomonasreinhardtii) |
PF00155(Aminotran_1_2) | 3 | PRO A 409GLY A 185TYR A 191 | None | 0.59A | 2vouB-3qguA:undetectable | 2vouB-3qguA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rfr | PMOB (Methylocystissp. M) |
PF04744(Monooxygenase_B) | 3 | PRO A 339GLY A 150TYR A 341 | None | 0.67A | 2vouB-3rfrA:undetectable | 2vouB-3rfrA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqx | 2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE (Coxiellaburnetii) |
PF00155(Aminotran_1_2) | 3 | PRO A 268GLY A 115TYR A 106 | None | 0.56A | 2vouB-3tqxA:undetectable | 2vouB-3tqxA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3upy | OXIDOREDUCTASE (Brucellaabortus) |
PF03447(NAD_binding_3) | 3 | PRO A 346GLY A 147TYR A 161 | None | 0.44A | 2vouB-3upyA:4.7 | 2vouB-3upyA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vr5 | V-TYPE SODIUM ATPASECATALYTIC SUBUNIT A (Enterococcushirae) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N)PF16886(ATP-synt_ab_Xtn) | 3 | PRO A 205GLY A 226TYR A 437 | None | 0.68A | 2vouB-3vr5A:undetectable | 2vouB-3vr5A:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wap | AUTOPHAGY-RELATEDPROTEIN 13,MICROTUBULE-ASSOCIATED PROTEINS 1A/1BLIGHT CHAIN 3C (Homo sapiens) |
PF02991(Atg8) | 3 | PRO A 47GLY A 122TYR A 114 | None | 0.58A | 2vouB-3wapA:undetectable | 2vouB-3wapA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wfz | LACTO-N-BIOSEPHOSPHORYLASE (Bifidobacteriumlongum) |
PF09508(Lact_bio_phlase)PF17385(LBP_M)PF17386(LBP_C) | 3 | PRO A 671GLY A 629TYR A 468 | None | 0.72A | 2vouB-3wfzA:undetectable | 2vouB-3wfzA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wjt | OUTER-MEMBRANELIPOPROTEIN LOLB (Escherichiacoli) |
PF03550(LolB) | 3 | PRO A 164GLY A 120TYR A 152 | None | 0.62A | 2vouB-3wjtA:undetectable | 2vouB-3wjtA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bbw | SIALIDASE(NEURAMINIDASE) (Bacteroidesthetaiotaomicron) |
PF13088(BNR_2)PF14873(BNR_assoc_N) | 3 | PRO A 96GLY A 81TYR A 99 | None | 0.70A | 2vouB-4bbwA:undetectable | 2vouB-4bbwA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cmw | DITERPENE SYNTHASE (Mycobacteriumtuberculosis) |
no annotation | 3 | PRO A 216GLY A 162TYR A 121 | None | 0.69A | 2vouB-4cmwA:undetectable | 2vouB-4cmwA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eqv | INVERTASE 2 (Saccharomycescerevisiae) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 3 | PRO A 15GLY A 18TYR A 41 | None | 0.67A | 2vouB-4eqvA:undetectable | 2vouB-4eqvA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ezi | UNCHARACTERIZEDPROTEIN (Legionellapneumophila) |
no annotation | 3 | PRO A 93GLY A 136TYR A 65 | None | 0.66A | 2vouB-4eziA:undetectable | 2vouB-4eziA:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fdu | PUTATIVE MULTIPLEINOSITOLPOLYPHOSPHATEHISTIDINEPHOSPHATASE 1 (Bacteroidesthetaiotaomicron) |
PF00328(His_Phos_2) | 3 | PRO A 290GLY A 286TYR A 194 | None | 0.71A | 2vouB-4fduA:undetectable | 2vouB-4fduA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fkz | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Bacillussubtilis) |
