SIMILAR PATTERNS OF AMINO ACIDS FOR 2VDY_B_HCYB1384_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR

(Bos taurus) 		PF00996
(GDI) 		5 SER A 167
VAL A 171
THR A 157
ILE A 206
PHE A 146
 None
 1.45A 2vdyB-1d5tA:
0.0		 2vdyB-1d5tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6o CAG-ALPHA

(Helicobacter
pylori) 		PF00437
(T2SSE) 		5 VAL A  56
THR A  32
PHE A  84
ILE A 130
PHE A  36
 None
 1.04A 2vdyB-1g6oA:
0.9		 2vdyB-1g6oA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hi2 EOSINOPHIL-DERIVED
NEUROTOXIN

(Homo sapiens) 		PF00074
(RnaseA) 		5 THR A  42
ILE A  30
ASN A  31
PHE A  43
HIS A  82
 None
 1.35A 2vdyB-1hi2A:
0.0		 2vdyB-1hi2A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imu HYPOTHETICAL PROTEIN
HI0257

(Haemophilus
influenzae) 		PF02482
(Ribosomal_S30AE) 		5 VAL A  77
ASN A  42
SER A   7
PHE A  39
HIS A  38
 None
 1.28A 2vdyB-1imuA:
undetectable		 2vdyB-1imuA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k38 BETA-LACTAMASE OXA-2

(Salmonella
enterica) 		PF00905
(Transpeptidase) 		5 SER A 147
GLN A 166
THR A  68
ASN A 143
PHE A  69
 None
 1.15A 2vdyB-1k38A:
0.0		 2vdyB-1k38A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7s FERRICHROME-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		5 VAL N 287
THR N 181
PHE N 191
PHE N 238
HIS N 240
 None
 1.29A 2vdyB-1k7sN:
undetectable		 2vdyB-1k7sN:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7s FERRICHROME-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		5 VAL N 287
THR N 181
PHE N 274
PHE N 238
HIS N 240
 None
 1.25A 2vdyB-1k7sN:
undetectable		 2vdyB-1k7sN:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 SER A 519
VAL A 520
ASN A 502
PHE A 499
TRP A 544
 None
 1.37A 2vdyB-1nr0A:
0.0		 2vdyB-1nr0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfw ANTIBODY (ANTI BETA
SUBUNIT) (HEAVY
CHAIN)

(Mus musculus) 		PF07686
(V-set) 		5 GLN I 299
PHE I 309
ARG I 238
ILE I 237
SER I 235
 None
 1.26A 2vdyB-1qfwI:
undetectable		 2vdyB-1qfwI:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfw ANTIBODY (ANTI BETA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI BETA
SUBUNIT) (LIGHT
CHAIN)

(Mus musculus) 		PF07686
(V-set) 		5 PHE I 309
ARG I 238
ILE I 237
SER I 235
HIS M 294
 None
 1.18A 2vdyB-1qfwI:
undetectable		 2vdyB-1qfwI:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfw ANTIBODY (ANTI BETA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI BETA
SUBUNIT) (LIGHT
CHAIN)

(Mus musculus) 		PF07686
(V-set) 		5 PHE I 309
ARG I 238
ILE I 237
SER I 235
PHE M 298
 None
 1.33A 2vdyB-1qfwI:
undetectable		 2vdyB-1qfwI:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfw ANTIBODY (ANTI BETA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI BETA
SUBUNIT) (LIGHT
CHAIN)

(Mus musculus) 		PF07686
(V-set) 		5 THR M 291
PHE I 309
ARG I 238
ILE I 237
SER I 235
 None
 1.20A 2vdyB-1qfwM:
0.0		 2vdyB-1qfwM:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 GLN A 147
PHE A 143
ARG A 135
ILE A 134
PHE A 164
 None
 1.32A 2vdyB-1si8A:
0.0		 2vdyB-1si8A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzv VARICELLA-ZOSTER
VIRUS PROTEASE

