SIMILAR PATTERNS OF AMINO ACIDS FOR 2VJ1_A_BEZA1303_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2r PROTEIN
(TRYPTOPHANYL TRNA
SYNTHETASE)

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		3 HIS A 150
MET A 129
MET A 105
 None
 0.94A 2vj1A-1d2rA:
undetectable		 2vj1A-1d2rA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 HIS A  22
MET A  19
MET A 105
 None
 0.98A 2vj1A-1g8kA:
0.0		 2vj1A-1g8kA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 HIS A  22
MET A  19
MET A 109
 None
 1.21A 2vj1A-1g8kA:
0.0		 2vj1A-1g8kA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1joi AZURIN

(Pseudomonas
fluorescens) 		PF00127
(Copper-bind) 		3 HIS A 117
MET A 121
MET A  44
 HIS  A 117 (-0.9A)
MET  A 121 (-0.0A)
MET  A  44 ( 0.0A)
 1.44A 2vj1A-1joiA:
0.0		 2vj1A-1joiA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum) 		PF03063
(Prismane) 		3 HIS A 527
MET A 492
MET A 306
 None
 1.33A 2vj1A-1jqkA:
0.0		 2vj1A-1jqkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum) 		PF03063
(Prismane) 		3 HIS A 527
MET A 492
MET A 307
 None
 1.17A 2vj1A-1jqkA:
0.0		 2vj1A-1jqkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt3 HEAT-LABILE
ENTEROTOXIN

(Escherichia
coli) 		PF01375
(Enterotoxin_a) 		3 HIS A  27
MET A  23
MET A  37
 None
 1.37A 2vj1A-1lt3A:
0.0		 2vj1A-1lt3A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltt HEAT-LABILE
ENTEROTOXIN, SUBUNIT
A

(Escherichia
coli) 		PF01375
(Enterotoxin_a) 		3 HIS A  27
MET A  23
MET A  37
 None
 1.32A 2vj1A-1lttA:
0.0		 2vj1A-1lttA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mda AMICYANIN

(Paracoccus
denitrificans) 		PF00127
(Copper-bind) 		3 HIS A  95
MET A  98
MET A  51
 CU  A   0 ( 3.1A)
CU  A   0 ( 2.8A)
None
 1.44A 2vj1A-1mdaA:
0.0		 2vj1A-1mdaA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohf NUDAURELIA CAPENSIS
OMEGA VIRUS CAPSID
PROTEIN

(Nudaurelia
capensis omega
virus) 		PF03566
(Peptidase_A21) 		3 HIS A 284
MET A 349
MET A 304
 None
 1.11A 2vj1A-1ohfA:
0.0		 2vj1A-1ohfA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrr SULFOLIPID
BIOSYNTHESIS (SQD1)
PROTEIN

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		3 HIS A 251
MET A 321
MET A 377
 None
 1.23A 2vj1A-1qrrA:
0.0		 2vj1A-1qrrA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhi HUMAN RHINOVIRUS 3
COAT PROTEIN

(Rhinovirus B) 		PF00073
(Rhv) 		3 HIS 2 130
MET 2 221
MET 2 173
 None
 1.25A 2vj1A-1rhi2:
undetectable		 2vj1A-1rhi2:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkr AZURIN-I

(Achromobacter
xylosoxidans) 		PF00127
(Copper-bind) 		3 HIS A 117
MET A 121
MET A  44
 CU  A 200 (-3.0A)
CU  A 200 (-3.1A)
None
 1.39A 2vj1A-1rkrA:
undetectable		 2vj1A-1rkrA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)

(Solanum
tuberosum) 		PF00834
(Ribul_P_3_epim) 		3 HIS A  74
MET A 147
MET A  76
 None
 1.21A 2vj1A-1rpxA:
undetectable		 2vj1A-1rpxA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjw NOGALONIC ACID
METHYL ESTER CYCLASE

