SIMILAR PATTERNS OF AMINO ACIDS FOR 2VCV_P_ASDP1224

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnv CONCANAVALIN B

(Canavalia
ensiformis) 		PF00704
(Glyco_hydro_18) 		4 LEU A  83
LEU A 172
ALA A 175
PHE A 181
 None
 0.82A 2vcvP-1cnvA:
0.0		 2vcvP-1cnvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnv CONCANAVALIN B

(Canavalia
ensiformis) 		PF00704
(Glyco_hydro_18) 		4 LEU A  83
LEU A 172
ALA A 175
PHE A 181
 None
 0.84A 2vcvP-1cnvA:
0.0		 2vcvP-1cnvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fkm PROTEIN (GYP1P)

(Saccharomyces
cerevisiae) 		PF00566
(RabGAP-TBC) 		4 LEU A 488
LEU A 619
ALA A 622
PHE A 574
 None
 0.83A 2vcvP-1fkmA:
0.6		 2vcvP-1fkmA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzj EGI

(Thermoascus
aurantiacus) 		PF00150
(Cellulase) 		4 LEU A 301
PRO A 303
ALA A 261
PHE A   4
 None
 0.84A 2vcvP-1gzjA:
0.0		 2vcvP-1gzjA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 PHE A  99
LEU A 134
ALA A 103
PHE A 115
 None
 0.86A 2vcvP-1hcyA:
0.0		 2vcvP-1hcyA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m22 PEPTIDE AMIDASE

(Stenotrophomonas
maltophilia) 		PF01425
(Amidase) 		4 LEU A 371
LEU A 385
ALA A 380
ALA A 139
 None
 0.81A 2vcvP-1m22A:
0.0		 2vcvP-1m22A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mkx PRETHROMBIN-2

(Bos taurus) 		PF00089
(Trypsin)
PF09396
(Thrombin_light) 		4 LEU K  14
LEU K 162
ALA K 183
PHE K 199
 None
 0.73A 2vcvP-1mkxK:
0.0		 2vcvP-1mkxK:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odu PUTATIVE
ALPHA-L-FUCOSIDASE

(Thermotoga
maritima) 		PF01120
(Alpha_L_fucos) 		4 LEU A 323
LEU A 321
ALA A 117
LEU A 348
 None
 0.70A 2vcvP-1oduA:
0.0		 2vcvP-1oduA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 662
ALA A 578
LEU A 571
ALA A 567
 None
 0.73A 2vcvP-1qgdA:
0.0		 2vcvP-1qgdA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		4 LEU A 438
LEU A 442
LEU A 167
ALA A 166
 None
 0.74A 2vcvP-1qhbA:
0.0		 2vcvP-1qhbA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhf PROTEIN
(PHOSPHOGLYCERATE
MUTASE)

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		4 LEU A  52
PRO A  49
LEU A  42
ALA A  38
 None
 0.75A 2vcvP-1qhfA:
undetectable		 2vcvP-1qhfA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		4 PHE A 319
ALA A 300
LEU A 297
PHE A  39
 None
 0.85A 2vcvP-1thgA:
undetectable		 2vcvP-1thgA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00106
(adh_short) 		4 LEU A 216
ALA A  17
LEU A  14
ALA A  73
 None
 0.78A 2vcvP-1uayA:
undetectable		 2vcvP-1uayA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		4 LEU A 420
LEU A 359
ALA A 358
PHE A 159
 None
 0.84A 2vcvP-1v4gA:
undetectable		 2vcvP-1v4gA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbr ENDO-1,4-BETA-XYLANA
SE B

(Thermotoga
maritima) 		PF00331
(Glyco_hydro_10) 		4 PHE A 796
LEU A 541
ALA A 551
PHE A 587
 None
 0.77A 2vcvP-1vbrA:
undetectable		 2vcvP-1vbrA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc9 NDX1