(Human
alphaherpesvirus
3) 		PF00716
(Peptidase_S21) 		5 SER A 120
VAL A 119
ILE A  48
ASN A  49
PHE A  73
 None
 1.38A 2vdyB-1vzvA:
undetectable		 2vdyB-1vzvA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi) 		PF05544
(Pro_racemase) 		5 VAL A 271
GLN A 195
ARG A 248
ILE A 251
ASN A 252
 None
 1.32A 2vdyB-1w61A:
undetectable		 2vdyB-1w61A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpn HYPOTHETICAL PROTEIN
PA1324

(Pseudomonas
aeruginosa) 		no annotation 5 VAL A 166
THR A 113
ILE A 131
SER A 133
PHE A 119
 None
 1.14A 2vdyB-1xpnA:
undetectable		 2vdyB-1xpnA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))

(Streptococcus
pyogenes) 		PF00390
(malic)
PF03949
(Malic_M) 		5 SER A 185
VAL A 189
PHE A 286
ILE A 175
PHE A 262
 None
 1.07A 2vdyB-2a9fA:
undetectable		 2vdyB-2a9fA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		5 SER A 196
GLN A  60
THR A  56
ILE A 244
SER A  89
 None
 1.45A 2vdyB-2cuyA:
undetectable		 2vdyB-2cuyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 SER A 485
THR A 479
ILE A 300
SER A 289
HIS A 393
 None
 1.25A 2vdyB-2e0wA:
undetectable		 2vdyB-2e0wA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		5 THR A 353
ARG A 377
ASN A 372
SER A 371
PHE A 364
 None
 1.37A 2vdyB-2epjA:
undetectable		 2vdyB-2epjA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mss PROTEIN (MUSASHI1)

(Mus musculus) 		PF00076
(RRM_1) 		5 VAL A 113
GLN A 131
PHE A 132
PHE A 129
HIS A 127
 None
 1.31A 2vdyB-2mssA:
undetectable		 2vdyB-2mssA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
NEDD8-CONJUGATING
ENZYME UBC12

(Homo sapiens) 		PF00179
(UQ_con)
PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		5 SER B2396
PHE C  80
ILE C 125
ASN C 126
PHE C  60
 None
 1.28A 2vdyB-2nvuB:
undetectable		 2vdyB-2nvuB:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN

(Homo sapiens) 		PF00782
(DSPc) 		5 THR A 102
PHE A 130
ILE A  95
ASN A  94
PHE A  99
 None
 1.15A 2vdyB-2r0bA:
undetectable		 2vdyB-2r0bA:
18.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN

(Rattus
norvegicus) 		PF00079
(Serpin) 		8 VAL A  17
GLN A 224
THR A 232
PHE A 234
ARG A 252
ILE A 255
PHE A 357
TRP A 362
 HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
HCY  A1375 (-4.9A)
None
HCY  A1375 ( 4.1A)
HCY  A1375 (-3.8A)
 0.61A 2vdyB-2v95A:
38.1		 2vdyB-2v95A:
60.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ve3 PUTATIVE CYTOCHROME
P450 120

(Synechocystis
sp. PCC 6803) 		PF00067
(p450) 		5 SER A 429
THR A  26
PHE A  52
SER A  83
PHE A  29
 REA  A1445 ( 4.3A)
None
None
None
REA  A1445 (-4.6A)
 1.08A 2vdyB-2ve3A:
undetectable		 2vdyB-2ve3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 THR A 276
PHE A 281
ILE A 237
ASN A 238
PHE A 274
 None
 1.25A 2vdyB-2xaxA:
undetectable		 2vdyB-2xaxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe SYNTAXIN1

(Monosiga
brevicollis) 		PF00804
(Syntaxin)
PF05739
(SNARE) 		5 SER B 257
VAL B 129
GLN B 243
ARG B 134
SER B 141
 None
 1.41A 2vdyB-2xheB:
undetectable		 2vdyB-2xheB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0l EARLY ANTIGEN
PROTEIN D

(Human
gammaherpesvirus
4) 		PF04929
(Herpes_DNAp_acc) 		5 SER A 247
VAL A 243
THR A 198
PHE A 267
ILE A 273
 None
 1.15A 2vdyB-2z0lA:
undetectable		 2vdyB-2z0lA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqw PUTATIVE CAPSID
PROTEIN OF PROPHAGE

