SIMILAR PATTERNS OF AMINO ACIDS FOR 2VOU_A_ACTA1397

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmu BGLI RESTRICTION
ENDONUCLEASE


(Bacillus
subtilis)
PF14562
(Endonuc_BglI)
3 PRO A 216
GLY A  86
TYR A  53
None
0.72A 2vouA-1dmuA:
undetectable
2vouA-1dmuA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE


(Escherichia
coli)
PF00155
(Aminotran_1_2)
3 PRO A 270
GLY A 117
TYR A 108
None
0.71A 2vouA-1fc4A:
0.0
2vouA-1fc4A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
3 PRO A 180
GLY A  20
TYR A 176
None
0.73A 2vouA-1hfuA:
undetectable
2vouA-1hfuA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE


(Mycobacterium
tuberculosis)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
3 PRO A  41
GLY A 337
TYR A 314
None
0.56A 2vouA-1hkwA:
0.1
2vouA-1hkwA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd5 APOPTOSIS 1
INHIBITOR


(Drosophila
melanogaster)
PF00653
(BIR)
3 PRO A 237
GLY A 258
TYR A 254
None
0.67A 2vouA-1jd5A:
undetectable
2vouA-1jd5A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kny KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE


(Staphylococcus
aureus)
PF07827
(KNTase_C)
3 PRO A  97
GLY A 178
TYR A 185
None
0.74A 2vouA-1knyA:
undetectable
2vouA-1knyA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lv7 FTSH

(Escherichia
coli)
PF00004
(AAA)
3 PRO A 177
GLY A 293
TYR A 173
None
0.59A 2vouA-1lv7A:
undetectable
2vouA-1lv7A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE


(Phanerochaete
chrysosporium)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
3 PRO A 275
GLY A 401
TYR A 550
None
0.73A 2vouA-1naaA:
10.6
2vouA-1naaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum)
PF01425
(Amidase)
3 PRO A 349
GLY A 357
TYR A 162
None
0.51A 2vouA-1ocmA:
undetectable
2vouA-1ocmA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae)
PF00082
(Peptidase_S8)
PF01483
(P_proprotein)
3 PRO A 275
GLY A 284
TYR A 327
None
0.69A 2vouA-1ot5A:
2.5
2vouA-1ot5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvj PYROGENIC EXOTOXIN B

(Streptococcus
pyogenes)
PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69)
3 PRO A 207
GLY A 210
TYR A 240
None
0.67A 2vouA-1pvjA:
undetectable
2vouA-1pvjA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8r CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUSA


(Escherichia
coli)
PF05866
(RusA)
3 PRO A  12
GLY A  31
TYR A  17
None
0.71A 2vouA-1q8rA:
undetectable
2vouA-1q8rA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (VIRUS
CAPSID PROTEIN VP2)


(Foot-and-mouth
disease virus)
PF00073
(Rhv)
3 PRO 2 176
GLY 2 164
TYR 2 162
None
0.67A 2vouA-1qgc2:
undetectable
2vouA-1qgc2:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyp BETA-FRUCTOSIDASE

(Thermotoga
maritima)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
3 PRO A  10
GLY A  13
TYR A  34
None
0.75A 2vouA-1uypA:
undetectable
2vouA-1uypA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE


(Thermus
thermophilus)
PF02602
(HEM4)
3 PRO A 162
GLY A  70
TYR A 163
None
0.56A 2vouA-1wcxA:
undetectable
2vouA-1wcxA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wls L-ASPARAGINASE

(Pyrococcus
horikoshii)
PF00710
(Asparaginase)
3 PRO A 100
GLY A 137
TYR A 188
None
0.73A 2vouA-1wlsA:
undetectable
2vouA-1wlsA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc3 PUTATIVE
FRUCTOKINASE


(Bacillus
subtilis)
PF00480
(ROK)
3 PRO A 269
GLY A 228
TYR A 125
None
0.67A 2vouA-1xc3A:
undetectable
2vouA-1xc3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE


