SIMILAR PATTERNS OF AMINO ACIDS FOR 2VN0_A_TDZA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4i METHYLENETETRAHYDROF
OLATE DEHYDROGENASE
/
METHENYLTETRAHYDROFO
LATE CYCLOHYDROLASE

(Homo sapiens) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 ILE A  70
LEU A  88
ASN A  89
VAL A  81
ILE A 118
 None
 1.18A 2vn0A-1a4iA:
undetectable		 2vn0A-1a4iA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		5 ILE A 133
ASN A 146
LEU A 148
VAL A 115
VAL A 180
 None
 1.01A 2vn0A-1airA:
0.0		 2vn0A-1airA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		5 ILE A  68
LEU A  79
VAL A  72
VAL A 148
ILE A 196
 None
 1.04A 2vn0A-1cg4A:
0.0		 2vn0A-1cg4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eks MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
C

(Escherichia
coli) 		PF01967
(MoaC) 		5 ILE A 126
THR A 125
LEU A  88
ASN A  87
VAL A  34
 None
 1.21A 2vn0A-1eksA:
undetectable		 2vn0A-1eksA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kae HISTIDINOL
DEHYDROGENASE

(Escherichia
coli) 		PF00815
(Histidinol_dh) 		5 ILE A 407
THR A 406
LEU A 395
VAL A 423
GLU A 398
 None
 1.20A 2vn0A-1kaeA:
0.0		 2vn0A-1kaeA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyl GLUTAMINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		5 ILE A 331
LEU A 327
VAL A 542
GLU A 323
ILE A 313
 None
 1.09A 2vn0A-1nylA:
0.0		 2vn0A-1nylA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)

(Homo sapiens) 		PF00092
(VWA) 		5 ILE B 416
THR B 412
VAL B 455
GLU B 495
THR B 497
 None
 1.14A 2vn0A-1qc5B:
undetectable		 2vn0A-1qc5B:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		5 ILE A 395
LEU A 341
VAL A 364
GLU A 366
ILE A 379
 None
 1.18A 2vn0A-1tdjA:
undetectable		 2vn0A-1tdjA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcb PROTEIN (ELONGIN C)

(Homo sapiens) 		PF03931
(Skp1_POZ) 		5 ILE B  42
THR B  41
PHE B  29
LEU B  21
VAL B  73
 None
 1.19A 2vn0A-1vcbB:
undetectable		 2vn0A-1vcbB:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 445
ASN A 444
VAL A 401
VAL A 418
THR A 375
 LEU  A 445 ( 0.6A)
ASN  A 444 ( 0.6A)
VAL  A 401 ( 0.6A)
VAL  A 418 ( 0.6A)
THR  A 375 ( 0.8A)
 1.19A 2vn0A-1wqaA:
0.0		 2vn0A-1wqaA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq1 PUTATIVE TROPINONE
REDUCATSE

(Arabidopsis
thaliana) 		PF13561
(adh_short_C2) 		5 ILE A 249
LEU A 236
VAL A 229
GLU A  33
ILE A  97
 None
 0.92A 2vn0A-1xq1A:
undetectable		 2vn0A-1xq1A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y51 PHOSPHOCARRIER
PROTEIN HPR

(Geobacillus
stearothermophilus) 		PF00381
(PTS-HPr) 		5 ILE A  14
LEU A  35
VAL A   8
GLU A   3
ILE A  33
 None
 1.19A 2vn0A-1y51A:
undetectable		 2vn0A-1y51A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr7 ATP(GTP)BINDING
PROTEIN

(Pyrococcus
abyssi) 		PF03029
(ATP_bind_1) 		5 ILE A 100
THR A 102
LEU A 122
ASN A 121
VAL A  33
 None
 1.18A 2vn0A-1yr7A:
undetectable		 2vn0A-1yr7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yub RRNA
METHYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF00398
(RrnaAD) 		5 THR A 180
ASN A 236
PHE A 235
LEU A 232
ILE A 137
 None
 1.19A 2vn0A-1yubA:
undetectable		 2vn0A-1yubA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbs HYPOTHETICAL PROTEIN
PG1100