(Escherichia
coli) 		PF03864
(Phage_cap_E) 		5 SER A 249
VAL A 248
THR A 287
PHE A  35
ILE A 208
 None
 1.41A 2vdyB-3bqwA:
undetectable		 2vdyB-3bqwA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		5 SER A 215
VAL A 180
GLN A 162
ILE A 201
PHE A 169
 None
 1.45A 2vdyB-3cc1A:
undetectable		 2vdyB-3cc1A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dui BETA-GALACTOSIDE-BIN
DING LECTIN

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		5 SER A 107
VAL A  99
ILE A  59
PHE A  46
HIS A  45
 None
 1.11A 2vdyB-3duiA:
undetectable		 2vdyB-3duiA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 SER A 634
THR A 610
PHE A 475
SER A 478
PHE A 613
 None
 1.42A 2vdyB-3dwbA:
undetectable		 2vdyB-3dwbA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Kluyveromyces
lactis) 		PF01408
(GFO_IDH_MocA) 		5 VAL A 440
THR A 215
PHE A 280
ASN A 206
PHE A 212
 None
 1.37A 2vdyB-3e1kA:
undetectable		 2vdyB-3e1kA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9r PHOSPHOMANNOMUTASE

(Trypanosoma
brucei) 		PF03332
(PMM) 		5 VAL A 239
THR A  42
PHE A  63
ILE A  30
PHE A   9
 None
 1.17A 2vdyB-3f9rA:
undetectable		 2vdyB-3f9rA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 THR A 379
ILE A  86
SER A 410
PHE A  67
HIS A  72
 None
 1.28A 2vdyB-3fedA:
undetectable		 2vdyB-3fedA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		PF00855
(PWWP) 		5 SER A 103
PHE A  80
ILE A 133
ASN A 129
PHE A  76
 None
 1.40A 2vdyB-3llrA:
undetectable		 2vdyB-3llrA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oy2 GLYCOSYLTRANSFERASE
B736L

(Paramecium
bursaria
Chlorella virus
NY2A) 		no annotation 5 SER A 282
PHE A 312
ILE A 302
ASN A 279
SER A 290
 None
 1.14A 2vdyB-3oy2A:
undetectable		 2vdyB-3oy2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 VAL A 270
PHE A 360
ILE A 313
ASN A 352
PHE A 277
 None
 1.05A 2vdyB-3pocA:
undetectable		 2vdyB-3pocA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnb OXACILLINASE

(Escherichia
coli) 		PF00905
(Transpeptidase) 		5 SER A 147
GLN A 166
THR A  68
ASN A 143
PHE A  69
 None
 1.25A 2vdyB-3qnbA:
undetectable		 2vdyB-3qnbA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1

(Saccharomyces
cerevisiae) 		PF06087
(Tyr-DNA_phospho) 		5 SER A 256
VAL A 257
ILE A 197
SER A 219
PHE A 262
 None
 1.44A 2vdyB-3sq7A:
undetectable		 2vdyB-3sq7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvi ASPARTOKINASE

(Clostridium
acetobutylicum) 		PF00696
(AA_kinase)
PF01842
(ACT) 		5 PHE A  67
ARG A 114
ILE A 102
ASN A 101
PHE A  71
 None
 1.38A 2vdyB-3tviA:
undetectable		 2vdyB-3tviA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u43 COLICIN-E2

(Escherichia
coli) 		no annotation 5 SER B  30
PHE B  50
ARG B 120
ILE B 119
ASN B 118
 None
 1.25A 2vdyB-3u43B:
undetectable		 2vdyB-3u43B:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uh8 ORF48

(Lactococcus
phage TP901-1) 		PF10651
(DUF2479) 		5 SER A  71
VAL A  69
THR A 114
ILE A  32
PHE A  98
 None
 1.19A 2vdyB-3uh8A:
undetectable		 2vdyB-3uh8A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uh8 ORF48

