SIMILAR PATTERNS OF AMINO ACIDS FOR 2VE3_B_REAB1445_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		5 THR A 212
ALA A 242
THR A 250
VAL A 255
GLY A 256
 None
 1.25A 2ve3B-1a5cA:
0.7		 2ve3B-1a5cA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jro XANTHINE
DEHYDROGENASE, CHAIN
A

(Rhodobacter
capsulatus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		5 ALA A 443
PHE A 422
VAL A 364
GLY A 385
PRO A 424
 None
 1.18A 2ve3B-1jroA:
1.4		 2ve3B-1jroA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jro XANTHINE
DEHYDROGENASE, CHAIN
A

(Rhodobacter
capsulatus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		5 ALA A 443
PHE A 422
VAL A 364
GLY A 386
PRO A 424
 None
 1.27A 2ve3B-1jroA:
1.4		 2ve3B-1jroA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0s RIBOSE-5-PHOSPHATE
ISOMERASE A

(Haemophilus
influenzae) 		PF06026
(Rib_5-P_isom_A) 		5 PHE A 130
ALA A  52
PHE A 113
ALA A 107
GLY A 197
 None
 1.25A 2ve3B-1m0sA:
0.0		 2ve3B-1m0sA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		5 ALA A 257
ALA A 250
VAL A  97
GLN A 151
PRO A  12
 None
 1.20A 2ve3B-1mxfA:
undetectable		 2ve3B-1mxfA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		5 THR A 165
ALA A 147
ALA A  38
THR A 118
GLY A 130
 None
None
None
None
POP  A1155 ( 4.9A)
 1.01A 2ve3B-1ocmA:
undetectable		 2ve3B-1ocmA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pff METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		5 ALA A 275
ALA A 313
THR A 160
GLY A 297
PRO A 156
 None
 1.17A 2ve3B-1pffA:
0.0		 2ve3B-1pffA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		5 ALA A 256
ALA A 331
VAL A 322
GLY A 323
GLN A 562
 None
 1.27A 2ve3B-1q50A:
0.0		 2ve3B-1q50A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1

(Canis lupus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 ALA A 118
ALA A  18
THR A  20
GLY A 184
GLN A 219
 None
 1.23A 2ve3B-1rp1A:
0.0		 2ve3B-1rp1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 THR A 365
ALA A 730
ALA A 440
GLY A 333
GLN A 404
 None
 1.18A 2ve3B-1sb3A:
undetectable		 2ve3B-1sb3A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		5 THR A 347
ALA A 382
ALA A 253
VAL A 291
GLY A 292
 None
 1.20A 2ve3B-1su7A:
undetectable		 2ve3B-1su7A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 THR A  97
ALA A   6
ALA A  68
GLY A  85
PRO A  92
 None
None
None
CL  A 600 (-3.9A)
None
 1.20A 2ve3B-1t34A:
undetectable		 2ve3B-1t34A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN

(Shigella
flexneri) 		PF02578
(Cu-oxidase_4) 		5 PHE A 172
PHE A 112
THR A 138
VAL A 134
GLY A 129
 None
 1.19A 2ve3B-1u05A:
undetectable		 2ve3B-1u05A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 242
PHE A 244
ALA A 307
THR A 410
GLY A 430
 None
 1.27A 2ve3B-1v10A:
undetectable		 2ve3B-1v10A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbk HYPOTHETICAL PROTEIN
PH1313

(Pyrococcus
horikoshii) 		PF02568
(ThiI)
PF02926
(THUMP) 		5 ALA A 241
PHE A 244
VAL A 259
GLY A 258
PRO A 283
 None
 1.06A 2ve3B-1vbkA:
undetectable		 2ve3B-1vbkA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		5 THR A 332
ALA A 340
THR A 349
VAL A 351
GLY A 352
 None
 1.03A 2ve3B-1vpeA:
undetectable		 2ve3B-1vpeA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woy METHIONYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF09334
(tRNA-synt_1g) 		5 PHE A  92
THR A  96
ALA A  60
VAL A  74
GLY A  76
 None
 1.29A 2ve3B-1woyA:
undetectable		 2ve3B-1woyA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 PHE A 510
ALA A 393
PHE A 495
ALA A 404
THR A 487
 None
 1.22A 2ve3B-1xb7A:
undetectable		 2ve3B-1xb7A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfp HEAVY CHAIN ANTIBODY