(Streptomyces
nogalater) 		PF07366
(SnoaL) 		3 HIS A 107
MET A 109
MET A  11
 None
 1.41A 2vj1A-1sjwA:
undetectable		 2vj1A-1sjwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		3 HIS A 284
MET A 288
MET A  51
 None
 1.36A 2vj1A-1t6pA:
undetectable		 2vj1A-1t6pA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00834
(Ribul_P_3_epim) 		3 HIS A  70
MET A 145
MET A  72
 ZN  A 900 (-3.3A)
None
None
 1.30A 2vj1A-1tqxA:
undetectable		 2vj1A-1tqxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us2 ENDO-BETA-1,4-XYLANA
SE

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10)
PF03426
(CBM_15) 		3 HIS A 363
MET A 346
MET A 300
 None
 1.19A 2vj1A-1us2A:
undetectable		 2vj1A-1us2A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		3 HIS A 226
MET A 191
MET A 199
 None
 1.34A 2vj1A-1x0uA:
undetectable		 2vj1A-1x0uA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8v RNA BINDING DOMAIN
OF RHO TRANSCRIPTION
TERMINATION FACTOR

(Escherichia
coli) 		PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		3 HIS A  42
MET A  21
MET A   1
 None
 1.33A 2vj1A-2a8vA:
undetectable		 2vj1A-2a8vA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azq CATECHOL
1,2-DIOXYGENASE

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		3 HIS A 155
MET A 132
MET A 122
 None
 1.42A 2vj1A-2azqA:
0.2		 2vj1A-2azqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN

(Ovis aries) 		PF00230
(MIP) 		3 HIS A 172
MET A 176
MET A 183
 None
 1.37A 2vj1A-2b6oA:
undetectable		 2vj1A-2b6oA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8y MALATE/L-LACTATE
DEHYDROGENASES

(Escherichia
coli) 		PF02615
(Ldh_2) 		3 HIS A 140
MET A  98
MET A 272
 None
 1.42A 2vj1A-2g8yA:
undetectable		 2vj1A-2g8yA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 HIS A   8
MET A  36
MET A 240
 None
 1.10A 2vj1A-2hnhA:
undetectable		 2vj1A-2hnhA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i80 D-ALANINE-D-ALANINE
LIGASE

(Staphylococcus
aureus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 HIS A  96
MET A 128
MET A 310
 G1L  A 400 (-3.4A)
None
G1L  A 400 (-4.0A)
 1.02A 2vj1A-2i80A:
undetectable		 2vj1A-2i80A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iaa AZURIN

(Alcaligenes
faecalis) 		PF00127
(Copper-bind) 		3 HIS C 117
MET C 121
MET C  44
 CU  C 130 (-3.3A)
CU  C 130 (-3.0A)
None
 1.38A 2vj1A-2iaaC:
undetectable		 2vj1A-2iaaC:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jlm PUTATIVE
PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE

(Acinetobacter
baylyi) 		PF13420
(Acetyltransf_4) 		3 HIS A  94
MET A 112
MET A 127
 None
 1.24A 2vj1A-2jlmA:
undetectable		 2vj1A-2jlmA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0m LIPID MODIFIED
AZURIN PROTEIN

(Neisseria
gonorrhoeae) 		PF00127
(Copper-bind) 		3 HIS A 118
MET A 122
MET A  47
 CU1  A 201 (-3.1A)
CU1  A 201 (-3.1A)
None
 1.42A 2vj1A-2n0mA:
undetectable		 2vj1A-2n0mA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqz SORTASE B

(Bacillus
anthracis) 		PF04203
(Sortase) 		3 HIS A 163
MET A 154
MET A  87
 None
 1.43A 2vj1A-2oqzA:
undetectable		 2vj1A-2oqzA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rs5 HUMAN RHINOVIRUS 14
COAT PROTEIN
(SUBUNIT VP2)

(Rhinovirus B) 		PF00073
(Rhv) 		3 HIS 2 130
MET 2 221
MET 2 173
 None
 1.22A 2vj1A-2rs52:
undetectable		 2vj1A-2rs52:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8s VESICLE TRANSPORT
THROUGH INTERACTION
WITH T-SNARES
HOMOLOG 1B

(Homo sapiens) 		PF05008
(V-SNARE) 		3 HIS V  15
MET V  62
MET V  77
 None
 1.38A 2vj1A-2v8sV:
undetectable		 2vj1A-2v8sV:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxg DIHYDRODIPICOLINATE
SYNTHASE