(Thermus
thermophilus) 		PF00293
(NUDIX) 		4 LEU A 108
LEU A 121
ALA A 120
PHE A  10
 None
 0.85A 2vcvP-1vc9A:
undetectable		 2vcvP-1vc9A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 LEU A 143
LEU A 144
ALA A 118
ALA A 101
 None
 0.81A 2vcvP-1vplA:
undetectable		 2vcvP-1vplA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		4 LEU C 719
PRO C 721
LEU C 687
ALA C 683
 None
 0.80A 2vcvP-1wa5C:
3.5		 2vcvP-1wa5C:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1e 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		4 LEU A 172
LEU A 217
LEU A  22
ALA A  21
 None
 0.84A 2vcvP-1x1eA:
undetectable		 2vcvP-1x1eA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x77 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF03358
(FMN_red) 		4 LEU A 170
ALA A  25
LEU A 162
ALA A 155
 None
 0.84A 2vcvP-1x77A:
undetectable		 2vcvP-1x77A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqa GLYOXALASE/BLEOMYCIN
RESISTANCE PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		4 LEU A   6
LEU A  20
ALA A  16
PHE A 106
 None
 0.80A 2vcvP-1xqaA:
undetectable		 2vcvP-1xqaA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqa GLYOXALASE/BLEOMYCIN
RESISTANCE PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		4 LEU A   8
LEU A   6
LEU A  26
PHE A  65
 None
 0.83A 2vcvP-1xqaA:
undetectable		 2vcvP-1xqaA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 LEU B 379
ALA B 218
LEU B 333
ALA B 262
 None
 0.83A 2vcvP-2amcB:
undetectable		 2vcvP-2amcB:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b42 XYLANASE INHIBITOR-I

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 LEU A 251
ALA A 345
LEU A 227
ALA A 210
 None
 0.83A 2vcvP-2b42A:
undetectable		 2vcvP-2b42A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 LEU A 228
LEU A 239
LEU A  47
ALA A  46
 None
 0.80A 2vcvP-2douA:
undetectable		 2vcvP-2douA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehw HYPOTHETICAL PROTEIN
TTHB059

(Thermus
thermophilus) 		PF11483
(DUF3209) 		4 LEU A  61
LEU A  64
LEU A  41
ALA A   8
 None
 0.77A 2vcvP-2ehwA:
undetectable		 2vcvP-2ehwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 PHE A 316
ALA A 303
LEU A 300
PHE A  70
 None
 0.59A 2vcvP-2fj0A:
undetectable		 2vcvP-2fj0A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU

(Streptococcus
pneumoniae) 		PF01895
(PhoU) 		4 LEU A 134
LEU A 133
ALA A  27
PHE A 193
 None
 0.75A 2vcvP-2i0mA:
undetectable		 2vcvP-2i0mA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l5v PROTEASOMAL
UBIQUITIN RECEPTOR
ADRM1

(Homo sapiens) 		PF16550
(RPN13_C) 		4 PHE A 377
LEU A 301
LEU A 361
ALA A 365
 None
 0.85A 2vcvP-2l5vA:
undetectable		 2vcvP-2l5vA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		4 LEU A 468
LEU A 441
ALA A 440
PHE A 411
 None
 0.84A 2vcvP-2uutA:
undetectable		 2vcvP-2uutA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1z ROP2

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		4 PHE A 325
LEU A 405
LEU A 321
ALA A 317
 None
 0.82A 2vcvP-2w1zA:
undetectable		 2vcvP-2w1zA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU B 464
LEU B 461
ALA B 529
ALA B 340
 None
None
HPA  B1780 ( 3.2A)
XAX  B1778 ( 4.1A)
 0.80A 2vcvP-2w55B:
undetectable		 2vcvP-2w55B:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 PHE A 414
PRO A 350
LEU A 334
ALA A 337
 None
 0.75A 2vcvP-2xh1A:
undetectable		 2vcvP-2xh1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF00106
(adh_short) 		4 LEU A 193
ALA A  15
LEU A  12
ALA A  73
 None
None
NAP  A 500 (-4.0A)
NAP  A 500 (-4.1A)
 0.84A 2vcvP-2yutA:
undetectable		 2vcvP-2yutA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE

(Thermus
thermophilus) 		PF03747
(ADP_ribosyl_GH) 		4 LEU A 174
ALA A 151
LEU A 148
PHE A 193
 None
 0.78A 2vcvP-2yzwA:
undetectable		 2vcvP-2yzwA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc8 N-ACYLAMINO ACID
RACEMASE

(Thermus
thermophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  86
LEU A  80
ALA A 106
ALA A   6
 None
 0.76A 2vcvP-2zc8A:
undetectable		 2vcvP-2zc8A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		4 PHE A  84
LEU A  22
LEU A 326
ALA A 333
 None
 0.79A 2vcvP-2zpaA:
undetectable		 2vcvP-2zpaA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3avs LYSINE-SPECIFIC
DEMETHYLASE 6A

(Homo sapiens) 		PF02373
(JmjC) 		4 LEU A 956
PRO A1107
LEU A 977
ALA A 976
 None
 0.80A 2vcvP-3avsA:
undetectable		 2vcvP-3avsA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt5 UNCHARACTERIZED
PROTEIN DUF305

(Deinococcus
radiodurans) 		PF03713
(DUF305) 		4 LEU A  68
LEU A  72
ALA A  51
LEU A  48
 None
 0.80A 2vcvP-3bt5A:
undetectable		 2vcvP-3bt5A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25

(Homo sapiens) 		PF05871
(ESCRT-II) 		4 PHE C 175
LEU C 149
LEU C 150
ALA C 162
 None
 0.64A 2vcvP-3cuqC:
undetectable		 2vcvP-3cuqC:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d19 CONSERVED
METALLOPROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		4 LEU A 112
LEU A  41
ALA A  56
PHE A  99
 None
 0.79A 2vcvP-3d19A:
undetectable		 2vcvP-3d19A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpi NAD+ SYNTHETASE

(Burkholderia
pseudomallei) 		PF02540
(NAD_synthase) 		4 PHE A  81
LEU A  86
LEU A 101
ALA A 106
 None
 0.85A 2vcvP-3dpiA:
undetectable		 2vcvP-3dpiA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewn THIJ/PFPI FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF01965
(DJ-1_PfpI) 		4 LEU A 181
LEU A 166
ALA A 271
ALA A 131
 None
 0.82A 2vcvP-3ewnA:
undetectable		 2vcvP-3ewnA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2

(Homo sapiens) 		PF05527
(DUF758) 		4 LEU A 184
LEU A 178
LEU A 102
ALA A 101
 None
 0.79A 2vcvP-3f4mA:
undetectable		 2vcvP-3f4mA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE

(Bartonella
henselae) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 LEU A  57
LEU A 154
LEU A 165
ALA A 168
 None
 0.82A 2vcvP-3girA:
undetectable		 2vcvP-3girA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hib PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF02889
(Sec63) 		4 PHE A1889
LEU A1983
LEU A1979
ALA A1886
 None
 0.85A 2vcvP-3hibA:
undetectable		 2vcvP-3hibA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htu VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25

(Homo sapiens) 		PF05871
(ESCRT-II) 		4 PHE A 175
LEU A 149
LEU A 150
ALA A 162
 None
 0.77A 2vcvP-3htuA:
undetectable		 2vcvP-3htuA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i47 ENOYL COA
HYDRATASE/ISOMERASE
(CROTONASE)

(Legionella
pneumophila) 		PF00378
(ECH_1) 		4 LEU A  91
ALA A 120
ALA A 104
PHE A  61
 None
 0.84A 2vcvP-3i47A:
undetectable		 2vcvP-3i47A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 PHE E 423
LEU E 247
ALA E 450
LEU E 447
 None
 0.66A 2vcvP-3kfuE:
undetectable		 2vcvP-3kfuE:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 GASTRIC INTRINSIC
FACTOR

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		4 PRO A 188
LEU A 151
ALA A 154
PHE A 199
 None
 0.85A 2vcvP-3kq4A:
undetectable		 2vcvP-3kq4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luy PROBABLE CHORISMATE
MUTASE