(Porphyromonas
gingivalis) 		PF01869
(BcrAD_BadFG) 		5 ILE A  31
THR A  12
LEU A  78
ASN A  79
ILE A  92
 None
 1.23A 2vn0A-1zbsA:
undetectable		 2vn0A-1zbsA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		5 ILE A  40
THR A   9
ASN A  77
VAL A 132
ILE A   4
 None
 1.07A 2vn0A-2b0tA:
undetectable		 2vn0A-2b0tA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9w MAST/STEM CELL
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF00047
(ig) 		5 THR A 391
PHE A 316
ASN A 314
VAL A 335
ILE A 313
 None
 1.23A 2vn0A-2e9wA:
undetectable		 2vn0A-2e9wA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwx TELOMERASE-BINDING
PROTEIN EST1A

(Homo sapiens) 		PF13638
(PIN_4) 		5 ILE A1256
LEU A1283
ASN A1281
VAL A1303
ILE A1278
 None
 1.16A 2vn0A-2hwxA:
undetectable		 2vn0A-2hwxA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inv INSULIN
FRUCTOTRANSFERASE

(Bacillus sp.
snu-7) 		no annotation 5 ILE A 297
ASN A 334
LEU A 312
VAL A 307
VAL A 360
 None
 1.13A 2vn0A-2invA:
0.0		 2vn0A-2invA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu8 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE

(Chlamydia
trachomatis) 		PF00132
(Hexapep)
PF04613
(LpxD) 		5 ILE A 185
VAL A 171
VAL A 233
GLU A 250
ILE A 263
 None
 1.07A 2vn0A-2iu8A:
undetectable		 2vn0A-2iu8A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kqr ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Brugia malayi) 		no annotation 5 ILE A  31
THR A  32
LEU A  22
GLU A  18
ILE A  41
 None
 1.18A 2vn0A-2kqrA:
undetectable		 2vn0A-2kqrA:
14.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		11 ILE A 106
THR A 107
ASN A 204
PHE A 205
LEU A 208
ASN A 209
VAL A 237
VAL A 296
GLU A 300
THR A 301
ILE A 476
 PLM  A 502 (-4.6A)
None
None
None
225  A 501 ( 4.3A)
None
None
None
None
HEM  A 500 ( 3.7A)
225  A 501 ( 3.9A)
 0.60A 2vn0A-2nnjA:
63.3		 2vn0A-2nnjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis) 		no annotation 5 ILE A 146
LEU A 167
VAL A 221
GLU A 222
ILE A 243
 None
 1.14A 2vn0A-2q9uA:
undetectable		 2vn0A-2q9uA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 THR A 493
LEU A 235
VAL A 477
THR A 243
ILE A 313
 None
 1.22A 2vn0A-2qveA:
undetectable		 2vn0A-2qveA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxy RESPONSE REGULATOR

(Thermotoga
maritima) 		PF00072
(Response_reg) 		5 ILE A  69
PHE A  43
LEU A  44
VAL A  78
VAL A  10
 None
 1.10A 2vn0A-2qxyA:
undetectable		 2vn0A-2qxyA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ

(Aquifex
aeolicus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ILE 1 193
THR 1 194
VAL 1 210
VAL 1 125
ILE 1 160
 None
 1.16A 2vn0A-2r6r1:
undetectable		 2vn0A-2r6r1:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rv9 GLUCANASE

(Paenibacillus
fukuinensis) 		PF00754
(F5_F8_type_C) 		5 ILE A  70
LEU A  58
ASN A  59
GLU A 127
ILE A  95
 None
 1.14A 2vn0A-2rv9A:
undetectable		 2vn0A-2rv9A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		5 ILE A  67
LEU A 167
ASN A 168
VAL A 116
VAL A 162
 None
None
None
SAH  A 400 (-3.5A)
None
 1.19A 2vn0A-2vp3A:
undetectable		 2vn0A-2vp3A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 ILE A 476
LEU A 332
VAL A 481
GLU A 327
ILE A 346
 None
 1.09A 2vn0A-2x0qA:
undetectable		 2vn0A-2x0qA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ILE A 381
LEU A 533
VAL A 451
VAL A 518
ILE A 537
 None
 1.17A 2vn0A-2x40A:
undetectable		 2vn0A-2x40A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B) 		5 ILE A 148
ASN A   2
VAL A  29
VAL A 119
THR A  23
 None
 1.03A 2vn0A-2xf4A:
undetectable		 2vn0A-2xf4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmo LMO2642 PROTEIN

(Listeria
monocytogenes) 		PF00149
(Metallophos) 		5 ILE A  98
LEU A 114
GLU A 107
THR A 155
ILE A 164
 None
 1.10A 2vn0A-2xmoA:
undetectable		 2vn0A-2xmoA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		5 ILE A 258
THR A 259
LEU A 390
ASN A  19
VAL A 385
 None
 1.18A 2vn0A-2zbzA:
31.7		 2vn0A-2zbzA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c30 AUTOINDUCER 2 SENSOR
KINASE/PHOSPHATASE
LUXQ

