SIMILAR PATTERNS OF AMINO ACIDS FOR 2VE3_A_REAA1445_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9l CLATHRIN

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link) 		5 LEU A 166
ALA A 199
VAL A 220
GLY A 222
GLN A 223
 None
 1.02A 2ve3A-1c9lA:
0.0		 2ve3A-1c9lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		5 THR A 108
ALA A  90
LEU A 137
ALA A 125
GLY A  80
 None
 1.01A 2ve3A-1gynA:
0.0		 2ve3A-1gynA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpc DIANTHIN 30

(Dianthus
caryophyllus) 		PF00161
(RIP) 		5 ALA A 178
PHE A  56
LEU A  20
PHE A  19
GLY A  66
 None
 0.99A 2ve3A-1lpcA:
0.0		 2ve3A-1lpcA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nui DNA PRIMASE/HELICASE

(Escherichia
virus T7) 		PF08273
(Prim_Zn_Ribbon)
PF13155
(Toprim_2) 		5 THR A 188
ALA A 219
LEU A 223
PHE A 196
GLY A 158
 None
 1.06A 2ve3A-1nuiA:
0.0		 2ve3A-1nuiA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		5 THR A 165
ALA A 147
ALA A  38
THR A 118
GLY A 130
 None
None
None
None
POP  A1155 ( 4.9A)
 1.03A 2ve3A-1ocmA:
0.0		 2ve3A-1ocmA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4c MALTOSE BINDING
PROTEIN FUSED WITH
DESIGNED HELICAL
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.08A 2ve3A-1y4cA:
undetectable		 2ve3A-1y4cA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpa PROTEIN (ACID
PHOSPHATASE)

(Homo sapiens) 		PF00328
(His_Phos_2) 		5 THR A1284
LEU A1321
PHE A1324
ALA A1325
GLY A1229
 None
 1.02A 2ve3A-2hpaA:
0.4		 2ve3A-2hpaA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL

(Arabidopsis
thaliana) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 THR A 224
ALA A 190
THR A 280
VAL A 274
GLY A 273
 None
 1.10A 2ve3A-2ix5A:
0.0		 2ve3A-2ix5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k18 PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF13848
(Thioredoxin_6) 		5 THR A  58
ALA A  17
PHE A  31
LEU A  20
ALA A  27
 None
 1.10A 2ve3A-2k18A:
0.0		 2ve3A-2k18A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyz HYPOTHETICAL PROTEIN
GAMMAHV.M3

(Murid
gammaherpesvirus
4) 		PF09213
(M3) 		5 ALA A 257
LEU A 284
THR A  18
VAL A  16
GLY A  15
 None
 1.08A 2ve3A-2nyzA:
undetectable		 2ve3A-2nyzA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxf URIDINE
PHOSPHORYLASE

(Salmonella
enterica) 		PF01048
(PNP_UDP_1) 		5 ALA A1139
ALA A1144
THR A1151
VAL A1153
GLY A1154
 None
 1.02A 2ve3A-2oxfA:
undetectable		 2ve3A-2oxfA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.09A 2ve3A-2vgqA:
undetectable		 2ve3A-2vgqA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 PHE A 526
TRP A 500
ALA A 494
ALA A 396
THR A 399
 None
 0.99A 2ve3A-2xymA:
undetectable		 2ve3A-2xymA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine leukemia
virus;
Escherichia
coli) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		5 ALA A 290
LEU A 306
PHE A 305
VAL A 319
GLY A  42
 None
 1.10A 2ve3A-2xz3A:
undetectable		 2ve3A-2xz3A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z55 ARCHAERHODOPSIN-2

(Halobacterium
sp. AUS-2) 		PF01036
(Bac_rhodopsin) 		6 ALA A 189
LEU A 216
PHE A 213
ALA A 212
VAL A 204
GLY A 202
 None
 1.21A 2ve3A-2z55A:
1.9		 2ve3A-2z55A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a18 ALDOXIME DEHYDRATASE

(Rhodococcus
erythropolis) 		PF13816
(Dehydratase_hem) 		5 PHE A  70
TRP A 117
ALA A  58
VAL A  48
GLY A  47
 None
 1.09A 2ve3A-3a18A:
undetectable		 2ve3A-3a18A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3c MALTOSE-BINDING
PERIPLASMIC PROTEIN,
LINKER,
MITOCHONDRIAL
INTERMEMBRANE SPACE
IMPORT AND ASSEMBLY
PROTEIN 40

