SIMILAR PATTERNS OF AMINO ACIDS FOR 2VMY_B_FFOB505

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4t PROTEIN (CU/ZN
SUPEROXIDE
DISMUTASE)

(Saccharomyces
cerevisiae) 		PF00080
(Sod_Cu) 		5 GLY A  12
LEU A   7
VAL A  17
ALA A  11
GLY A  44
 None
 0.99A 2vmyA-1b4tA:
undetectable		 2vmyA-1b4tA:
17.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		7 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 175
ASN A 345
ARG A 363
 None
None
PLP  A2291 ( 3.8A)
None
PLP  A2291 (-2.9A)
None
None
 0.68A 2vmyA-1cj0A:
51.2		 2vmyA-1cj0A:
45.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A  15
SER A  85
ALA A  84
SER A 349
GLY A 347
 None
 0.89A 2vmyA-1e5mA:
undetectable		 2vmyA-1e5mA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g29 MALTOSE TRANSPORT
PROTEIN MALK

(Thermococcus
litoralis) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 GLY 1  41
LEU 1   6
VAL 1   4
ALA 1  18
GLY 1  51
 POP  1 501 (-3.1A)
None
None
None
None
 0.97A 2vmyA-1g291:
undetectable		 2vmyA-1g291:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 LEU A 579
GLY A 577
LEU A 583
ALA A 433
GLY A 482
 None
MPD  A 803 (-3.6A)
ACT  A 805 ( 4.8A)
MPD  A 803 (-3.6A)
None
 1.03A 2vmyA-1kwgA:
undetectable		 2vmyA-1kwgA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 GLY A 391
LEU A 400
VAL A 403
SER A 319
ALA A 317
 None
 1.02A 2vmyA-1l0wA:
undetectable		 2vmyA-1l0wA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 LEU A  62
GLY A  64
LEU A  60
SER A  66
GLY A 167
 None
 1.06A 2vmyA-1t6pA:
undetectable		 2vmyA-1t6pA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tl2 PROTEIN
(TACHYLECTIN-2)

(Tachypleus
tridentatus) 		PF14517
(Tachylectin) 		5 LEU A   7
GLY A  18
LEU A 234
ALA A  32
GLY A 224
 None
None
None
None
NDG  A 238 (-3.2A)
 0.94A 2vmyA-1tl2A:
undetectable		 2vmyA-1tl2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tl2 PROTEIN
(TACHYLECTIN-2)

(Tachypleus
tridentatus) 		PF14517
(Tachylectin) 		5 LEU A  54
GLY A  65
LEU A  46
ALA A  79
GLY A  36
 None
None
None
None
NDG  A 237 (-3.0A)
 0.94A 2vmyA-1tl2A:
undetectable		 2vmyA-1tl2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcr HYPOTHETICAL PROTEIN
PTD012

(Homo sapiens) 		PF08925
(DUF1907) 		5 GLY A  98
LEU A 250
VAL A 248
ALA A 158
GLY A 127
 ACY  A2001 (-3.2A)
None
None
None
None
 1.03A 2vmyA-1xcrA:
undetectable		 2vmyA-1xcrA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzh CYTOCHROME C
PEROXIDASE

(Rhodobacter
capsulatus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 GLY A  63
HIS A  58
ASN A  82
PRO A 252
GLY A 251
 None
HEC  A 802 (-3.2A)
CA  A 401 (-3.0A)
None
None
 0.90A 2vmyA-1zzhA:
undetectable		 2vmyA-1zzhA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 GLY A  44
LEU A   9
VAL A   7
ALA A  21
GLY A  54
 POP  A1293 (-3.1A)
None
None
None
None
 1.01A 2vmyA-2d62A:
undetectable		 2vmyA-2d62A:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE

(Thermus
thermophilus) 		PF00464
(SHMT) 		5 HIS A 122
LEU A 123
VAL A 129
SER A 172
ASN A 342
 PLP  A 510 (-3.5A)
None
None
PLP  A 510 ( 3.2A)
None
 0.96A 2vmyA-2dkjA:
61.7		 2vmyA-2dkjA:
66.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE

(Thermus
thermophilus) 		PF00464
(SHMT) 		9 LEU A 117
GLY A 120
HIS A 122
LEU A 123
VAL A 129
SER A 172
ALA A 173
ASN A 340
ARG A 358
 None
None
PLP  A 510 (-3.5A)
None
None
PLP  A 510 ( 3.2A)
None
None
SO4  A2520 (-2.9A)
 0.57A 2vmyA-2dkjA:
61.7		 2vmyA-2dkjA:
66.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		5 LEU A 451
GLY A 449
LEU A 372
SER A 585
ALA A 584
 None
 1.02A 2vmyA-2e28A:
undetectable		 2vmyA-2e28A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 415
LEU A 182
VAL A 184
SER A 167
GLY A 168
 None
 1.07A 2vmyA-2e6kA:
undetectable		 2vmyA-2e6kA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		5 GLY A 164
LEU A 167
ALA A 190
SER A 105
GLY A 102
 None
 0.97A 2vmyA-2eceA:
undetectable		 2vmyA-2eceA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glx 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Ensifer
adhaerens) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A  91
LEU A 287
SER A 301
ALA A 302
SER A  70
 None
 0.87A 2vmyA-2glxA:
undetectable		 2vmyA-2glxA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		5 GLY A 320
ALA A 299
ASN A 184
SER A  56
GLY A  58
 None
FMN  A4401 ( 4.0A)
FMN  A4401 (-4.6A)
None
FMN  A4401 (-3.7A)
 1.05A 2vmyA-2gouA:
undetectable		 2vmyA-2gouA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN

(Homo sapiens) 		PF00588
(SpoU_methylase) 		5 GLY A  42
VAL A  54
SER A  72
SER A  32
GLY A  58
 None
 0.98A 2vmyA-2ha8A:
undetectable		 2vmyA-2ha8A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8x URACIL-DNA
GLYCOSYLASE

(Human
gammaherpesvirus
4) 		PF03167
(UDG) 		5 GLY A  96
ALA A  98
ASN A 149
PRO A 159
GLY A 160
 None
 1.00A 2vmyA-2j8xA:
undetectable		 2vmyA-2j8xA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfn GLUTAMATE RACEMASE

(Escherichia
coli) 		PF01177
(Asp_Glu_race) 		5 LEU A 187
LEU A 214
VAL A 200
ALA A 182
GLY A 161
 None
 1.05A 2vmyA-2jfnA:
undetectable		 2vmyA-2jfnA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og7 ASPARAGINE OXYGENASE

(Streptomyces
coelicolor) 		PF02668
(TauD) 		5 GLY A 182
LEU A 170
VAL A 168
ALA A 181
GLY A 145
 None
None
None
None
AHB  A7002 (-3.0A)
 1.00A 2vmyA-2og7A:
undetectable		 2vmyA-2og7A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 259
ALA A 286
ASN A 392
SER A 167
GLY A 343
 None
 1.08A 2vmyA-2rjtA:
undetectable		 2vmyA-2rjtA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6j RNA HELICASE

(Kokobera virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		5 LEU A 105
VAL A 110
SER A 266
ALA A 268
PRO A 135
 None
 1.08A 2vmyA-2v6jA:
undetectable		 2vmyA-2v6jA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A 309
LEU A 284
SER A 307
ALA A 308
ASN A 242
 BEZ  A1529 (-3.5A)
None
None
BEZ  A1529 (-3.6A)
None
 1.04A 2vmyA-2v7bA:
3.4		 2vmyA-2v7bA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A  82
GLY A  84
LEU A  79
ALA A  55
SER A 130
 None
 1.01A 2vmyA-2vk4A:
undetectable		 2vmyA-2vk4A:
23.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		8 GLY A 120
HIS A 122
LEU A 123
VAL A 129
SER A 172
ALA A 173
ASN A 339
ARG A 357
 None
PLP  A 501 ( 3.4A)
None
None
ALO  A 502 (-3.9A)
None
None
ALO  A 502 (-3.0A)
 0.89A 2vmyA-2vmxA:
67.4		 2vmyA-2vmxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		9 GLY A 120
HIS A 122
SER A 172
ALA A 173
ASN A 339
SER A 349
PRO A 350
GLY A 351
ARG A 357
 None
PLP  A 501 ( 3.4A)
ALO  A 502 (-3.9A)
None
None
None
None
None
ALO  A 502 (-3.0A)
 0.94A 2vmyA-2vmxA:
67.4		 2vmyA-2vmxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		8 GLY A 120
HIS A 122
VAL A 129
SER A 172
ALA A 173
ASN A 339
GLY A 351
ARG A 357
 None
PLP  A 501 ( 3.4A)
None
ALO  A 502 (-3.9A)
None
None
None
ALO  A 502 (-3.0A)
 0.99A 2vmyA-2vmxA:
67.4		 2vmyA-2vmxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		6 LEU A 117
GLY A 120
HIS A 122
LEU A 123
VAL A 129
SER A 172
 None
None
PLP  A 501 ( 3.4A)
None
None
ALO  A 502 (-3.9A)
 1.22A 2vmyA-2vmxA:
67.4		 2vmyA-2vmxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgo RANASPUMIN-2