(Vibrio cholerae) 		PF09308
(LuxQ-periplasm) 		5 ILE A 167
LEU A 143
ASN A 141
VAL A 165
ILE A 123
 None
 1.22A 2vn0A-3c30A:
undetectable		 2vn0A-3c30A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622

(Lactobacillus
plantarum) 		PF04263
(TPK_catalytic) 		5 ILE A 129
LEU A 131
ASN A 136
VAL A  97
ILE A 209
 None
 1.21A 2vn0A-3cq9A:
undetectable		 2vn0A-3cq9A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n DIHYDROOROTASE

(Aquifex
aeolicus) 		PF01979
(Amidohydro_1) 		5 ILE A 191
PHE A 263
ASN A 259
VAL A 196
ILE A 324
 None
 1.20A 2vn0A-3d6nA:
undetectable		 2vn0A-3d6nA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e20 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT

(Schizosaccharomyces
pombe) 		PF03143
(GTP_EFTU_D3) 		5 ILE A 473
VAL A 541
VAL A 499
GLU A 509
ILE A 513
 None
 1.02A 2vn0A-3e20A:
undetectable		 2vn0A-3e20A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exs RMPD
(HEXULOSE-6-PHOSPHAT
E SYNTHASE)

(Streptococcus
mutans) 		PF00215
(OMPdecase) 		5 ILE A 199
THR A 200
LEU A   8
ASN A   7
VAL A  27
 None
 1.21A 2vn0A-3exsA:
undetectable		 2vn0A-3exsA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A  49
THR A  43
LEU A 107
VAL A 115
ILE A  86
 None
 1.18A 2vn0A-3fpcA:
undetectable		 2vn0A-3fpcA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g65 CHECKPOINT PROTEIN
HUS1

(Homo sapiens) 		PF04005
(Hus1) 		5 LEU C 192
VAL C 201
GLU C 195
THR C 196
ILE C 234
 None
 1.03A 2vn0A-3g65C:
undetectable		 2vn0A-3g65C:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		5 ILE A  69
LEU A  80
VAL A  73
VAL A 149
ILE A 197
 None
 1.00A 2vn0A-3hidA:
undetectable		 2vn0A-3hidA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpf MUCONATE
CYCLOISOMERASE

(Oceanobacillus
iheyensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A  96
LEU A  60
VAL A  26
GLU A   7
ILE A   3
 None
 1.18A 2vn0A-3hpfA:
undetectable		 2vn0A-3hpfA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr8 PROTEIN RECA

(Thermotoga
maritima) 		PF00154
(RecA) 		5 ILE A  63
LEU A 177
VAL A 184
VAL A 131
GLU A 129
 None
 1.16A 2vn0A-3hr8A:
undetectable		 2vn0A-3hr8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hx1 SLR1951 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00498
(FHA) 		5 ILE A  42
LEU A  56
VAL A  25
ARG A  23
VAL A 110
 None
 1.16A 2vn0A-3hx1A:
undetectable		 2vn0A-3hx1A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		5 PHE A  99
LEU A  54
ASN A  55
VAL A 308
VAL A 103
 None
None
None
FAD  A 600 (-3.6A)
None
 1.16A 2vn0A-3i3lA:
undetectable		 2vn0A-3i3lA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Leishmania
mexicana) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 ILE B 419
LEU B 450
VAL B 443
GLU B 445
THR B  41
 None
None
None
None
NA  B 601 (-2.8A)
 1.08A 2vn0A-3igzB:
undetectable		 2vn0A-3igzB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ira CONSERVED PROTEIN

(Methanosarcina
mazei) 		PF03190
(Thioredox_DsbH) 		5 ILE A 163
PHE A  42
ASN A 107
VAL A 152
ILE A 123
 None
 1.20A 2vn0A-3iraA:
undetectable		 2vn0A-3iraA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Lactobacillus
brevis) 		PF13407
(Peripla_BP_4) 		5 ILE A 236
THR A 237
LEU A 260
ASN A 259
VAL A 271
 None
 1.05A 2vn0A-3jy6A:
undetectable		 2vn0A-3jy6A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kar KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		5 ILE A 499
LEU A 622
ASN A 623
THR A 557
ILE A 604
 None
 1.15A 2vn0A-3karA:
undetectable		 2vn0A-3karA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nc3 CYTOCHROME P450 CYPX