PF02350(Epimerase_2) | 3 | PRO A 292GLY A 310TYR A 350 | None | 0.63A | 2vouB-4fkzA:3.6 | 2vouB-4fkzA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fzy | EXODEOXYRIBONUCLEASE10 (Escherichiacoli) |
PF00929(RNase_T) | 3 | PRO A 93GLY A 73TYR A 77 | None | 0.71A | 2vouB-4fzyA:undetectable | 2vouB-4fzyA:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g6b | CITRATE SYNTHASE (Escherichiacoli) |
PF00285(Citrate_synt) | 3 | PRO A 313GLY A 64TYR A 311 | None | 0.69A | 2vouB-4g6bA:undetectable | 2vouB-4g6bA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hiz | ENDOSIALIDASE (Enterobacteriaphage phi92) |
PF12217(End_beta_propel)PF12218(End_N_terminal)PF12219(End_tail_spike) | 3 | PRO A 473GLY A 548TYR A 559 | None | 0.62A | 2vouB-4hizA:undetectable | 2vouB-4hizA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igl | YENB (Yersiniaentomophaga) |
PF03534(SpvB)PF12255(TcdB_toxin_midC)PF12256(TcdB_toxin_midN) | 3 | PRO A1449GLY A 889TYR A 900 | GOL A1502 ( 3.6A)NoneNone | 0.48A | 2vouB-4iglA:undetectable | 2vouB-4iglA:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jf7 | HEMAGGLUTININ-NEURAMINIDASE (Mammalianrubulavirus 5) |
no annotation | 3 | PRO D 304GLY D 391TYR D 402 | None | 0.69A | 2vouB-4jf7D:undetectable | 2vouB-4jf7D:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kjv | E3 UBIQUITIN-PROTEINLIGASE XIAP (Homo sapiens) |
PF00653(BIR) | 3 | PRO A 174GLY A 195TYR A 191 | None | 0.64A | 2vouB-4kjvA:undetectable | 2vouB-4kjvA:13.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l9c | F-BOX ONLY PROTEIN 7 (Homo sapiens) |
PF11566(PI31_Prot_N) | 3 | PRO A 254GLY A 232TYR A 234 | None | 0.73A | 2vouB-4l9cA:undetectable | 2vouB-4l9cA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9x | TCDB2, TCCC3 (Photorhabdusluminescens) |
PF03534(SpvB)PF12255(TcdB_toxin_midC)PF12256(TcdB_toxin_midN) | 3 | PRO A1467GLY A 910TYR A 921 | None | 0.57A | 2vouB-4o9xA:undetectable | 2vouB-4o9xA:11.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oxc | E3 UBIQUITIN-PROTEINLIGASE XIAP (Homo sapiens) |
PF00653(BIR) | 3 | PRO A 37GLY A 58TYR A 54 | None | 0.67A | 2vouB-4oxcA:undetectable | 2vouB-4oxcA:15.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tvm | CITRATE SYNTHASE (Mycobacteriumtuberculosis) |
PF00285(Citrate_synt) | 3 | PRO A 317GLY A 67TYR A 315 | None | 0.67A | 2vouB-4tvmA:undetectable | 2vouB-4tvmA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wvt | E3 UBIQUITIN-PROTEINLIGASE XIAP (Homo sapiens) |
PF00653(BIR) | 3 | PRO A 174GLY A 195TYR A 191 | None | 0.73A | 2vouB-4wvtA:undetectable | 2vouB-4wvtA:13.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yu5 | IMMUNE INHIBITOR A,METALLOPROTEASE (Bacillus cereus) |
PF05547(Peptidase_M6) | 3 | PRO A 666GLY A 719TYR A 668 | None | 0.59A | 2vouB-4yu5A:undetectable | 2vouB-4yu5A:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yxt | POLYKETIDEBIOSYNTHESIS3-HYDROXY-3-METHYLGLUTARYL-ACP SYNTHASEPKSG (Bacillussubtilis) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 3 | PRO A 286GLY A 313TYR A 246 | None | 0.69A | 2vouB-4yxtA:undetectable | 2vouB-4yxtA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z8x | ATP-DEPENDENT ZINCMETALLOPROTEASE FTSH (Aquifexaeolicus) |