(Escherichia
coli;
Saccharomyces
cerevisiae;
synthetic
construct) 		PF06747
(CHCH)
PF13416
(SBP_bac_8) 		5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.05A 2ve3A-3a3cA:
undetectable		 2ve3A-3a3cA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2y METALLOPEPTIDASE
CONTAINING
CO-CATALYTIC
METALLOACTIVE SITE

(Shewanella
denitrificans) 		PF04952
(AstE_AspA) 		5 THR A 246
ALA A 262
LEU A 195
ALA A 242
GLY A  73
 None
 1.08A 2ve3A-3b2yA:
undetectable		 2ve3A-3b2yA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 PHE A 421
LEU A 104
ALA A 101
VAL A 134
GLY A 133
 MYA  A   1 ( 3.7A)
None
None
None
None
 1.02A 2ve3A-3b96A:
0.4		 2ve3A-3b96A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csg MALTOSE-BINDING
PROTEIN MONOBODY YS1
FUSION

(Escherichia
coli) 		PF00041
(fn3)
PF13416
(SBP_bac_8) 		5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.04A 2ve3A-3csgA:
undetectable		 2ve3A-3csgA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr2 EXPORTED
GLUCONOLACTONASE

(Xanthomonas
campestris) 		PF08450
(SGL) 		5 PHE A 284
ALA A 234
ALA A 219
THR A 201
GLY A 250
 None
 1.07A 2ve3A-3dr2A:
undetectable		 2ve3A-3dr2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoq PUTATIVE ZINC
PROTEASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 PHE A  53
ALA A 187
LEU A 196
ALA A 200
THR A 204
 None
 0.81A 2ve3A-3eoqA:
undetectable		 2ve3A-3eoqA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.10A 2ve3A-3f5fA:
undetectable		 2ve3A-3f5fA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Burkholderia
pseudomallei) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 PHE A  10
ALA A  77
LEU A  33
ALA A  32
GLY A  67
 None
 1.01A 2ve3A-3gnnA:
undetectable		 2ve3A-3gnnA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsz RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 PHE A 526
TRP A 500
ALA A 494
ALA A 396
THR A 399
 None
 0.97A 2ve3A-3gszA:
undetectable		 2ve3A-3gszA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieh PUTATIVE
METALLOPEPTIDASE

(Shewanella
baltica) 		PF04952
(AstE_AspA) 		5 THR A 246
ALA A 262
LEU A 195
ALA A 242
GLY A  73
 None
 1.02A 2ve3A-3iehA:
undetectable		 2ve3A-3iehA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inn PANTOTHENATE
SYNTHETASE

(Brucella
melitensis) 		PF02569
(Pantoate_ligase) 		5 THR A  29
ALA A  92
LEU A  75
ALA A  79
VAL A  87
 ATP  A 300 ( 4.5A)
None
None
None
None
 0.98A 2ve3A-3innA:
undetectable		 2ve3A-3innA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izk CHAPERONIN

(Methanococcus
maripaludis) 		PF00118
(Cpn60_TCP1) 		5 ALA A 295
LEU A 228
PHE A 257
VAL A 206
GLY A 205
 None
 0.87A 2ve3A-3izkA:
0.0		 2ve3A-3izkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg3 ORANGE
CAROTENOID-BINDING
PROTEIN

(Synechocystis
sp. PCC 6803) 		PF02136
(NTF2)
PF09150
(Carot_N) 		5 ALA A  67
LEU A  94
ALA A  82
VAL A 122
GLN A 119
 None
 1.10A 2ve3A-3mg3A:
undetectable		 2ve3A-3mg3A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp6 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,LINKER,SAGA-
ASSOCIATED FACTOR 29