(Bacillus
subtilis) 		PF00067
(p450) 		5 ASN A 111
LEU A 115
VAL A 139
VAL A 366
GLU A 113
 None
 1.20A 2vn0A-3nc3A:
30.9		 2vn0A-3nc3A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		5 ILE A 280
VAL A 419
GLU A 261
THR A 262
ILE A 241
 None
 1.14A 2vn0A-3okyA:
undetectable		 2vn0A-3okyA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7t ADENYLOSUCCINATE
SYNTHETASE

(Campylobacter
jejuni) 		PF00709
(Adenylsucc_synt) 		5 ILE A  69
LEU A  80
VAL A  73
VAL A 145
ILE A 192
 None
 1.02A 2vn0A-3r7tA:
undetectable		 2vn0A-3r7tA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb9 DNA POLYMERASE III
SUBUNIT BETA

(Mycobacterium
tuberculosis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 ILE A  89
THR A  90
LEU A 118
VAL A 100
GLU A 103
 None
 1.08A 2vn0A-3rb9A:
undetectable		 2vn0A-3rb9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		5 ILE A 505
ASN A 676
VAL A 441
VAL A 683
THR A 589
 None
 1.05A 2vn0A-3wfzA:
undetectable		 2vn0A-3wfzA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqu CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		5 ILE A 205
LEU A 336
VAL A 304
VAL A 297
GLU A 294
 None
 1.22A 2vn0A-3wquA:
undetectable		 2vn0A-3wquA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt0 CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		5 ILE A 205
LEU A 336
VAL A 304
VAL A 297
GLU A 294
 None
 1.22A 2vn0A-3wt0A:
undetectable		 2vn0A-3wt0A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ILE A 354
LEU A 263
ASN A  57
VAL A 317
VAL A  65
 None
 1.12A 2vn0A-3zu0A:
undetectable		 2vn0A-3zu0A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ILE A 340
VAL A 467
VAL A 473
GLU A 474
ILE A 459
 None
 1.15A 2vn0A-4b3iA:
undetectable		 2vn0A-4b3iA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffl PYLC

(Methanosarcina
barkeri) 		PF02655
(ATP-grasp_3) 		5 ILE A   4
PHE A  93
LEU A  92
VAL A  70
ILE A 223
 None
 1.14A 2vn0A-4fflA:
undetectable		 2vn0A-4fflA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		6 ILE A  66
THR A  65
LEU A 138
VAL A  59
GLU A 133
ILE A 193
 None
 1.43A 2vn0A-4g7aA:
undetectable		 2vn0A-4g7aA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gua NON-STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF01661
(Macro)
PF01707
(Peptidase_C9) 		5 ILE A1488
THR A1353
LEU A1475
ASN A1473
GLU A1469
 None
 1.24A 2vn0A-4guaA:
undetectable		 2vn0A-4guaA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jci PROLINE RACEMASE

(Chromohalobacter
salexigens) 		PF05544
(Pro_racemase) 		5 ILE A 189
PHE A 212
LEU A 211
ASN A 222
VAL A 153
 None
 0.98A 2vn0A-4jciA:
undetectable		 2vn0A-4jciA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00012
(HSP70) 		5 ILE A 191
LEU A 171
VAL A 216
VAL A  56
GLU A 179
 None
 1.13A 2vn0A-4kboA:
undetectable		 2vn0A-4kboA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00012
(HSP70) 		5 ILE A 191
THR A 192
LEU A 171
VAL A 216
GLU A 179
 None
 1.09A 2vn0A-4kboA:
undetectable		 2vn0A-4kboA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4klk PHAGE-RELATED
PROTEIN DUF2815

(Enterococcus
faecalis) 		PF10991
(DUF2815) 		5 ILE A 158
VAL A  21
VAL A 103
THR A  79
ILE A  41
 None
 0.92A 2vn0A-4klkA:
undetectable		 2vn0A-4klkA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		5 LEU A 382
VAL A 348
GLU A 377
THR A 374
ILE A 303
 None
 1.20A 2vn0A-4my5A:
undetectable		 2vn0A-4my5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		5 ILE B1289
THR B1290
LEU B1321
ASN B1319
VAL B1281
 None
 1.17A 2vn0A-4plbB:
0.9		 2vn0A-4plbB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(unidentified) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 ILE A  63
LEU A  22
VAL A 299
GLU A 301
ILE A  30
 FAD  A 401 ( 4.1A)
None
None
None
None
 1.23A 2vn0A-4pytA:
undetectable		 2vn0A-4pytA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		5 ILE A  93
THR A  89
ASN A  70
VAL A 138
VAL A  79
 None
 1.11A 2vn0A-4q0mA:
undetectable		 2vn0A-4q0mA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlo HOMOSERINE
O-ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF00561
(Abhydrolase_1) 		5 LEU A  39
ASN A 125
GLU A 147
THR A 257
ILE A 126
 None
 1.10A 2vn0A-4qloA:
undetectable		 2vn0A-4qloA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsi STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2