(Methanocaldococcus
jannaschii) 		PF00701
(DHDPS) 		3 HIS A 231
MET A 215
MET A 238
 None
 1.18A 2vj1A-2yxgA:
undetectable		 2vj1A-2yxgA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT BETA

(Rhodococcus
erythropolis) 		PF02211
(NHase_beta) 		3 HIS B  66
MET B  69
MET B  62
 None
 1.24A 2vj1A-2zpbB:
undetectable		 2vj1A-2zpbB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		3 HIS A 180
MET A 344
MET A 360
 None
 0.92A 2vj1A-3afgA:
undetectable		 2vj1A-3afgA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay2 LIPID MODIFIED
AZURIN PROTEIN

(Neisseria
gonorrhoeae) 		PF00127
(Copper-bind) 		3 HIS A 171
MET A 175
MET A 100
 ZN  A1001 (-3.2A)
ZN  A1001 (-3.5A)
None
 1.42A 2vj1A-3ay2A:
undetectable		 2vj1A-3ay2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct7 D-ALLULOSE-6-PHOSPHA
TE 3-EPIMERASE

(Escherichia
coli) 		PF00834
(Ribul_P_3_epim) 		3 HIS A  63
MET A 135
MET A  65
 MG  A 232 (-3.3A)
MG  A 232 ( 4.9A)
MG  A 232 ( 4.8A)
 1.31A 2vj1A-3ct7A:
undetectable		 2vj1A-3ct7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		3 HIS A 332
MET A 470
MET A 329
 None
 1.38A 2vj1A-3cwgA:
undetectable		 2vj1A-3cwgA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8r PROBABLE SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
E

(Chromobacterium
violaceum) 		PF03102
(NeuB)
PF08666
(SAF) 		3 HIS A  16
MET A  80
MET A  12
 None
 1.14A 2vj1A-3g8rA:
undetectable		 2vj1A-3g8rA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS B 209
MET B 238
MET B 397
 CU  B 686 (-3.1A)
None
None
 1.05A 2vj1A-3hhsB:
undetectable		 2vj1A-3hhsB:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i70 AGRIN

(Gallus gallus) 		PF03146
(NtA) 		3 HIS A  99
MET A 104
MET A  95
 None
 1.21A 2vj1A-3i70A:
undetectable		 2vj1A-3i70A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 9

(Thermus
thermophilus) 		PF12838
(Fer4_7) 		3 HIS 9  41
MET 9 136
MET 9  95
 SF4  9 183 (-4.5A)
None
None
 1.31A 2vj1A-3i9v9:
undetectable		 2vj1A-3i9v9:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juu PORPHYRANASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 HIS A 107
MET A 134
MET A 269
 None
 1.08A 2vj1A-3juuA:
undetectable		 2vj1A-3juuA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kje CO
DEHYDROGENASE/ACETYL
-COA SYNTHASE
COMPLEX, ACCESSORY
PROTEIN COOC

(Carboxydothermus
hydrogenoformans) 		PF01656
(CbiA) 		3 HIS A 145
MET A 137
MET A 102
 None
 0.93A 2vj1A-3kjeA:
undetectable		 2vj1A-3kjeA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l23 SUGAR PHOSPHATE
ISOMERASE/EPIMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		3 HIS A 198
MET A 200
MET A 160
 None
 1.11A 2vj1A-3l23A:
undetectable		 2vj1A-3l23A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 HIS A 119
MET A 431
MET A 150
 None
 1.15A 2vj1A-3m07A:
undetectable		 2vj1A-3m07A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF00385
(Chromo) 		3 HIS W 661
MET W 723
MET W 697
 None
 1.23A 2vj1A-3mwyW:
undetectable		 2vj1A-3mwyW:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Roseobacter
denitrificans) 		PF01039
(Carboxyl_trans) 		3 HIS B 250
MET B 216
MET B 223
 None
 1.20A 2vj1A-3n6rB:
undetectable		 2vj1A-3n6rB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9o PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF02373
(JmjC) 		3 HIS A 506
MET A 368
MET A 361
 None
 1.33A 2vj1A-3n9oA:
undetectable		 2vj1A-3n9oA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9o PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF02373
(JmjC) 		3 HIS A 620
MET A 660
MET A 592
 None
 1.31A 2vj1A-3n9oA:
undetectable		 2vj1A-3n9oA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogz UDP-SUGAR
PYROPHOSPHORYLASE