(Engystomops
pustulosus) 		no annotation 5 LEU A  26
GLY A  22
LEU A  44
VAL A  39
GLY A  83
 None
 1.08A 2vmyA-2wgoA:
undetectable		 2vmyA-2wgoA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 GLY A 376
VAL A 497
PRO A 340
GLY A 320
ARG A 373
 None
 0.96A 2vmyA-2wtzA:
undetectable		 2vmyA-2wtzA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 LEU A 146
GLY A 142
SER A  48
ALA A  49
GLY A  19
 None
None
None
FAD  A 601 (-3.3A)
None
 1.01A 2vmyA-2wu5A:
undetectable		 2vmyA-2wu5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 134
LEU A  97
VAL A  93
ALA A  67
GLY A 161
 None
 1.02A 2vmyA-2x3eA:
undetectable		 2vmyA-2x3eA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF01661
(Macro) 		5 GLY A 181
HIS A 188
VAL A 170
SER A 268
GLY A 228
 None
 1.01A 2vmyA-2x47A:
undetectable		 2vmyA-2x47A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9p PIMD PROTEIN

(Streptomyces
natalensis) 		PF00067
(p450) 		5 LEU A 172
GLY A 174
LEU A 168
ALA A 187
GLY A 230
 None
 1.08A 2vmyA-2x9pA:
undetectable		 2vmyA-2x9pA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB

(Escherichia
coli) 		PF13360
(PQQ_2) 		5 GLY A 113
LEU A  97
VAL A  95
SER A 126
ALA A 151
 None
 1.04A 2vmyA-2ymsA:
undetectable		 2vmyA-2ymsA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z84 UFM1-SPECIFIC
PROTEASE 1

(Mus musculus) 		PF07910
(Peptidase_C78) 		5 LEU A 127
GLY A 129
VAL A 202
GLY A 160
ARG A 133
 None
 1.03A 2vmyA-2z84A:
undetectable		 2vmyA-2z84A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE

(Pseudomonas sp.
ATCC 19121) 		PF00155
(Aminotran_1_2) 		5 GLY A 480
SER A  25
ALA A  24
SER A 499
GLY A  38
 None
 0.99A 2vmyA-2zy2A:
9.4		 2vmyA-2zy2A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli) 		PF01343
(Peptidase_S49) 		5 LEU A 522
SER A 498
ALA A 493
SER A 431
GLY A 509
 None
 1.05A 2vmyA-3bf0A:
undetectable		 2vmyA-3bf0A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7r ESTERASE

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		5 LEU A 221
ALA A 156
ASN A  87
SER A 204
GLY A 207
 None
None
None
CL  A1100 ( 4.7A)
None
 1.06A 2vmyA-3d7rA:
undetectable		 2vmyA-3d7rA:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		7 GLY A 124
HIS A 126
LEU A 127
VAL A 133
ALA A 176
ASN A 345
ARG A 363
 None
PLP  A 418 (-4.1A)
PLP  A 418 ( 4.7A)
None
None
None
None
 0.99A 2vmyA-3g8mA:
53.2		 2vmyA-3g8mA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		5 LEU A 121
HIS A 126
LEU A 127
VAL A 133
ASN A 347
 None
PLP  A 418 (-4.1A)
PLP  A 418 ( 4.7A)
None
None
 1.03A 2vmyA-3g8mA:
53.2		 2vmyA-3g8mA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1

(Mycobacterium
tuberculosis) 		PF00464
(SHMT) 		7 LEU A 118
GLY A 121
HIS A 123
LEU A 124
SER A 173
ALA A 174
ASN A 345
 None
None
LLP  A 227 ( 3.6A)
None
None
None
None
 0.93A 2vmyA-3h7fA:
54.1		 2vmyA-3h7fA:
55.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1