(Sarocladium
strictum)
PF01565
(FAD_binding_4)
PF08031
(BBE)
3 PRO A 398
GLY A 403
TYR A 399
None
0.72A 2vouA-1zr6A:
undetectable
2vouA-1zr6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaa ALPHA-AMYLASE

(Aspergillus
niger)
PF00128
(Alpha-amylase)
PF09260
(DUF1966)
3 PRO A 341
GLY A  33
TYR A 342
None
0.65A 2vouA-2aaaA:
undetectable
2vouA-2aaaA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT


(Thermus
aquaticus)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
3 PRO A 125
GLY A  48
TYR A  74
None
0.59A 2vouA-2hpiA:
undetectable
2vouA-2hpiA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE


(Oxalobacter
formigenes)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
3 PRO A 100
GLY A  71
TYR A 226
None
None
ADP  A1556 ( 4.8A)
0.68A 2vouA-2ji9A:
undetectable
2vouA-2ji9A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE


(Paramecium
bursaria
Chlorella virus
1)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
3 PRO A 316
GLY A 276
TYR A 278
None
0.69A 2vouA-2nv9A:
undetectable
2vouA-2nv9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osy ENDOGLYCOCERAMIDASE
II


(Rhodococcus sp.)
PF00150
(Cellulase)
3 PRO A  43
GLY A 376
TYR A  45
None
0.59A 2vouA-2osyA:
undetectable
2vouA-2osyA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poi BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 4


(Homo sapiens)
PF00653
(BIR)
3 PRO A  37
GLY A  58
TYR A  54
None
0.72A 2vouA-2poiA:
undetectable
2vouA-2poiA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY


(Streptococcus
pneumoniae)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
3 PRO A 341
GLY A 367
TYR A 364
None
0.67A 2vouA-2pokA:
1.9
2vouA-2pokA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9t DING

(Pseudomonas
fluorescens)
PF12849
(PBP_like_2)
3 PRO A  10
GLY A  60
TYR A  27
None
0.74A 2vouA-2q9tA:
undetectable
2vouA-2q9tA:
23.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vou 2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE


(Paenarthrobacter
nicotinovorans)
PF00070
(Pyr_redox)
3 PRO A 311
GLY A 318
TYR A 357
ACT  A1397 (-4.1A)
FAD  A1395 ( 3.3A)
ACT  A1397 (-4.5A)
0.02A 2vouA-2vouA:
72.1
2vouA-2vouA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN


(Streptococcus
pneumoniae)
PF13519
(VWA_2)
3 PRO A 390
GLY A 516
TYR A 448
None
0.44A 2vouA-2ww8A:
undetectable
2vouA-2ww8A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE


(Streptococcus
agalactiae)
PF07470
(Glyco_hydro_88)
3 PRO A 357
GLY A 375
TYR A  61
None
0.73A 2vouA-2zzrA:
undetectable
2vouA-2zzrA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anw PUTATIVE
UNCHARACTERIZED
PROTEIN


(Thermococcus
kodakarensis)
no annotation 3 PRO A 168
GLY A 150
TYR A 156
None
0.72A 2vouA-3anwA:
undetectable
2vouA-3anwA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN


(Methylobacillus
flagellatus)
PF03069
(FmdA_AmdA)
3 PRO A 385
GLY A 312
TYR A 328
None
0.71A 2vouA-3b9tA:
undetectable
2vouA-3b9tA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb7 INTERPAIN A

(Prevotella
intermedia)
PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69)
3 PRO A 169
GLY A 172
TYR A 199
None
0.55A 2vouA-3bb7A:
undetectable
2vouA-3bb7A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bba INTERPAIN A

(Prevotella
intermedia)
PF01640
(Peptidase_C10)
3 PRO A 169
GLY A 172
TYR A 199
None
0.51A 2vouA-3bbaA:
undetectable
2vouA-3bbaA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beo UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Bacillus
anthracis)
PF02350
(Epimerase_2)
3 PRO A 294
GLY A 312
TYR A 352
None
0.72A 2vouA-3beoA:
2.4
2vouA-3beoA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8c METHYL-ACCEPTING
CHEMOTAXIS PROTEIN


