SIMILAR PATTERNS OF AMINO ACIDS FOR 2VOU_A_ACTA1397
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dmu | BGLI RESTRICTIONENDONUCLEASE (Bacillussubtilis) |
PF14562(Endonuc_BglI) | 3 | PRO A 216GLY A 86TYR A 53 | None | 0.72A | 2vouA-1dmuA:undetectable | 2vouA-1dmuA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fc4 | 2-AMINO-3-KETOBUTYRATE CONENZYME ALIGASE (Escherichiacoli) |
PF00155(Aminotran_1_2) | 3 | PRO A 270GLY A 117TYR A 108 | None | 0.71A | 2vouA-1fc4A:0.0 | 2vouA-1fc4A:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hfu | LACCASE 1 (Coprinopsiscinerea) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 3 | PRO A 180GLY A 20TYR A 176 | None | 0.73A | 2vouA-1hfuA:undetectable | 2vouA-1hfuA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hkw | DIAMINOPIMELATEDECARBOXYLASE (Mycobacteriumtuberculosis) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 3 | PRO A 41GLY A 337TYR A 314 | None | 0.56A | 2vouA-1hkwA:0.1 | 2vouA-1hkwA:24.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jd5 | APOPTOSIS 1INHIBITOR (Drosophilamelanogaster) |
PF00653(BIR) | 3 | PRO A 237GLY A 258TYR A 254 | None | 0.67A | 2vouA-1jd5A:undetectable | 2vouA-1jd5A:13.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kny | KANAMYCINNUCLEOTIDYLTRANSFERASE (Staphylococcusaureus) |
PF07827(KNTase_C) | 3 | PRO A 97GLY A 178TYR A 185 | None | 0.74A | 2vouA-1knyA:undetectable | 2vouA-1knyA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lv7 | FTSH (Escherichiacoli) |
PF00004(AAA) | 3 | PRO A 177GLY A 293TYR A 173 | None | 0.59A | 2vouA-1lv7A:undetectable | 2vouA-1lv7A:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1naa | CELLOBIOSEDEHYDROGENASE (Phanerochaetechrysosporium) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 3 | PRO A 275GLY A 401TYR A 550 | None | 0.73A | 2vouA-1naaA:10.6 | 2vouA-1naaA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ocm | MALONAMIDASE E2 (Bradyrhizobiumjaponicum) |
PF01425(Amidase) | 3 | PRO A 349GLY A 357TYR A 162 | None | 0.51A | 2vouA-1ocmA:undetectable | 2vouA-1ocmA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ot5 | KEXIN (Saccharomycescerevisiae) |
PF00082(Peptidase_S8)PF01483(P_proprotein) | 3 | PRO A 275GLY A 284TYR A 327 | None | 0.69A | 2vouA-1ot5A:2.5 | 2vouA-1ot5A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pvj | PYROGENIC EXOTOXIN B (Streptococcuspyogenes) |
PF01640(Peptidase_C10)PF13734(Inhibitor_I69) | 3 | PRO A 207GLY A 210TYR A 240 | None | 0.67A | 2vouA-1pvjA:undetectable | 2vouA-1pvjA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8r | CROSSOVER JUNCTIONENDODEOXYRIBONUCLEASE RUSA (Escherichiacoli) |
PF05866(RusA) | 3 | PRO A 12GLY A 31TYR A 17 | None | 0.71A | 2vouA-1q8rA:undetectable | 2vouA-1q8rA:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgc | PROTEIN (VIRUSCAPSID PROTEIN VP2) (Foot-and-mouthdisease virus) |
PF00073(Rhv) | 3 | PRO 2 176GLY 2 164TYR 2 162 | None | 0.67A | 2vouA-1qgc2:undetectable | 2vouA-1qgc2:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uyp | BETA-FRUCTOSIDASE (Thermotogamaritima) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 3 | PRO A 10GLY A 13TYR A 34 | None | 0.75A | 2vouA-1uypA:undetectable | 2vouA-1uypA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wcx | UROPORPHYRINOGEN IIISYNTHASE (Thermusthermophilus) |