(Bifidobacterium
adolescentis) 		PF00800
(PDT) 		4 LEU A 180
ALA A  50
LEU A  47
ALA A  79
 None
 0.58A 2vcvP-3luyA:
undetectable		 2vcvP-3luyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myo TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 1

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		4 LEU A  59
LEU A  23
LEU A 310
ALA A 253
 None
 0.77A 2vcvP-3myoA:
undetectable		 2vcvP-3myoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		4 LEU A 313
ALA A 337
ALA A 326
PHE A 316
 None
 0.73A 2vcvP-3n0lA:
undetectable		 2vcvP-3n0lA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB

(Thermus
thermophilus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ALA A  95
LEU A  74
ALA A   5
PHE A  57
 None
 0.83A 2vcvP-3oa0A:
undetectable		 2vcvP-3oa0A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ono RIBOSE/GALACTOSE
ISOMERASE

(Vibrio
parahaemolyticus) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		4 LEU A   5
ALA A  55
LEU A  51
ALA A  77
 None
 0.83A 2vcvP-3onoA:
undetectable		 2vcvP-3onoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oox PUTATIVE 2OG-FE(II)
OXYGENASE FAMILY
PROTEIN

(Caulobacter
vibrioides) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 LEU A 198
LEU A 226
LEU A  25
ALA A 147
 None
 0.82A 2vcvP-3ooxA:
undetectable		 2vcvP-3ooxA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 PHE A 251
LEU A 281
ALA A 253
PHE A 258
 None
 0.85A 2vcvP-3otrA:
undetectable		 2vcvP-3otrA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Neisseria
meningitidis) 		PF00793
(DAHP_synth_1) 		4 LEU A  28
LEU A  32
ALA A  53
PHE A  51
 None
 0.85A 2vcvP-3stgA:
undetectable		 2vcvP-3stgA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD

(Mycobacterium
marinum) 		PF02668
(TauD) 		4 LEU A 144
LEU A 141
LEU A 201
ALA A 203
 None
 0.85A 2vcvP-3swtA:
undetectable		 2vcvP-3swtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 4 PHE B 734
LEU B 757
ALA B 760
PHE B 767
 None
 0.67A 2vcvP-3tixB:
undetectable		 2vcvP-3tixB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 PHE A2593
LEU A2516
ALA A2519
PHE A2528
 None
 0.69A 2vcvP-3vkgA:
undetectable		 2vcvP-3vkgA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 LEU A 265
LEU A 221
ALA A 186
PHE A 203
 None
 0.76A 2vcvP-3vu2A:
undetectable		 2vcvP-3vu2A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10

(Thermoanaerobacterium
saccharolyticum) 		PF00331
(Glyco_hydro_10) 		4 LEU A 154
LEU A 160
LEU A  88
ALA A 171
 None
 0.85A 2vcvP-3w25A:
undetectable		 2vcvP-3w25A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz3 TRAM PROTEIN

(Plasmid R64) 		PF11393
(T4BSS_DotI_IcmL) 		4 LEU A 122
LEU A 138
ALA A 137
PHE A 108
 None
 0.85A 2vcvP-3wz3A:
undetectable		 2vcvP-3wz3A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		4 LEU A 119
ALA A 177
LEU A 175
ALA A 157
 None
 0.82A 2vcvP-3x3yA:
undetectable		 2vcvP-3x3yA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)

(Sulfolobus
solfataricus) 		PF00266
(Aminotran_5) 		4 PHE A  96
LEU A 184
LEU A 200
LEU A  73
 None
 0.82A 2vcvP-3zrpA:
undetectable		 2vcvP-3zrpA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amm DYNE8

(Micromonospora
chersina) 		PF00698
(Acyl_transf_1) 		4 LEU A 480
LEU A 539
ALA A 542
PHE A 529
 None
 0.63A 2vcvP-4ammA:
undetectable		 2vcvP-4ammA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6g PUTATIVE ESTERASE