(Camelus
dromedarius) 		PF07686
(V-set) 		5 ALA A   6
ALA A  97
VAL A   2
GLY A  26
PRO A  31
 FMT  A 403 (-3.5A)
None
None
None
None
 1.22A 2ve3B-1xfpA:
undetectable		 2ve3B-1xfpA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ALA A 289
THR A 324
VAL A 320
GLY A 319
PRO A 306
 None
 1.25A 2ve3B-1zfjA:
undetectable		 2ve3B-1zfjA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 THR A  39
PHE A 477
ALA A 159
GLN A 116
PRO A 476
 MPD  A1004 (-3.7A)
MPD  A1004 (-4.5A)
None
None
None
 1.07A 2ve3B-2e7zA:
undetectable		 2ve3B-2e7zA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh9 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		5 ALA A  56
ALA A 283
VAL A 271
GLY A 270
GLN A 269
 None
None
None
None
MLR  A2913 (-4.3A)
 1.28A 2ve3B-2gh9A:
undetectable		 2ve3B-2gh9A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL

(Arabidopsis
thaliana) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 THR A 224
ALA A 190
THR A 280
VAL A 274
GLY A 273
 None
 1.08A 2ve3B-2ix5A:
1.0		 2ve3B-2ix5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2je2 CYTOCHROME P460

(Nitrosomonas
europaea) 		PF16694
(Cytochrome_P460) 		5 ALA A 144
PHE A  62
THR A  68
VAL A  46
GLY A  25
 None
None
HEC  A1171 (-3.8A)
HEC  A1171 (-4.4A)
None
 1.17A 2ve3B-2je2A:
undetectable		 2ve3B-2je2A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ALA A 235
PHE A 277
ALA A 172
THR A 174
GLY A  79
 None
 1.25A 2ve3B-2nlxA:
undetectable		 2ve3B-2nlxA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		5 THR A 130
ALA A 150
ALA A 119
VAL A 122
GLY A 123
 None
 1.03A 2ve3B-2o1xA:
undetectable		 2ve3B-2o1xA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6p GLYCOSYL TRANSFERASE

(Streptomyces
fradiae) 		PF06722
(DUF1205) 		5 ALA A   7
ALA A  21
THR A  22
VAL A  46
GLY A  45
 None
 1.12A 2ve3B-2p6pA:
undetectable		 2ve3B-2p6pA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A1033
ALA A1222
VAL A1021
GLY A1402
PRO A1399
 None
 0.97A 2ve3B-2pffA:
undetectable		 2ve3B-2pffA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcv SUPEROXIDE DISMUTASE
[MN]

(Bacillus
subtilis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ALA A 120
PHE A 112
VAL A 189
GLY A  94
PRO A  97
 None
 1.13A 2ve3B-2rcvA:
undetectable		 2ve3B-2rcvA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 PHE A 622
ALA A 406
THR A 413
VAL A 391
GLY A 361
 None
 1.14A 2ve3B-2x05A:
undetectable		 2ve3B-2x05A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		5 ALA A 748
PHE A 707
ALA A 745
THR A 740
VAL A 736
 None
 1.26A 2ve3B-2xsgA:
undetectable		 2ve3B-2xsgA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 PHE A 526
TRP A 500
ALA A 494
ALA A 396
THR A 399
 None
 0.96A 2ve3B-2xymA:
undetectable		 2ve3B-2xymA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b98 PROSTAGLANDIN I2
SYNTHASE

(Danio rerio) 		PF00067
(p450) 		5 THR A 328
ALA A 282
ALA A 427
GLY A 464
PRO A 413
 None
None
HEM  A 600 ( 3.7A)
None
None
 1.27A 2ve3B-3b98A:
33.0		 2ve3B-3b98A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr2 EXPORTED
GLUCONOLACTONASE