PF02602(HEM4) | 3 | PRO A 162GLY A 70TYR A 163 | None | 0.56A | 2vouA-1wcxA:undetectable | 2vouA-1wcxA:25.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wls | L-ASPARAGINASE (Pyrococcushorikoshii) |
PF00710(Asparaginase) | 3 | PRO A 100GLY A 137TYR A 188 | None | 0.73A | 2vouA-1wlsA:undetectable | 2vouA-1wlsA:24.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xc3 | PUTATIVEFRUCTOKINASE (Bacillussubtilis) |
PF00480(ROK) | 3 | PRO A 269GLY A 228TYR A 125 | None | 0.67A | 2vouA-1xc3A:undetectable | 2vouA-1xc3A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zr6 | GLUCOOLIGOSACCHARIDEOXIDASE (Sarocladiumstrictum) |
PF01565(FAD_binding_4)PF08031(BBE) | 3 | PRO A 398GLY A 403TYR A 399 | None | 0.72A | 2vouA-1zr6A:undetectable | 2vouA-1zr6A:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aaa | ALPHA-AMYLASE (Aspergillusniger) |
PF00128(Alpha-amylase)PF09260(DUF1966) | 3 | PRO A 341GLY A 33TYR A 342 | None | 0.65A | 2vouA-2aaaA:undetectable | 2vouA-2aaaA:25.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hpi | DNA POLYMERASE IIIALPHA SUBUNIT (Thermusaquaticus) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 3 | PRO A 125GLY A 48TYR A 74 | None | 0.59A | 2vouA-2hpiA:undetectable | 2vouA-2hpiA:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ji9 | OXALYL-COADECARBOXYLASE (Oxalobacterformigenes) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 3 | PRO A 100GLY A 71TYR A 226 | NoneNoneADP A1556 ( 4.8A) | 0.68A | 2vouA-2ji9A:undetectable | 2vouA-2ji9A:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nv9 | A207R PROTEIN,ARGININEDECARBOXYLASE (ParameciumbursariaChlorella virus1) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 3 | PRO A 316GLY A 276TYR A 278 | None | 0.69A | 2vouA-2nv9A:undetectable | 2vouA-2nv9A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2osy | ENDOGLYCOCERAMIDASEII (Rhodococcus sp.) |
PF00150(Cellulase) | 3 | PRO A 43GLY A 376TYR A 45 | None | 0.59A | 2vouA-2osyA:undetectable | 2vouA-2osyA:24.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2poi | BACULOVIRAL IAPREPEAT-CONTAININGPROTEIN 4 (Homo sapiens) |
PF00653(BIR) | 3 | PRO A 37GLY A 58TYR A 54 | None | 0.72A | 2vouA-2poiA:undetectable | 2vouA-2poiA:14.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pok | PEPTIDASE,M20/M25/M40 FAMILY (Streptococcuspneumoniae) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 3 | PRO A 341GLY A 367TYR A 364 | None | 0.67A | 2vouA-2pokA:1.9 | 2vouA-2pokA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q9t | DING (Pseudomonasfluorescens) |
PF12849(PBP_like_2) | 3 | PRO A 10GLY A 60TYR A 27 | None | 0.74A | 2vouA-2q9tA:undetectable | 2vouA-2q9tA:23.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2vou | 2,6-DIHYDROXYPYRIDINE HYDROXYLASE (Paenarthrobacternicotinovorans) |
PF00070(Pyr_redox) | 3 | PRO A 311GLY A 318TYR A 357 | ACT A1397 (-4.1A)FAD A1395 ( 3.3A)ACT A1397 (-4.5A) | 0.02A | 2vouA-2vouA:72.1 | 2vouA-2vouA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ww8 | CELL WALL SURFACEANCHOR FAMILYPROTEIN (Streptococcuspneumoniae) |
PF13519(VWA_2) | 3 | PRO A 390GLY A 516TYR A 448 | None | 0.44A | 2vouA-2ww8A:undetectable | 2vouA-2ww8A:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zzr | UNSATURATEDGLUCURONYL HYDROLASE (Streptococcusagalactiae) |