(Escherichia
coli;
Saccharomyces
cerevisiae;
unidentified) 		PF07039
(DUF1325)
PF13416
(SBP_bac_8) 		5 ALA A1002
LEU A1018
PHE A1017
VAL A1031
GLY A 754
 None
 1.11A 2ve3A-3mp6A:
undetectable		 2ve3A-3mp6A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq9 BONE MARROW STROMAL
ANTIGEN 2 FUSED TO
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16716
(BST2) 		5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.09A 2ve3A-3mq9A:
undetectable		 2ve3A-3mq9A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF13416
(SBP_bac_8) 		5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.11A 2ve3A-3oaiA:
undetectable		 2ve3A-3oaiA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q41 GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
ZETA-1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 ALA A 291
LEU A 325
PHE A 340
THR A 140
GLY A 333
 None
 1.10A 2ve3A-3q41A:
undetectable		 2ve3A-3q41A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbo PHOSPHOSERINE
AMINOTRANSFERASE

(Yersinia pestis) 		PF00266
(Aminotran_5) 		5 ALA A 217
LEU A 221
ALA A  82
VAL A 190
GLY A 189
 None
 1.07A 2ve3A-3qboA:
undetectable		 2ve3A-3qboA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmj ENOYL-COA HYDRATASE,
ECHA8_6

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 ALA A 110
LEU A 127
ALA A 170
VAL A 150
GLY A 151
 None
 1.08A 2ve3A-3qmjA:
undetectable		 2ve3A-3qmjA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vte TETRAHYDROCANNABINOL
IC ACID SYNTHASE

(Cannabis sativa) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ALA A 147
LEU A 248
PHE A 171
VAL A 181
GLY A 182
 None
None
None
None
FAD  A 607 (-3.3A)
 1.09A 2ve3A-3vteA:
undetectable		 2ve3A-3vteA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus;
Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.08A 2ve3A-3waiA:
undetectable		 2ve3A-3waiA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE

(Methanothermobacter
thermautotrophicus) 		PF02374
(ArsA_ATPase) 		5 ALA A 242
LEU A 153
THR A 146
GLY A  26
GLN A 260
 None
None
None
ADP  A 401 (-3.3A)
ADP  A 401 ( 3.9A)
 0.90A 2ve3A-3zq6A:
undetectable		 2ve3A-3zq6A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dns FAD-LINKED
OXIDOREDUCTASE BG60

(Cynodon
dactylon) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ALA A 123
LEU A 224
PHE A 147
VAL A 157
GLY A 158
 None
None
None
None
FAD  A 501 ( 3.8A)
 0.96A 2ve3A-4dnsA:
undetectable		 2ve3A-4dnsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvj PUTATIVE
ZINC-DEPENDENT
ALCOHOL
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 LEU A 162
PHE A 158
ALA A 157
VAL A 184
GLY A 183
 None
 1.02A 2ve3A-4dvjA:
undetectable		 2ve3A-4dvjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.06A 2ve3A-4dxbA:
undetectable		 2ve3A-4dxbA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etn LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE YWLE

(Bacillus
subtilis) 		PF01451
(LMWPc) 		5 ALA A  19
LEU A  55
ALA A  51
THR A  48
GLY A  45
 None
 1.07A 2ve3A-4etnA:
undetectable		 2ve3A-4etnA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN

(Synechocystis
sp. PCC 6803) 		PF00502
(Phycobilisome) 		5 THR B  45
ALA B  98
THR B 101
VAL A   9
GLN A  15
 None
 1.10A 2ve3A-4f0tB:
undetectable		 2ve3A-4f0tB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gji L-RHAMNOSE ISOMERASE

(Pseudomonas
stutzeri) 		no annotation 5 ALA A 294
LEU A 302
PHE A 306
ALA A 349
GLN A  89
 None
 0.88A 2ve3A-4gjiA:
undetectable		 2ve3A-4gjiA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grd PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT

(Burkholderia
cenocepacia) 		PF00731
(AIRC) 		5 ALA A 135
LEU A  95
ALA A  71
VAL A  41
GLY A  40
 None
 1.02A 2ve3A-4grdA:
undetectable		 2ve3A-4grdA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Candida
albicans;
Escherichia
coli) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 ALA A-106
LEU A -90
PHE A -91
VAL A -77
GLY A-354
 None
 1.09A 2ve3A-4h1gA:
undetectable		 2ve3A-4h1gA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 ALA A 265
LEU A 281
PHE A 280
VAL A 294
GLY A  17
 None
 1.10A 2ve3A-4ifpA:
undetectable		 2ve3A-4ifpA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 ALA A 265
LEU A 281
PHE A 280
VAL A 294
GLY A  17
 None
 1.05A 2ve3A-4ikmA:
undetectable		 2ve3A-4ikmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 ALA A 265
LEU A 281
PHE A 280
VAL A 294
GLY A  17
 None
 1.11A 2ve3A-4irlA:
0.3		 2ve3A-4irlA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdz SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C)
PF17210
(SdrD_B) 		5 ALA A 406
THR A 519
VAL A 446
GLY A 447
GLN A 528
 None
 0.88A 2ve3A-4jdzA:
undetectable		 2ve3A-4jdzA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je0 SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		5 ALA A 171
THR A 284
VAL A 211
GLY A 212
GLN A 293
 None
 1.01A 2ve3A-4je0A:
undetectable		 2ve3A-4je0A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.10A 2ve3A-4kegA:
undetectable		 2ve3A-4kegA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		5 ALA A 266
LEU A 282
PHE A 281
VAL A 295
GLY A  18
 None
 1.08A 2ve3A-4logA:
undetectable		 2ve3A-4logA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mow GLUCOSE
1-DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 THR A 122
LEU A  85
ALA A  78
VAL A  61
GLY A  62
 None
 1.08A 2ve3A-4mowA:
undetectable		 2ve3A-4mowA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2x MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ATP-DEPENDENT CLP
PROTEASE ADAPTOR
PROTEIN CLPS
CONTAINING PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Plasmodium
falciparum) 		PF02617
(ClpS)
PF13416
(SBP_bac_8) 		5 ALA A 265
LEU A 281
PHE A 280
VAL A 294
GLY A  17
 None
 1.10A 2ve3A-4o2xA:
undetectable		 2ve3A-4o2xA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		5 ALA A 106
LEU A  31
PHE A  28
ALA A 123
GLY A  12
 None
 1.08A 2ve3A-4ouaA:
undetectable		 2ve3A-4ouaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum pratense) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ALA A 121
LEU A 222
PHE A 145
VAL A 155
GLY A 156
 None
None
None
None
FAD  A 601 ( 3.6A)
 1.04A 2ve3A-4pveA:
undetectable		 2ve3A-4pveA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF01648
(ACPS)
PF13416
(SBP_bac_8) 		5 ALA A 265
LEU A 281
PHE A 280
VAL A 294
GLY A  17
 None
 1.09A 2ve3A-4qvhA:
undetectable		 2ve3A-4qvhA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1

(Escherichia
coli;
Rattus
norvegicus) 		PF03359
(GKAP)
PF13416
(SBP_bac_8) 		5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.08A 2ve3A-4r0yA:
1.4		 2ve3A-4r0yA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		5 ALA A 266
LEU A 282
PHE A 281
VAL A 295
GLY A  18
 None
None
None
None
EDO  A2203 ( 3.9A)
 1.08A 2ve3A-4rwfA:
undetectable		 2ve3A-4rwfA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toi 30S RIBOSOMAL
PROTEIN S2,RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		PF00318
(Ribosomal_S2)
PF00575
(S1) 		5 ALA A 216
LEU A  54
THR A  46
VAL A  14
GLY A  13
 None
 1.01A 2ve3A-4toiA:
undetectable		 2ve3A-4toiA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA

(Clostridioides
difficile;
Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.10A 2ve3A-4tsmA:
undetectable		 2ve3A-4tsmA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB

(Escherichia
coli;
Staphylococcus
aureus) 		PF00717
(Peptidase_S24)
PF13416
(SBP_bac_8) 		5 ALA A 270
LEU A 286
PHE A 285
VAL A 299
GLY A  22
 None
 1.11A 2ve3A-4wviA:
undetectable		 2ve3A-4wviA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C

(Acinetobacter
baumannii;
Escherichia
coli) 		PF00114
(Pilin)
PF13416
(SBP_bac_8) 		5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.09A 2ve3A-4xa2A:
undetectable		 2ve3A-4xa2A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xai MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TAILLESS
ORTHOLOG

(Escherichia
coli;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		5 ALA A 266
LEU A 282
PHE A 281
VAL A 295
GLY A  18
 None
 1.08A 2ve3A-4xaiA:
2.2		 2ve3A-4xaiA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb4 ORANGE
CAROTENOID-BINDING
PROTEIN

