SIMILAR PATTERNS OF AMINO ACIDS FOR 2VMY_A_FFOA505_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ay2 TYPE 4 PILIN

(Neisseria
gonorrhoeae) 		PF00114
(Pilin) 		5 GLY A  65
SER A  63
ALA A  64
SER A  71
PRO A  70
 None
NAG  A 161 (-1.4A)
None
None
None
 1.35A 2vmyB-1ay2A:
undetectable		 2vmyB-1ay2A:
15.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		5 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 175
 None
None
PLP  A2291 ( 3.8A)
None
PLP  A2291 (-2.9A)
 0.47A 2vmyB-1cj0A:
51.2		 2vmyB-1cj0A:
45.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		5 LEU A 121
GLY A 124
HIS A 126
SER A 175
ARG A 363
 None
None
PLP  A2291 ( 3.8A)
PLP  A2291 (-2.9A)
None
 0.52A 2vmyB-1cj0A:
51.2		 2vmyB-1cj0A:
45.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 GLY A 111
VAL A 242
ALA A 167
ASN A 171
PRO A 179
 None
 1.02A 2vmyB-1ex9A:
undetectable		 2vmyB-1ex9A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 GLY A 111
VAL A 242
ALA A 167
ASN A 171
SER A 181
 None
 1.25A 2vmyB-1ex9A:
undetectable		 2vmyB-1ex9A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE

(Pseudomonas sp.
KKS102) 		PF00903
(Glyoxalase) 		5 LEU B  64
GLY B   6
LEU B 113
SER B   1
GLY B 165
 None
 1.38A 2vmyB-1kwcB:
undetectable		 2vmyB-1kwcB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 LEU A 123
HIS A 121
ALA A 153
PRO A 346
GLY A 343
 None
 1.20A 2vmyB-1l5jA:
undetectable		 2vmyB-1l5jA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 LEU A1222
VAL A 753
ALA A1117
SER A1078
PRO A1079
 None
 1.37A 2vmyB-1ofeA:
2.2		 2vmyB-1ofeA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tfd TRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		5 GLY A 127
LEU A  66
SER A 125
ALA A 126
SER A 180
 CO3  A 900 (-3.6A)
None
CO3  A 900 (-4.1A)
CO3  A 900 (-3.6A)
None
 1.26A 2vmyB-1tfdA:
undetectable		 2vmyB-1tfdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tl2 PROTEIN
(TACHYLECTIN-2)

(Tachypleus
tridentatus) 		PF14517
(Tachylectin) 		5 LEU A   7
GLY A  18
LEU A 234
ALA A  32
GLY A 224
 None
None
None
None
NDG  A 238 (-3.2A)
 0.98A 2vmyB-1tl2A:
undetectable		 2vmyB-1tl2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 352
SER A 252
ALA A 348
ASN A 321
GLY A  95
 None
COA  A1001 (-3.7A)
None
None
None
 1.10A 2vmyB-1wl4A:
undetectable		 2vmyB-1wl4A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcr HYPOTHETICAL PROTEIN
PTD012

(Homo sapiens) 		PF08925
(DUF1907) 		5 GLY A  98
LEU A 250
VAL A 248
ALA A 158
GLY A 127
 ACY  A2001 (-3.2A)
None
None
None
None
 1.08A 2vmyB-1xcrA:
undetectable		 2vmyB-1xcrA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chr CHLOROMUCONATE
CYCLOISOMERASE

(Cupriavidus
necator) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 311
VAL A 315
ALA A 102
SER A 267
GLY A 296
 None
 1.18A 2vmyB-2chrA:
undetectable		 2vmyB-2chrA:
23.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE

(Thermus
thermophilus) 		PF00464
(SHMT) 		8 LEU A 117
GLY A 120
HIS A 122
LEU A 123
VAL A 129
SER A 172
ALA A 173
ARG A 358
 None
None
PLP  A 510 (-3.5A)
None
None
PLP  A 510 ( 3.2A)
None
SO4  A2520 (-2.9A)
 0.47A 2vmyB-2dkjA:
60.4		 2vmyB-2dkjA:
66.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 605
HIS A 473
LEU A 430
ALA A 606
SER A 577
 None
 1.37A 2vmyB-2e6kA:
undetectable		 2vmyB-2e6kA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		5 GLY A 164
LEU A 167
ALA A 190
SER A 105
GLY A 102
 None
 0.89A 2vmyB-2eceA:
undetectable		 2vmyB-2eceA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		5 LEU A  77
GLY A 106
VAL A  51
ALA A 107
SER A  98
 None
 1.23A 2vmyB-2ef4A:
2.5		 2vmyB-2ef4A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glx 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Ensifer
adhaerens) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A  91
LEU A 287
SER A 301
ALA A 302
SER A  70
 None
 0.91A 2vmyB-2glxA:
undetectable		 2vmyB-2glxA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		5 LEU A 204
LEU A  49
VAL A 254
ALA A 186
GLY A 235
 None
 1.20A 2vmyB-2gsnA:
undetectable		 2vmyB-2gsnA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 377
SER A 277
ALA A 373
ASN A 346
GLY A 126
 None
 1.16A 2vmyB-2iikA:
undetectable		 2vmyB-2iikA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iut DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		5 LEU A 484
LEU A 480
VAL A 701
ALA A 492
GLY A 509
 None
 1.29A 2vmyB-2iutA:
undetectable		 2vmyB-2iutA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuu DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		5 LEU A 484
LEU A 480
VAL A 701
ALA A 492
GLY A 509
 None
 1.29A 2vmyB-2iuuA:
2.0		 2vmyB-2iuuA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		5 GLY A 196
LEU A 413
SER A 194
ALA A 195
SER A 116
 GLY  A 196 ( 0.0A)
LEU  A 413 ( 0.6A)
SER  A 194 ( 0.0A)
ALA  A 195 ( 0.0A)
SER  A 116 ( 0.0A)
 1.03A 2vmyB-2ogsA:
undetectable		 2vmyB-2ogsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ook HYPOTHETICAL PROTEIN

(Shewanella
frigidimarina) 		PF11964
(SpoIIAA-like) 		5 LEU A  76
LEU A  23
VAL A  21
SER A  46
GLY A  43
 None
 1.13A 2vmyB-2ookA:
undetectable		 2vmyB-2ookA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qib TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 LEU A 109
VAL A 116
SER A  69
ALA A  68
SER A  30
 None
None
P6G  A 701 ( 4.3A)
P6G  A 701 ( 3.9A)
None
 1.27A 2vmyB-2qibA:
undetectable		 2vmyB-2qibA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		5 LEU A 112
LEU A 145
ALA A 195
SER A 117
GLY A 119
 None
 1.11A 2vmyB-2uutA:
undetectable		 2vmyB-2uutA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 GLY A 137
VAL B 289
SER A 135
ASN B  99
ARG B  71
 SRM  B 503 (-4.2A)
SH0  A 503 (-3.5A)
SRM  B 503 (-2.9A)
None
SRM  B 503 (-3.0A)
 1.30A 2vmyB-2v4jA:
undetectable		 2vmyB-2v4jA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		5 LEU A 118
GLY A 120
VAL A 144
SER A  87
PRO A 139
 None
None
None
None
TRS  A1478 (-4.1A)
 1.35A 2vmyB-2vg8A:
3.1		 2vmyB-2vg8A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vj5 PROTEIN MXIC