PF07470(Glyco_hydro_88) | 3 | PRO A 357GLY A 375TYR A 61 | None | 0.73A | 2vouA-2zzrA:undetectable | 2vouA-2zzrA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3anw | PUTATIVEUNCHARACTERIZEDPROTEIN (Thermococcuskodakarensis) |
no annotation | 3 | PRO A 168GLY A 150TYR A 156 | None | 0.72A | 2vouA-3anwA:undetectable | 2vouA-3anwA:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9t | TWIN-ARGININETRANSLOCATIONPATHWAY SIGNALPROTEIN (Methylobacillusflagellatus) |
PF03069(FmdA_AmdA) | 3 | PRO A 385GLY A 312TYR A 328 | None | 0.71A | 2vouA-3b9tA:undetectable | 2vouA-3b9tA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bb7 | INTERPAIN A (Prevotellaintermedia) |
PF01640(Peptidase_C10)PF13734(Inhibitor_I69) | 3 | PRO A 169GLY A 172TYR A 199 | None | 0.55A | 2vouA-3bb7A:undetectable | 2vouA-3bb7A:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bba | INTERPAIN A (Prevotellaintermedia) |
PF01640(Peptidase_C10) | 3 | PRO A 169GLY A 172TYR A 199 | None | 0.51A | 2vouA-3bbaA:undetectable | 2vouA-3bbaA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3beo | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Bacillusanthracis) |
PF02350(Epimerase_2) | 3 | PRO A 294GLY A 312TYR A 352 | None | 0.72A | 2vouA-3beoA:2.4 | 2vouA-3beoA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c8c | METHYL-ACCEPTINGCHEMOTAXIS PROTEIN (Vibrio cholerae) |
PF02743(dCache_1) | 3 | PRO A 149GLY A 127TYR A 155 | None | 0.56A | 2vouA-3c8cA:undetectable | 2vouA-3c8cA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fmc | PUTATIVESUCCINYLGLUTAMATEDESUCCINYLASE /ASPARTOACYLASE (Shewanellaamazonensis) |
PF04952(AstE_AspA) | 3 | PRO A 342GLY A 304TYR A 358 | None | 0.57A | 2vouA-3fmcA:undetectable | 2vouA-3fmcA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h2i | ESTERASE (Xanthomonasoryzae) |
PF03583(LIP) | 3 | PRO A 165GLY A 77TYR A 79 | None | 0.73A | 2vouA-3h2iA:undetectable | 2vouA-3h2iA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l22 | SUSD SUPERFAMILYPROTEIN (Bacteroidesfragilis) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 3 | PRO A 161GLY A 426TYR A 447 | None | 0.66A | 2vouA-3l22A:undetectable | 2vouA-3l22A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1t | PUTATIVEPHOSPHOHYDROLASE (Shewanellaamazonensis) |
PF08668(HDOD) | 3 | PRO A 204GLY A 215TYR A 210 | None | 0.70A | 2vouA-3m1tA:undetectable | 2vouA-3m1tA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rfr | PMOB (Methylocystissp. M) |
PF04744(Monooxygenase_B) | 3 | PRO A 339GLY A 150TYR A 341 | None | 0.65A | 2vouA-3rfrA:undetectable | 2vouA-3rfrA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqx | 2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE (Coxiellaburnetii) |
PF00155(Aminotran_1_2) | 3 | PRO A 268GLY A 115TYR A 106 | None | 0.66A | 2vouA-3tqxA:undetectable | 2vouA-3tqxA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uam | CHITIN BINDINGDOMAIN (Burkholderiapseudomallei) |
PF03067(LPMO_10) | 3 | PRO A 161GLY A 164TYR A 159 | None | 0.74A | 2vouA-3uamA:undetectable | 2vouA-3uamA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uc0 | ENVELOPE PROTEIN (Dengue virus) |