(Xanthomonas
campestris) 		PF08450
(SGL) 		5 PHE A 284
ALA A 234
ALA A 219
THR A 201
GLY A 250
 None
 1.07A 2ve3B-3dr2A:
undetectable		 2ve3B-3dr2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exh PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
BETA, MITOCHONDRIAL

(Homo sapiens) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 THR B 256
ALA B 284
ALA B 292
THR B 261
VAL B 210
 None
 1.22A 2ve3B-3exhB:
undetectable		 2ve3B-3exhB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsz RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 PHE A 526
TRP A 500
ALA A 494
ALA A 396
THR A 399
 None
 0.97A 2ve3B-3gszA:
undetectable		 2ve3B-3gszA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 ALA A1033
ALA A1222
VAL A1021
GLY A1402
PRO A1399
 None
 0.97A 2ve3B-3hmjA:
undetectable		 2ve3B-3hmjA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hu5 ISOCHORISMATASE
FAMILY PROTEIN

(Desulfovibrio
vulgaris) 		PF00857
(Isochorismatase) 		5 ALA A  12
PHE A 112
ALA A 147
VAL A 126
GLY A 125
 None
 1.27A 2ve3B-3hu5A:
undetectable		 2ve3B-3hu5A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis) 		PF01266
(DAO) 		5 PHE A 210
ALA A  18
ALA A 337
GLY A 313
PRO A 310
 None
 1.16A 2ve3B-3if9A:
undetectable		 2ve3B-3if9A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		5 ALA A 144
PHE A 102
THR A 448
GLY A  69
PRO A 453
 None
 1.19A 2ve3B-3lscA:
undetectable		 2ve3B-3lscA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkh NITROALKANE OXIDASE

(Podospora
anserina) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		5 THR A 391
ALA A 287
ALA A 366
GLY A 278
PRO A 396
 None
 1.28A 2ve3B-3mkhA:
undetectable		 2ve3B-3mkhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nc3 CYTOCHROME P450 CYPX

(Bacillus
subtilis) 		PF00067
(p450) 		5 THR A 392
ALA A 233
ALA A  68
VAL A 161
GLY A 160
 None
HEM  A 406 (-3.5A)
None
None
None
 1.08A 2ve3B-3nc3A:
15.5		 2ve3B-3nc3A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 THR A 301
ALA A 339
ALA A 398
THR A 396
PRO A 273
 None
 1.15A 2ve3B-3oytA:
undetectable		 2ve3B-3oytA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjz N-TYPE ATP
PYROPHOSPHATASE
SUPERFAMILY

(Pyrococcus
furiosus) 		PF01902
(Diphthami_syn_2) 		5 PHE A 197
ALA A 123
PHE A 140
ALA A 181
GLN A  58
 None
 1.22A 2ve3B-3rjzA:
undetectable		 2ve3B-3rjzA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2y SULFIDE-QUINONE
REDUCTASE, PUTATIVE

(Acidithiobacillus
ferrooxidans) 		PF07992
(Pyr_redox_2) 		5 THR A 321
ALA A 366
VAL A 204
GLY A 203
GLN A 202
 FAD  A 500 (-4.0A)
None
None
None
None
 1.23A 2ve3B-3t2yA:
undetectable		 2ve3B-3t2yA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN

(Escherichia
coli) 		PF00374
(NiFeSe_Hases) 		5 ALA L 414
THR L 532
GLY L 546
GLN L   8
PRO L 401
 None
FCO  L 601 (-3.7A)
None
None
None
 1.28A 2ve3B-3uscL:
0.8		 2ve3B-3uscL:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ALA A1575
THR A1643
VAL A1618
GLY A1619
PRO A1590
 None
 1.23A 2ve3B-3va7A:
undetectable		 2ve3B-3va7A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		5 PHE A 563
ALA A  37
VAL A 465
GLY A 464
GLN A 871
 None
 1.13A 2ve3B-3w9iA:
0.4		 2ve3B-3w9iA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3woy CLIP-ASSOCIATING
PROTEIN 2

(Homo sapiens) 		PF12348
(CLASP_N) 		5 THR A 159
ALA A 200
PHE A 171
ALA A 175
GLY A 139
 None
 1.27A 2ve3B-3woyA:
undetectable		 2ve3B-3woyA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy8 SERINE PROTEASE