(Vibrio cholerae)
PF02743
(dCache_1)
3 PRO A 149
GLY A 127
TYR A 155
None
0.56A 2vouA-3c8cA:
undetectable
2vouA-3c8cA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE


(Shewanella
amazonensis)
PF04952
(AstE_AspA)
3 PRO A 342
GLY A 304
TYR A 358
None
0.57A 2vouA-3fmcA:
undetectable
2vouA-3fmcA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2i ESTERASE

(Xanthomonas
oryzae)
PF03583
(LIP)
3 PRO A 165
GLY A  77
TYR A  79
None
0.73A 2vouA-3h2iA:
undetectable
2vouA-3h2iA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN


(Bacteroides
fragilis)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
3 PRO A 161
GLY A 426
TYR A 447
None
0.66A 2vouA-3l22A:
undetectable
2vouA-3l22A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1t PUTATIVE
PHOSPHOHYDROLASE


(Shewanella
amazonensis)
PF08668
(HDOD)
3 PRO A 204
GLY A 215
TYR A 210
None
0.70A 2vouA-3m1tA:
undetectable
2vouA-3m1tA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfr PMOB

(Methylocystis
sp. M)
PF04744
(Monooxygenase_B)
3 PRO A 339
GLY A 150
TYR A 341
None
0.65A 2vouA-3rfrA:
undetectable
2vouA-3rfrA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqx 2-AMINO-3-KETOBUTYRA
TE COENZYME A LIGASE


(Coxiella
burnetii)
PF00155
(Aminotran_1_2)
3 PRO A 268
GLY A 115
TYR A 106
None
0.66A 2vouA-3tqxA:
undetectable
2vouA-3tqxA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uam CHITIN BINDING
DOMAIN


(Burkholderia
pseudomallei)
PF03067
(LPMO_10)
3 PRO A 161
GLY A 164
TYR A 159
None
0.74A 2vouA-3uamA:
undetectable
2vouA-3uamA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc0 ENVELOPE PROTEIN

(Dengue virus)
PF00869
(Flavi_glycoprot)
3 PRO A 166
GLY A 134
TYR A 137
None
0.69A 2vouA-3uc0A:
undetectable
2vouA-3uc0A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus)
PF03447
(NAD_binding_3)
3 PRO A 346
GLY A 147
TYR A 161
None
0.54A 2vouA-3upyA:
4.4
2vouA-3upyA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE


(Bacteroides
thetaiotaomicron)
PF07494
(Reg_prop)
PF07495
(Y_Y_Y)
3 PRO A 709
GLY A  75
TYR A 710
None
0.74A 2vouA-3va6A:
undetectable
2vouA-3va6A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A


(Enterococcus
hirae)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn)
3 PRO A 205
GLY A 226
TYR A 437
None
0.71A 2vouA-3vr5A:
undetectable
2vouA-3vr5A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1y MICROTUBULE-ASSOCIAT
ED PROTEIN 1A/1B,
LIGHT CHAIN 3


(Trypanosoma
brucei)
PF02991
(Atg8)
3 PRO A  32
GLY A 121
TYR A 113
None
0.74A 2vouA-3w1yA:
undetectable
2vouA-3w1yA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wap AUTOPHAGY-RELATED
PROTEIN 13,
MICROTUBULE-ASSOCIAT
ED PROTEINS 1A/1B
LIGHT CHAIN 3C


(Homo sapiens)
PF02991
(Atg8)
3 PRO A  47
GLY A 122
TYR A 114
None
0.55A 2vouA-3wapA:
undetectable
2vouA-3wapA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjt OUTER-MEMBRANE
LIPOPROTEIN LOLB


(Escherichia
coli)
PF03550
(LolB)
3 PRO A 164
GLY A 120
TYR A 152
None
0.71A 2vouA-3wjtA:
undetectable
2vouA-3wjtA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbw SIALIDASE
(NEURAMINIDASE)