(Lactococcus
phage TP901-1) 		PF10651
(DUF2479) 		5 SER A  71
VAL A  69
THR A 114
PHE A 117
ILE A  32
 None
 1.44A 2vdyB-3uh8A:
undetectable		 2vdyB-3uh8A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uiw GLUTAREDOXIN 2

(Danio rerio) 		PF00462
(Glutaredoxin) 		5 VAL A  57
ILE A  23
ASN A  27
SER A  26
PHE A  19
 None
 1.44A 2vdyB-3uiwA:
undetectable		 2vdyB-3uiwA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v10 RHUSIOPATHIAE
SURFACE PROTEIN B

(Erysipelothrix
rhusiopathiae) 		PF05737
(Collagen_bind) 		5 SER A 181
THR A 166
PHE A  59
ILE A  57
SER A 148
 None
 1.34A 2vdyB-3v10A:
undetectable		 2vdyB-3v10A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wlw ANTIBODY L CHAIN

(Homo sapiens) 		no annotation 5 SER L  11
VAL L  10
PHE L  64
ILE L  77
HIS L  41
 None
 1.33A 2vdyB-3wlwL:
undetectable		 2vdyB-3wlwL:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpm LATHERIN

(Equus caballus) 		PF01273
(LBP_BPI_CETP) 		5 SER A  93
VAL A  94
GLN A  43
THR A  39
ILE A 159
 None
 1.31A 2vdyB-3zpmA:
undetectable		 2vdyB-3zpmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 VAL A 591
THR A 487
ASN A 405
SER A 404
PHE A 490
 None
 1.17A 2vdyB-3zu0A:
undetectable		 2vdyB-3zu0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Mycobacterium
tuberculosis) 		PF01116
(F_bP_aldolase) 		5 SER A  31
VAL A  34
THR A  94
PHE A 125
PHE A  52
 None
None
NA  A1347 (-3.6A)
None
None
 1.37A 2vdyB-4a22A:
undetectable		 2vdyB-4a22A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2y EOSINOPHIL CATIONIC
PROTEIN

(Homo sapiens) 		PF00074
(RnaseA) 		5 THR A  42
ILE A  30
ASN A  31
PHE A  43
HIS A  82
 None
 1.39A 2vdyB-4a2yA:
undetectable		 2vdyB-4a2yA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axv MPAA

(Vibrio
campbellii) 		PF04952
(AstE_AspA) 		5 SER A  59
THR A 207
ILE A  43
PHE A 155
HIS A 156
 None
None
None
None
ZN  A 301 (-3.2A)
 1.28A 2vdyB-4axvA:
undetectable		 2vdyB-4axvA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b67 L-ORNITHINE N5
MONOOXYGENASE

(Aspergillus
fumigatus) 		PF13434
(K_oxygenase) 		5 SER A 417
VAL A 419
THR A 203
ILE A 451
PHE A 186
 None
 1.00A 2vdyB-4b67A:
undetectable		 2vdyB-4b67A:
21.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		7 SER A  19
VAL A  22
GLN A 232
PHE A 242
ARG A 260
ILE A 263
PHE A 366
 None
 1.04A 2vdyB-4c41A:
57.2		 2vdyB-4c41A:
96.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		8 VAL A  22
GLN A 232
THR A 240
PHE A 242
ARG A 260
ILE A 263
SER A 267
PHE A 366
 None
 0.98A 2vdyB-4c41A:
57.2		 2vdyB-4c41A:
96.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		8 VAL A  22
GLN A 232
THR A 240
PHE A 242
ILE A 263
ASN A 264
PHE A 366
HIS A 368
 None
 0.83A 2vdyB-4c41A:
57.2		 2vdyB-4c41A:
96.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		8 VAL A  22
GLN A 232
THR A 240
PHE A 242
ILE A 263
ASN A 264
SER A 267
PHE A 366
 None
 0.63A 2vdyB-4c41A:
57.2		 2vdyB-4c41A:
96.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ekd GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(Q) SUBUNIT
ALPHA

