SIMILAR PATTERNS OF AMINO ACIDS FOR 2VMY_A_FFOA505_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		5 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
 None
 0.72A 2vmyA-1cj0A:
51.2		 2vmyA-1cj0A:
45.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqd HUMAN MONOCLONAL
BO2C11 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU B 149
TYR B 177
TYR B 146
PRO B  41
 None
 1.42A 2vmyA-1iqdB:
undetectable		 2vmyA-1iqdB:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mec MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP1)

(Cardiovirus A) 		no annotation 4 TYR 1  37
TYR 1 242
PHE 1 120
PRO 1 119
 None
 1.20A 2vmyA-1mec1:
undetectable		 2vmyA-1mec1:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		4 GLU A 338
LYS A 324
PHE A 325
PRO A 321
 None
 1.40A 2vmyA-1nj8A:
undetectable		 2vmyA-1nj8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shx EPHRIN-A5

(Mus musculus) 		PF00812
(Ephrin) 		4 GLU A 120
TYR A 140
TYR A 142
PHE A 134
 None
 1.36A 2vmyA-1shxA:
undetectable		 2vmyA-1shxA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tme THEILER'S MURINE
ENCEPHALOMYELITIS
VIRUS (SUBUNIT VP1)

(Cardiovirus B) 		no annotation 4 TYR 1  37
TYR 1 238
PHE 1 120
PRO 1 119
 None
 1.19A 2vmyA-1tme1:
undetectable		 2vmyA-1tme1:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtm COAT PROTEIN

(Tobacco mild
green mosaic
virus) 		PF00721
(TMV_coat) 		4 TYR P  68
TYR P  70
PHE P  62
PRO P  63
 None
 1.41A 2vmyA-1vtmP:
undetectable		 2vmyA-1vtmP:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		4 GLU A 236
TYR A  63
LYS A 278
PRO A 234
 None
 1.28A 2vmyA-2a5hA:
undetectable		 2vmyA-2a5hA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284

(Homo sapiens) 		PF00179
(UQ_con) 		4 GLU A  52
TYR A  49
PHE A  54
PRO A  79
 None
 1.39A 2vmyA-2a7lA:
undetectable		 2vmyA-2a7lA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 GLU A 297
TYR A 409
LYS A 249
PHE A 339
 None
None
AMP  A1563 (-3.5A)
AMP  A1563 (-3.3A)
 1.34A 2vmyA-2cfmA:
undetectable		 2vmyA-2cfmA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE

(Thermus
thermophilus) 		PF00464
(SHMT) 		5 GLU A  53
TYR A  60
TYR A  61
PHE A 252
PRO A 253
 None
 0.24A 2vmyA-2dkjA:
61.7		 2vmyA-2dkjA:
66.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg9 ADP-RIBOSYL CYCLASE
1

(Mus musculus) 		PF02267
(Rib_hydrolayse) 		4 TYR A  73
LYS A 125
PHE A 147
PRO A 122
 None
 1.47A 2vmyA-2eg9A:
undetectable		 2vmyA-2eg9A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyx PROTEIN DIPZ

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 GLU A 468
TYR A 572
LYS A 473
PRO A 467
 None
 1.25A 2vmyA-2hyxA:
undetectable		 2vmyA-2hyxA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 1

(Mus musculus) 		PF04099
(Sybindin) 		4 GLU C  75
TYR C  74
TYR C  73
PRO C  77
 None
 1.21A 2vmyA-2j3tC:
undetectable		 2vmyA-2j3tC:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2olw RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 GLU A  65
LYS A  46
PHE A  66
PRO A  47
 None
 1.43A 2vmyA-2olwA:
undetectable		 2vmyA-2olwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyo UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Deinococcus
geothermalis) 		PF02627
(CMD) 		4 GLU A 189
TYR A 190
PHE A  40
PRO A  42
 None
 1.47A 2vmyA-2oyoA:
undetectable		 2vmyA-2oyoA:
20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		5 GLU A  53
TYR A  51
LYS A 248
PHE A 251
PRO A 252
 None
 1.43A 2vmyA-2vmxA:
67.4		 2vmyA-2vmxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		5 GLU A  53
TYR A  60
TYR A  61
PHE A 251
PRO A 252
 None
 0.26A 2vmyA-2vmxA:
67.4		 2vmyA-2vmxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		5 GLU A  53
TYR A  61
LYS A 248
PHE A 251
PRO A 252
 None
 0.58A 2vmyA-2vmxA:
67.4		 2vmyA-2vmxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wo3 EPHRIN-A2

(Homo sapiens) 		PF00812
(Ephrin) 		4 GLU B 128
TYR B 148
TYR B 150
PHE B 142
 None
 1.40A 2vmyA-2wo3B:
undetectable		 2vmyA-2wo3B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		4 TYR A 408
TYR A  82
PHE A 399
PRO A 411
 None
 1.31A 2vmyA-2ykyA:
22.4		 2vmyA-2ykyA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjq PHAGE-RELATED
PROTEIN