PF00869(Flavi_glycoprot) | 3 | PRO A 166GLY A 134TYR A 137 | None | 0.69A | 2vouA-3uc0A:undetectable | 2vouA-3uc0A:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3upy | OXIDOREDUCTASE (Brucellaabortus) |
PF03447(NAD_binding_3) | 3 | PRO A 346GLY A 147TYR A 161 | None | 0.54A | 2vouA-3upyA:4.4 | 2vouA-3upyA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va6 | TWO-COMPONENT SYSTEMSENSOR HISTIDINEKINASE (Bacteroidesthetaiotaomicron) |
PF07494(Reg_prop)PF07495(Y_Y_Y) | 3 | PRO A 709GLY A 75TYR A 710 | None | 0.74A | 2vouA-3va6A:undetectable | 2vouA-3va6A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vr5 | V-TYPE SODIUM ATPASECATALYTIC SUBUNIT A (Enterococcushirae) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N)PF16886(ATP-synt_ab_Xtn) | 3 | PRO A 205GLY A 226TYR A 437 | None | 0.71A | 2vouA-3vr5A:undetectable | 2vouA-3vr5A:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w1y | MICROTUBULE-ASSOCIATED PROTEIN 1A/1B,LIGHT CHAIN 3 (Trypanosomabrucei) |
PF02991(Atg8) | 3 | PRO A 32GLY A 121TYR A 113 | None | 0.74A | 2vouA-3w1yA:undetectable | 2vouA-3w1yA:14.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wap | AUTOPHAGY-RELATEDPROTEIN 13,MICROTUBULE-ASSOCIATED PROTEINS 1A/1BLIGHT CHAIN 3C (Homo sapiens) |
PF02991(Atg8) | 3 | PRO A 47GLY A 122TYR A 114 | None | 0.55A | 2vouA-3wapA:undetectable | 2vouA-3wapA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wjt | OUTER-MEMBRANELIPOPROTEIN LOLB (Escherichiacoli) |
PF03550(LolB) | 3 | PRO A 164GLY A 120TYR A 152 | None | 0.71A | 2vouA-3wjtA:undetectable | 2vouA-3wjtA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bbw | SIALIDASE(NEURAMINIDASE) (Bacteroidesthetaiotaomicron) |
PF13088(BNR_2)PF14873(BNR_assoc_N) | 3 | PRO A 96GLY A 81TYR A 99 | None | 0.72A | 2vouA-4bbwA:undetectable | 2vouA-4bbwA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cmw | DITERPENE SYNTHASE (Mycobacteriumtuberculosis) |
no annotation | 3 | PRO A 216GLY A 162TYR A 121 | None | 0.70A | 2vouA-4cmwA:undetectable | 2vouA-4cmwA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e4g | METHYLMALONATE-SEMIALDEHYDEDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00171(Aldedh) | 3 | PRO A 385GLY A 365TYR A 272 | None | 0.72A | 2vouA-4e4gA:2.2 | 2vouA-4e4gA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ezi | UNCHARACTERIZEDPROTEIN (Legionellapneumophila) |
no annotation | 3 | PRO A 93GLY A 136TYR A 65 | None | 0.67A | 2vouA-4eziA:undetectable | 2vouA-4eziA:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fdu | PUTATIVE MULTIPLEINOSITOLPOLYPHOSPHATEHISTIDINEPHOSPHATASE 1 (Bacteroidesthetaiotaomicron) |
PF00328(His_Phos_2) | 3 | PRO A 290GLY A 286TYR A 194 | None | 0.67A | 2vouA-4fduA:undetectable | 2vouA-4fduA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fkz | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Bacillussubtilis) |
PF02350(Epimerase_2) | 3 | PRO A 292GLY A 310TYR A 350 | None | 0.72A | 2vouA-4fkzA:3.5 | 2vouA-4fkzA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fzy | EXODEOXYRIBONUCLEASE10 (Escherichiacoli) |
PF00929(RNase_T) | 3 | PRO A 93GLY A 73TYR A 77 | None | 0.70A | 2vouA-4fzyA:undetectable | 2vouA-4fzyA:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g6b | CITRATE SYNTHASE (Escherichiacoli) |