(Saccharomyces
cerevisiae) 		PF06470
(SMC_hinge) 		5 ILE A 680
LEU A 552
VAL A 504
VAL A 526
ILE A 625
 None
 1.14A 2vn0A-4rsiA:
undetectable		 2vn0A-4rsiA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Aggregatibacter
actinomycetemcomitans) 		PF01522
(Polysacc_deac_1) 		5 ILE A 274
LEU A  57
ASN A  56
VAL A  36
ILE A  59
 None
 1.21A 2vn0A-4u10A:
undetectable		 2vn0A-4u10A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 ILE A  51
LEU A 425
VAL A  58
THR A  13
ILE A  33
 None
 1.16A 2vn0A-4v1yA:
undetectable		 2vn0A-4v1yA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pyrococcus
horikoshii) 		PF01867
(Cas_Cas1) 		5 ASN A 180
VAL A 271
VAL A 244
GLU A 167
ILE A 170
 None
 1.21A 2vn0A-4wj0A:
undetectable		 2vn0A-4wj0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN

(Helicobacter
pylori) 		no annotation 5 ILE A 477
THR A 473
LEU A  36
ASN A 524
VAL A 494
 None
 0.96A 2vn0A-4zh7A:
undetectable		 2vn0A-4zh7A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9i SOLUTE CARRIER
FAMILY 15 MEMBER 2

(Rattus
norvegicus) 		no annotation 5 ILE A 517
LEU A 537
ASN A 528
VAL A 551
VAL A 559
 None
 1.09A 2vn0A-5a9iA:
undetectable		 2vn0A-5a9iA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5u L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		5 ILE A  93
THR A  89
ASN A  70
VAL A 138
VAL A  79
 None
 1.13A 2vn0A-5b5uA:
undetectable		 2vn0A-5b5uA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f67 INACTIVATION-NO-AFTE
R-POTENTIAL D
PROTEIN

(Drosophila
melanogaster) 		PF00595
(PDZ) 		5 LEU A 375
ASN A 401
VAL A 379
VAL A 407
GLU A 403
 None
 1.15A 2vn0A-5f67A:
undetectable		 2vn0A-5f67A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT SKI6

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ILE B 126
THR B  51
LEU B 104
GLU B 109
ILE B 158
 None
 1.09A 2vn0A-5g06B:
undetectable		 2vn0A-5g06B:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF03971
(IDH) 		5 ILE A  44
THR A  13
ASN A  81
VAL A 136
ILE A   8
 None
 1.17A 2vn0A-5kvuA:
undetectable		 2vn0A-5kvuA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ILE A 116
THR A 117
LEU A 155
VAL A 165
ILE A 108
 None
 1.20A 2vn0A-5lx8A:
undetectable		 2vn0A-5lx8A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp2 CAMELID NANOBODY
VHH04
TYPE II SECRETION
SYSTEM PROTEIN D

(Lama glama;
Pseudomonas
aeruginosa) 		no annotation 5 ILE A 183
LEU A  95
VAL A  89
THR C 102
ILE A  72
 None
 1.14A 2vn0A-5mp2A:
undetectable		 2vn0A-5mp2A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		5 ILE A 913
LEU A 932
ASN A 930
VAL A 874
GLU A 848
 None
 1.20A 2vn0A-5mzaA:
undetectable		 2vn0A-5mzaA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 5 THR A  39
VAL A  48
GLU A  50
THR A 246
ILE A   4
 None
None
FAD  A 601 (-2.7A)
None
None
 1.22A 2vn0A-5nitA:
undetectable		 2vn0A-5nitA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2v NUCLEOLYSIN TIA-1
ISOFORM P40

