SIMILAR PATTERNS OF AMINO ACIDS FOR 2VL2_B_BEZB1162

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e33 ARYLSULFATASE A

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		4 PRO P 284
GLY P 283
LEU P 251
PHE P 247
 None
 0.95A 2vl2B-1e33P:
undetectable		 2vl2B-1e33P:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		4 PRO A 445
GLY A 446
LEU A 243
PHE A 259
 None
 0.89A 2vl2B-1e6zA:
undetectable		 2vl2B-1e6zA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkp HYDANTOINASE

(Thermus sp.) 		PF01979
(Amidohydro_1) 		4 PRO A  58
LEU A 374
PHE A 375
THR A 311
 None
 0.91A 2vl2B-1gkpA:
undetectable		 2vl2B-1gkpA:
18.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4o PEROXIREDOXIN 5

(Homo sapiens) 		PF08534
(Redoxin) 		7 PRO A  40
THR A  44
PRO A  45
GLY A  46
LEU A 116
PHE A 120
THR A 147
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
None
None
BEZ  A1162 ( 4.0A)
 0.29A 2vl2B-1h4oA:
34.3		 2vl2B-1h4oA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		4 THR A 363
GLY A 359
PHE A 387
THR A 352
 None
 0.94A 2vl2B-1jmyA:
undetectable		 2vl2B-1jmyA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miu BREAST CANCER TYPE 2
SUSCEPTIBILITY
PROTEIN

(Mus musculus) 		PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical) 		4 THR A2528
PRO A2529
GLY A2530
LEU A2575
 None
 0.67A 2vl2B-1miuA:
undetectable		 2vl2B-1miuA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mje BREAST CANCER 2

(Mus musculus) 		PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical) 		4 THR A2528
PRO A2529
GLY A2530
LEU A2575
 None
 0.80A 2vl2B-1mjeA:
undetectable		 2vl2B-1mjeA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		4 THR A  35
GLY A 127
LEU A 168
PHE A 156
 None
 1.03A 2vl2B-1qs8A:
undetectable		 2vl2B-1qs8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 THR A 106
PRO A 107
GLY A 108
LEU A  87
 None
 0.56A 2vl2B-1r9jA:
undetectable		 2vl2B-1r9jA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 THR A 342
GLY A 337
LEU A 390
PHE A 394
 None
 0.95A 2vl2B-1rblA:
undetectable		 2vl2B-1rblA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ssf TRANSFORMATION
RELATED PROTEIN 53
BINDING PROTEIN 1

(Mus musculus) 		PF09038
(53-BP1_Tudor) 		4 PRO A 127
GLY A 126
LEU A  12
PHE A   9
 None
 0.96A 2vl2B-1ssfA:
undetectable		 2vl2B-1ssfA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux1 CYTIDINE DEAMINASE

(Bacillus
subtilis) 		PF00383
(dCMP_cyt_deam_1) 		4 THR A  79
PRO A  80
GLY A  81
PHE A  24
 None
None
None
THU  A 138 (-4.7A)
 1.02A 2vl2B-1ux1A:
undetectable		 2vl2B-1ux1A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		4 THR A  19
PRO A  20
LEU A  58
PHE A 274
 None
 0.92A 2vl2B-1xr5A:
undetectable		 2vl2B-1xr5A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 THR A 124
PRO A 125
GLY A 126
THR A  36
 None
 0.74A 2vl2B-1ykwA:
undetectable		 2vl2B-1ykwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4v PEROXIREDOXIN DOT5

(Saccharomyces
cerevisiae) 		PF00578
(AhpC-TSA) 		4 PRO A 100
THR A 104
PRO A 105
GLY A 106
 None
 0.57A 2vl2B-2a4vA:
19.9		 2vl2B-2a4vA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anl PLASMEPSIN IV

(Plasmodium
malariae) 		PF00026
(Asp) 		4 THR A  35
GLY A 127
LEU A 168
PHE A 156
 None
 0.94A 2vl2B-2anlA:
undetectable		 2vl2B-2anlA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4w HYPOTHETICAL
PROTEIN, CONSERVED

