SIMILAR PATTERNS OF AMINO ACIDS FOR 2VIN_A_505A1247

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a0j TRYPSIN

(Salmo salar) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.25A 2vinA-1a0jA:
16.6		 2vinA-1a0jA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
GLY A 216
GLY A 226
 0GJ  A 245 (-3.1A)
0GJ  A 245 (-1.4A)
0GJ  A 245 (-3.5A)
0GJ  A 245 ( 4.2A)
 0.43A 2vinA-1a5iA:
36.3		 2vinA-1a5iA:
39.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1afq BOVINE
GAMMA-CHYMOTRYPSIN

(Bos taurus) 		PF00089
(Trypsin) 		5 SER C 190
SER C 195
VAL C 213
GLY C 216
GLY C 226
 None
0FG  C 301 ( 3.0A)
None
0FG  C 301 (-3.4A)
0FG  C 301 ( 4.4A)
 0.57A 2vinA-1afqC:
11.1		 2vinA-1afqC:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
 0.48A 2vinA-1bqyA:
10.1		 2vinA-1bqyA:
32.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bru ELASTASE

(Sus scrofa) 		PF00089
(Trypsin) 		4 SER P 190
SER P 195
VAL P 213
GLY P 216
 1NB  P   1 (-3.5A)
1NB  P   1 ( 1.2A)
None
1NB  P   1 ( 4.4A)
 0.54A 2vinA-1bruP:
37.1		 2vinA-1bruP:
36.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dlk THROMBIN HEAVY CHAIN

(Bos taurus) 		PF00089
(Trypsin) 		5 SER B 190
SER B 195
VAL B 213
GLY B 216
GLY B 226
 None
 0.58A 2vinA-1dlkB:
35.7		 2vinA-1dlkB:
33.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ekb ENTEROPEPTIDASE

(Bos taurus) 		PF00089
(Trypsin) 		5 ASP B 189
SER B 190
SER B 195
GLY B 216
GLY B 226
 None
 0.29A 2vinA-1ekbB:
37.2		 2vinA-1ekbB:
34.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elv COMPLEMENT C1S
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		6 ASP A 611
SER A 612
SER A 617
VAL A 638
GLY A 641
GLY A 648
 None
None
SO4  A2001 ( 2.7A)
None
None
None
 0.37A 2vinA-1elvA:
31.0		 2vinA-1elvA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ept PORCINE E-TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		6 ASP C 189
SER C 190
SER C 195
VAL C 213
GLY C 216
GLY C 226
 None
 0.28A 2vinA-1eptC:
12.9		 2vinA-1eptC:
24.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1euf DUODENASE

(Bos taurus) 		PF00089
(Trypsin) 		4 SER A 190
SER A 195
VAL A 213
GLY A 216
 None
 0.37A 2vinA-1eufA:
12.5		 2vinA-1eufA:
34.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fi8 NATURAL KILLER CELL
PROTEASE 1

(Rattus
norvegicus) 		PF00089
(Trypsin) 		4 SER A 190
SER A 195
VAL A 213
GLY A 216
 None
 0.31A 2vinA-1fi8A:
9.3		 2vinA-1fi8A:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis aries) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
GLY A 216
GLY A 226
 PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
 0.34A 2vinA-1fiwA:
37.1		 2vinA-1fiwA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
GLY A 216
GLY A 226
 PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
 0.33A 2vinA-1fizA:
14.1		 2vinA-1fizA:
32.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fq3 GRANZYME B

(Homo sapiens) 		PF00089
(Trypsin) 		4 SER A 190
SER A 195
VAL A 213
GLY A 216
 None
SO4  A 800 (-2.4A)
None
None
 0.70A 2vinA-1fq3A:
5.3		 2vinA-1fq3A:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.32A 2vinA-1fxyA:
10.6		 2vinA-1fxyA:
34.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		5 ASP A 145
SER A 200
VAL A 334
GLY A 329
GLY A 141
 None
 1.04A 2vinA-1gk2A:
undetectable		 2vinA-1gk2A:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gvl KALLIKREIN 6