(Mycobacterium
tuberculosis) 		PF00464
(SHMT) 		7 LEU A 118
HIS A 123
LEU A 124
SER A 173
ALA A 174
ASN A 345
ARG A 363
 None
LLP  A 227 ( 3.6A)
None
None
None
None
None
 1.41A 2vmyA-3h7fA:
54.1		 2vmyA-3h7fA:
55.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 930
GLY A 870
LEU A 936
ASN A 881
GLY A 887
 None
 0.99A 2vmyA-3hmjA:
2.3		 2vmyA-3hmjA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3p GLUTAMINE AMIDO
TRANSFERASE

(Methylobacillus
flagellatus) 		PF00117
(GATase) 		5 GLY A  87
HIS A 170
LEU A 166
SER A 145
GLY A 101
 None
 0.87A 2vmyA-3m3pA:
undetectable		 2vmyA-3m3pA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3maj DNA PROCESSING CHAIN
A

(Rhodopseudomonas
palustris) 		PF02481
(DNA_processg_A) 		5 GLY A 152
LEU A 147
ALA A 154
SER A 235
GLY A 237
 None
 1.02A 2vmyA-3majA:
undetectable		 2vmyA-3majA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY

(Paenarthrobacter
aurescens) 		PF04198
(Sugar-bind) 		5 GLY A 284
SER A 286
ALA A 285
GLY A 293
ARG A 312
 None
 1.01A 2vmyA-3nzeA:
undetectable		 2vmyA-3nzeA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 GLY A 825
SER A 760
ALA A 759
SER A 749
GLY A 750
 None
 0.82A 2vmyA-3opyA:
undetectable		 2vmyA-3opyA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 260
ALA A 285
ASN A 389
SER A 167
GLY A 340
 None
 1.08A 2vmyA-3oytA:
undetectable		 2vmyA-3oytA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		5 LEU A 275
GLY A 113
LEU A 104
VAL A 102
GLY A  81
 None
 0.98A 2vmyA-3qfwA:
undetectable		 2vmyA-3qfwA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		5 LEU A 275
GLY A 114
LEU A 104
VAL A 102
GLY A  81
 None
 1.04A 2vmyA-3qfwA:
undetectable		 2vmyA-3qfwA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3us8 ISOCITRATE
DEHYDROGENASE [NADP]

(Sinorhizobium
meliloti) 		PF00180
(Iso_dh) 		5 LEU A  44
LEU A  13
SER A  94
PRO A  95
GLY A  97
 None
None
SO4  A 501 (-2.3A)
SO4  A 501 ( 4.7A)
None
 1.03A 2vmyA-3us8A:
undetectable		 2vmyA-3us8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v77 PUTATIVE
FUMARYLACETOACETATE
ISOMERASE/HYDROLASE

(Oleispira
antarctica) 		PF01557
(FAA_hydrolase) 		5 LEU A  99
GLY A  98
LEU A 205
VAL A 223
GLY A 197
 None
 1.00A 2vmyA-3v77A:
undetectable		 2vmyA-3v77A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N) 		5 LEU A 246
GLY A 386
LEU A   5
ALA A 370
GLY A 178
 None
 0.92A 2vmyA-3v7iA:
undetectable		 2vmyA-3v7iA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo4 INTERLEUKIN-18
RECEPTOR 1

(Homo sapiens) 		no annotation 5 LEU B  83
LEU B  68
ASN B  91
GLY B  94
ARG B  75
 None
None
NAG  B 901 (-1.9A)
None
NAG  B 901 ( 4.1A)
 0.97A 2vmyA-3wo4B:
undetectable		 2vmyA-3wo4B:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxx ACRH
AOPB

(Aeromonas
hydrophila;
Aeromonas
hydrophila) 		no annotation
PF04888
(SseC) 		5 LEU B  50
GLY A  41
LEU A  72
ALA A  53
GLY B  47
 None
 1.03A 2vmyA-3wxxB:
undetectable		 2vmyA-3wxxB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdn MONOAMINE OXIDASE N

(Aspergillus
niger) 		PF01593
(Amino_oxidase) 		5 LEU A 310
GLY A 333
LEU A 313
ALA A 332
GLY A 444
 None
 0.96A 2vmyA-3zdnA:
undetectable		 2vmyA-3zdnA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhb R-IMINE REDUCTASE

(Streptomyces
kanamyceticus) 		PF03446
(NAD_binding_2) 		5 GLY A 139
LEU A 109
VAL A  80
ALA A 138
GLY A 167
 NAP  A1307 ( 4.4A)
None
None
None
None
 0.94A 2vmyA-3zhbA:
undetectable		 2vmyA-3zhbA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhb R-IMINE REDUCTASE