(Synechocystis
sp. PCC 6803) 		PF09150
(Carot_N) 		5 ALA A  67
LEU A  94
ALA A  82
VAL A 122
GLN A 119
 None
 1.11A 2ve3A-4xb4A:
undetectable		 2ve3A-4xb4A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli) 		PF00245
(Alk_phosphatase) 		5 THR A 192
ALA A 157
PHE A 211
ALA A 149
GLY A 257
 None
 1.11A 2ve3A-4yr1A:
undetectable		 2ve3A-4yr1A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Thermoplasma
acidophilum) 		PF01884
(PcrB) 		5 PHE A  78
ALA A 159
LEU A 194
VAL A 200
GLY A 201
 1GP  A 501 (-4.8A)
None
None
None
1GP  A 501 (-3.4A)
 0.96A 2ve3A-5b69A:
undetectable		 2ve3A-5b69A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12

(Escherichia
coli;
Zoarces
americanus) 		PF01547
(SBP_bac_1) 		5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.10A 2ve3A-5c7rA:
undetectable		 2ve3A-5c7rA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MALTOSE-BIND
ING PERIPLASMIC
PROTEIN,PILA FUSION
PROTEIN

(Acinetobacter
nosocomialis;
Escherichia
coli) 		PF00114
(Pilin)
PF01547
(SBP_bac_1) 		5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.11A 2ve3A-5cfvA:
undetectable		 2ve3A-5cfvA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19

(Escherichia
coli;
Tetrahymena
thermophila) 		PF13416
(SBP_bac_8) 		5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.09A 2ve3A-5dfmA:
undetectable		 2ve3A-5dfmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		5 LEU A 593
PHE A 565
ALA A 567
THR A 535
GLY A 510
 None
 1.05A 2ve3A-5gkqA:
undetectable		 2ve3A-5gkqA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG

(Escherichia
coli;
Serratia) 		PF13416
(SBP_bac_8) 		5 ALA A 266
LEU A 282
PHE A 281
VAL A 295
GLY A  18
 None
 1.03A 2ve3A-5gxvA:
undetectable		 2ve3A-5gxvA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 ALA A 265
LEU A 281
PHE A 280
VAL A 294
GLY A  17
 None
 1.11A 2ve3A-5h7nA:
undetectable		 2ve3A-5h7nA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		5 TRP A 197
ALA A 218
LEU A 310
ALA A 313
GLY A 267
 None
 1.11A 2ve3A-5hctA:
undetectable		 2ve3A-5hctA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1

(Homo sapiens) 		PF04622
(ERG2_Sigma1R) 		5 ALA A  46
LEU A  61
PHE A  58
ALA A  57
GLY A 131
 None
 1.05A 2ve3A-5hk2A:
undetectable		 2ve3A-5hk2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz7 COMP

(Neisseria
meningitidis) 		PF13416
(SBP_bac_8)
PF16732
(ComP_DUS) 		5 ALA A 265
LEU A 281
PHE A 280
VAL A 294
GLY A  17
 None
 1.11A 2ve3A-5hz7A:
undetectable		 2ve3A-5hz7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		5 ALA A 319
LEU A 335
PHE A 334
VAL A 348
GLY A  71
 None
 1.10A 2ve3A-5hzwA:
undetectable		 2ve3A-5hzwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikn DNA PRIMASE/HELICASE

(Escherichia
virus T7) 		PF03796
(DnaB_C)
PF13155
(Toprim_2) 		5 THR D 188
ALA D 219
LEU D 223
PHE D 196
GLY D 158
 None
 1.05A 2ve3A-5iknD:
undetectable		 2ve3A-5iknD:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 5 PHE B 672
ALA B 308
LEU B 309
VAL B 323
GLY B 324
 None
 1.06A 2ve3A-5iz5B:
undetectable		 2ve3A-5iz5B:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ALA C 264
LEU C 280
PHE C 279
VAL C 293
GLY C  16
 None
 1.11A 2ve3A-5jj4C:
undetectable		 2ve3A-5jj4C:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 5 THR A  81
ALA A  35
ALA A 130
THR A 131
GLY A  94
 None
None
FAD  A 401 (-4.7A)
FAD  A 401 (-4.0A)
FAD  A 402 (-3.3A)
 1.05A 2ve3A-5jriA:
undetectable		 2ve3A-5jriA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3w CPUTA1