(Neisseria
meningitidis) 		PF00756
(Esterase) 		4 ALA A 155
LEU A 152
ALA A 200
PHE A 233
 None
 0.81A 2vcvP-4b6gA:
undetectable		 2vcvP-4b6gA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ber PHOSPHOCHOLINE
TRANSFERASE ANKX

(Legionella
pneumophila) 		PF02661
(Fic)
PF12796
(Ank_2) 		4 LEU A  25
ALA A  52
LEU A  49
PHE A 311
 None
 0.79A 2vcvP-4berA:
undetectable		 2vcvP-4berA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dna PROBABLE GLUTATHIONE
REDUCTASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 273
LEU A 117
ALA A  34
PHE A   9
 FAD  A 500 (-4.3A)
None
None
None
 0.71A 2vcvP-4dnaA:
undetectable		 2vcvP-4dnaA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		4 LEU A 488
ALA A 567
LEU A 564
ALA A 533
 None
 0.84A 2vcvP-4fusA:
undetectable		 2vcvP-4fusA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 LEU A 132
LEU A 127
LEU A 150
ALA A 146
 None
 0.75A 2vcvP-4h1sA:
undetectable		 2vcvP-4h1sA:
18.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		6 PHE A  10
LEU A 107
LEU A 108
PRO A 110
LEU A 213
ALA A 216
 None
LZ6  A 301 (-4.4A)
None
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
 0.68A 2vcvP-4hj2A:
36.3		 2vcvP-4hj2A:
90.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 LEU A 285
ALA A 309
LEU A 306
ALA A 165
 None
 0.74A 2vcvP-4i93A:
undetectable		 2vcvP-4i93A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jfc ENOYL-COA HYDRATASE

(Polaromonas sp.
JS666) 		PF00378
(ECH_1) 		4 LEU A 223
LEU A 227
ALA A 218
LEU A 214
 None
 0.76A 2vcvP-4jfcA:
undetectable		 2vcvP-4jfcA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo0 CMLA

(Streptomyces
venezuelae) 		PF12706
(Lactamase_B_2) 		4 LEU A 341
LEU A 345
LEU A  24
PHE A 313
 None
 0.81A 2vcvP-4jo0A:
undetectable		 2vcvP-4jo0A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 SILKWORM STORAGE
PROTEIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 PHE A 105
LEU A 140
ALA A 109
PHE A 121
 None
 0.56A 2vcvP-4l37A:
undetectable		 2vcvP-4l37A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Homo sapiens) 		PF01008
(IF-2B) 		4 LEU A  53
LEU A  57
ALA A  99
LEU A 103
 None
 0.55A 2vcvP-4ldqA:
undetectable		 2vcvP-4ldqA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk5 ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 LEU A  99
ALA A 128
ALA A 112
PHE A  70
 None
 0.85A 2vcvP-4lk5A:
undetectable		 2vcvP-4lk5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 PHE A 127
ALA A 191
LEU A 170
ALA A 169
 None
 0.84A 2vcvP-4o1oA:
undetectable		 2vcvP-4o1oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oca UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF01041
(DegT_DnrJ_EryC1) 		5 PRO A 156
ALA A 130
LEU A  74
ALA A  70
PHE A 205
 None
 1.34A 2vcvP-4ocaA:
undetectable		 2vcvP-4ocaA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A4397
ALA A4511
LEU A4507
PHE A4639
 None
 0.74A 2vcvP-4opeA:
undetectable		 2vcvP-4opeA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozu CORONIN

(Toxoplasma
gondii) 		PF00400
(WD40)
PF08953
(DUF1899)
PF16300
(WD40_4) 		4 PHE A 164
LEU A 184
ALA A 145
ALA A 165
 None
 0.75A 2vcvP-4ozuA:
undetectable		 2vcvP-4ozuA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		4 LEU A 191
LEU A 195
LEU A 209
ALA A 253
 None
 0.78A 2vcvP-4p58A:
undetectable		 2vcvP-4p58A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 LEU A 464
LEU A 504
PRO A 506
LEU A 509
ALA A 436
 None
 1.19A 2vcvP-4ph9A:
undetectable		 2vcvP-4ph9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmh PECTINESTERASE