PF00285(Citrate_synt) | 3 | PRO A 313GLY A 64TYR A 311 | None | 0.58A | 2vouA-4g6bA:undetectable | 2vouA-4g6bA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igl | YENB (Yersiniaentomophaga) |
PF03534(SpvB)PF12255(TcdB_toxin_midC)PF12256(TcdB_toxin_midN) | 3 | PRO A1449GLY A 889TYR A 900 | GOL A1502 ( 3.6A)NoneNone | 0.55A | 2vouA-4iglA:undetectable | 2vouA-4iglA:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jf7 | HEMAGGLUTININ-NEURAMINIDASE (Mammalianrubulavirus 5) |
no annotation | 3 | PRO D 304GLY D 391TYR D 402 | None | 0.67A | 2vouA-4jf7D:undetectable | 2vouA-4jf7D:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kjv | E3 UBIQUITIN-PROTEINLIGASE XIAP (Homo sapiens) |
PF00653(BIR) | 3 | PRO A 174GLY A 195TYR A 191 | None | 0.66A | 2vouA-4kjvA:undetectable | 2vouA-4kjvA:13.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l9c | F-BOX ONLY PROTEIN 7 (Homo sapiens) |
PF11566(PI31_Prot_N) | 3 | PRO A 254GLY A 232TYR A 234 | None | 0.72A | 2vouA-4l9cA:undetectable | 2vouA-4l9cA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ll6 | MYOSIN-4 (Saccharomycescerevisiae) |
PF01843(DIL) | 3 | PRO A1397GLY A1404TYR A1395 | None | 0.72A | 2vouA-4ll6A:undetectable | 2vouA-4ll6A:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9x | TCDB2, TCCC3 (Photorhabdusluminescens) |
PF03534(SpvB)PF12255(TcdB_toxin_midC)PF12256(TcdB_toxin_midN) | 3 | PRO A1467GLY A 910TYR A 921 | None | 0.69A | 2vouA-4o9xA:undetectable | 2vouA-4o9xA:11.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oxc | E3 UBIQUITIN-PROTEINLIGASE XIAP (Homo sapiens) |
PF00653(BIR) | 3 | PRO A 37GLY A 58TYR A 54 | None | 0.68A | 2vouA-4oxcA:undetectable | 2vouA-4oxcA:15.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qi4 | CELLOBIOSEDEHYDROGENASE (Crassicarponhotsonii) |
PF00732(GMC_oxred_N)PF00734(CBM_1)PF05199(GMC_oxred_C) | 3 | PRO A 288GLY A 413TYR A 563 | None | 0.72A | 2vouA-4qi4A:5.5 | 2vouA-4qi4A:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tvm | CITRATE SYNTHASE (Mycobacteriumtuberculosis) |
PF00285(Citrate_synt) | 3 | PRO A 317GLY A 67TYR A 315 | None | 0.57A | 2vouA-4tvmA:undetectable | 2vouA-4tvmA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wvt | E3 UBIQUITIN-PROTEINLIGASE XIAP (Homo sapiens) |
PF00653(BIR) | 3 | PRO A 174GLY A 195TYR A 191 | None | 0.74A | 2vouA-4wvtA:undetectable | 2vouA-4wvtA:13.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yu5 | IMMUNE INHIBITOR A,METALLOPROTEASE (Bacillus cereus) |
PF05547(Peptidase_M6) | 3 | PRO A 666GLY A 719TYR A 668 | None | 0.62A | 2vouA-4yu5A:undetectable | 2vouA-4yu5A:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yxt | POLYKETIDEBIOSYNTHESIS3-HYDROXY-3-METHYLGLUTARYL-ACP SYNTHASEPKSG (Bacillussubtilis) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 3 | PRO A 286GLY A 313TYR A 246 | None | 0.73A | 2vouA-4yxtA:undetectable | 2vouA-4yxtA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z2a | FURIN (Homo sapiens) |
PF00082(Peptidase_S8)PF01483(P_proprotein) | 3 | PRO A 256GLY A 265TYR A 308 | None | 0.71A | 2vouA-4z2aA:undetectable | 2vouA-4z2aA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z8x | ATP-DEPENDENT ZINCMETALLOPROTEASE FTSH (Aquifexaeolicus) |