(Shigella
flexneri) 		PF07201
(HrpJ) 		5 LEU A 273
HIS A 307
LEU A 267
SER A 306
ALA A 305
 None
 1.22A 2vmyB-2vj5A:
undetectable		 2vmyB-2vj5A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A  82
GLY A  84
LEU A  79
ALA A  55
SER A 130
 None
 1.00A 2vmyB-2vk4A:
undetectable		 2vmyB-2vk4A:
23.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		7 GLY A 120
ALA A 173
ASN A 341
SER A 349
PRO A 350
GLY A 351
ARG A 357
 None
None
None
None
None
None
ALO  A 502 (-3.0A)
 0.46A 2vmyB-2vmxA:
67.7		 2vmyB-2vmxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		7 GLY A 120
HIS A 122
ALA A 173
ASN A 341
SER A 349
GLY A 351
ARG A 357
 None
PLP  A 501 ( 3.4A)
None
None
None
None
ALO  A 502 (-3.0A)
 0.57A 2vmyB-2vmxA:
67.7		 2vmyB-2vmxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		6 GLY A 120
HIS A 122
LEU A 123
VAL A 129
ALA A 173
ARG A 357
 None
PLP  A 501 ( 3.4A)
None
None
None
ALO  A 502 (-3.0A)
 0.52A 2vmyB-2vmxA:
67.7		 2vmyB-2vmxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		6 GLY A 120
HIS A 122
VAL A 129
ALA A 173
ASN A 341
ARG A 357
 None
PLP  A 501 ( 3.4A)
None
None
None
ALO  A 502 (-3.0A)
 0.44A 2vmyB-2vmxA:
67.7		 2vmyB-2vmxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		6 HIS A 122
LEU A 123
VAL A 129
SER A 172
ALA A 173
ARG A 357
 PLP  A 501 ( 3.4A)
None
None
ALO  A 502 (-3.9A)
None
ALO  A 502 (-3.0A)
 0.72A 2vmyB-2vmxA:
67.7		 2vmyB-2vmxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		7 HIS A 122
SER A 172
ALA A 173
ASN A 341
SER A 349
GLY A 351
ARG A 357
 PLP  A 501 ( 3.4A)
ALO  A 502 (-3.9A)
None
None
None
None
ALO  A 502 (-3.0A)
 0.66A 2vmyB-2vmxA:
67.7		 2vmyB-2vmxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		6 HIS A 122
VAL A 129
SER A 172
ALA A 173
ASN A 341
ARG A 357
 PLP  A 501 ( 3.4A)
None
ALO  A 502 (-3.9A)
None
None
ALO  A 502 (-3.0A)
 0.66A 2vmyB-2vmxA:
67.7		 2vmyB-2vmxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 LEU A 146
GLY A 142
SER A  48
ALA A  49
GLY A  19
 None
None
None
FAD  A 601 (-3.3A)
None
 0.96A 2vmyB-2wu5A:
undetectable		 2vmyB-2wu5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wua ACETOACETYL COA
THIOLASE

(Helianthus
annuus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 390
SER A 290
ALA A 386
ASN A 359
GLY A 139
 None
 1.12A 2vmyB-2wuaA:
undetectable		 2vmyB-2wuaA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfx UPF0100 PROTEIN
MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		5 GLY A 284
HIS A 207
VAL A 277
ASN A 159
GLY A 164
 None
 1.08A 2vmyB-3cfxA:
undetectable		 2vmyB-3cfxA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqy ANHYDRO-N-ACETYLMURA
MIC ACID KINASE

(Shewanella
oneidensis) 		PF03702
(AnmK) 		5 GLY A 141
SER A 357
ALA A 356
ASN A 349
GLY A 363
 None
 0.99A 2vmyB-3cqyA:
undetectable		 2vmyB-3cqyA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9h CDNA FLJ77766,
HIGHLY SIMILAR TO
HOMO SAPIENS ANKYRIN
REPEAT AND SOCS
BOX-CONTAINING 9
(ASB9), TRANSCRIPT
VARIANT 2, MRNA

(Homo sapiens) 		PF12796
(Ank_2) 		5 LEU A 171
LEU A 187
ALA A 142
SER A 201
PRO A 202
 None
 1.28A 2vmyB-3d9hA:
undetectable		 2vmyB-3d9hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwi CYSTEINE SYNTHASE B

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 LEU A  37
GLY A 277
LEU A  22
ALA A 278
GLY A 267
 None
 1.15A 2vmyB-3dwiA:
undetectable		 2vmyB-3dwiA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 208
SER A 210
ALA A 207
SER A 199
PRO A 200
 None
 1.36A 2vmyB-3e60A:
undetectable		 2vmyB-3e60A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejg NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
229E) 		PF01661
(Macro) 		5 GLY A  42
ALA A  40
ASN A  36
SER A 122
GLY A  91
 None
 1.19A 2vmyB-3ejgA:
undetectable		 2vmyB-3ejgA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3el6 ERYTHROMYCIN
DEHYDRATASE

(Saccharopolyspora
erythraea) 		PF14765
(PS-DH) 		5 GLY A  86
LEU A  82
VAL A  56
ALA A  87
GLY A  31
 None
 1.38A 2vmyB-3el6A:
undetectable		 2vmyB-3el6A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1p PROTEIN PHNP

(Escherichia
coli) 		PF12706
(Lactamase_B_2) 		5 LEU A  88
GLY A  84
ALA A  55
SER A  65
GLY A  67
 None
 1.29A 2vmyB-3g1pA:
undetectable		 2vmyB-3g1pA:
20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		5 GLY A 124
HIS A 126
LEU A 127
VAL A 133
ARG A 363
 None
PLP  A 418 (-4.1A)
PLP  A 418 ( 4.7A)
None
None
 0.67A 2vmyB-3g8mA:
53.2		 2vmyB-3g8mA:
58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE

(Rauvolfia
serpentina) 		PF00561
(Abhydrolase_1) 		5 GLY A  90
LEU A 187
SER A  87
ALA A 112
SER A 120
 None
EVS  A1000 (-4.6A)
EVS  A1000 (-1.4A)
None
None
 1.32A 2vmyB-3gzjA:
undetectable		 2vmyB-3gzjA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6x SOLUTE-BINDING
PROTEIN MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		5 GLY A 284
HIS A 207
VAL A 277
ASN A 159
GLY A 164
 None
 1.13A 2vmyB-3k6xA:
undetectable		 2vmyB-3k6xA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY

(Chlorobaculum
tepidum) 		PF00294
(PfkB) 		5 LEU A  62
SER A  37
ALA A  36
SER A   8
GLY A  27
 None
None
None
AMP  A 509 (-2.7A)
AMP  A 509 (-3.4A)
 1.04A 2vmyB-3kd6A:
undetectable		 2vmyB-3kd6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3maj DNA PROCESSING CHAIN
A

(Rhodopseudomonas
palustris) 		PF02481
(DNA_processg_A) 		5 GLY A 152
LEU A 147
ALA A 154
SER A 235
GLY A 237
 None
 1.00A 2vmyB-3majA:
undetectable		 2vmyB-3majA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyb POLY(A) RNA
POLYMERASE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		5 LEU A 350
LEU A 342
VAL A 325
SER A 434
GLY A 384
 None
 1.39A 2vmyB-3nybA:
undetectable		 2vmyB-3nybA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 406
GLY A 261
ALA A 262
ASN A 169
GLY A 189
 None
 0.95A 2vmyB-3o04A:
undetectable		 2vmyB-3o04A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqd L-LACTATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 291
HIS A 188
LEU A 289
SER A 187
GLY A 176
 None
 1.35A 2vmyB-3pqdA:
2.4		 2vmyB-3pqdA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qka ENOYL-COA HYDRATASE,
ECHA5

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 LEU A 111
GLY A  63
VAL A  16
ALA A  64
PRO A  87
 None
 1.38A 2vmyB-3qkaA:
undetectable		 2vmyB-3qkaA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qka ENOYL-COA HYDRATASE,
ECHA5

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 LEU A 111
GLY A 107
VAL A  16
ALA A  64
PRO A  87
 None
 1.24A 2vmyB-3qkaA:
undetectable		 2vmyB-3qkaA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxz ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 LEU A 175
LEU A 146
VAL A 154
ALA A 113
SER A 166
 None
 1.25A 2vmyB-3qxzA:
undetectable		 2vmyB-3qxzA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkj ANKYRIN REPEAT AND
SOCS BOX PROTEIN 9

(Homo sapiens) 		PF07525
(SOCS_box)
PF12796
(Ank_2) 		5 LEU A 171
LEU A 187
ALA A 142
SER A 201
PRO A 202
 None
 1.23A 2vmyB-3zkjA:
undetectable		 2vmyB-3zkjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY C 358
SER C 258
ALA C 354
ASN C 327
GLY C  95
 None
 1.15A 2vmyB-4b3iC:
undetectable		 2vmyB-4b3iC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 VAL A 255
SER A  96
ALA A  95
PRO A 186
GLY A 187
 None
 1.18A 2vmyB-4cakA:
undetectable		 2vmyB-4cakA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		5 LEU A 139
LEU A 398
SER A 144
GLY A  99
ARG A 403
 None
 1.35A 2vmyB-4d2jA:
undetectable		 2vmyB-4d2jA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 352
SER A 252
ALA A 348
ASN A 321
GLY A  96
 None
 1.09A 2vmyB-4dd5A:
undetectable		 2vmyB-4dd5A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvf BETA-HEXOSAMINIDASE

(Salmonella
enterica) 		PF00933
(Glyco_hydro_3) 		5 LEU A 269
GLY A 272
VAL A 288
PRO A   3
GLY A   2
 None
 1.29A 2vmyB-4gvfA:
undetectable		 2vmyB-4gvfA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihe THNT PROTEIN

(Streptomyces
cattleya) 		PF03576
(Peptidase_S58) 		5 LEU A 213
GLY A 198
LEU A 100
VAL A  98
ALA A 375
 None
 1.24A 2vmyB-4iheA:
undetectable		 2vmyB-4iheA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inf METAL-DEPENDENT
HYDROLASE