(Homo sapiens) 		PF00089
(Trypsin) 		4 SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.63A 2vinA-1gvlA:
7.4		 2vinA-1gvlA:
38.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4w TRYPSIN IVA

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 250 (-2.9A)
BEN  A 250 (-2.9A)
BEN  A 250 (-3.6A)
None
BEN  A 250 (-3.9A)
BEN  A 250 (-3.3A)
 0.27A 2vinA-1h4wA:
15.5		 2vinA-1h4wA:
38.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		6 ASP E 189
SER E 190
SER E 195
VAL E 213
GLY E 216
GLY E 226
 None
 0.36A 2vinA-1h9hE:
10.8		 2vinA-1h9hE:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1id5 THROMBIN

(Bos taurus) 		PF00089
(Trypsin) 		5 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
 None
 0.49A 2vinA-1id5H:
35.1		 2vinA-1id5H:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		6 ASP T 189
GLN T 192
SER T 195
VAL T 213
GLY T 216
GLY T 226
 ZEN  T   1 ( 3.8A)
None
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
 0.72A 2vinA-1j17T:
14.5		 2vinA-1j17T:
36.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		5 ASP H 189
GLN H 192
SER H 195
VAL H 213
GLY H 226
 None
 0.65A 2vinA-1kigH:
14.0		 2vinA-1kigH:
32.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		5 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
 None
 0.52A 2vinA-1kigH:
14.0		 2vinA-1kigH:
32.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mbq TRYPSIN

(Oncorhynchus
keta) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A1222 (-2.9A)
BEN  A1222 (-2.9A)
None
BEN  A1222 (-3.5A)
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
 0.41A 2vinA-1mbqA:
17.4		 2vinA-1mbqA:
34.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		4 SER A 193
GLN A 189
GLY A 402
GLY A 485
 None
 0.73A 2vinA-1mt5A:
undetectable		 2vinA-1mt5A:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1npm NEUROPSIN

(Mus musculus) 		PF00089
(Trypsin) 		5 ASP A 189
GLN A 192
SER A 195
GLY A 216
GLY A 226
 None
 0.63A 2vinA-1npmA:
11.5		 2vinA-1npmA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o5f SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP H 189
GLN H 192
SER H 195
VAL H 213
GLY H 216
GLY H 226
 CR9  H 256 (-2.4A)
CR9  H 256 ( 4.4A)
CR9  H 256 (-1.5A)
CR9  H 256 (-4.3A)
CR9  H 256 ( 3.8A)
CR9  H 256 (-3.0A)
 0.44A 2vinA-1o5fH:
36.2		 2vinA-1o5fH:
37.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohf NUDAURELIA CAPENSIS
OMEGA VIRUS CAPSID
PROTEIN

(Nudaurelia
capensis omega
virus) 		PF03566
(Peptidase_A21) 		4 SER A 303
GLN A 326
GLY A 492
GLY A 490
 None
 0.74A 2vinA-1ohfA:
undetectable		 2vinA-1ohfA:
17.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1op2 VENOM SERINE
PROTEINASE

(Deinagkistrodon
acutus) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.55A 2vinA-1op2A:
9.2		 2vinA-1op2A:
31.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 190
SER A 195
GLY A 216
GLY A 226
 0G6  A   1 (-2.9A)
0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
 0.40A 2vinA-1orfA:
10.7		 2vinA-1orfA:
29.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pfx FACTOR IXA

(Sus scrofa) 		PF00089
(Trypsin) 		6 ASP C 189
SER C 190
GLN C 192
SER C 195
GLY C 216
GLY C 226
 0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
None
0G6  C 301 (-1.4A)
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.51A 2vinA-1pfxC:
10.6		 2vinA-1pfxC:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pq5 TRYPSIN