PF00004(AAA)PF01434(Peptidase_M41) | 3 | PRO A 177GLY A 294TYR A 173 | None | 0.62A | 2vouA-4z8xA:undetectable | 2vouA-4z8xA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) |
PF00117(GATase)PF06418(CTP_synth_N) | 3 | PRO A 364GLY A 308TYR A 317 | None | 0.71A | 2vouA-4zdkA:undetectable | 2vouA-4zdkA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b2d | HN PROTEIN (Mumpsrubulavirus) |
PF00423(HN) | 3 | PRO A 321GLY A 408TYR A 419 | None | 0.69A | 2vouA-5b2dA:undetectable | 2vouA-5b2dA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by4 | PROTEIN TOLR (Escherichiacoli) |
PF02472(ExbD) | 3 | PRO A 88GLY A 72TYR A 74 | None NA A 203 ( 4.7A) NA A 203 (-4.3A) | 0.57A | 2vouA-5by4A:undetectable | 2vouA-5by4A:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5chc | DMSO REDUCTASEFAMILY TYPE IIENZYME,MOLYBDOPTERINSUBUNIT (Azospira oryzae) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 3 | PRO A 172GLY A 183TYR A 165 | None | 0.70A | 2vouA-5chcA:undetectable | 2vouA-5chcA:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d4k | POLYMERICIMMUNOGLOBULINRECEPTOR (Homo sapiens) |
PF07686(V-set) | 3 | PRO A 26GLY A 73TYR A 24 | None | 0.75A | 2vouA-5d4kA:undetectable | 2vouA-5d4kA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dpw | MICROTUBULE-ASSOCIATED PROTEINS 1A/1BLIGHT CHAIN 3C (Homo sapiens) |
PF02991(Atg8) | 3 | PRO A 28GLY A 103TYR A 95 | None | 0.74A | 2vouA-5dpwA:undetectable | 2vouA-5dpwA:12.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e2g | BETA-LACTAMASE (Burkholderiacenocepacia) |
PF00144(Beta-lactamase) | 3 | PRO A 259GLY A 281TYR A 269 | None | 0.60A | 2vouA-5e2gA:undetectable | 2vouA-5e2gA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e2h | BETA-LACTAMASE (Mycolicibacteriumsmegmatis) |
PF00144(Beta-lactamase) | 3 | PRO A 258GLY A 280TYR A 268 | None | 0.69A | 2vouA-5e2hA:undetectable | 2vouA-5e2hA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fhc | ANTIBODY 100 FABHEAVY CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 3 | PRO A 213GLY A 190TYR A 194 | None | 0.65A | 2vouA-5fhcA:undetectable | 2vouA-5fhcA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g06 | EXOSOME COMPLEXCOMPONENT CSL4 (Saccharomycescerevisiae) |
PF10447(EXOSC1) | 3 | PRO I 19GLY I 22TYR I 35 | None | 0.47A | 2vouA-5g06I:undetectable | 2vouA-5g06I:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i2t | PERIODIC TRYPTOPHANPROTEIN 2 (Saccharomycescerevisiae) |
PF00400(WD40) | 3 | PRO A 32GLY A 18TYR A 15 | None | 0.75A | 2vouA-5i2tA:undetectable | 2vouA-5i2tA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i68 | ALCOHOL OXIDASE 1 (Komagataellapastoris) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 3 | PRO A 391GLY A 614TYR A 422 | None | 0.59A | 2vouA-5i68A:9.4 | 2vouA-5i68A:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kz5 | CYSTEINEDESULFURASE,MITOCHONDRIAL (Homo sapiens) |
PF00266(Aminotran_5) | 3 | PRO 1 68GLY 1 411TYR 1 260 | None | 0.57A | 2vouA-5kz51:undetectable | 2vouA-5kz51:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lt9 | METHYL-ACCEPTINGCHEMOTAXIS PROTEINPCTB (Pseudomonasaeruginosa) |
PF02743(dCache_1) | 3 | PRO A 123GLY A 103TYR A 129 | None | 0.63A | 2vouA-5lt9A:undetectable | 2vouA-5lt9A:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ltv | CHEMOTACTICTRANSDUCER PCTC (Pseudomonasaeruginosa) |