(Leishmania
major) 		PF08950
(DUF1861) 		4 PRO A  36
THR A  43
LEU A  20
PHE A  71
 None
 1.02A 2vl2B-2b4wA:
undetectable		 2vl2B-2b4wA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 THR A 110
PRO A 111
GLY A 112
LEU A  91
 None
 0.44A 2vl2B-2e6kA:
undetectable		 2vl2B-2e6kA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Thermus
caldophilus) 		PF01116
(F_bP_aldolase) 		4 THR A  61
GLY A  57
LEU A  79
PHE A  96
 None
 1.04A 2vl2B-2fjkA:
undetectable		 2vl2B-2fjkA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF03480
(DctP) 		4 PRO A 195
THR A 178
PRO A 179
GLY A 180
 None
 1.03A 2vl2B-2hpgA:
undetectable		 2vl2B-2hpgA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iun AVIAN ADENOVIRUS
CELO LONG FIBRE

(Fowl
aviadenovirus A) 		PF16812
(AdHead_fibreRBD) 		4 THR A 781
PRO A 782
LEU A 755
PHE A 757
 None
 0.68A 2vl2B-2iunA:
undetectable		 2vl2B-2iunA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jtc STREPTOPAIN

(Streptococcus
pyogenes) 		PF01640
(Peptidase_C10) 		4 PRO A  26
PRO A 133
LEU A  73
PHE A  80
 None
 0.98A 2vl2B-2jtcA:
undetectable		 2vl2B-2jtcA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p23 FIBROBLAST GROWTH
FACTOR 19

(Homo sapiens) 		PF00167
(FGF) 		4 PRO A  52
GLY A  51
LEU A 153
PHE A 159
 None
 0.90A 2vl2B-2p23A:
undetectable		 2vl2B-2p23A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6g PROGESTERONE
5-BETA-REDUCTASE

(Digitalis
lanata) 		PF01370
(Epimerase) 		4 THR A  51
PRO A  52
GLY A  53
LEU A  42
 None
 0.55A 2vl2B-2v6gA:
undetectable		 2vl2B-2v6gA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24

(Trypanosoma
brucei) 		PF00913
(Trypan_glycop) 		4 GLY A 208
LEU A 183
PHE A 184
THR A 109
 None
 0.91A 2vl2B-2vsgA:
undetectable		 2vl2B-2vsgA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE

(Thermotoga
maritima) 		PF00483
(NTP_transferase) 		4 THR A 310
PRO A 311
LEU A  28
THR A  20
 None
 0.85A 2vl2B-2x60A:
undetectable		 2vl2B-2x60A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 THR A 474
PRO A 473
GLY A 446
LEU A 450
 None
 1.02A 2vl2B-3ak5A:
undetectable		 2vl2B-3ak5A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asa LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Chlamydia
trachomatis) 		PF00155
(Aminotran_1_2) 		4 THR A 355
PRO A 356
GLY A 357
PHE A  16
 None
 0.95A 2vl2B-3asaA:
undetectable		 2vl2B-3asaA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		4 PRO A 143
GLY A 142
LEU A 179
PHE A 174
 AMP  A 501 (-4.6A)
None
None
None
 0.88A 2vl2B-3b1rA:
undetectable		 2vl2B-3b1rA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans) 		no annotation 4 THR A 633
PRO A 634
GLY A 635
LEU A 564
 None
 0.95A 2vl2B-3c2gA:
undetectable		 2vl2B-3c2gA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE

(Homo sapiens) 		PF03403
(PAF-AH_p_II) 		4 THR A 361
GLY A 366
LEU A 121
PHE A 125
 None
 1.02A 2vl2B-3d5eA:
undetectable		 2vl2B-3d5eA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drn PEROXIREDOXIN,
BACTERIOFERRITIN
COMIGRATORY PROTEIN
HOMOLOG

(Sulfolobus
solfataricus) 		PF00578
(AhpC-TSA) 		4 PRO A  38
THR A  42
PRO A  43
GLY A  44
 CIT  A 500 (-3.6A)
CIT  A 500 (-2.9A)
CIT  A 500 (-3.6A)
CIT  A 500 (-2.9A)
 0.40A 2vl2B-3drnA:
19.2		 2vl2B-3drnA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebv CHINITASE A