(Streptomyces
kanamyceticus) 		PF03446
(NAD_binding_2) 		5 GLY A 139
LEU A 109
VAL A  80
ALA A 138
GLY A 168
 NAP  A1307 ( 4.4A)
None
None
None
None
 0.99A 2vmyA-3zhbA:
undetectable		 2vmyA-3zhbA:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		6 GLY A 119
HIS A 121
VAL A 127
SER A 171
ASN A 344
ARG A 363
 None
 1.19A 2vmyA-4bhdA:
49.2		 2vmyA-4bhdA:
37.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Pyrobaculum
neutrophilum) 		PF00215
(OMPdecase) 		5 LEU A  76
LEU A  60
VAL A  34
SER A  45
GLY A  43
 None
 1.06A 2vmyA-4df1A:
undetectable		 2vmyA-4df1A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		5 GLY A 584
LEU A 502
SER A 582
ALA A 609
ASN A 650
 None
None
SLA  A 801 (-1.3A)
None
None
 1.00A 2vmyA-4fwgA:
undetectable		 2vmyA-4fwgA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha6 PYRIDOXINE 4-OXIDASE

(Mesorhizobium
loti) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 270
GLY A 268
ALA A 494
SER A 386
GLY A 385
 None
FAD  A 601 (-3.6A)
FAD  A 601 (-3.6A)
None
None
 1.04A 2vmyA-4ha6A:
undetectable		 2vmyA-4ha6A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcx ISOCITRATE
DEHYDROGENASE [NADP]

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		5 LEU A  47
LEU A  16
SER A  97
PRO A  98
GLY A 100
 None
 1.01A 2vmyA-4hcxA:
undetectable		 2vmyA-4hcxA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00361
(Proton_antipo_M) 		5 LEU M 160
LEU M 116
VAL M 120
ALA N 353
GLY N 344
 None
 1.05A 2vmyA-4heaM:
undetectable		 2vmyA-4heaM:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifr 2-AMINO-3-CARBOXYMUC
ONATE 6-SEMIALDEHYDE
DECARBOXYLASE

(Pseudomonas
fluorescens) 		PF04909
(Amidohydro_2) 		5 LEU A 277
LEU A 280
ALA A 317
ASN A 325
GLY A 292
 None
 0.96A 2vmyA-4ifrA:
undetectable		 2vmyA-4ifrA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Polaromonas sp.
JS666) 		no annotation 5 GLY C  15
VAL C  91
ALA C  17
SER C 143
GLY C 188
 None
None
None
NAP  C 304 (-3.3A)
NAP  C 304 (-4.8A)
 1.07A 2vmyA-4iqgC:
3.4		 2vmyA-4iqgC:
24.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		5 GLY A 124
ALA A 177
SER A 354
PRO A 355
ARG A 362
 None
 1.01A 2vmyA-4j5uA:
60.2		 2vmyA-4j5uA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		5 GLY A 124
SER A 176
ALA A 177
PRO A 355
ARG A 362
 None
 0.99A 2vmyA-4j5uA:
60.2		 2vmyA-4j5uA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		7 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 176
ALA A 177
ARG A 362
 None
None
LLP  A 230 ( 3.5A)
None
None
None
None
 0.99A 2vmyA-4j5uA:
60.2		 2vmyA-4j5uA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		7 LEU A 121
HIS A 126
LEU A 127
SER A 176
ALA A 177
ASN A 344
ARG A 362
 None
LLP  A 230 ( 3.5A)
None
None
None
None
None
 1.16A 2vmyA-4j5uA:
60.2		 2vmyA-4j5uA:
57.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 LEU A 258
GLY A 260
ALA A 287
ASN A 396
SER A 170
GLY A 167
 None
 1.27A 2vmyA-4jb6A:
undetectable		 2vmyA-4jb6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A 204
LEU A 224
ALA A 216
ASN A 249
PRO A 240
 None
 1.03A 2vmyA-4o1oA:
undetectable		 2vmyA-4o1oA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
falciparum) 		PF00464
(SHMT) 		6 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 354
 None
None
PLP  A 701 (-3.6A)
None
None
None
 0.69A 2vmyA-4o6zA:
56.0		 2vmyA-4o6zA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
falciparum) 		PF00464
(SHMT) 		6 LEU A 124
GLY A 127
LEU A 130
VAL A 141
ASN A 354
ARG A 371
 None
 0.84A 2vmyA-4o6zA:
56.0		 2vmyA-4o6zA:
39.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p53 CYCLASE