(Fusarium
oxysporum) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 210
GLY A 213
GLY A 223
 ARG  A 703 (-2.0A)
ARG  A 703 (-2.5A)
ARG  A 703 (-2.3A)
ARG  A 703 (-4.5A)
ARG  A 703 ( 3.7A)
ARG  A 703 (-2.6A)
 0.30A 2vinA-1pq5A:
13.7		 2vinA-1pq5A:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		6 ASP A 627
SER A 628
SER A 633
VAL A 653
GLY A 656
GLY A 667
 NA  A 800 ( 4.6A)
GOL  A 701 (-3.4A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
 0.38A 2vinA-1q3xA:
33.2		 2vinA-1q3xA:
26.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sgf NERVE GROWTH FACTOR

(Mus musculus) 		PF00089
(Trypsin) 		4 ASP G 189
SER G 195
GLY G 216
GLY G 226
 None
 0.59A 2vinA-1sgfG:
13.8		 2vinA-1sgfG:
34.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnd TRANSDUCIN

(Bos taurus) 		PF00503
(G-alpha) 		4 SER A  40
SER A  43
GLY A 199
GLY A  36
 GSP  A 351 (-3.2A)
MG  A 352 ( 2.2A)
GSP  A 351 (-3.6A)
None
 0.79A 2vinA-1tndA:
undetectable		 2vinA-1tndA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLN A 147
VAL A 153
GLY A  66
GLY A  85
 None
 0.73A 2vinA-1uufA:
undetectable		 2vinA-1uufA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1via SHIKIMATE KINASE

(Campylobacter
jejuni) 		PF01202
(SKI) 		4 SER A  15
SER A  18
GLY A  82
GLY A  11
 None
None
SO4  A 176 (-3.4A)
None
 0.76A 2vinA-1viaA:
undetectable		 2vinA-1viaA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		5 SER A 175
GLN A 188
SER A 214
GLY A 354
GLY A 352
 None
None
None
PO4  A 500 (-3.1A)
None
 1.39A 2vinA-1vlpA:
undetectable		 2vinA-1vlpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLN A 435
VAL A 413
GLY A 366
GLY A 416
 None
 0.74A 2vinA-1xdiA:
undetectable		 2vinA-1xdiA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		5 SER A 199
GLN A 212
SER A 231
GLY A 370
GLY A 368
 None
 1.31A 2vinA-1ybeA:
undetectable		 2vinA-1ybeA:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ym0 FIBRINOTIC ENZYME
COMPONENT B

(Eisenia fetida) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 226
 None
 0.67A 2vinA-1ym0A:
36.0		 2vinA-1ym0A:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ym0 FIBRINOTIC ENZYME
COMPONENT B

(Eisenia fetida) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.33A 2vinA-1ym0A:
36.0		 2vinA-1ym0A:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zca G ALPHA I/12

(Mus musculus) 		PF00503
(G-alpha) 		4 SER A  66
SER A  69
GLY A 228
GLY A  62
 GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
 0.71A 2vinA-1zcaA:
undetectable		 2vinA-1zcaA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
GLY A 216
GLY A 226
 368  A 901 (-2.8A)
368  A 901 (-1.4A)
368  A 901 (-3.6A)
368  A 901 (-3.5A)
 0.39A 2vinA-1zlrA:
10.2		 2vinA-1zlrA:
34.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		4 GLN A 213
VAL A 196
GLY A 152
GLY A 154
 None
 0.79A 2vinA-2a7sA:
undetectable		 2vinA-2a7sA:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aip PROTEIN C ACTIVATOR

(Agkistrodon
contortrix) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
SO4  A 301 (-2.8A)
None
None
 0.65A 2vinA-2aipA:
9.4		 2vinA-2aipA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eek TRYPSIN-1

(Gadus morhua) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 301 (-2.7A)
BEN  A 301 (-2.8A)
BEN  A 301 (-3.4A)
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
 0.25A 2vinA-2eekA:
16.4		 2vinA-2eekA:
34.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP A 189
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 DT8  A 700 (-3.5A)
DT8  A 700 (-3.9A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
 0.47A 2vinA-2ei8A:
14.1		 2vinA-2ei8A:
32.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		4 GLN A  43
VAL A  89
GLY A  46
GLY A  94
 None
 0.66A 2vinA-2f1nA:
undetectable		 2vinA-2f1nA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f91 HEPATOPANCREAS
TRYPSIN