PF00004(AAA)PF01434(Peptidase_M41) | 3 | PRO A 177GLY A 294TYR A 173 | None | 0.61A | 2vouB-4z8xA:undetectable | 2vouB-4z8xA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) |
PF00117(GATase)PF06418(CTP_synth_N) | 3 | PRO A 364GLY A 308TYR A 317 | None | 0.56A | 2vouB-4zdkA:undetectable | 2vouB-4zdkA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zem | TRANSLATIONINITIATION FACTOREIF2B-LIKEPROTEIN,TRANSLATIONINITIATION FACTOREIF2B-LIKE PROTEIN (Chaetomiumthermophilum) |
PF01008(IF-2B) | 3 | PRO A 341GLY A 306TYR A 377 | None | 0.71A | 2vouB-4zemA:undetectable | 2vouB-4zemA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by4 | PROTEIN TOLR (Escherichiacoli) |
PF02472(ExbD) | 3 | PRO A 88GLY A 72TYR A 74 | None NA A 203 ( 4.7A) NA A 203 (-4.3A) | 0.67A | 2vouB-5by4A:undetectable | 2vouB-5by4A:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5chc | DMSO REDUCTASEFAMILY TYPE IIENZYME,MOLYBDOPTERINSUBUNIT (Azospira oryzae) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 3 | PRO A 172GLY A 183TYR A 165 | None | 0.68A | 2vouB-5chcA:undetectable | 2vouB-5chcA:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dpw | MICROTUBULE-ASSOCIATED PROTEINS 1A/1BLIGHT CHAIN 3C (Homo sapiens) |
PF02991(Atg8) | 3 | PRO A 28GLY A 103TYR A 95 | None | 0.73A | 2vouB-5dpwA:undetectable | 2vouB-5dpwA:12.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e2g | BETA-LACTAMASE (Burkholderiacenocepacia) |
PF00144(Beta-lactamase) | 3 | PRO A 259GLY A 281TYR A 269 | None | 0.62A | 2vouB-5e2gA:undetectable | 2vouB-5e2gA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e2h | BETA-LACTAMASE (Mycolicibacteriumsmegmatis) |
PF00144(Beta-lactamase) | 3 | PRO A 258GLY A 280TYR A 268 | None | 0.72A | 2vouB-5e2hA:undetectable | 2vouB-5e2hA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fhc | ANTIBODY 100 FABHEAVY CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 3 | PRO A 213GLY A 190TYR A 194 | None | 0.60A | 2vouB-5fhcA:undetectable | 2vouB-5fhcA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g06 | EXOSOME COMPLEXCOMPONENT CSL4 (Saccharomycescerevisiae) |
PF10447(EXOSC1) | 3 | PRO I 19GLY I 22TYR I 35 | None | 0.55A | 2vouB-5g06I:undetectable | 2vouB-5g06I:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i1w | CRMK (Actinoalloteichussp. WH1-2216-6) |
PF01565(FAD_binding_4)PF08031(BBE) | 3 | PRO A 120GLY A 146TYR A 151 | None | 0.71A | 2vouB-5i1wA:undetectable | 2vouB-5i1wA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i68 | ALCOHOL OXIDASE 1 (Komagataellapastoris) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 3 | PRO A 391GLY A 614TYR A 422 | None | 0.69A | 2vouB-5i68A:7.8 | 2vouB-5i68A:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kp7 | CURD (Mooreaproducens) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 3 | PRO A 286GLY A 313TYR A 246 | None | 0.72A | 2vouB-5kp7A:undetectable | 2vouB-5kp7A:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kwn | E3 UBIQUITIN-PROTEINLIGASE COP1 (Arabidopsisthaliana) |