(Mus musculus) 		PF00503
(G-alpha) 		5 VAL A 199
ILE A 348
ASN A 352
SER A 268
PHE A 201
 None
 1.42A 2vdyB-4ekdA:
undetectable		 2vdyB-4ekdA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4f THREONINE SYNTHASE

(Brucella
melitensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		5 SER A 287
THR A 409
ILE A 389
ASN A 281
SER A 305
 None
PLP  A 501 (-3.1A)
None
None
None
 1.42A 2vdyB-4f4fA:
undetectable		 2vdyB-4f4fA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn2 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		5 SER A 144
GLN A 169
THR A  64
ASN A 140
PHE A  65
 None
 1.27A 2vdyB-4gn2A:
undetectable		 2vdyB-4gn2A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Thermomonospora
curvata) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		5 SER A  18
THR A 249
PHE A 250
ILE A 227
SER A 216
 None
 1.41A 2vdyB-4lrsA:
undetectable		 2vdyB-4lrsA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mll BETA-LACTAMASE OXA-1

(Escherichia
coli) 		PF00905
(Transpeptidase) 		5 SER A 147
GLN A 172
THR A  68
ASN A 143
PHE A  69
 None
 1.27A 2vdyB-4mllA:
undetectable		 2vdyB-4mllA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 SER A 767
VAL A 786
THR A 842
PHE A 802
HIS A 804
 None
 1.26A 2vdyB-4nenA:
undetectable		 2vdyB-4nenA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY

(Homo sapiens) 		PF07686
(V-set) 		5 SER B 145
VAL B 144
PHE B 198
ILE B 211
HIS B 175
 None
 1.45A 2vdyB-4nikB:
undetectable		 2vdyB-4nikB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8u DNA POLYMERASE IV

(Escherichia
coli) 		PF00817
(IMS)
PF11798
(IMS_HHH)
PF11799
(IMS_C) 		5 SER B 140
VAL B   8
ILE B 127
PHE B  91
HIS B  86
 None
 1.31A 2vdyB-4r8uB:
undetectable		 2vdyB-4r8uB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8u DNA POLYMERASE IV

(Escherichia
coli) 		PF00817
(IMS)
PF11798
(IMS_HHH)
PF11799
(IMS_C) 		5 VAL B   8
ARG B 128
ILE B 127
PHE B  91
HIS B  86
 None
 1.38A 2vdyB-4r8uB:
undetectable		 2vdyB-4r8uB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 SER A1842
THR A1906
PHE A1918
ILE A1848
SER A1852
 None
 1.25A 2vdyB-4rh7A:
undetectable		 2vdyB-4rh7A:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rul DNA TOPOISOMERASE 1

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01396
(zf-C4_Topoisom)
PF01751
(Toprim)
PF08272
(Topo_Zn_Ribbon) 		5 SER A  29
VAL A   8
PHE A 151
ILE A  17
ASN A  18
 None
 1.42A 2vdyB-4rulA:
undetectable		 2vdyB-4rulA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3l MAJOR PILIN PROTEIN

(Streptococcus
pneumoniae) 		no annotation 5 SER A 337
PHE A 305
ILE A 244
ASN A 371
PHE A 261
 None
 1.36A 2vdyB-4s3lA:
undetectable		 2vdyB-4s3lA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		5 VAL A 314
GLN A 218
ILE A 118
SER A 216
HIS A 222
 None
 1.40A 2vdyB-4wgkA:
undetectable		 2vdyB-4wgkA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl1 DELTA-LIKE PROTEIN

(Rattus
norvegicus) 		PF01414
(DSL)
PF07657
(MNNL) 		5 SER B 170
PHE B  89
ARG B  33
ILE B  91
ASN B 101
 None
 1.29A 2vdyB-4xl1B:
undetectable		 2vdyB-4xl1B:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xlw DELTA-LIKE PROTEIN

(Rattus
norvegicus) 		PF01414
(DSL)
PF07657
(MNNL) 		5 SER B 170
PHE B  89
ARG B  33
ILE B  91
ASN B 101
 None
 1.41A 2vdyB-4xlwB:
undetectable		 2vdyB-4xlwB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr9 CALS8