(Paenarthrobacter
nicotinovorans) 		no annotation 5 ALA A  79
PHE A  56
ALA A 216
THR A  37
GLY A  27
 None
 1.14A 2ve3B-3wy8A:
undetectable		 2ve3B-3wy8A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 PHE A 238
ALA A 156
ALA A 272
VAL A 303
GLY A 302
 None
 1.11A 2ve3B-4b52A:
undetectable		 2ve3B-4b52A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 PHE A 238
ALA A 160
ALA A 272
VAL A 303
GLY A 302
 None
 1.19A 2ve3B-4b52A:
undetectable		 2ve3B-4b52A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		5 ALA A 417
THR A 535
GLY A 549
GLN A   8
PRO A 404
 None
NFU  A1004 (-3.7A)
None
None
None
 1.17A 2ve3B-4c3oA:
undetectable		 2ve3B-4c3oA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		5 PHE A 311
ALA A 366
VAL A 346
GLY A 331
PRO A 340
 EDO  A1503 (-3.6A)
None
None
None
None
 1.10A 2ve3B-4c7gA:
undetectable		 2ve3B-4c7gA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e84 D-BETA-D-HEPTOSE
7-PHOSPHATE KINASE

(Burkholderia
cenocepacia) 		PF00294
(PfkB) 		5 THR A 308
ALA A 274
ALA A  60
VAL A  98
GLY A  97
 None
 1.01A 2ve3B-4e84A:
undetectable		 2ve3B-4e84A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ALA A  38
ALA A 230
VAL A 270
GLY A 269
GLN A 267
 None
None
None
COA  A2598 (-3.6A)
COA  A2598 (-4.7A)
 1.17A 2ve3B-4eudA:
undetectable		 2ve3B-4eudA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 PHE A 179
ALA A  17
VAL A 275
GLY A 274
GLN A 182
 None
 1.14A 2ve3B-4fn5A:
undetectable		 2ve3B-4fn5A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2o FIXK2 PROTEIN

(Bradyrhizobium
japonicum) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 ALA A 162
ALA A 201
THR A 197
GLY A 192
GLN A  81
 None
 1.29A 2ve3B-4i2oA:
undetectable		 2ve3B-4i2oA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH) 		5 ALA A 286
THR A 321
VAL A 317
GLY A 316
PRO A 303
 None
 1.20A 2ve3B-4ix2A:
undetectable		 2ve3B-4ix2A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8b COATOMER ALPHA
SUBUNIT

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		5 THR A 305
PHE A 303
ALA A 144
VAL A 100
GLY A  58
 None
 1.29A 2ve3B-4j8bA:
undetectable		 2ve3B-4j8bA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdz SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C)
PF17210
(SdrD_B) 		5 ALA A 406
THR A 519
VAL A 446
GLY A 447
GLN A 528
 None
 0.89A 2ve3B-4jdzA:
undetectable		 2ve3B-4jdzA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je0 SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		5 ALA A 171
THR A 284
VAL A 211
GLY A 212
GLN A 293
 None
 1.04A 2ve3B-4je0A:
undetectable		 2ve3B-4je0A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4x AMPHI

(Streptomyces
nodosus) 		PF08659
(KR) 		5 ALA A 431
ALA A 184
THR A 181
VAL A 219
GLY A 218
 None
 1.29A 2ve3B-4l4xA:
undetectable		 2ve3B-4l4xA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmp ALANINE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 THR A 314
ALA A  24
THR A  27
VAL A  33
GLY A   4
 None
 1.08A 2ve3B-4lmpA:
undetectable		 2ve3B-4lmpA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5j UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 5 ALA A 255
PHE A  69
ALA A  85
VAL A 353
GLY A 357
 None
 1.15A 2ve3B-4o5jA:
undetectable		 2ve3B-4o5jA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqq DEOXYRIBONUCLEOSIDE
REGULATOR

(Bacillus
subtilis) 		PF04198
(Sugar-bind) 		5 ALA A 216
PHE A 224
THR A 260
VAL A 175
GLY A 143
 None
 1.28A 2ve3B-4oqqA:
undetectable		 2ve3B-4oqqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE

(Cupriavidus
necator) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 THR A 163
ALA A 115
THR A  83
VAL A 108
GLY A 109
 None
 1.24A 2ve3B-4pzcA:
undetectable		 2ve3B-4pzcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rho UNCHARACTERIZED
PROTEIN

(Burkholderia
pseudomallei) 		PF15579
(Imm52) 		5 ALA A 187
ALA A 133
THR A 137
VAL A 191
GLY A 199
 None
 1.14A 2ve3B-4rhoA:
undetectable		 2ve3B-4rhoA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase) 		5 ALA A 318
ALA A 437
THR A 436
GLY A 520
PRO A 527
 None
 1.03A 2ve3B-4u3tA:
undetectable		 2ve3B-4u3tA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w78 HYDRATASE CHSH1
HYDRATASE CHSH2

(Mycobacterium
tuberculosis) 		PF13452
(MaoC_dehydrat_N)
no annotation 		5 TRP A 150
THR A  73
ALA A  67
THR B  56
GLN A 146
 None
 1.20A 2ve3B-4w78A:
undetectable		 2ve3B-4w78A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr9 CALS8

(Micromonospora
echinospora) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 ALA A 403
PHE A 381
ALA A 400
VAL A 354
GLY A 353
 None
 0.98A 2ve3B-4xr9A:
undetectable		 2ve3B-4xr9A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli) 		PF00245
(Alk_phosphatase) 		5 THR A 192
ALA A 157
PHE A 211
ALA A 149
GLY A 257
 None
 1.11A 2ve3B-4yr1A:
undetectable		 2ve3B-4yr1A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zda ISOCITRATE
DEHYDROGENASE (NADP)
ICD2

(Mycolicibacterium
smegmatis) 		PF03971
(IDH) 		5 ALA A 377
THR A 375
VAL A 250
GLY A 249
PRO A 329
 None
 1.26A 2ve3B-4zdaA:
undetectable		 2ve3B-4zdaA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 PHE A 484
ALA A 527
VAL A 514
GLY A 512
GLN A 489
 None
 1.29A 2ve3B-5df0A:
undetectable		 2ve3B-5df0A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		5 TRP D 230
ALA D 231
THR D 320
GLY D 260
PRO D 257
 None
 1.05A 2ve3B-5disD:
undetectable		 2ve3B-5disD:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia annua) 		PF00724
(Oxidored_FMN) 		5 PHE A  54
ALA A 165
ALA A 223
VAL A 229
GLY A 230
 None
 1.11A 2ve3B-5dxxA:
undetectable		 2ve3B-5dxxA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkv ESTERASE A

(Caulobacter
vibrioides) 		PF00144
(Beta-lactamase) 		5 THR A 289
ALA A  79
PHE A 326
GLY A 266
PRO A 340
 None
 1.23A 2ve3B-5gkvA:
undetectable		 2ve3B-5gkvA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ALA A1575
THR A1643
VAL A1618
GLY A1619
PRO A1590
 None
 1.19A 2ve3B-5i8iA:
undetectable		 2ve3B-5i8iA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 5 THR A  81
ALA A  35
ALA A 130
THR A 131
GLY A  94
 None
None
FAD  A 401 (-4.7A)
FAD  A 401 (-4.0A)
FAD  A 402 (-3.3A)
 1.07A 2ve3B-5jriA:
undetectable		 2ve3B-5jriA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		5 TRP A1230
ALA A1231
THR A1320
GLY A1260
PRO A1257
 B3P  A1401 (-3.3A)
None
None
None
None
 1.19A 2ve3B-5k94A:
undetectable		 2ve3B-5k94A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ke1 OUTER MEMBRANE
PROTEIN ICSA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF03212
(Pertactin)
PF12951
(PATR) 		5 ALA A 713
ALA A 652
THR A 661
VAL A 692
GLY A 691
 None
 1.26A 2ve3B-5ke1A:
undetectable		 2ve3B-5ke1A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kem EBOLA SECRETED
GLYCOPROTEIN