PF00400(WD40) | 3 | PRO A 624GLY A 588TYR A 615 | None | 0.70A | 2vouB-5kwnA:undetectable | 2vouB-5kwnA:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kz5 | CYSTEINEDESULFURASE,MITOCHONDRIAL (Homo sapiens) |
PF00266(Aminotran_5) | 3 | PRO 1 68GLY 1 411TYR 1 260 | None | 0.55A | 2vouB-5kz51:undetectable | 2vouB-5kz51:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lt9 | METHYL-ACCEPTINGCHEMOTAXIS PROTEINPCTB (Pseudomonasaeruginosa) |
PF02743(dCache_1) | 3 | PRO A 123GLY A 103TYR A 129 | None | 0.72A | 2vouB-5lt9A:undetectable | 2vouB-5lt9A:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ltv | CHEMOTACTICTRANSDUCER PCTC (Pseudomonasaeruginosa) |
PF02743(dCache_1) | 3 | PRO A 126GLY A 105TYR A 132 | None | 0.57A | 2vouB-5ltvA:undetectable | 2vouB-5ltvA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lxz | SECRETED PROTEIN (Streptomyceslividans) |
PF07646(Kelch_2)PF09118(DUF1929) | 3 | PRO B 455GLY B 511TYR B 544 | None | 0.68A | 2vouB-5lxzB:undetectable | 2vouB-5lxzB:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ncc | FATTY ACIDPHOTODECARBOXYLASE (Chlorellavariabilis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 3 | PRO A 127GLY A 271TYR A 419 | None | 0.67A | 2vouB-5nccA:4.8 | 2vouB-5nccA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t65 | METHYL-ACCEPTINGCHEMOTAXIS PROTEINPCTA (Pseudomonasaeruginosa) |
PF02743(dCache_1) | 3 | PRO A 123GLY A 103TYR A 129 | None | 0.63A | 2vouB-5t65A:undetectable | 2vouB-5t65A:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u3c | CTP SYNTHASE (Escherichiacoli) |
PF00117(GATase)PF06418(CTP_synth_N) | 3 | PRO A 350GLY A 296TYR A 305 | None | 0.64A | 2vouB-5u3cA:undetectable | 2vouB-5u3cA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u8z | CAROTENOID OXYGENASE1 (Neurosporacrassa) |
PF03055(RPE65) | 3 | PRO A 174GLY A 158TYR A 155 | None | 0.70A | 2vouB-5u8zA:undetectable | 2vouB-5u8zA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5utt | SORTASE (Actinomycesoris) |
PF04203(Sortase) | 3 | PRO A 84GLY A 138TYR A 177 | None | 0.58A | 2vouB-5uttA:undetectable | 2vouB-5uttA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vhi | 26S PROTEASOMENON-ATPASEREGULATORY SUBUNIT 8 (Homo sapiens) |
PF00004(AAA) | 3 | PRO d 136GLY d 100TYR d 132 | None | 0.59A | 2vouB-5vhid:undetectable | 2vouB-5vhid:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7n | DIAMINOPIMELATEDECARBOXYLASE (Corynebacteriumglutamicum) |
no annotation | 3 | PRO A 44GLY A 336TYR A 313 | None | 0.60A | 2vouB-5x7nA:undetectable | 2vouB-5x7nA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfo | PHD FINGER PROTEIN 1 (Homo sapiens) |
PF00628(PHD) | 3 | PRO A 168GLY A 192TYR A 169 | None | 0.73A | 2vouB-5xfoA:undetectable | 2vouB-5xfoA:25.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y7o | UGGT (Thermomycesdupontii) |
PF06427(UDP-g_GGTase) | 3 | PRO A 223GLY A 43TYR A 122 | None | 0.60A | 2vouB-5y7oA:undetectable | 2vouB-5y7oA:17.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f39 | COMPLEMENT C1RSUBCOMPONENT (Homo sapiens) |
no annotation | 3 | PRO A 199GLY A 276TYR A 197 | None CA A 303 ( 3.9A)None | 0.51A | 2vouB-6f39A:undetectable | 2vouB-6f39A:undetectable |