(Micromonospora
echinospora) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 SER A 394
VAL A 420
PHE A 444
ARG A 419
PHE A 446
 None
 1.44A 2vdyB-4xr9A:
undetectable		 2vdyB-4xr9A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135

(Acanthamoeba
polyphaga
mimivirus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A  10
THR A 598
PHE A 268
ILE A 266
SER A 310
 None
 1.40A 2vdyB-4z26A:
undetectable		 2vdyB-4z26A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5but KTR SYSTEM POTASSIUM
UPTAKE PROTEIN B

(Bacillus
subtilis) 		PF02386
(TrkH) 		5 SER I 187
PHE I 202
ILE I 198
ASN I 195
PHE I 281
 None
 1.37A 2vdyB-5butI:
undetectable		 2vdyB-5butI:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		5 SER A 639
VAL A 603
PHE A 205
ILE A 619
ASN A 617
 None
 1.17A 2vdyB-5bv9A:
undetectable		 2vdyB-5bv9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ctm BETA-LACTAMASE

(Bacillus
pumilus) 		PF00905
(Transpeptidase) 		5 SER A 181
GLN A 200
THR A 102
ASN A 177
PHE A 103
 None
 1.29A 2vdyB-5ctmA:
undetectable		 2vdyB-5ctmA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5drz HIV ANTIBODY F240
HEAVY CHAIN
HIV ANTIBODY F240
LIGHT CHAIN

(Homo sapiens) 		no annotation 5 PHE H 100
ARG H  38
ILE H  37
SER H  35
PHE L  98
 None
 1.42A 2vdyB-5drzH:
undetectable		 2vdyB-5drzH:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e13 NON-SECRETORY
RIBONUCLEASE

(Homo sapiens) 		PF00074
(RnaseA) 		5 THR A  42
ILE A  30
ASN A  31
PHE A  43
HIS A  82
 None
 1.36A 2vdyB-5e13A:
undetectable		 2vdyB-5e13A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2f BETA-LACTAMASE YBXI

(Bacillus
subtilis) 		PF00905
(Transpeptidase) 		5 SER A 156
GLN A 175
THR A  77
ASN A 152
PHE A  78
 None
 1.35A 2vdyB-5e2fA:
undetectable		 2vdyB-5e2fA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 SER C 496
THR C 136
ILE C 420
PHE C 158
HIS C 272
 None
 1.45A 2vdyB-5fseC:
undetectable		 2vdyB-5fseC:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 HEAVY CHAIN
(ANTI-LID)

(Mus musculus) 		no annotation 5 GLN X  78
THR X  21
ARG X  98
ILE X  29
PHE X  79
 None
 1.45A 2vdyB-5gs0X:
undetectable		 2vdyB-5gs0X:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1

(Schizosaccharomyces
pombe) 		PF04146
(YTH) 		5 VAL A 391
ARG A 351
ILE A 382
SER A 378
PHE A 393
 None
 1.27A 2vdyB-5h8aA:
undetectable		 2vdyB-5h8aA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9p GALECTIN-3

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 PHE A 192
ARG A 144
ILE A 145
ASN A 160
PHE A 163
 None
TD2  A 301 (-3.5A)
None
TD2  A 301 (-4.0A)
None
 1.45A 2vdyB-5h9pA:
undetectable		 2vdyB-5h9pA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hci GPN-LOOP GTPASE 1

(Saccharomyces
cerevisiae) 		PF03029
(ATP_bind_1) 		5 THR A   5
PHE A 127
ARG A  91
ILE A  90
PHE A 131
 None
 1.29A 2vdyB-5hciA:
undetectable		 2vdyB-5hciA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		5 SER A 152
PHE A  83
ILE A  92
ASN A  93
PHE A 121
 None
 1.44A 2vdyB-5hdhA:
undetectable		 2vdyB-5hdhA:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hgc SERPIN