(Astacus
leptodactylus) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 227
 None
 0.33A 2vinA-2f91A:
37.1		 2vinA-2f91A:
34.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 ASP A 135
GLN A 118
VAL A 169
GLY A 128
GLY A 137
 None
 1.33A 2vinA-2i5gA:
undetectable		 2vinA-2i5gA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT

(Homo sapiens) 		PF00503
(G-alpha) 		4 SER A  44
SER A  47
GLY A 203
GLY A  40
 GDP  A 401 (-3.6A)
MG  A 356 ( 1.9A)
ALF  A 355 (-3.3A)
None
 0.76A 2vinA-2ik8A:
undetectable		 2vinA-2ik8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jet CHYMOTRYPSINOGEN B
CHAIN C

(Rattus
norvegicus) 		PF00089
(Trypsin) 		4 SER C 195
VAL C 213
GLY C 216
GLY C 226
 None
 0.72A 2vinA-2jetC:
9.7		 2vinA-2jetC:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 245 (-3.0A)
BEN  A 245 (-3.3A)
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
 0.30A 2vinA-2oq5A:
37.0		 2vinA-2oq5A:
35.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C

(Neurospora
crassa) 		PF00225
(Kinesin) 		4 SER A 148
SER A 151
GLY A 302
GLY A 144
 ADP  A1002 (-3.4A)
MG  A1001 ( 1.9A)
None
None
 0.70A 2vinA-2owmA:
undetectable		 2vinA-2owmA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pks THROMBIN HEAVY CHAIN
FRAGMENT

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP C 229
SER C 235
VAL C 255
GLY C 258
GLY C 268
 G44  C 101 (-2.6A)
G44  C 101 (-3.5A)
None
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
 0.47A 2vinA-2pksC:
undetectable		 2vinA-2pksC:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnm PROTEASE VP4

(Infectious
pancreatic
necrosis virus) 		PF01768
(Birna_VP4) 		4 GLN A 635
VAL A 589
GLY A 593
GLY A 591
 None
 0.77A 2vinA-2pnmA:
undetectable		 2vinA-2pnmA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psy KALLIKREIN-5

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.43A 2vinA-2psyA:
10.3		 2vinA-2psyA:
35.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3f RAS-RELATED
GTP-BINDING PROTEIN
D

(Homo sapiens) 		PF04670
(Gtr1_RagA) 		4 SER A  54
SER A  57
GLY A 101
GLY A  50
 GNP  A 401 (-3.5A)
MG  A 301 ( 2.1A)
GNP  A 401 (-3.2A)
None
 0.75A 2vinA-2q3fA:
undetectable		 2vinA-2q3fA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC

(Escherichia
coli) 		PF01032
(FecCD) 		5 SER A  94
SER A 246
VAL A 243
GLY A 254
GLY A  89
 None
 1.37A 2vinA-2qi9A:
undetectable		 2vinA-2qi9A:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qy0 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP B 631
GLN B 634
SER B 637
VAL B 657
GLY B 660
GLY B 668
 None
 0.60A 2vinA-2qy0B:
31.1		 2vinA-2qy0B:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
GLN A 192
SER A 195
GLY A 216
GLY A 226
 None
 0.51A 2vinA-2r0lA:
37.4		 2vinA-2r0lA:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP U 189
SER U 190
VAL U 213
GLY U 216
GLY U 226
 4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.31A 2vinA-2r2wU:
46.7		 2vinA-2r2wU:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE

(Homo sapiens) 		PF00089
(Trypsin) 		4 SER U 190
SER U 195
VAL U 213
GLY U 216
 4PG  U 300 (-2.7A)
4PG  U 300 (-3.5A)
None
4PG  U 300 (-3.3A)
 0.77A 2vinA-2r2wU:
46.7		 2vinA-2r2wU:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP S 189
SER S 190
SER S 195
GLY S 216
GLY S 226
 None
 0.30A 2vinA-2wpmS:
15.3		 2vinA-2wpmS:
30.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT

(Rattus
norvegicus) 		PF01602
(Adaptin_N) 		4 GLN A 476
VAL A 483
GLY A 505
GLY A 501
 None
 0.68A 2vinA-2xa7A:
undetectable		 2vinA-2xa7A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT

(Arabidopsis
thaliana) 		PF00503
(G-alpha) 		4 SER A  49
SER A  52
GLY A 221
GLY A  45
 GSP  A1382 (-3.4A)
MG  A1381 ( 2.0A)
GSP  A1382 (-3.4A)
None
 0.70A 2vinA-2xtzA:
undetectable		 2vinA-2xtzA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 SER A  65
SER A  68
VAL A  69
CYH A 100
GLY A 128
 None
 1.46A 2vinA-2ycbA:
undetectable		 2vinA-2ycbA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP A 203
SER A 204
GLN A 206
SER A 209
VAL A 227
GLY A 230
GLY A 240
 11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
None
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
 0.36A 2vinA-2zecA:
34.4		 2vinA-2zecA:
35.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 SER A 634
VAL A 601
GLY A 704
GLY A 708
 None
 0.72A 2vinA-3aqpA:
undetectable		 2vinA-3aqpA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beu TRYPSIN

(Streptomyces
griseus) 		PF00089
(Trypsin) 		6 ASP A 189
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 247 (-3.0A)
SO4  A 246 ( 4.1A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.76A 2vinA-3beuA:
32.1		 2vinA-3beuA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bu1 LIPOCALIN

(Argas
monolakensis) 		PF02098
(His_binding) 		5 ASP A  94
SER A  88
SER A   8
VAL A   7
GLY A  15
 HSM  A 301 (-2.9A)
None
None
None
None
 1.34A 2vinA-3bu1A:
undetectable		 2vinA-3bu1A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clj PROTEIN NRD1

(Saccharomyces
cerevisiae) 		PF04818
(CTD_bind) 		5 SER A  60
SER A 116
GLY A  64
CYH A  57
GLY A  23
 None
 1.37A 2vinA-3cljA:
undetectable		 2vinA-3cljA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT

(Mus musculus) 		PF00503
(G-alpha) 		4 SER A  59
SER A  62
GLY A 225
GLY A  55
 GDP  A 775 (-3.4A)
MG  A 675 ( 2.7A)
None
None
 0.70A 2vinA-3cx6A:
undetectable		 2vinA-3cx6A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT

(Mus musculus) 		PF00503
(G-alpha) 		5 SER A 268
SER A 248
VAL A 247
GLY A  57
GLY A  55
 None
None
None
GDP  A 775 ( 4.2A)
None
 1.21A 2vinA-3cx6A:
undetectable		 2vinA-3cx6A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqg HEAT SHOCK 70 KDA
PROTEIN F

(Caenorhabditis
elegans) 		PF00012
(HSP70) 		4 GLN A 522
VAL A 497
GLY A 519
GLY A 517
 None
 0.78A 2vinA-3dqgA:
undetectable		 2vinA-3dqgA:
19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
 0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
 0.48A 2vinA-3f6uH:
33.3		 2vinA-3f6uH:
35.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		4 SER A 145
VAL A 166
GLY A 160
GLY A 149
 None
 0.67A 2vinA-3gafA:
undetectable		 2vinA-3gafA:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gov MASP-1

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP B 640
SER B 646
VAL B 666
GLY B 669
GLY B 679
 None
 0.64A 2vinA-3govB:
34.3		 2vinA-3govB:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gym PROSTASIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.48A 2vinA-3gymA:
34.5		 2vinA-3gymA:
36.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 GLN A 110
VAL A 166
GLY A 137
GLY A 198
 None
 0.70A 2vinA-3h7lA:
undetectable		 2vinA-3h7lA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hur ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 GLN A 226
SER A 229
GLY A  44
GLY A  46
 SO4  A 395 (-4.6A)
None
None
None
 0.76A 2vinA-3hurA:
undetectable		 2vinA-3hurA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwj HEN1