(Novosphingobium
aromaticivorans) 		PF04909
(Amidohydro_2) 		5 LEU A  47
GLY A  49
ALA A  52
PRO A  92
GLY A  93
 OXD  A 407 (-4.5A)
None
None
None
None
 1.14A 2vmyB-4infA:
undetectable		 2vmyB-4infA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isy CYSTEINE DESULFURASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		5 LEU A 316
GLY A 320
LEU A 374
VAL A 378
ALA A   2
 None
 1.28A 2vmyB-4isyA:
29.2		 2vmyB-4isyA:
24.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		5 GLY A 124
ALA A 177
ASN A 346
PRO A 355
ARG A 362
 None
 0.86A 2vmyB-4j5uA:
60.1		 2vmyB-4j5uA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		5 GLY A 124
ALA A 177
ASN A 346
SER A 354
PRO A 355
 None
 1.02A 2vmyB-4j5uA:
60.1		 2vmyB-4j5uA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		6 LEU A 121
GLY A 124
HIS A 126
LEU A 127
ALA A 177
ARG A 362
 None
None
LLP  A 230 ( 3.5A)
None
None
None
 0.97A 2vmyB-4j5uA:
60.1		 2vmyB-4j5uA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		5 LEU A 121
HIS A 126
LEU A 127
SER A 176
ARG A 362
 None
LLP  A 230 ( 3.5A)
None
None
None
 1.02A 2vmyB-4j5uA:
60.1		 2vmyB-4j5uA:
57.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN

(Escherichia
coli) 		PF01103
(Bac_surface_Ag) 		5 GLY A 279
LEU A 339
SER A 305
GLY A 471
ARG A 281
 None
 1.18A 2vmyB-4n74A:
undetectable		 2vmyB-4n74A:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
falciparum) 		PF00464
(SHMT) 		5 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
 None
None
PLP  A 701 (-3.6A)
None
None
 0.41A 2vmyB-4o6zA:
56.2		 2vmyB-4o6zA:
39.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq8 DESIGNED PROTEIN
OR465

(synthetic
construct) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU A  97
GLY A  95
LEU A  88
SER A 100
GLY A  78
 None
 1.16A 2vmyB-4pq8A:
undetectable		 2vmyB-4pq8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psj OR464

(synthetic
construct) 		PF12354
(Internalin_N)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  97
GLY A  95
LEU A  88
SER A 100
GLY A  78
 None
 1.17A 2vmyB-4psjA:
undetectable		 2vmyB-4psjA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfe ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		5 LEU A 111
GLY A 107
VAL A  16
ALA A  64
PRO A  87
 None
 1.24A 2vmyB-4qfeA:
undetectable		 2vmyB-4qfeA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjk PHOSPHOPANTETHEINYL
TRANSFERASE PPTT

(Mycobacterium
tuberculosis) 		PF01648
(ACPS) 		5 LEU A  19
VAL A   7
ALA A 107
SER A  90
GLY A 112
 None
None
None
COA  A 301 ( 4.9A)
None
 1.10A 2vmyB-4qjkA:
undetectable		 2vmyB-4qjkA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u89 PHOSPHOPANTETHEINYL
TRANSFERASE PPTT

(Mycobacterium
tuberculosis) 		PF01648
(ACPS) 		5 LEU A  19
VAL A   7
ALA A 107
SER A  90
GLY A 112
 None
 1.15A 2vmyB-4u89A:
undetectable		 2vmyB-4u89A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubt ACETYL-COA
ACETYLTRANSFERASE
FADA5

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 346
SER A 246
ALA A 342
ASN A 315
GLY A  96
 None
COA  A 401 (-3.7A)
None
None
None
 1.12A 2vmyB-4ubtA:
undetectable		 2vmyB-4ubtA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubt ACETYL-COA
ACETYLTRANSFERASE
FADA5

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 346
SER A 246
ASN A 315
SER A 354
GLY A  96
 None
COA  A 401 (-3.7A)
None
None
None
 1.28A 2vmyB-4ubtA:
undetectable		 2vmyB-4ubtA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
ALPHA

(Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY) 		5 LEU A  10
GLY A  86
SER A  88
SER A  77
GLY A  75
 None
 1.24A 2vmyB-4wvmA:
undetectable		 2vmyB-4wvmA:
19.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		5 LEU A 115
GLY A 118
ALA A 171
ASN A 341
ARG A 357
 None
None
None
None
CAC  A 502 (-3.1A)
 0.62A 2vmyB-4wxbA:
58.0		 2vmyB-4wxbA:
58.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yb9 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5