(Taeniopygia
guttata) 		PF00079
(Serpin) 		5 THR A 254
PHE A 256
ILE A 277
SER A 281
PHE A 380
 HCY  A 501 ( 4.1A)
HCY  A 501 (-4.8A)
HCY  A 501 ( 4.2A)
HCY  A 501 (-3.0A)
HCY  A 501 (-4.2A)
 0.62A 2vdyB-5hgcA:
43.9		 2vdyB-5hgcA:
42.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idu ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN

(Paraburkholderia
phymatum) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 SER A 127
VAL A 126
GLN A 233
ILE A 110
PHE A 177
 None
 1.31A 2vdyB-5iduA:
undetectable		 2vdyB-5iduA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm0 ALPHA-MANNOSIDASE,AL
PHA-MANNOSIDASE,ALPH
A-MANNOSIDASE

(Saccharomyces
cerevisiae) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 THR A 951
PHE A 887
ILE A 864
SER A 857
HIS A 943
 None
 1.40A 2vdyB-5jm0A:
undetectable		 2vdyB-5jm0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		no annotation 5 SER A 395
PHE A 422
ILE A 459
SER A 350
PHE A 427
 None
 1.17A 2vdyB-5lj6A:
undetectable		 2vdyB-5lj6A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		5 VAL A 209
PHE A 756
ASN A 766
SER A 185
PHE A 248
 None
 1.41A 2vdyB-5lq3A:
undetectable		 2vdyB-5lq3A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8m YTH
DOMAIN-CONTAINING
PROTEIN MMI1

(Schizosaccharomyces
pombe) 		no annotation 5 VAL A 391
ARG A 351
ILE A 382
SER A 378
PHE A 393
 None
None
None
GOL  A 502 (-2.8A)
None
 1.28A 2vdyB-5o8mA:
undetectable		 2vdyB-5o8mA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5omm CAPSID PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		5 SER A 387
VAL A 386
ARG A 356
ILE A 338
PHE A 378
 EDO  A 603 (-3.9A)
None
None
None
None
 1.41A 2vdyB-5ommA:
undetectable		 2vdyB-5ommA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9p RIBOSOME BIOGENESIS
PROTEIN 15

(Saccharomyces
cerevisiae) 		no annotation 5 SER B  96
VAL B  95
GLN B 113
PHE B 114
PHE B 111
 CL  B 206 ( 4.6A)
None
None
None
None
 1.31A 2vdyB-5t9pB:
undetectable		 2vdyB-5t9pB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veo ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Mus musculus) 		PF01663
(Phosphodiest) 		5 VAL A 235
THR A  48
ILE A 351
PHE A  51
HIS A  52
 None
 1.00A 2vdyB-5veoA:
undetectable		 2vdyB-5veoA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4t PHOTOACTIVATED
ADENYLYL CYCLASE

(Cyanobacteria) 		PF00211
(Guanylate_cyc)
PF04940
(BLUF) 		5 SER A  15
GLN A  48
ILE A  22
SER A  26
PHE A  46
 None
FMN  A 401 (-2.9A)
FMN  A 401 (-4.2A)
FMN  A 401 (-2.9A)
FMN  A 401 (-3.4A)
 1.44A 2vdyB-5x4tA:
undetectable		 2vdyB-5x4tA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR

(Synechocystis
sp. PCC 6803) 		no annotation 5 SER A 124
VAL A 123
ARG A  94
ILE A 282
SER A 280
 None
 1.25A 2vdyB-5y2wA:
undetectable		 2vdyB-5y2wA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		no annotation 5 SER A 261
VAL A 268
PHE A 372
ARG A 274
ILE A 277
 None
 1.22A 2vdyB-5yh5A:
undetectable		 2vdyB-5yh5A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 5 GLN A 770
PHE A1005
ARG A 839
ILE A 843
HIS A 952
 None
 1.22A 2vdyB-6bf6A:
undetectable		 2vdyB-6bf6A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqw BACTERIAL ACTIN ALFA

(Bacillus
subtilis) 		no annotation 5 SER A 189
VAL A 176
ILE A 215
ASN A 214
PHE A 208
 None
 1.30A 2vdyB-6bqwA:
undetectable		 2vdyB-6bqwA:
16.67