(Bacteroides
thetaiotaomicron)
PF13088
(BNR_2)
PF14873
(BNR_assoc_N)
3 PRO A  96
GLY A  81
TYR A  99
None
0.72A 2vouA-4bbwA:
undetectable
2vouA-4bbwA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmw DITERPENE SYNTHASE

(Mycobacterium
tuberculosis)
no annotation 3 PRO A 216
GLY A 162
TYR A 121
None
0.70A 2vouA-4cmwA:
undetectable
2vouA-4cmwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00171
(Aldedh)
3 PRO A 385
GLY A 365
TYR A 272
None
0.72A 2vouA-4e4gA:
2.2
2vouA-4e4gA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN


(Legionella
pneumophila)
no annotation 3 PRO A  93
GLY A 136
TYR A  65
None
0.67A 2vouA-4eziA:
undetectable
2vouA-4eziA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdu PUTATIVE MULTIPLE
INOSITOL
POLYPHOSPHATE
HISTIDINE
PHOSPHATASE 1


(Bacteroides
thetaiotaomicron)
PF00328
(His_Phos_2)
3 PRO A 290
GLY A 286
TYR A 194
None
0.67A 2vouA-4fduA:
undetectable
2vouA-4fduA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Bacillus
subtilis)
PF02350
(Epimerase_2)
3 PRO A 292
GLY A 310
TYR A 350
None
0.72A 2vouA-4fkzA:
3.5
2vouA-4fkzA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzy EXODEOXYRIBONUCLEASE
10


(Escherichia
coli)
PF00929
(RNase_T)
3 PRO A  93
GLY A  73
TYR A  77
None
0.70A 2vouA-4fzyA:
undetectable
2vouA-4fzyA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6b CITRATE SYNTHASE

(Escherichia
coli)
PF00285
(Citrate_synt)
3 PRO A 313
GLY A  64
TYR A 311
None
0.58A 2vouA-4g6bA:
undetectable
2vouA-4g6bA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga)
PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN)
3 PRO A1449
GLY A 889
TYR A 900
GOL  A1502 ( 3.6A)
None
None
0.55A 2vouA-4iglA:
undetectable
2vouA-4iglA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf7 HEMAGGLUTININ-NEURAM
INIDASE


(Mammalian
rubulavirus 5)
no annotation 3 PRO D 304
GLY D 391
TYR D 402
None
0.67A 2vouA-4jf7D:
undetectable
2vouA-4jf7D:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjv E3 UBIQUITIN-PROTEIN
LIGASE XIAP


(Homo sapiens)
PF00653
(BIR)
3 PRO A 174
GLY A 195
TYR A 191
None
0.66A 2vouA-4kjvA:
undetectable
2vouA-4kjvA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9c F-BOX ONLY PROTEIN 7

(Homo sapiens)
PF11566
(PI31_Prot_N)
3 PRO A 254
GLY A 232
TYR A 234
None
0.72A 2vouA-4l9cA:
undetectable
2vouA-4l9cA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll6 MYOSIN-4

(Saccharomyces
cerevisiae)
PF01843
(DIL)
3 PRO A1397
GLY A1404
TYR A1395
None
0.72A 2vouA-4ll6A:
undetectable
2vouA-4ll6A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens)
PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN)
3 PRO A1467
GLY A 910
TYR A 921
None
0.69A 2vouA-4o9xA:
undetectable
2vouA-4o9xA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP


(Homo sapiens)
PF00653
(BIR)
3 PRO A  37
GLY A  58
TYR A  54
None
0.68A 2vouA-4oxcA:
undetectable
2vouA-4oxcA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE


(Crassicarpon
hotsonii)
PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
3 PRO A 288
GLY A 413
TYR A 563
None
0.72A 2vouA-4qi4A:
5.5
2vouA-4qi4A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvm CITRATE SYNTHASE

(Mycobacterium
tuberculosis)
PF00285
(Citrate_synt)
3 PRO A 317
GLY A  67
TYR A 315
None
0.57A 2vouA-4tvmA:
undetectable
2vouA-4tvmA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvt E3 UBIQUITIN-PROTEIN
LIGASE XIAP