(Bos taurus) 		PF00083
(Sugar_tr) 		5 LEU D 196
GLY D 117
SER D 119
SER D  41
PRO D  42
 None
 1.33A 2vmyB-4yb9D:
undetectable		 2vmyB-4yb9D:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yla AROMATIC
PRENYLTRANSFERASE

(Marinactinospora
thermotolerans) 		PF11991
(Trp_DMAT) 		5 GLY A 182
LEU A 190
VAL A 236
ALA A 184
GLY A 217
 SO4  A 402 (-3.2A)
None
None
None
None
 1.38A 2vmyB-4ylaA:
undetectable		 2vmyB-4ylaA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		5 LEU A 294
GLY A 298
PRO A 228
GLY A 229
ARG A 259
 None
 0.80A 2vmyB-4yyfA:
undetectable		 2vmyB-4yyfA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4v NUCLEOPROTEIN,PHOSPH
OPROTEIN

(Measles
morbillivirus) 		PF00973
(Paramyxo_ncap)
PF13825
(Paramyxo_PNT) 		5 LEU A  60
LEU A  32
SER A  64
PRO A  65
GLY A  66
 None
 0.93A 2vmyB-5e4vA:
undetectable		 2vmyB-5e4vA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 HIS A 532
SER A 552
ASN A 597
PRO A 548
GLY A 547
 None
 1.22A 2vmyB-5e9aA:
undetectable		 2vmyB-5e9aA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f38 ACETYL-COA
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY B 348
SER B 248
ALA B 344
ASN B 317
GLY B  91
 None
COZ  B 401 (-3.9A)
None
None
None
 1.13A 2vmyB-5f38B:
undetectable		 2vmyB-5f38B:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 5 LEU B  87
LEU B 162
SER B  67
PRO B  68
GLY B  69
 None
 1.21A 2vmyB-5hzgB:
undetectable		 2vmyB-5hzgB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inw PUTATIVE
ANGIOTENSINOGEN

(Lampetra
fluviatilis) 		PF00079
(Serpin) 		5 LEU A 359
LEU A  91
VAL A  95
ALA A 115
SER A 356
 None
 1.21A 2vmyB-5inwA:
undetectable		 2vmyB-5inwA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2e GLUTAMATE RECEPTOR
IONOTROPIC,
DELTA-2,GLUTAMATE
RECEPTOR IONOTROPIC,
DELTA-2

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 LEU A 508
GLY A 497
LEU A 512
VAL A 445
GLY A 771
 None
 1.07A 2vmyB-5l2eA:
undetectable		 2vmyB-5l2eA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li8 PUTATIVE CYTOCHROME
P450 126

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 LEU A  12
ALA A  55
SER A   8
GLY A   6
ARG A  31
 None
 0.90A 2vmyB-5li8A:
undetectable		 2vmyB-5li8A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Mycolicibacterium
thermoresistibile) 		no annotation 5 LEU A  65
GLY A  87
LEU A 256
ALA A  85
GLY A 340
 None
 1.06A 2vmyB-5ou3A:
2.0		 2vmyB-5ou3A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL

(Homo sapiens) 		no annotation 7 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.56A 2vmyB-5v7iA:
52.1		 2vmyB-5v7iA:
43.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 5 GLY A 476
LEU A 467
VAL A 445
ALA A 312
GLY A 486
 None
 1.00A 2vmyB-5wabA:
2.9		 2vmyB-5wabA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
vivax) 		no annotation 7 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.73A 2vmyB-5xmrA:
57.3		 2vmyB-5xmrA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE

(Streptomyces
pristinaespiralis) 		no annotation 5 LEU A 120
GLY A 123
LEU A 116
VAL A  11
GLY A  19
 None
 1.32A 2vmyB-5yu1A:
undetectable		 2vmyB-5yu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c62 BIURET HYDROLASE

(Pseudomonas sp.
ADP) 		no annotation 5 LEU A 165
GLY A 218
LEU A 107
SER A 154
GLY A 168
 None
 0.99A 2vmyB-6c62A:
undetectable		 2vmyB-6c62A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 9 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.64A 2vmyB-6cczA:
57.4		 2vmyB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 LEU A 274
GLY A 276
VAL A 320
ALA A 246
GLY A  26
 None
 1.09A 2vmyB-6eu6A:
undetectable		 2vmyB-6eu6A:
undetectable