PF02743(dCache_1) | 3 | PRO A 126GLY A 105TYR A 132 | None | 0.54A | 2vouA-5ltvA:undetectable | 2vouA-5ltvA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n9j | MEDIATOR OF RNAPOLYMERASE IITRANSCRIPTIONSUBUNIT 10MEDIATOR OF RNAPOLYMERASE IITRANSCRIPTIONSUBUNIT 19 (Schizosaccharomycespombe;Schizosaccharomycespombe) |
PF09748(Med10)PF08633(Rox3) | 3 | PRO C 17GLY B 137TYR C 15 | None | 0.68A | 2vouA-5n9jC:undetectable | 2vouA-5n9jC:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ncc | FATTY ACIDPHOTODECARBOXYLASE (Chlorellavariabilis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 3 | PRO A 127GLY A 271TYR A 419 | None | 0.65A | 2vouA-5nccA:11.1 | 2vouA-5nccA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5or7 | CAPSID PROTEIN (Norwalk virus) |
no annotation | 3 | PRO A 415GLY A 320TYR A 370 | None | 0.74A | 2vouA-5or7A:undetectable | 2vouA-5or7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t65 | METHYL-ACCEPTINGCHEMOTAXIS PROTEINPCTA (Pseudomonasaeruginosa) |
PF02743(dCache_1) | 3 | PRO A 123GLY A 103TYR A 129 | None | 0.60A | 2vouA-5t65A:undetectable | 2vouA-5t65A:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u8z | CAROTENOID OXYGENASE1 (Neurosporacrassa) |
PF03055(RPE65) | 3 | PRO A 174GLY A 158TYR A 155 | None | 0.75A | 2vouA-5u8zA:undetectable | 2vouA-5u8zA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uj5 | ADRENODOXIN (Encephalitozooncuniculi) |
PF00111(Fer2) | 3 | PRO A 78GLY A 94TYR A 72 | None | 0.73A | 2vouA-5uj5A:undetectable | 2vouA-5uj5A:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5utt | SORTASE (Actinomycesoris) |
PF04203(Sortase) | 3 | PRO A 84GLY A 138TYR A 177 | None | 0.67A | 2vouA-5uttA:undetectable | 2vouA-5uttA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vhi | 26S PROTEASOMENON-ATPASEREGULATORY SUBUNIT 8 (Homo sapiens) |
PF00004(AAA) | 3 | PRO d 136GLY d 100TYR d 132 | None | 0.70A | 2vouA-5vhid:undetectable | 2vouA-5vhid:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wmm | NRPS (Micromonosporasp. ML1) |
no annotation | 3 | PRO A 827GLY A 763TYR A 807 | None | 0.69A | 2vouA-5wmmA:undetectable | 2vouA-5wmmA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7n | DIAMINOPIMELATEDECARBOXYLASE (Corynebacteriumglutamicum) |
no annotation | 3 | PRO A 44GLY A 336TYR A 313 | None | 0.62A | 2vouA-5x7nA:undetectable | 2vouA-5x7nA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfo | PHD FINGER PROTEIN 1 (Homo sapiens) |
PF00628(PHD) | 3 | PRO A 168GLY A 192TYR A 169 | None | 0.69A | 2vouA-5xfoA:undetectable | 2vouA-5xfoA:25.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfr | METAL-RESPONSEELEMENT-BINDINGTRANSCRIPTION FACTOR2 (Homo sapiens) |
PF00628(PHD) | 3 | PRO A 183GLY A 207TYR A 184 | None | 0.70A | 2vouA-5xfrA:undetectable | 2vouA-5xfrA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y7o | UGGT (Thermomycesdupontii) |
PF06427(UDP-g_GGTase) | 3 | PRO A 223GLY A 43TYR A 122 | None | 0.60A | 2vouA-5y7oA:undetectable | 2vouA-5y7oA:17.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f39 | COMPLEMENT C1RSUBCOMPONENT (Homo sapiens) |
no annotation | 3 | PRO A 199GLY A 276TYR A 197 | None CA A 303 ( 3.9A)None | 0.41A | 2vouA-6f39A:undetectable | 2vouA-6f39A:undetectable |