(Curtobacterium
pusillum) 		PF01063
(Aminotran_4) 		5 TRP A 267
ALA A 275
LEU A 300
PHE A 242
VAL A 221
 None
 1.06A 2ve3A-5k3wA:
undetectable		 2ve3A-5k3wA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		5 ALA A1264
LEU A1280
PHE A1279
VAL A1293
GLY A  16
 None
 1.11A 2ve3A-5k94A:
undetectable		 2ve3A-5k94A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kel EBOLA SURFACE
GLYCOPROTEIN, GP1

(Zaire
ebolavirus) 		PF01611
(Filo_glycop) 		5 THR A  83
PHE A  88
ALA A 148
GLY A 143
GLN A 221
 None
 1.04A 2ve3A-5kelA:
undetectable		 2ve3A-5kelA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lh9 OMEGA TRANSAMINASE

(Pseudomonas sp.) 		PF00202
(Aminotran_3) 		5 ALA A 332
LEU A 293
PHE A 111
ALA A 295
GLY A  99
 None
 0.85A 2ve3A-5lh9A:
undetectable		 2ve3A-5lh9A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Streptomyces
venezuelae) 		PF00982
(Glyco_transf_20) 		5 THR A 165
ALA A 146
PHE A 198
ALA A 193
THR A 218
 None
 1.08A 2ve3A-5lqdA:
undetectable		 2ve3A-5lqdA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi) 		PF00883
(Peptidase_M17) 		5 LEU A 131
ALA A 130
THR A  83
GLY A  51
GLN A  55
 None
 1.11A 2ve3A-5ntfA:
undetectable		 2ve3A-5ntfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 6 LEU A 538
PHE A 541
ALA A 542
THR A 545
VAL A 264
GLY A 266
 None
 1.24A 2ve3A-5ohsA:
undetectable		 2ve3A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ook PHYCOCYANIN, ALPHA
SUBUNIT
PHYCOCYANIN, BETA
SUBUNIT

(Acaryochloris
marina) 		no annotation 5 THR B  45
ALA B  98
THR B 101
VAL A   9
GLN A  15
 None
 1.06A 2ve3A-5ookB:
undetectable		 2ve3A-5ookB:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		5 TRP A 197
ALA A 218
LEU A 310
ALA A 313
GLY A 267
 None
 1.10A 2ve3A-5p60A:
undetectable		 2ve3A-5p60A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucr PANTOTHENATE
SYNTHETASE

(Neisseria
gonorrhoeae) 		PF02569
(Pantoate_ligase) 		5 THR A  25
ALA A  88
LEU A  71
ALA A  75
VAL A  83
 ANP  A 301 ( 4.6A)
None
None
None
None
 0.98A 2ve3A-5ucrA:
undetectable		 2ve3A-5ucrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA

(Acinetobacter
baumannii;
Escherichia
coli) 		no annotation 5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.10A 2ve3A-5vawA:
undetectable		 2ve3A-5vawA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa3 PYRIDINE SYNTHASE
TBTD

(Thermobispora
bispora) 		no annotation 5 PHE A 308
ALA A 343
LEU A 224
ALA A 228
GLY A 179
 None
 0.94A 2ve3A-5wa3A:
undetectable		 2ve3A-5wa3A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1e ICMS

(Legionella
pneumophila) 		PF12608
(T4bSS_IcmS) 		5 ALA A  46
LEU A  58
PHE A  76
ALA A  60
GLY A  37
 None
 1.07A 2ve3A-5x1eA:
undetectable		 2ve3A-5x1eA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zct -

(-) 		no annotation 5 ALA A  97
LEU A 242
ALA A 237
VAL A 258
GLN A 177
 None
None
None
None
ANP  A 401 (-3.7A)
 1.09A 2ve3A-5zctA:
undetectable		 2ve3A-5zctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage JBD30) 		no annotation 5 ALA A 344
LEU A 360
PHE A 359
VAL A 373
GLY A  96
 None
 1.08A 2ve3A-6anvA:
undetectable		 2ve3A-6anvA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.08A 2ve3A-6apxA:
undetectable		 2ve3A-6apxA:
21.33