(Streptomyces
coelicolor) 		PF00704
(Glyco_hydro_18) 		4 THR A  43
PRO A  44
GLY A  45
THR A  98
 None
 0.60A 2vl2B-3ebvA:
undetectable		 2vl2B-3ebvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ei8 LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		4 GLY A 280
LEU A 135
PHE A 300
THR A 265
 None
 0.97A 2vl2B-3ei8A:
undetectable		 2vl2B-3ei8A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ei8 LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		4 THR A 390
PRO A 391
GLY A 392
PHE A  39
 None
 0.88A 2vl2B-3ei8A:
undetectable		 2vl2B-3ei8A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gff IROE-LIKE SERINE
HYDROLASE

(Shewanella
oneidensis) 		PF00756
(Esterase) 		4 THR A  90
PRO A  91
GLY A 111
THR A  94
 None
 0.98A 2vl2B-3gffA:
undetectable		 2vl2B-3gffA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		4 THR C 408
GLY C 411
LEU C 333
PHE C 334
 None
 0.75A 2vl2B-3gi8C:
undetectable		 2vl2B-3gi8C:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ

(Carboxydothermus
hydrogenoformans) 		PF14450
(FtsA) 		4 PRO A 262
PRO A 257
GLY A 231
LEU A  53
 None
None
ATP  A 301 (-3.5A)
None
 0.94A 2vl2B-3h1qA:
undetectable		 2vl2B-3h1qA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2y GTPASE FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01926
(MMR_HSR1) 		4 THR A 218
PRO A 219
GLY A 220
LEU A  63
 None
 0.80A 2vl2B-3h2yA:
undetectable		 2vl2B-3h2yA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibg ATPASE, SUBUNIT OF
THE GET COMPLEX

(Aspergillus
fumigatus) 		PF02374
(ArsA_ATPase) 		4 THR A 159
GLY A  32
LEU A 169
PHE A 168
 None
 1.02A 2vl2B-3ibgA:
undetectable		 2vl2B-3ibgA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3id9 MUTT/NUDIX FAMILY
PROTEIN

(Bacillus
thuringiensis) 		PF00293
(NUDIX) 		4 PRO A  49
GLY A  26
LEU A 130
PHE A 135
 None
 0.98A 2vl2B-3id9A:
undetectable		 2vl2B-3id9A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixr BACTERIOFERRITIN
COMIGRATORY PROTEIN

(Xylella
fastidiosa) 		PF00578
(AhpC-TSA) 		4 PRO A  40
THR A  44
PRO A  45
GLY A  46
 None
 0.47A 2vl2B-3ixrA:
18.6		 2vl2B-3ixrA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxo TRKA-N DOMAIN
PROTEIN

(Thermotoga sp.
RQ2) 		PF02080
(TrkA_C) 		4 PRO A 187
THR A 191
GLY A 189
LEU A 199
 None
 0.93A 2vl2B-3jxoA:
undetectable		 2vl2B-3jxoA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keb PROBABLE THIOL
PEROXIDASE

(Chromobacterium
violaceum) 		no annotation 4 PRO A 136
GLY A  64
LEU A 130
THR A 156
 None
 0.81A 2vl2B-3kebA:
17.2		 2vl2B-3kebA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfl METHIONYL-TRNA
SYNTHETASE

(Leishmania
major) 		PF09334
(tRNA-synt_1g) 		4 THR A 215
PRO A 216
PHE A 288
THR A 255
 None
ME8  A 801 (-4.4A)
None
None
 0.98A 2vl2B-3kflA:
3.4		 2vl2B-3kflA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PRO A   4
GLY A   3
LEU A  68
PHE A  97
 None
 0.93A 2vl2B-3kw7A:
undetectable		 2vl2B-3kw7A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrn UNCHARACTERIZED
PROTEIN PF1083

(Pyrococcus
furiosus) 		PF01593
(Amino_oxidase) 		4 PRO A 181
PRO A  83
GLY A  85
LEU A 183
 None
 0.80A 2vl2B-3nrnA:
undetectable		 2vl2B-3nrnA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 THR A 331
GLY A 333
LEU A 371
PHE A 353
 None
 0.99A 2vl2B-3oeeA:
undetectable		 2vl2B-3oeeA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvd CAPSID

(Norwalk virus) 		PF08435
(Calici_coat_C) 		4 THR A 319
PRO A 320
GLY A 321
LEU A 272
 None
 0.98A 2vl2B-3pvdA:
undetectable		 2vl2B-3pvdA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqm MLR3007 PROTEIN