(Zaire
ebolavirus) 		PF01611
(Filo_glycop) 		5 ALA A 158
ALA A  82
THR A  77
VAL A  75
GLY A  74
 None
 1.19A 2ve3B-5kemA:
undetectable		 2ve3B-5kemA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ALA A 318
ALA A 437
THR A 436
GLY A 520
PRO A 527
 None
 1.07A 2ve3B-5kshA:
undetectable		 2ve3B-5kshA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF03971
(IDH) 		5 ALA A 377
THR A 375
VAL A 250
GLY A 249
PRO A 329
 None
 1.23A 2ve3B-5kvuA:
undetectable		 2ve3B-5kvuA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC

(Streptomyces
sp. BC16019) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 PHE A  58
ALA A 475
ALA A  91
THR A  89
GLY A  83
 None
 1.28A 2ve3B-5lhkA:
undetectable		 2ve3B-5lhkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtv EH DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		PF00350
(Dynamin_N)
PF16880
(EHD_N) 		5 ALA A 209
PHE A 174
ALA A 182
VAL A  67
GLY A  68
 None
 1.14A 2ve3B-5mtvA:
undetectable		 2ve3B-5mtvA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4c PROLYL
OLIGOPEPTIDASE

(Galerina
marginata) 		no annotation 5 PHE A 132
THR A 170
VAL A 161
GLY A 144
GLN A 106
 None
 1.27A 2ve3B-5n4cA:
undetectable		 2ve3B-5n4cA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nag KYNURENINE
3-MONOOXYGENASE

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		5 PHE A 319
PHE A 266
ALA A 262
GLY A 192
GLN A 189
 8R5  A 502 (-4.9A)
None
None
None
None
 1.24A 2ve3B-5nagA:
undetectable		 2ve3B-5nagA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2

(Porphyromonas
gingivalis) 		no annotation 5 PHE B  48
ALA B 176
THR B 174
VAL B  44
GLY B  43
 None
 1.12A 2ve3B-5nfiB:
undetectable		 2ve3B-5nfiB:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Listeria
monocytogenes) 		PF00478
(IMPDH) 		5 ALA A 287
THR A 322
VAL A 318
GLY A 317
PRO A 304
 None
GOL  A 503 (-2.6A)
None
None
None
 1.18A 2ve3B-5upyA:
undetectable		 2ve3B-5upyA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Burkholderia
multivorans) 		PF00155
(Aminotran_1_2) 		5 PHE A 250
ALA A 227
ALA A 189
THR A 178
VAL A 207
 None
 1.25A 2ve3B-5vnxA:
undetectable		 2ve3B-5vnxA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x88 CUTINASE

(Malbranchea
cinnamomea) 		no annotation 5 THR A  83
ALA A 116
ALA A 121
VAL A  65
GLY A  66
 None
 1.23A 2ve3B-5x88A:
undetectable		 2ve3B-5x88A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 5 ALA A2221
PHE A2094
ALA A2093
THR A2065
GLN A2305
 None
 1.27A 2ve3B-5y2aA:
undetectable		 2ve3B-5y2aA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4f ANKYRIN-2

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		5 THR A 729
ALA A 734
ALA A 710
THR A 714
GLY A 750
 None
 1.28A 2ve3B-5y4fA:
undetectable		 2ve3B-5y4fA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1

(Danio rerio) 		no annotation 5 ALA A 126
ALA A 313
THR A 317
VAL A 494
GLY A 492
 HEM  A 601 (-3.8A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
None
None
 1.26A 2ve3B-6b82A:
37.4		 2ve3B-6b82A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3u ULVAN LYASE

(Nonlabens
ulvanivorans) 		no annotation 5 PHE A 198
ALA A  84
VAL A 283
GLY A 146
GLN A 195
 None
 1.15A 2ve3B-6d3uA:
undetectable		 2ve3B-6d3uA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gw5 -

(-) 		no annotation 5 ALA A 251
PHE A  69
ALA A  85
VAL A 349
GLY A 353
 None
 1.14A 2ve3B-6gw5A:
undetectable		 2ve3B-6gw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		5 ALA B 303
PHE B 277
PHE B 282
ALA B 255
THR B 258
 None
 1.18A 2ve3B-6reqB:
undetectable		 2ve3B-6reqB:
22.09