(Sitophilus
oryzae) 		PF01095
(Pectinesterase) 		4 LEU A 181
LEU A 195
ALA A 234
PHE A 236
 None
 0.81A 2vcvP-4pmhA:
undetectable		 2vcvP-4pmhA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0z ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD

(Homo sapiens) 		PF02661
(Fic) 		4 PHE A 351
LEU A 376
ALA A 355
PHE A 334
 None
 0.85A 2vcvP-4u0zA:
undetectable		 2vcvP-4u0zA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		4 LEU A1316
ALA A1341
LEU A1338
ALA A1354
 None
 0.80A 2vcvP-4u48A:
1.6		 2vcvP-4u48A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um2 TELOMERASE-BINDING
PROTEIN EST1A

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		4 LEU A 595
LEU A 599
LEU A 609
PHE A 655
 None
 0.76A 2vcvP-4um2A:
3.6		 2vcvP-4um2A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 718
ALA A 742
LEU A 739
ALA A 597
 None
 0.74A 2vcvP-4xcuA:
undetectable		 2vcvP-4xcuA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 LEU A1014
LEU A1011
ALA A1079
ALA A 910
 None
None
URC  A3007 (-3.4A)
URC  A3007 (-4.0A)
 0.73A 2vcvP-4yswA:
undetectable		 2vcvP-4yswA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE

(Pseudomonas
aeruginosa) 		PF00378
(ECH_1) 		4 LEU A 114
ALA A 121
ALA A 177
PHE A 172
 None
 0.67A 2vcvP-4zu2A:
undetectable		 2vcvP-4zu2A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah4 DNA POLYMERASE III
SUBUNIT BETA

(Mycolicibacterium
smegmatis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PHE A 299
LEU A 338
ALA A 361
ALA A 271
 None
 0.83A 2vcvP-5ah4A:
undetectable		 2vcvP-5ah4A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 4 PHE A 415
LEU A 589
LEU A 586
ALA A 621
 None
 0.78A 2vcvP-5b7iA:
undetectable		 2vcvP-5b7iA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2e BETA-LACTAMASE

(Yersinia
enterocolitica) 		PF13354
(Beta-lactamase2) 		4 PHE A 128
ALA A 175
ALA A  55
PHE A  51
 None
 0.81A 2vcvP-5e2eA:
undetectable		 2vcvP-5e2eA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eog PROTEIN MAB-21-LIKE
1

(Homo sapiens) 		PF03281
(Mab-21) 		4 LEU A 321
LEU A 324
LEU A  94
ALA A 229
 None
 0.80A 2vcvP-5eogA:
undetectable		 2vcvP-5eogA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2x ADRENOCORTICAL
DYSPLASIA PROTEIN
HOMOLOG

(Homo sapiens) 		PF10341
(TPP1) 		4 PHE A 173
LEU A 183
ALA A 161
ALA A 142
 None
 0.80A 2vcvP-5i2xA:
undetectable		 2vcvP-5i2xA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq5 MACRO DOMAIN

(Mayaro virus) 		no annotation 4 LEU A 128
LEU A 129
ALA A  93
ALA A 137
 None
 0.74A 2vcvP-5iq5A:
undetectable		 2vcvP-5iq5A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj2 A-KINASE ANCHOR
PROTEIN 7 ISOFORM
GAMMA

(Homo sapiens) 		PF10469
(AKAP7_NLS) 		5 LEU A 166
LEU A 183
LEU A 193
ALA A 196
PHE A 216
 None
 1.26A 2vcvP-5jj2A:
undetectable		 2vcvP-5jj2A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm4 KINESIN-5

(Ustilago maydis) 		no annotation 4 LEU K 229
LEU K 226
LEU K 123
ALA K 134
 None
 0.77A 2vcvP-5mm4K:
undetectable		 2vcvP-5mm4K:
16.06