(Streptomyces
hygroscopicus) 		PF01761
(DHQ_synthase) 		5 LEU A 219
GLY A 374
LEU A 215
ALA A 223
GLY A 327
 None
 0.97A 2vmyA-4p53A:
3.8		 2vmyA-4p53A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		5 GLY A 116
LEU A  85
VAL A 103
ASN A  61
GLY A  67
 None
 1.08A 2vmyA-4perA:
undetectable		 2vmyA-4perA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4piv FATTY ACID SYNTHASE

(Homo sapiens) 		PF08242
(Methyltransf_12)
PF08659
(KR) 		5 LEU A1497
GLY A1499
LEU A1493
SER A1411
PRO A1412
 None
 1.06A 2vmyA-4pivA:
2.2		 2vmyA-4pivA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjk PHOSPHOPANTETHEINYL
TRANSFERASE PPTT

(Mycobacterium
tuberculosis) 		PF01648
(ACPS) 		6 LEU A  19
LEU A  11
VAL A   7
ALA A 107
SER A  90
GLY A 112
 None
None
None
None
COA  A 301 ( 4.9A)
None
 1.44A 2vmyA-4qjkA:
undetectable		 2vmyA-4qjkA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqt D-HYDANTOINASE

(Brucella suis) 		PF01979
(Amidohydro_1) 		5 GLY A  13
VAL A 387
ALA A  48
PRO A  55
GLY A  56
 None
 1.08A 2vmyA-4tqtA:
undetectable		 2vmyA-4tqtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		5 GLY A 334
HIS A  86
VAL A 216
SER A  82
GLY A 234
 None
 1.04A 2vmyA-4u4eA:
undetectable		 2vmyA-4u4eA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u89 PHOSPHOPANTETHEINYL
TRANSFERASE PPTT

(Mycobacterium
tuberculosis) 		PF01648
(ACPS) 		6 LEU A  19
LEU A  11
VAL A   7
ALA A 107
SER A  90
GLY A 112
 None
 1.47A 2vmyA-4u89A:
undetectable		 2vmyA-4u89A:
24.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		6 LEU A 115
GLY A 118
SER A 170
ALA A 171
ASN A 339
ARG A 357
 None
None
CAC  A 502 ( 4.8A)
None
None
CAC  A 502 (-3.1A)
 0.83A 2vmyA-4wxbA:
58.1		 2vmyA-4wxbA:
58.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 278
GLY A 276
LEU A  80
ALA A 538
GLY A 423
 None
FAD  A 601 (-3.5A)
None
FAD  A 601 (-3.5A)
None
 1.00A 2vmyA-4ynuA:
undetectable		 2vmyA-4ynuA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		5 LEU A 294
GLY A 298
PRO A 228
GLY A 229
ARG A 259
 None
 0.69A 2vmyA-4yyfA:
undetectable		 2vmyA-4yyfA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		5 LEU A 294
GLY A 299
PRO A 228
GLY A 229
ARG A 259
 None
 1.06A 2vmyA-4yyfA:
undetectable		 2vmyA-4yyfA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		5 LEU A 294
LEU A 247
PRO A 228
GLY A 229
ARG A 259
 None
 1.08A 2vmyA-4yyfA:
undetectable		 2vmyA-4yyfA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0m ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 LEU A  53
LEU A  18
VAL A   5
PRO A  87
GLY A  86
 None
 1.08A 2vmyA-4z0mA:
undetectable		 2vmyA-4z0mA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0m ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		6 LEU A 111
GLY A 107
LEU A  18
VAL A  16
ALA A  64
PRO A  87
 None
 1.39A 2vmyA-4z0mA:
undetectable		 2vmyA-4z0mA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0m ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 LEU A 111
LEU A  18
VAL A  16
ASN A  75
PRO A  87
 None
 1.08A 2vmyA-4z0mA:
undetectable		 2vmyA-4z0mA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by7 3-OXOACYL-ACP
SYNTHASE III

(Verrucosispora
maris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 127
LEU A  90
VAL A  86
ALA A  58
GLY A 163
 None
 1.06A 2vmyA-5by7A:
undetectable		 2vmyA-5by7A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2m PREDICTED PROTEIN