(Leishmania
major) 		PF01704
(UDPGP) 		3 HIS A 224
MET A 406
MET A 168
 None
 1.43A 2vj1A-3ogzA:
undetectable		 2vj1A-3ogzA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov0 CYTOCHROME C FAMILY
PROTEIN

(Geobacter
sulfurreducens) 		PF14522
(Cytochrome_C7) 		3 HIS A 158
MET A  91
MET A 161
 HEM  A 606 (-3.2A)
HEM  A 606 ( 3.7A)
None
 1.39A 2vj1A-3ov0A:
undetectable		 2vj1A-3ov0A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9u THIOREDOXIN
REDUCTASE

(Campylobacter
jejuni) 		PF07992
(Pyr_redox_2) 		3 HIS A  76
MET A  70
MET A  30
 None
 1.34A 2vj1A-3r9uA:
undetectable		 2vj1A-3r9uA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		3 HIS A 155
MET A 157
MET A 221
 None
 1.39A 2vj1A-3rc0A:
0.6		 2vj1A-3rc0A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8

(Homo sapiens) 		PF00076
(RRM_1)
PF13532
(2OG-FeII_Oxy_2) 		3 HIS A 292
MET A 282
MET A 260
 MN  A 402 ( 3.6A)
None
AKG  A 403 (-4.7A)
 1.36A 2vj1A-3thtA:
undetectable		 2vj1A-3thtA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty9 POLYNUCLEOTIDE
2',3'-CYCLIC
PHOSPHATE
PHOSPHODIESTERASE /
POLYNUCLEOTIDE
5'-HYDROXYL-KINASE /
POLYNUCLEOTIDE
3'-PHOSPHATASE

(Ruminiclostridium
thermocellum) 		PF16536
(PNKP-ligase_C)
PF16542
(PNKP_ligase) 		3 HIS A 532
MET A 609
MET A 738
 AMP  A 900 (-4.6A)
None
None
 0.83A 2vj1A-3ty9A:
undetectable		 2vj1A-3ty9A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9j F-BOX/LRR-REPEAT
PROTEIN 5

(Homo sapiens) 		PF01814
(Hemerythrin) 		3 HIS A  57
MET A  18
MET A 127
 FE  A 201 (-3.4A)
None
None
 1.41A 2vj1A-3u9jA:
undetectable		 2vj1A-3u9jA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgf MALTO-OLIGOSYLTREHAL
OSE TREHALOHYDROLASE

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF09071
(Alpha-amyl_C) 		3 HIS A 108
MET A 415
MET A 139
 None
 1.13A 2vj1A-3vgfA:
undetectable		 2vj1A-3vgfA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 HIS A  88
MET A  95
MET A  62
 None
 0.95A 2vj1A-3wigA:
undetectable		 2vj1A-3wigA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		3 HIS A 567
MET A 560
MET A 413
 None
 1.12A 2vj1A-3wnpA:
undetectable		 2vj1A-3wnpA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 383
MET A 335
MET A 404
 None
 1.23A 2vj1A-3zx1A:
undetectable		 2vj1A-3zx1A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia porcellus) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 HIS A 361
MET A 365
MET A 336
 None
 1.33A 2vj1A-4bc7A:
undetectable		 2vj1A-4bc7A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		3 HIS V 479
MET V 619
MET V 484
 None
 1.34A 2vj1A-4bxsV:
undetectable		 2vj1A-4bxsV:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyo ASPARTYL
AMINOPEPTIDASE