(Homo sapiens)
PF00653
(BIR)
3 PRO A 174
GLY A 195
TYR A 191
None
0.74A 2vouA-4wvtA:
undetectable
2vouA-4wvtA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE


(Bacillus cereus)
PF05547
(Peptidase_M6)
3 PRO A 666
GLY A 719
TYR A 668
None
0.62A 2vouA-4yu5A:
undetectable
2vouA-4yu5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG


(Bacillus
subtilis)
PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C)
3 PRO A 286
GLY A 313
TYR A 246
None
0.73A 2vouA-4yxtA:
undetectable
2vouA-4yxtA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens)
PF00082
(Peptidase_S8)
PF01483
(P_proprotein)
3 PRO A 256
GLY A 265
TYR A 308
None
0.71A 2vouA-4z2aA:
undetectable
2vouA-4z2aA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH


(Aquifex
aeolicus)
PF00004
(AAA)
PF01434
(Peptidase_M41)
3 PRO A 177
GLY A 294
TYR A 173
None
0.62A 2vouA-4z8xA:
undetectable
2vouA-4z8xA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdk CTP SYNTHASE

(Mycobacterium
tuberculosis)
PF00117
(GATase)
PF06418
(CTP_synth_N)
3 PRO A 364
GLY A 308
TYR A 317
None
0.71A 2vouA-4zdkA:
undetectable
2vouA-4zdkA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2d HN PROTEIN

(Mumps
rubulavirus)
PF00423
(HN)
3 PRO A 321
GLY A 408
TYR A 419
None
0.69A 2vouA-5b2dA:
undetectable
2vouA-5b2dA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by4 PROTEIN TOLR

(Escherichia
coli)
PF02472
(ExbD)
3 PRO A  88
GLY A  72
TYR A  74
None
NA  A 203 ( 4.7A)
NA  A 203 (-4.3A)
0.57A 2vouA-5by4A:
undetectable
2vouA-5by4A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT


(Azospira oryzae)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
3 PRO A 172
GLY A 183
TYR A 165
None
0.70A 2vouA-5chcA:
undetectable
2vouA-5chcA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR


(Homo sapiens)
PF07686
(V-set)
3 PRO A  26
GLY A  73
TYR A  24
None
0.75A 2vouA-5d4kA:
undetectable
2vouA-5d4kA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpw MICROTUBULE-ASSOCIAT
ED PROTEINS 1A/1B
LIGHT CHAIN 3C


(Homo sapiens)
PF02991
(Atg8)
3 PRO A  28
GLY A 103
TYR A  95
None
0.74A 2vouA-5dpwA:
undetectable
2vouA-5dpwA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2g BETA-LACTAMASE

(Burkholderia
cenocepacia)
PF00144
(Beta-lactamase)
3 PRO A 259
GLY A 281
TYR A 269
None
0.60A 2vouA-5e2gA:
undetectable
2vouA-5e2gA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2h BETA-LACTAMASE

(Mycolicibacterium
smegmatis)
PF00144
(Beta-lactamase)
3 PRO A 258
GLY A 280
TYR A 268
None
0.69A 2vouA-5e2hA:
undetectable
2vouA-5e2hA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhc ANTIBODY 100 FAB
HEAVY CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
3 PRO A 213
GLY A 190
TYR A 194
None
0.65A 2vouA-5fhcA:
undetectable
2vouA-5fhcA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT CSL4


(Saccharomyces
cerevisiae)
PF10447
(EXOSC1)
3 PRO I  19
GLY I  22
TYR I  35
None
0.47A 2vouA-5g06I:
undetectable
2vouA-5g06I:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2


(Saccharomyces
cerevisiae)
PF00400
(WD40)
3 PRO A  32
GLY A  18
TYR A  15
None
0.75A 2vouA-5i2tA:
undetectable
2vouA-5i2tA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
3 PRO A 391
GLY A 614
TYR A 422
None
0.59A 2vouA-5i68A:
9.4
2vouA-5i68A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL


(Homo sapiens)
PF00266
(Aminotran_5)
3 PRO 1  68
GLY 1 411
TYR 1 260
None
0.57A 2vouA-5kz51:
undetectable
2vouA-5kz51:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lt9 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTB


(Pseudomonas
aeruginosa)
PF02743
(dCache_1)
3 PRO A 123
GLY A 103
TYR A 129
None
0.63A 2vouA-5lt9A:
undetectable
2vouA-5lt9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltv CHEMOTACTIC
TRANSDUCER PCTC


(Pseudomonas
aeruginosa)
PF02743
(dCache_1)
3 PRO A 126
GLY A 105
TYR A 132
None
0.54A 2vouA-5ltvA:
undetectable
2vouA-5ltvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 10
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 19


(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe)
PF09748
(Med10)
PF08633
(Rox3)
3 PRO C  17
GLY B 137
TYR C  15
None
0.68A 2vouA-5n9jC:
undetectable
2vouA-5n9jC:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE


(Chlorella
variabilis)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
3 PRO A 127
GLY A 271
TYR A 419
None
0.65A 2vouA-5nccA:
11.1
2vouA-5nccA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or7 CAPSID PROTEIN

(Norwalk virus)
no annotation 3 PRO A 415
GLY A 320
TYR A 370
None
0.74A 2vouA-5or7A:
undetectable
2vouA-5or7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA


(Pseudomonas
aeruginosa)
PF02743
(dCache_1)
3 PRO A 123
GLY A 103
TYR A 129
None
0.60A 2vouA-5t65A:
undetectable
2vouA-5t65A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8z CAROTENOID OXYGENASE
1


(Neurospora
crassa)
PF03055
(RPE65)
3 PRO A 174
GLY A 158
TYR A 155
None
0.75A 2vouA-5u8zA:
undetectable
2vouA-5u8zA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj5 ADRENODOXIN

(Encephalitozoon
cuniculi)
PF00111
(Fer2)
3 PRO A  78
GLY A  94
TYR A  72
None
0.73A 2vouA-5uj5A:
undetectable
2vouA-5uj5A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utt SORTASE

(Actinomyces
oris)
PF04203
(Sortase)
3 PRO A  84
GLY A 138
TYR A 177
None
0.67A 2vouA-5uttA:
undetectable
2vouA-5uttA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8


(Homo sapiens)
PF00004
(AAA)
3 PRO d 136
GLY d 100
TYR d 132
None
0.70A 2vouA-5vhid:
undetectable
2vouA-5vhid:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1)
no annotation 3 PRO A 827
GLY A 763
TYR A 807
None
0.69A 2vouA-5wmmA:
undetectable
2vouA-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7n DIAMINOPIMELATE
DECARBOXYLASE


(Corynebacterium
glutamicum)
no annotation 3 PRO A  44
GLY A 336
TYR A 313
None
0.62A 2vouA-5x7nA:
undetectable
2vouA-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfo PHD FINGER PROTEIN 1

(Homo sapiens)
PF00628
(PHD)
3 PRO A 168
GLY A 192
TYR A 169
None
0.69A 2vouA-5xfoA:
undetectable
2vouA-5xfoA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfr METAL-RESPONSE
ELEMENT-BINDING
TRANSCRIPTION FACTOR
2


(Homo sapiens)
PF00628
(PHD)
3 PRO A 183
GLY A 207
TYR A 184
None
0.70A 2vouA-5xfrA:
undetectable
2vouA-5xfrA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii)
PF06427
(UDP-g_GGTase)
3 PRO A 223
GLY A  43
TYR A 122
None
0.60A 2vouA-5y7oA:
undetectable
2vouA-5y7oA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f39 COMPLEMENT C1R
SUBCOMPONENT


(Homo sapiens)
no annotation 3 PRO A 199
GLY A 276
TYR A 197
None
CA  A 303 ( 3.9A)
None
0.41A 2vouA-6f39A:
undetectable
2vouA-6f39A:
undetectable