(Nematostella
vectensis) 		PF14517
(Tachylectin) 		5 LEU A  64
GLY A  75
LEU A  56
ALA A  90
GLY A  46
 None
 0.98A 2vmyA-5c2mA:
undetectable		 2vmyA-5c2mA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm3 L-GLUTAMINE
SYNTHETASE

(Chromohalobacter
salexigens) 		PF00120
(Gln-synt_C) 		5 LEU A 368
GLY A 366
LEU A 128
ALA A 363
SER A 266
 None
None
None
None
ADP  A 501 (-2.9A)
 0.96A 2vmyA-5dm3A:
undetectable		 2vmyA-5dm3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4v NUCLEOPROTEIN,PHOSPH
OPROTEIN

(Measles
morbillivirus) 		PF00973
(Paramyxo_ncap)
PF13825
(Paramyxo_PNT) 		5 LEU A  60
LEU A  32
SER A  64
PRO A  65
GLY A  66
 None
 0.98A 2vmyA-5e4vA:
undetectable		 2vmyA-5e4vA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffq SHUY-LIKE PROTEIN

(Escherichia
coli) 		PF13460
(NAD_binding_10) 		5 LEU A 148
VAL A  14
SER A 106
PRO A 150
GLY A 151
 None
PO4  A 301 (-3.9A)
None
None
None
 1.06A 2vmyA-5ffqA:
3.8		 2vmyA-5ffqA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		5 LEU A 310
GLY A 319
ALA A 277
SER A 349
GLY A 348
 None
 1.05A 2vmyA-5izdA:
undetectable		 2vmyA-5izdA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls2 LYSM TYPE RECEPTOR
KINASE

(Lotus japonicus) 		no annotation 5 LEU A 165
LEU A  34
ASN A  69
SER A 217
GLY A 216
 None
 1.00A 2vmyA-5ls2A:
undetectable		 2vmyA-5ls2A:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		4 GLU A  57
TYR A  64
TYR A  65
PHE A 257
 None
 0.84A 2vmyB-1cj0A:
51.2		 2vmyB-1cj0A:
45.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE

(Thermus
thermophilus) 		PF00464
(SHMT) 		4 GLU A  53
TYR A  60
TYR A  61
PHE A 252
 None
 0.33A 2vmyB-2dkjA:
60.4		 2vmyB-2dkjA:
66.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		4 GLU A  53
TYR A  60
TYR A  61
PHE A 251
 None
 0.30A 2vmyB-2vmxA:
67.7		 2vmyB-2vmxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		4 GLU A  57
TYR A  64
TYR A  65
PHE A 257
 None
 0.98A 2vmyB-3g8mA:
53.2		 2vmyB-3g8mA:
58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3o PUTATIVE
D-GLYCERO-D-MANNO-HE
PTOSE 7-PHOSPHATE
KINASE

(Campylobacter
jejuni) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 GLU A 173
TYR A  31
TYR A  28
PHE A 171
 None
 1.27A 2vmyB-4n3oA:
undetectable		 2vmyB-4n3oA:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Psychromonas
ingrahamii) 		PF00464
(SHMT) 		4 GLU A  57
TYR A  64
TYR A  65
PHE A 257
 None
 0.38A 2vmyB-4p3mA:
44.2		 2vmyB-4p3mA:
55.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		4 GLU A  51
TYR A  58
TYR A  59
PHE A 250
 None
 0.97A 2vmyB-4wxbA:
58.0		 2vmyB-4wxbA:
58.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 GLU A  98
TYR A 105
TYR A 106
PHE A 320
 None
 0.75A 2vmyB-5v7iA:
52.1		 2vmyB-5v7iA:
43.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		4 GLU A  56
TYR A  63
TYR A  64
PHE A 256
 None
 1.05A 2vmyB-5vmbA:
55.7		 2vmyB-5vmbA:
57.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 GLU B 734
TYR B 714
TYR B 716
PHE B1048
 None
 1.49A 2vmyB-5vniB:
undetectable		 2vmyB-5vniB:
19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
vivax) 		no annotation 4 GLU A  56
TYR A  63
TYR A  64
PHE A 266
 None
 0.76A 2vmyB-5xmrA:
57.3		 2vmyB-5xmrA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 4 GLU A 136
TYR A 143
TYR A 144
PHE A 349
 None
 0.32A 2vmyB-6cczA:
57.4		 2vmyB-6cczA:
undetectable