(Bordetella
bronchiseptica) 		PF03864
(Phage_cap_E) 		4 TYR A 264
TYR A 266
PHE A  49
PRO A 260
 None
 1.24A 2vmyA-3bjqA:
undetectable		 2vmyA-3bjqA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcd GALACTOSE MUTAROTASE
RELATED ENZYME

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		4 GLU A 124
TYR A 115
PHE A 287
PRO A 254
 None
 1.22A 2vmyA-3dcdA:
undetectable		 2vmyA-3dcdA:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		5 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
 None
 0.85A 2vmyA-3g8mA:
53.2		 2vmyA-3g8mA:
58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 GLU A 210
TYR A 263
PHE A 214
PRO A 310
 None
 1.25A 2vmyA-3h2zA:
undetectable		 2vmyA-3h2zA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl1 FERRITIN LIKE
PROTEIN

(Caulobacter
vibrioides) 		PF12902
(Ferritin-like) 		4 GLU A 121
TYR A  28
LYS A 229
PRO A 231
 UNL  A 317 (-2.7A)
None
None
None
 1.42A 2vmyA-3hl1A:
undetectable		 2vmyA-3hl1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks7 PUTATIVE PUTATIVE
PNGASE F

(Bacteroides
fragilis) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 GLU A 373
TYR A 280
PHE A 311
PRO A 313
 EDO  A 420 ( 3.5A)
None
EDO  A 418 ( 4.4A)
EDO  A 420 (-4.5A)
 1.13A 2vmyA-3ks7A:
undetectable		 2vmyA-3ks7A:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		4 GLU A  52
TYR A  50
PHE A 250
PRO A 251
 None
 1.44A 2vmyA-3n0lA:
56.0		 2vmyA-3n0lA:
55.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		4 GLU A  52
TYR A  59
PHE A 250
PRO A 251
 None
 0.71A 2vmyA-3n0lA:
56.0		 2vmyA-3n0lA:
55.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		4 GLU A  52
TYR A  59
TYR A  60
PRO A 251
 None
 0.87A 2vmyA-3n0lA:
56.0		 2vmyA-3n0lA:
55.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pgy SERINE
HYDROXYMETHYLTRANSFE
RASE

(Staphylococcus
aureus) 		PF00464
(SHMT) 		4 GLU A  53
TYR A  51
PHE A 251
PRO A 252
 None
 1.19A 2vmyA-3pgyA:
58.8		 2vmyA-3pgyA:
71.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6m 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		4 GLU A 137
TYR A 190
LYS A 111
PRO A 112
 None
 1.33A 2vmyA-3w6mA:
undetectable		 2vmyA-3w6mA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zul FLUORESCENT PROTEIN
DRONPA

(Echinophyllia
sp. SC22) 		PF01353
(GFP) 		4 TYR A 114
TYR A 116
PHE A  68
PRO A  33
 None
GYC  A  63 ( 4.8A)
None
None
 1.46A 2vmyA-3zulA:
undetectable		 2vmyA-3zulA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		4 TYR A 394
TYR A  69
PHE A 385
PRO A 397
 None
 1.29A 2vmyA-4aoaA:
23.3		 2vmyA-4aoaA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		4 GLU A 136
TYR A 133
TYR A 132
PRO A 431
 None
 1.27A 2vmyA-4arcA:
undetectable		 2vmyA-4arcA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		4 TYR A 457
TYR A 164
PHE A 407
PRO A 414
 None
 1.25A 2vmyA-4ckbA:
undetectable		 2vmyA-4ckbA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk1 PUTATIVE THIOREDOXIN
REDUCTASE

(Bacillus
anthracis) 		PF07992
(Pyr_redox_2) 		4 GLU C 114
TYR C 126
PHE C 231
PRO C 275
 FAD  C 500 (-3.7A)
FAD  C 500 (-4.3A)
None
None
 1.35A 2vmyA-4fk1C:
undetectable		 2vmyA-4fk1C:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		4 GLU A  57
TYR A  65
PHE A 256
PRO A 257
 None
 0.40A 2vmyA-4j5uA:
60.2		 2vmyA-4j5uA:
57.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3o PUTATIVE
D-GLYCERO-D-MANNO-HE
PTOSE 7-PHOSPHATE
KINASE

(Campylobacter
jejuni) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 GLU A 173
TYR A  31
TYR A  28
PHE A 171
 None
 1.25A 2vmyA-4n3oA:
undetectable		 2vmyA-4n3oA:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
falciparum) 		PF00464
(SHMT) 		4 GLU A  56
TYR A  63
PHE A 266
PRO A 267
 None
 0.68A 2vmyA-4o6zA:
56.0		 2vmyA-4o6zA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
falciparum) 		PF00464
(SHMT) 		4 GLU A  56
TYR A  63
TYR A  64
PRO A 267
 None
 0.73A 2vmyA-4o6zA:
56.0		 2vmyA-4o6zA:
39.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onq DNA
METHYLTRANSFERASE