(Homo sapiens) 		PF02127
(Peptidase_M18) 		3 HIS A 216
MET A 221
MET A 238
 None
 1.06A 2vj1A-4dyoA:
undetectable		 2vj1A-4dyoA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF02811
(PHP) 		3 HIS A  53
MET A  81
MET A 285
 None
 1.15A 2vj1A-4gx8A:
undetectable		 2vj1A-4gx8A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 HIS A 250
MET A 240
MET A 274
 None
 1.14A 2vj1A-4id7A:
undetectable		 2vj1A-4id7A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		3 HIS A 213
MET A 205
MET A 230
 None
 0.93A 2vj1A-4j9uA:
undetectable		 2vj1A-4j9uA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		3 HIS A 290
MET A 311
MET A 294
 FAD  A 401 (-3.9A)
None
None
 1.32A 2vj1A-4kpuA:
undetectable		 2vj1A-4kpuA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE

(Toxoplasma
gondii) 		PF00834
(Ribul_P_3_epim) 		3 HIS A  71
MET A 148
MET A  73
 ZN  A 303 (-3.2A)
None
None
 1.25A 2vj1A-4nu7A:
undetectable		 2vj1A-4nu7A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ord THIOESTERASE
SUPERFAMILY MEMBER 2

(Danio rerio) 		PF03061
(4HBT) 		3 HIS A  49
MET A  60
MET A  43
 None
 1.11A 2vj1A-4ordA:
undetectable		 2vj1A-4ordA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqk MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
TRUNCATED
REPLICATION PROTEIN
REPA

(Escherichia
coli;
Staphylococcus
aureus) 		PF13416
(SBP_bac_8) 		3 HIS A 470
MET A 474
MET A 417
 None
 1.32A 2vj1A-4pqkA:
undetectable		 2vj1A-4pqkA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 HIS A 490
MET A 880
MET A 433
 None
 1.36A 2vj1A-4qiwA:
undetectable		 2vj1A-4qiwA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgl FILAMENTATION
INDUCED BY CAMP
PROTEIN FIC

(Desulfovibrio
alaskensis) 		PF02661
(Fic) 		3 HIS A 112
MET A 191
MET A 116
 None
None
UNL  A 401 ( 4.7A)
 1.21A 2vj1A-4rglA:
0.2		 2vj1A-4rglA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		3 HIS A 441
MET A 443
MET A 694
 None
 1.18A 2vj1A-4u1rA:
undetectable		 2vj1A-4u1rA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 223
MET A 251
MET A 410
 CU  A 801 (-3.0A)
None
None
 1.07A 2vj1A-4yzwA:
undetectable		 2vj1A-4yzwA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk6 QUINOLINATE SYNTHASE
A

(Pyrococcus
horikoshii) 		PF02445
(NadA) 		3 HIS A  21
MET A  61
MET A 259
 NTM  A 402 ( 3.9A)
NTM  A 402 (-3.5A)
None
 1.28A 2vj1A-4zk6A:
undetectable		 2vj1A-4zk6A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus;
Influenza C
virus) 		PF00603
(Flu_PA)
PF00602
(Flu_PB1) 		3 HIS B  32
MET A 501
MET B  30
 None
 0.98A 2vj1A-5d9aB:
undetectable		 2vj1A-5d9aB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwu CYTOKINE RECEPTOR
COMMON SUBUNIT BETA

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		3 HIS B 370
MET B 340
MET B 363
 None
 1.03A 2vj1A-5dwuB:
undetectable		 2vj1A-5dwuB:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 HIS A 872
MET A 870
MET A 894
 None
 1.32A 2vj1A-5epgA:
undetectable		 2vj1A-5epgA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 HIS A 467
MET A 470
MET A 757
 None
 1.27A 2vj1A-5favA:
undetectable		 2vj1A-5favA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 HIS A   8
MET A  36
MET A 240
 None
 1.03A 2vj1A-5fkuA:
undetectable		 2vj1A-5fkuA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 HIS A  36
MET A  42
MET A  12
 None
 1.13A 2vj1A-5hx6A:
undetectable		 2vj1A-5hx6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh0 SMALL GTP-BINDING
PROTEIN