(Mesorhizobium
loti) 		PF01063
(Aminotran_4) 		4 GLY A  10
LEU A  46
PHE A  48
THR A 118
 None
CL  A 250 (-4.3A)
None
EDO  A 270 (-2.7A)
 1.03A 2vl2B-3qqmA:
undetectable		 2vl2B-3qqmA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Mycobacteroides
abscessus) 		PF00106
(adh_short) 		4 THR A 126
GLY A 105
LEU A  83
THR A  13
 NAD  A 279 (-3.1A)
NAD  A 279 (-3.6A)
None
None
 0.96A 2vl2B-3s55A:
undetectable		 2vl2B-3s55A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3su8 PLEXIN-B1

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		4 PRO X1584
PRO X1578
GLY X1579
LEU X1640
 None
 0.79A 2vl2B-3su8X:
undetectable		 2vl2B-3su8X:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tav METHIONINE
AMINOPEPTIDASE

(Mycobacteroides
abscessus) 		PF00557
(Peptidase_M24) 		4 THR A 154
GLY A 200
LEU A   4
PHE A   5
 None
 0.84A 2vl2B-3tavA:
undetectable		 2vl2B-3tavA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts3 CAPSID POLYPROTEIN

(Avastrovirus 3) 		PF16580
(Astro_capsid_p2) 		4 PRO A 429
THR A 523
GLY A 508
LEU A 426
 None
 1.03A 2vl2B-3ts3A:
undetectable		 2vl2B-3ts3A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzg HYPOTHETICAL PROTEIN
BVU_2266

(Bacteroides
vulgatus) 		no annotation 4 THR A  61
GLY A  59
LEU A 209
PHE A 206
 None
 0.91A 2vl2B-3tzgA:
undetectable		 2vl2B-3tzgA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 THR A 126
PRO A 127
GLY A 128
LEU A 107
 None
 0.51A 2vl2B-3uk1A:
undetectable		 2vl2B-3uk1A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 THR A 254
GLY A 239
LEU A 249
THR A 233
 None
 1.04A 2vl2B-3wdjA:
undetectable		 2vl2B-3wdjA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak1 BT_4661

(Bacteroides
thetaiotaomicron) 		PF16319
(DUF4958) 		4 GLY A  81
LEU A  72
PHE A  61
THR A  78
 None
 0.81A 2vl2B-4ak1A:
undetectable		 2vl2B-4ak1A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 THR A 291
PRO A 292
GLY A 293
LEU A 175
 None
 0.75A 2vl2B-4c7gA:
undetectable		 2vl2B-4c7gA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		4 THR A  90
GLY A 138
LEU A 109
PHE A 105
 None
 0.99A 2vl2B-4c90A:
undetectable		 2vl2B-4c90A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgk PHYTOENE
DEHYDROGENASE

(Pantoea
ananatis) 		PF01593
(Amino_oxidase) 		4 PRO A 143
THR A  58
GLY A 212
LEU A 189
 None
 1.01A 2vl2B-4dgkA:
undetectable		 2vl2B-4dgkA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY

(Bacillus
subtilis) 		PF00171
(Aldedh) 		4 PRO A 385
PRO A 328
GLY A 327
THR A 364
 None
 1.02A 2vl2B-4dngA:
undetectable		 2vl2B-4dngA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isy CYSTEINE DESULFURASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		4 PRO A 375
GLY A 376
LEU A 354
PHE A 304
 None
 1.03A 2vl2B-4isyA:
undetectable		 2vl2B-4isyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1

(Homo sapiens) 		PF16363
(GDP_Man_Dehyd) 		4 THR A 105
GLY A 101
LEU A 140
PHE A 138
 None
 1.02A 2vl2B-4lk3A:
undetectable		 2vl2B-4lk3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 PRO A 338
GLY A 339
LEU A 475
PHE A 477
 None
 0.96A 2vl2B-4lq1A:
undetectable		 2vl2B-4lq1A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 THR A 342
GLY A 337
LEU A 390
PHE A 394
 None
 0.94A 2vl2B-4mkvA:
undetectable		 2vl2B-4mkvA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 THR A 360
GLY A 356
LEU A 277
PHE A 391
 None
 0.99A 2vl2B-4nzsA:
undetectable		 2vl2B-4nzsA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox6 CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN
CCMK