(Trichormus
variabilis) 		PF08242
(Methyltransf_12) 		5 ASP A 311
SER A 316
GLN A 321
GLY A 292
GLY A 290
 None
 1.40A 2vinA-3jwjA:
undetectable		 2vinA-3jwjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ASP A 159
SER A 169
GLY A 121
CYH A 155
GLY A 119
 None
 1.42A 2vinA-3m49A:
undetectable		 2vinA-3m49A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE

(Bacteroides
ovatus) 		no annotation 4 SER A 290
SER A 224
GLY A 239
GLY A 270
 None
 0.72A 2vinA-3n6zA:
undetectable		 2vinA-3n6zA:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP B 189
SER B 195
VAL B 213
GLY B 216
GLY B 226
 None
 0.45A 2vinA-3r3gB:
34.6		 2vinA-3r3gB:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR1

(Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA) 		4 SER A  17
SER A  20
GLY A  64
GLY A  13
 GNP  A 500 (-3.6A)
MG  A 600 ( 2.0A)
GNP  A 500 (-3.8A)
None
 0.76A 2vinA-3r7wA:
undetectable		 2vinA-3r7wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE

(Gloydius
saxatilis) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
VAL A 209
GLY A 212
GLY A 223
 None
 0.60A 2vinA-3s69A:
9.3		 2vinA-3s69A:
29.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6o DYNAMIN-1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 SER A  36
SER A  39
GLY A 149
GLY A  32
 GCP  A 801 (-4.0A)
MG  A 802 ( 2.0A)
GCP  A 801 (-3.6A)
None
 0.79A 2vinA-3w6oA:
undetectable		 2vinA-3w6oA:
21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w94 ENTEROPEPTIDASE-1

(Oryzias latipes) 		PF00089
(Trypsin) 		6 ASP A 973
SER A 974
GLN A 976
SER A 979
GLY A1000
GLY A1010
 None
 0.53A 2vinA-3w94A:
37.1		 2vinA-3w94A:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjc GTPASE IMAP FAMILY
MEMBER 7

(Homo sapiens) 		PF04548
(AIG1) 		4 SER A  19
SER A  22
GLY A  66
GLY A  15
 GNP  A1297 (-3.9A)
MG  A1296 ( 2.4A)
GNP  A1297 ( 4.3A)
None
 0.69A 2vinA-3zjcA:
undetectable		 2vinA-3zjcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxw FACTOR XA

(Pseudonaja
textilis) 		PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		5 ASP A 356
SER A 362
VAL A 380
GLY A 383
GLY A 393
 0GJ  A1411 (-2.7A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
 0.40A 2vinA-4bxwA:
9.5		 2vinA-4bxwA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		5 ASP A 647
SER A 645
GLN A 588
GLY A 606
GLY A 625
 None
 1.39A 2vinA-4ci8A:
undetectable		 2vinA-4ci8A:
17.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d9r COMPLEMENT FACTOR D

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 None
 0.63A 2vinA-4d9rA:
13.8		 2vinA-4d9rA:
32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP A 181
SER A 182
GLY A 208
GLY A 218
 None
 0.29A 2vinA-4dgjA:
37.0		 2vinA-4dgjA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP H 627
SER H 628
VAL H 653
GLY H 656
GLY H 667
 None
 0.41A 2vinA-4fxgH:
33.5		 2vinA-4fxgH:
31.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1

(Bothrops
jararacussu) 		PF00089
(Trypsin) 		5 ASP A 172
SER A 178
VAL A 192
GLY A 195
GLY A 206
 None
 0.65A 2vinA-4gsoA:
undetectable		 2vinA-4gsoA:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP E 639
SER E 645
VAL E 665
GLY E 668
GLY E 680
 None
 0.39A 2vinA-4iw4E:
33.0		 2vinA-4iw4E:
30.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites virus) 		PF01768
(Birna_VP4) 		4 GLN A 635
VAL A 589
GLY A 593
GLY A 591
 None
 0.71A 2vinA-4izkA:
undetectable		 2vinA-4izkA:
21.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k8y KALLIKREIN-4

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.38A 2vinA-4k8yA:
16.2		 2vinA-4k8yA:
33.85