(Nicotiana
tabacum) 		PF00145
(DNA_methylase) 		4 GLU A 294
TYR A 293
TYR A 333
PRO A 566
 None
 1.37A 2vmyA-4onqA:
undetectable		 2vmyA-4onqA:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Psychromonas
ingrahamii) 		PF00464
(SHMT) 		5 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
 None
 0.57A 2vmyA-4p3mA:
44.1		 2vmyA-4p3mA:
55.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p79 CLAUDIN-15

(Mus musculus) 		PF00822
(PMP22_Claudin) 		4 GLU A  46
TYR A 156
PHE A  65
PRO A  66
 None
 1.49A 2vmyA-4p79A:
undetectable		 2vmyA-4p79A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po2 HEAT SHOCK 70 KDA
PROTEIN 1A/1B

(Homo sapiens) 		PF00012
(HSP70) 		4 GLU A 543
TYR A 431
LYS A 550
PHE A 547
 None
 1.28A 2vmyA-4po2A:
undetectable		 2vmyA-4po2A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)

(Methylobacterium
extorquens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 GLU A  28
TYR A  26
PHE A  30
PRO A 210
 None
 1.31A 2vmyA-4px1A:
undetectable		 2vmyA-4px1A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uym 14-ALPHA STEROL
DEMETHYLASE

(Aspergillus
fumigatus) 		PF00067
(p450) 		4 GLU A 466
TYR A 470
PHE A 456
PRO A 455
 None
None
HEM  A 580 (-4.5A)
None
 1.45A 2vmyA-4uymA:
undetectable		 2vmyA-4uymA:
23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		5 GLU A  51
TYR A  58
TYR A  59
PHE A 250
PRO A 251
 None
 0.85A 2vmyA-4wxbA:
58.1		 2vmyA-4wxbA:
58.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 GLU A 186
TYR A 215
TYR A 213
PRO A 192
 None
 1.46A 2vmyA-4zxlA:
undetectable		 2vmyA-4zxlA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8f HUMAN SAFFOLD
VIRUS-3 VP1

(Cardiovirus B) 		no annotation 4 TYR A  37
TYR A 243
PHE A 122
PRO A 121
 None
 1.20A 2vmyA-5a8fA:
undetectable		 2vmyA-5a8fA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfc VP1

(Cardiovirus B) 		no annotation 4 TYR A  37
TYR A 243
PHE A 122
PRO A 121
 None
 1.20A 2vmyA-5cfcA:
undetectable		 2vmyA-5cfcA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE

(Legionella
pneumophila) 		PF04389
(Peptidase_M28) 		4 GLU A 393
TYR A 323
LYS A 115
PRO A 117
 None
 1.18A 2vmyA-5gneA:
undetectable		 2vmyA-5gneA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		4 GLU A 473
TYR A 477
PHE A 463
PRO A 462
 None
None
HEM  A 601 (-4.4A)
None
 1.32A 2vmyA-5hs1A:
undetectable		 2vmyA-5hs1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 4 GLU A 804
TYR A 746
PHE A 819
PRO A 436
 6A9  A 903 ( 4.9A)
6A9  A 903 (-3.9A)
6A9  A 903 ( 4.9A)
6A9  A 903 (-4.3A)
 1.45A 2vmyA-5mhfA:
undetectable		 2vmyA-5mhfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj1 DNA TOPOISOMERASE 1

(Mycobacterium
tuberculosis) 		no annotation 4 GLU A 369
TYR A 370
PHE A 464
PRO A 465
 None
 1.49A 2vmyA-5uj1A:
undetectable		 2vmyA-5uj1A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 GLU A  98
TYR A 105
TYR A 106
PHE A 320
PRO A 321
 None
 0.65A 2vmyA-5v7iA:
52.1		 2vmyA-5v7iA:
43.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		5 GLU A  56
TYR A  63
TYR A  64
PHE A 256
PRO A 257
 None
 0.96A 2vmyA-5vmbA:
55.5		 2vmyA-5vmbA:
57.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
vivax) 		no annotation 5 GLU A  56
TYR A  63
TYR A  64
PHE A 266
PRO A 267
 None
 0.65A 2vmyA-5xmrA:
57.2		 2vmyA-5xmrA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 5 GLU A 136
TYR A 143
TYR A 144
PHE A 349
PRO A 350
 None
None
None
None
SEY  A 607 (-4.7A)
 0.39A 2vmyA-6cczA:
57.3		 2vmyA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cf8 LYTIC
TRANSGLYCOSYLASE

(Campylobacter
jejuni) 		no annotation 4 GLU A  28
TYR A  20
PHE A 316
PRO A 315
 None
 1.42A 2vmyA-6cf8A:
undetectable		 2vmyA-6cf8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exp SIRV3 ACRID1 (GP02)
ANTI-CRISPR PROTEIN

(Sulfolobus
islandicus
rudivirus 3) 		no annotation 4 GLU A  58
TYR A  76
PHE A  60
PRO A  46
 None
 1.23A 2vmyA-6expA:
undetectable		 2vmyA-6expA:
undetectable