(Synechococcus
elongatus) 		PF00936
(BMC) 		4 PRO A  15
THR A  68
PRO A  69
GLY A  70
 None
 0.90A 2vl2B-4ox6A:
undetectable		 2vl2B-4ox6A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 THR B 430
GLY B 694
LEU B 426
THR B 692
 None
 1.03A 2vl2B-4qiwB:
undetectable		 2vl2B-4qiwB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvj VP1

(Norwalk virus) 		PF08435
(Calici_coat_C) 		4 PRO A 430
THR A 385
PRO A 386
GLY A 387
 None
 0.98A 2vl2B-4qvjA:
undetectable		 2vl2B-4qvjA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnl POSSIBLE GALACTOSE
MUTAROTASE

(Streptomyces
platensis) 		PF01263
(Aldose_epim) 		4 PRO A 310
THR A 205
PRO A 206
PHE A 318
 None
 0.96A 2vl2B-4rnlA:
undetectable		 2vl2B-4rnlA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmk PROTEIN (THYMIDYLATE
KINASE)

(Escherichia
coli) 		PF02223
(Thymidylate_kin) 		4 PRO A 133
GLY A  98
LEU A 128
PHE A 131
 None
 0.82A 2vl2B-4tmkA:
undetectable		 2vl2B-4tmkA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 THR L 293
GLY L 291
LEU L 392
PHE L 296
 None
None
MPD  L 604 ( 4.4A)
None
 0.73A 2vl2B-4u9iL:
undetectable		 2vl2B-4u9iL:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 THR A 715
PRO A 716
PHE A 669
THR A 948
 None
None
GLY  A1402 (-4.8A)
None
 0.99A 2vl2B-4zxiA:
undetectable		 2vl2B-4zxiA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		4 THR A  87
PRO A  88
GLY A  99
PHE A  36
 None
 0.99A 2vl2B-5a2aA:
undetectable		 2vl2B-5a2aA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5av7 LECTIN

(Calystegia
sepium) 		PF01419
(Jacalin) 		4 PRO A  11
GLY A  10
LEU A  99
PHE A  90
 None
 0.98A 2vl2B-5av7A:
undetectable		 2vl2B-5av7A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj5 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycolicibacterium
thermoresistibile) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		4 THR A 107
PRO A 108
GLY A  26
LEU A 693
 None
 1.02A 2vl2B-5cj5A:
undetectable		 2vl2B-5cj5A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coa IRIDOID SYNTHASE

(Catharanthus
roseus) 		no annotation 4 THR A  54
PRO A  55
GLY A  56
LEU A  45
 None
 0.58A 2vl2B-5coaA:
2.3		 2vl2B-5coaA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elx ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 PRO A 198
THR A 215
PRO A 216
GLY A 217
 U  B   5 ( 4.3A)
U  B   5 ( 3.5A)
U  B   4 ( 3.8A)
U  B   5 ( 3.3A)
 0.63A 2vl2B-5elxA:
undetectable		 2vl2B-5elxA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5enu ALKYL HYDROPEROXIDE
REDUCTASE/ THIOL
SPECIFIC
ANTIOXIDANT/ MAL
ALLERGEN

(Burkholderia
ambifaria) 		PF00578
(AhpC-TSA) 		4 PRO A  37
THR A  41
PRO A  42
GLY A  43
 None
 0.33A 2vl2B-5enuA:
18.6		 2vl2B-5enuA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		4 GLY A  16
LEU A  61
PHE A  56
THR A  21
 None
 0.77A 2vl2B-5eowA:
undetectable		 2vl2B-5eowA:
21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5epf PEROXIREDOXIN

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 PRO A  45
THR A  49
PRO A  50
GLY A  51
 None
 0.56A 2vl2B-5epfA:
20.7		 2vl2B-5epfA:
30.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5equ SNON,SNON

(Streptomyces
nogalater) 		PF05721
(PhyH) 		4 THR A 127
PRO A 126
GLY A 216
THR A 162
 AKG  A 301 (-3.0A)
None
None
None
 1.04A 2vl2B-5equA:
undetectable		 2vl2B-5equA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f29 NA+/H+
ANTIPORTER-LIKE
PROTEIN

