SIMILAR PATTERNS OF AMINO ACIDS FOR 2VMY_B_FFOB505_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		4 GLU A  57
TYR A  64
TYR A  65
PHE A 257
 None
 0.84A 2vmyB-1cj0A:
51.2		 2vmyB-1cj0A:
45.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE

(Thermus
thermophilus) 		PF00464
(SHMT) 		4 GLU A  53
TYR A  60
TYR A  61
PHE A 252
 None
 0.33A 2vmyB-2dkjA:
60.4		 2vmyB-2dkjA:
66.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		4 GLU A  53
TYR A  60
TYR A  61
PHE A 251
 None
 0.30A 2vmyB-2vmxA:
67.7		 2vmyB-2vmxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		4 GLU A  57
TYR A  64
TYR A  65
PHE A 257
 None
 0.98A 2vmyB-3g8mA:
53.2		 2vmyB-3g8mA:
58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3o PUTATIVE
D-GLYCERO-D-MANNO-HE
PTOSE 7-PHOSPHATE
KINASE

(Campylobacter
jejuni) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 GLU A 173
TYR A  31
TYR A  28
PHE A 171
 None
 1.27A 2vmyB-4n3oA:
undetectable		 2vmyB-4n3oA:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Psychromonas
ingrahamii) 		PF00464
(SHMT) 		4 GLU A  57
TYR A  64
TYR A  65
PHE A 257
 None
 0.38A 2vmyB-4p3mA:
44.2		 2vmyB-4p3mA:
55.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		4 GLU A  51
TYR A  58
TYR A  59
PHE A 250
 None
 0.97A 2vmyB-4wxbA:
58.0		 2vmyB-4wxbA:
58.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 GLU A  98
TYR A 105
TYR A 106
PHE A 320
 None
 0.75A 2vmyB-5v7iA:
52.1		 2vmyB-5v7iA:
43.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		4 GLU A  56
TYR A  63
TYR A  64
PHE A 256
 None
 1.05A 2vmyB-5vmbA:
55.7		 2vmyB-5vmbA:
57.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 GLU B 734
TYR B 714
TYR B 716
PHE B1048
 None
 1.49A 2vmyB-5vniB:
undetectable		 2vmyB-5vniB:
19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
vivax) 		no annotation 4 GLU A  56
TYR A  63
TYR A  64
PHE A 266
 None
 0.76A 2vmyB-5xmrA:
57.3		 2vmyB-5xmrA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 4 GLU A 136
TYR A 143
TYR A 144
PHE A 349
 None
 0.32A 2vmyB-6cczA:
57.4		 2vmyB-6cczA:
undetectable