(Thermosipho
melanesiensis) 		PF01926
(MMR_HSR1) 		3 HIS A 348
MET A 373
MET A 359
 None
 1.28A 2vj1A-5kh0A:
undetectable		 2vj1A-5kh0A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lad PUTATIVE GTP-BINDING
PROTEIN

(Thermotoga
maritima) 		PF01926
(MMR_HSR1) 		3 HIS A 352
MET A 377
MET A 299
 None
 1.21A 2vj1A-5ladA:
undetectable		 2vj1A-5ladA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lad PUTATIVE GTP-BINDING
PROTEIN

(Thermotoga
maritima) 		PF01926
(MMR_HSR1) 		3 HIS A 352
MET A 377
MET A 363
 None
 1.11A 2vj1A-5ladA:
undetectable		 2vj1A-5ladA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
8, MITOCHONDRIAL

(Ovis aries;
Ovis aries) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N)
PF06455
(NADH5_C)
no annotation 		3 HIS v 104
MET L 283
MET L 290
 None
 0.99A 2vj1A-5lnkv:
undetectable		 2vj1A-5lnkv:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 3 HIS B 132
MET B 147
MET B 221
 None
 1.12A 2vj1A-5ltmB:
undetectable		 2vj1A-5ltmB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 HIS W 661
MET W 697
MET W 723
 None
 1.21A 2vj1A-5o9gW:
undetectable		 2vj1A-5o9gW:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium) 		PF02310
(B12-binding) 		3 HIS A 633
MET A 697
MET A 608
 None
 0.73A 2vj1A-5ul4A:
undetectable		 2vj1A-5ul4A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 HIS A 234
MET A 224
MET A 242
 None
 0.93A 2vj1A-5vo1A:
undetectable		 2vj1A-5vo1A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wd8 LEM22

(Legionella
pneumophila) 		no annotation 3 HIS A  48
MET A  21
MET A  52
 None
 1.24A 2vj1A-5wd8A:
undetectable		 2vj1A-5wd8A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 3 HIS A  57
MET A 485
MET A 630
 None
 1.15A 2vj1A-5wdxA:
6.7		 2vj1A-5wdxA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		3 HIS A 568
MET A 561
MET A 414
 None
 1.15A 2vj1A-5x7hA:
undetectable		 2vj1A-5x7hA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E

(Pseudomonas sp.
AIU 813) 		no annotation 3 HIS A 490
MET A 496
MET A 351
 None
 1.18A 2vj1A-5yb7A:
undetectable		 2vj1A-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2g L-AMINO ACID OXIDASE

(Naja atra) 		no annotation 3 HIS A 373
MET A 108
MET A 387
 None
 1.32A 2vj1A-5z2gA:
undetectable		 2vj1A-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zm4 DIOXYGENASE ANDA

(Aspergillus
stellatus) 		no annotation 3 HIS A  79
MET A  73
MET A 125
 AKG  A 302 (-4.2A)
9FU  A 303 ( 4.5A)
AKG  A 302 ( 4.7A)
 1.42A 2vj1A-5zm4A:
undetectable		 2vj1A-5zm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 3 HIS A 125
MET A 129
MET A 274
 None
 1.29A 2vj1A-6cipA:
undetectable		 2vj1A-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 3 HIS X 521
MET X 487
MET X 302
 None
 1.23A 2vj1A-6elqX:
undetectable		 2vj1A-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Saccharomyces
cerevisiae) 		no annotation 3 HIS B 125
MET B 167
MET B 188
 None
 1.23A 2vj1A-6emkB:
undetectable		 2vj1A-6emkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g74 QUINOLINATE SYNTHASE
A

(Thermotoga
maritima) 		no annotation 3 HIS A  19
MET A  59
MET A 257
 PHT  A 302 (-4.0A)
PHT  A 302 ( 4.9A)
None
 1.30A 2vj1A-6g74A:
undetectable		 2vj1A-6g74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g74 QUINOLINATE SYNTHASE
A

(Thermotoga
maritima) 		no annotation 3 HIS A  19
MET A 257
MET A  59
 PHT  A 302 (-4.0A)
None
PHT  A 302 ( 4.9A)
 1.40A 2vj1A-6g74A:
undetectable		 2vj1A-6g74A:
undetectable