(Staphylococcus
aureus) 		PF02080
(TrkA_C) 		4 PRO A 183
THR A 187
GLY A 185
LEU A 195
 2BA  A 301 (-4.6A)
None
2BA  A 301 (-2.9A)
None
 1.03A 2vl2B-5f29A:
undetectable		 2vl2B-5f29A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 THR A 395
PRO A 394
GLY A 393
LEU A 383
 None
 0.99A 2vl2B-5fp1A:
undetectable		 2vl2B-5fp1A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d PUTRESCINE
AMINOTRANSFERASE,IMM
UNOGLOBULIN
G-BINDING PROTEIN A

(Escherichia
coli;
Staphylococcus
aureus) 		PF00202
(Aminotran_3)
PF02216
(B) 		4 THR A 137
PRO A 138
GLY A 139
THR A 315
 None
 0.74A 2vl2B-5h7dA:
undetectable		 2vl2B-5h7dA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 PRO A 476
GLY A 475
LEU A 645
PHE A 646
 None
 0.95A 2vl2B-5i51A:
undetectable		 2vl2B-5i51A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijj SPX DOMAIN

(Chaetomium
thermophilum) 		PF03105
(SPX) 		4 THR A 127
LEU A  44
PHE A  48
THR A 137
 None
None
ACT  A 503 ( 3.7A)
None
 1.04A 2vl2B-5ijjA:
undetectable		 2vl2B-5ijjA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipg BACTERIOFERRITIN
COMIGRATORY PROTEIN

(Xanthomonas
campestris) 		PF00578
(AhpC-TSA) 		4 PRO A  41
THR A  45
PRO A  46
GLY A  47
 None
 0.47A 2vl2B-5ipgA:
17.8		 2vl2B-5ipgA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		4 THR A 422
PRO A 421
GLY A 394
LEU A 398
 None
 1.01A 2vl2B-5j44A:
undetectable		 2vl2B-5j44A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4r WELO5

(Hapalosiphon
welwitschii) 		no annotation 4 PRO A 142
PRO A 139
LEU A  96
PHE A 100
 None
 0.98A 2vl2B-5j4rA:
undetectable		 2vl2B-5j4rA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		4 PRO A 430
GLY A 429
LEU A 394
THR A 141
 None
 0.88A 2vl2B-5m10A:
undetectable		 2vl2B-5m10A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PRO A   5
GLY A   4
LEU A  69
PHE A  98
 None
 0.92A 2vl2B-5mewA:
undetectable		 2vl2B-5mewA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na7 PUTATIVE
DIPEPTIDYL-PEPTIDASE
III

(Bacteroides
thetaiotaomicron) 		no annotation 4 THR A 518
GLY A 515
PHE A 419
THR A 510
 None
 0.93A 2vl2B-5na7A:
undetectable		 2vl2B-5na7A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okl AFAMIN

(Homo sapiens) 		no annotation 4 PRO A  84
GLY A  82
LEU A  45
PHE A  30
 None
 1.04A 2vl2B-5oklA:
undetectable		 2vl2B-5oklA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Lassa
mammarenavirus) 		PF00798
(Arena_glycoprot) 		4 THR a 274
PRO a 275
GLY a 276
THR a 296
 None
 0.83A 2vl2B-5vk2a:
undetectable		 2vl2B-5vk2a:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vu2 CAPSID PROTEIN
E2 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus;
Chikungunya
virus) 		no annotation
no annotation 		4 THR Q 403
PRO Q 404
GLY Q 405
PHE I 178
 None
 0.99A 2vl2B-5vu2Q:
undetectable		 2vl2B-5vu2Q:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		no annotation 4 THR A 147
PRO A 149
GLY A 150
LEU A 141
 PHB  A 602 (-4.5A)
PHB  A 602 (-4.7A)
None
GOL  A 603 (-4.5A)
 0.95A 2vl2B-5w1eA:
undetectable		 2vl2B-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1

(Homo sapiens) 		PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3) 		4 PRO A  57
THR A  86
PRO A  87
GLY A  88
 None
 0.96A 2vl2B-5xjyA:
undetectable		 2vl2B-5xjyA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 4 THR A 345
PRO A 346
GLY A 347
THR A 313
 None
 0.72A 2vl2B-6aunA:
undetectable		 2vl2B-6aunA:
undetectable