SIMILAR PATTERNS OF AMINO ACIDS FOR 2VFU_A_MTLA1419

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus;
Bos taurus) 		PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid)
PF07748
(Glyco_hydro_38C) 		5 SER C 555
HIS D 690
VAL D 681
GLN C 558
LYS C 532
 None
 1.29A 2vfuA-1o7dC:
0.1		 2vfuA-1o7dC:
18.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		12 SER A 106
HIS A 248
PRO A 249
VAL A 250
HIS A 274
PHE A 275
GLN A 288
THR A 318
ARG A 322
HIS A 343
THR A 345
LYS A 375
 SFD  A1418 (-2.9A)
None
None
None
None
None
SFD  A1418 (-3.2A)
None
SFD  A1418 (-2.9A)
SFD  A1418 (-3.4A)
None
SFD  A1418 (-2.7A)
 0.32A 2vfuA-2vfvA:
72.0		 2vfuA-2vfvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		5 SER A 106
HIS A 274
PHE A 275
THR A 345
ARG A 322
 SFD  A1418 (-2.9A)
None
None
None
SFD  A1418 (-2.9A)
 1.11A 2vfuA-2vfvA:
72.0		 2vfuA-2vfvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT

(Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N) 		5 SER A 314
HIS A 107
PRO A 108
VAL A 109
THR A 303
 None
 1.31A 2vfuA-3pcoA:
1.2		 2vfuA-3pcoA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kca ENDO-1,5-ALPHA-L-ARA
BINANASE

(Bos taurus) 		PF00085
(Thioredoxin)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		5 VAL A 517
HIS A 506
THR A 623
HIS A 553
THR A 631
 None
 1.46A 2vfuA-4kcaA:
0.0		 2vfuA-4kcaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ook METHIONINE
AMINOPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF00557
(Peptidase_M24) 		5 SER A  93
HIS A 205
HIS A 140
PHE A 211
THR A 271
 None
CO  A 302 (-3.2A)
None
None
NA  A 305 ( 3.9A)
 1.44A 2vfuA-4ookA:
0.0		 2vfuA-4ookA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwd DNA POLYMERASE
PROCESSIVITY FACTOR

(Human
betaherpesvirus
5) 		PF03325
(Herpes_PAP) 		5 VAL A 130
GLN A  51
THR A  79
THR A  39
LYS A  60
 None
6EV  A 302 (-3.3A)
6EV  A 302 (-4.3A)
None
6EV  A 302 (-1.4A)
 1.17A 2vfuA-5iwdA:
0.0		 2vfuA-5iwdA:
20.55