(Homo sapiens) 		PF00076
(RRM_1) 		5 ILE A  71
LEU A  26
VAL A  18
VAL A  11
ILE A  30
 None
 1.24A 2vn0A-5o2vA:
undetectable		 2vn0A-5o2vA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3m PROTOCATECHUATE
DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF01977
(UbiD) 		5 ILE A 216
VAL A 245
VAL A 167
GLU A 255
ILE A 208
 None
 1.15A 2vn0A-5o3mA:
undetectable		 2vn0A-5o3mA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqj TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		no annotation 5 PHE W  15
LEU W  12
ASN W  11
VAL W 102
ILE W   8
 None
 1.17A 2vn0A-5oqjW:
undetectable		 2vn0A-5oqjW:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqm TRANSCRIPTION FACTOR
TFIIE SUBUNIT

(Saccharomyces
cerevisiae) 		no annotation 5 PHE W  15
LEU W  12
ASN W  11
VAL W 102
ILE W   8
 None
 1.17A 2vn0A-5oqmW:
undetectable		 2vn0A-5oqmW:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suj UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 ILE A 229
LEU A 194
GLU A 169
THR A 150
ILE A 198
 None
 1.18A 2vn0A-5sujA:
undetectable		 2vn0A-5sujA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suj UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 ILE A 229
PHE A 195
LEU A 194
GLU A 169
THR A 150
 None
 1.20A 2vn0A-5sujA:
undetectable		 2vn0A-5sujA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tse LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Acinetobacter
baumannii) 		no annotation 5 ILE A 106
THR A 115
ASN A  64
VAL A  38
THR A  35
 None
 1.09A 2vn0A-5tseA:
undetectable		 2vn0A-5tseA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1w P2X PURINOCEPTOR

(Ailuropoda
melanoleuca) 		PF00864
(P2X_receptor) 		5 ILE A  58
ASN A 195
ASN A 207
THR A  63
ILE A 256
 None
 1.23A 2vn0A-5u1wA:
undetectable		 2vn0A-5u1wA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwy THIOREDOXIN
REDUCTASE

(Streptococcus
pyogenes) 		PF07992
(Pyr_redox_2) 		5 ILE A   7
THR A 107
ASN A  84
VAL A  79
VAL A 243
 None
FAD  A 401 (-4.2A)
None
FAD  A 401 (-4.2A)
None
 1.23A 2vn0A-5uwyA:
undetectable		 2vn0A-5uwyA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1s RADICAL SAM

(Streptococcus
suis) 		PF04055
(Radical_SAM)
PF13394
(Fer4_14) 		5 ILE A 111
LEU A 171
ASN A 170
VAL A 155
GLU A 177
 None
 1.23A 2vn0A-5v1sA:
undetectable		 2vn0A-5v1sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wat HOMOSERINE KINASE

(Corynebacterium
glutamicum) 		no annotation 5 ILE A  72
LEU A 117
VAL A  88
VAL A  13
GLU A 305
 None
 1.10A 2vn0A-5watA:
undetectable		 2vn0A-5watA:
11.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 5 ASN A 204
LEU A 208
VAL A 237
GLU A 300
THR A 301
 LSN  A 501 (-3.7A)
LSN  A 501 (-3.9A)
LSN  A 501 (-4.5A)
None
HEM  A 504 (-4.0A)
 1.03A 2vn0A-5xxiA:
51.3		 2vn0A-5xxiA:
78.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR

(Galdieria
sulphuraria) 		PF03151
(TPT) 		5 ILE A 390
PHE A 199
VAL A 364
GLU A 245
THR A 244
 OLC  A 505 ( 3.9A)
None
OLC  A 505 ( 4.2A)
OLC  A 505 (-3.7A)
None
 1.04A 2vn0A-5y79A:
undetectable		 2vn0A-5y79A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zby HYDROGENASE
MATURATION PROTEASE
HYCI

(Thermococcus
kodakarensis) 		no annotation 5 ILE A  16
LEU A 155
ASN A 157
VAL A  71
GLU A   5
 None
 1.20A 2vn0A-5zbyA:
undetectable		 2vn0A-5zbyA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 5 ILE A 710
THR A 711
LEU A 593
ASN A 594
GLU A 587
 None
None
None
NAG  A 925 (-1.9A)
None
 1.13A 2vn0A-6c01A:
undetectable		 2vn0A-6c01A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et9 ACETYL-COA
ACETYLTRANSFERASE
THIOLASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 5 THR A 240
LEU A 298
VAL A 383
GLU A 282
ILE A 278
 None
 1.24A 2vn0A-6et9A:
undetectable		 2vn0A-6et9A:
10.69