SIMILAR PATTERNS OF AMINO ACIDS FOR 2VFT_A_SORA1419

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyh PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
BETA SUBUNIT
PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT

(Homo sapiens;
Mus musculus) 		PF13472
(Lipase_GDSL_2)
PF00400
(WD40) 		5 HIS C 381
VAL C 400
HIS A  67
THR C 384
ARG C 316
 None
 1.46A 2vftA-1vyhC:
0.0		 2vftA-1vyhC:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhi IMMUNOGENIC PROTEIN
MPT64

(Mycobacterium
tuberculosis) 		PF11738
(DUF3298) 		5 HIS A 102
PRO A 103
THR A 105
GLU A 187
THR A 106
 None
 1.34A 2vftA-2hhiA:
0.0		 2vftA-2hhiA:
18.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		12 HIS A 248
PRO A 249
VAL A 250
HIS A 274
PHE A 275
GLN A 288
THR A 318
GLU A 320
ARG A 322
HIS A 343
THR A 345
LYS A 375
 None
None
None
None
None
SFD  A1418 (-3.2A)
None
SFD  A1418 ( 4.7A)
SFD  A1418 (-2.9A)
SFD  A1418 (-3.4A)
None
SFD  A1418 (-2.7A)
 0.23A 2vftA-2vfvA:
71.6		 2vftA-2vfvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iib PEPTIDASE M28

(Shewanella
amazonensis) 		PF04389
(Peptidase_M28) 		5 PRO A  90
VAL A  91
THR A 335
GLU A 339
HIS A 340
 None
 1.43A 2vftA-3iibA:
0.0		 2vftA-3iibA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxr MAGNESIUM
TRANSPORTER,
PUTATIVE

(Shewanella
oneidensis) 		PF00571
(CBS)
PF03448
(MgtE_N) 		5 VAL A 104
PHE A  80
THR A 103
GLU A 149
ARG A 162
 None
 1.43A 2vftA-3kxrA:
0.0		 2vftA-3kxrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2e SHIKIMATE KINASE

(Helicobacter
pylori) 		PF01202
(SKI) 		5 HIS A  85
THR A  32
GLU A  60
ARG A  57
THR A  78
 None
None
None
OSA  A1001 (-3.9A)
None
 1.27A 2vftA-3n2eA:
0.0		 2vftA-3n2eA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kca ENDO-1,5-ALPHA-L-ARA
BINANASE

(Bos taurus) 		PF00085
(Thioredoxin)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		5 VAL A 517
HIS A 506
THR A 623
HIS A 553
THR A 631
 None
 1.44A 2vftA-4kcaA:
0.0		 2vftA-4kcaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf4 CARBOXYPEPTIDASE A1

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 VAL A 143
PHE A 131
GLN A 198
GLU A 138
THR A 197
 None
 1.37A 2vftA-4uf4A:
1.1		 2vftA-4uf4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwd DNA POLYMERASE
PROCESSIVITY FACTOR

(Human
betaherpesvirus
5) 		PF03325
(Herpes_PAP) 		5 VAL A 130
GLN A  51
THR A  79
THR A  39
LYS A  60
 None
6EV  A 302 (-3.3A)
6EV  A 302 (-4.3A)
None
6EV  A 302 (-1.4A)
 1.14A 2vftA-5iwdA:
undetectable		 2vftA-5iwdA:
20.55