SIMILAR PATTERNS OF AMINO ACIDS FOR 2VCV_L_ASDL1224

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1adv ADENOVIRUS
SINGLE-STRANDED
DNA-BINDING PROTEIN

(Human
mastadenovirus
C) 		PF02236
(Viral_DNA_bi)
PF03728
(Viral_DNA_Zn_bi) 		4 PRO A 393
LEU A 476
ALA A 479
PHE A 247
 None
 1.03A 2vcvL-1advA:
0.0		 2vcvL-1advA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgc GRANULOCYTE
COLONY-STIMULATING
FACTOR

(Bos taurus) 		PF16647
(GCSF) 		4 PRO A  58
LEU A  89
ALA A  92
PHE A 141
 None
 1.00A 2vcvL-1bgcA:
2.2		 2vcvL-1bgcA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN

(Thermococcus
litoralis) 		PF01547
(SBP_bac_1) 		4 PHE A 253
LEU A 133
ALA A 252
PHE A 167
 None
 0.94A 2vcvL-1eu8A:
0.8		 2vcvL-1eu8A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2p AMINOPEPTIDASE

(Streptomyces
griseus) 		PF04389
(Peptidase_M28) 		4 PHE A 159
ALA A 271
ALA A  82
PHE A 125
 None
 0.98A 2vcvL-1f2pA:
0.0		 2vcvL-1f2pA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 PHE B 339
LEU B 157
ALA B 338
PHE B 110
 None
 1.07A 2vcvL-1ffvB:
0.0		 2vcvL-1ffvB:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A

(Sorghum bicolor) 		PF00450
(Peptidase_S10) 		4 PRO A  17
LEU A  91
ALA A  79
PHE A  22
 None
 1.01A 2vcvL-1gxsA:
0.0		 2vcvL-1gxsA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		4 PRO A 127
LEU A 120
ALA A 116
PHE A  80
 None
 1.06A 2vcvL-1hjuA:
0.0		 2vcvL-1hjuA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I

(Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 PHE A 175
ALA A 452
PHE A 127
PHE A 124
 None
 1.07A 2vcvL-1i1qA:
0.0		 2vcvL-1i1qA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 PHE B 342
LEU B 160
ALA B 341
PHE B 113
 None
 1.06A 2vcvL-1n60B:
0.0		 2vcvL-1n60B:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odt CEPHALOSPORIN C
DEACETYLASE

(Bacillus
subtilis) 		PF05448
(AXE1) 		4 PRO C 197
ALA C 190
ALA C 160
PHE C 113
 None
 0.95A 2vcvL-1odtC:
0.0		 2vcvL-1odtC:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE

(Bacillus
subtilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 278
ALA A 311
PHE A 320
PHE A 322
 None
 1.01A 2vcvL-1tkkA:
undetectable		 2vcvL-1tkkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txk GLUCANS BIOSYNTHESIS
PROTEIN G

(Escherichia
coli) 		PF04349
(MdoG) 		4 PRO A 186
ALA A 214
LEU A 209
PHE A 381
 None
 1.00A 2vcvL-1txkA:
undetectable		 2vcvL-1txkA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5j KIAA1355 PROTEIN

(Homo sapiens) 		PF00041
(fn3) 		4 PRO A  30
LEU A  37
ALA A  84
PHE A  87
 None
 1.05A 2vcvL-1v5jA:
undetectable		 2vcvL-1v5jA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Borreliella
burgdorferi) 		PF02127
(Peptidase_M18) 		4 PHE A 268
LEU A  43
ALA A  46
PHE A  51
 None
 0.83A 2vcvL-1y7eA:
undetectable		 2vcvL-1y7eA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 PRO A 372
LEU A 377
ALA A 380
PHE A 385
 None
 0.86A 2vcvL-1yq2A:
undetectable		 2vcvL-1yq2A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		4 ALA A 260
LEU A 143
ALA A 139
PHE A 169
 None
 0.96A 2vcvL-1ywfA:
undetectable		 2vcvL-1ywfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zao RIO2 SERINE KINASE

(Archaeoglobus
fulgidus) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		4 PHE A 107
ALA A 105
PHE A 121
PHE A  74
 None
 1.02A 2vcvL-1zaoA:
undetectable		 2vcvL-1zaoA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b42 XYLANASE INHIBITOR-I

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 PHE A 102
ALA A 176
LEU A   4
ALA A 104
 None
 1.00A 2vcvL-2b42A:
undetectable		 2vcvL-2b42A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chc PROTEIN RV3472

(Mycobacterium
tuberculosis) 		PF13577
(SnoaL_4) 		4 ALA A  62
LEU A 154
ALA A 158
PHE A  45
 None
 1.09A 2vcvL-2chcA:
undetectable		 2vcvL-2chcA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3y URACIL-DNA
GLYCOSYLASE

(Thermus
thermophilus) 		PF03167
(UDG) 		4 PHE A  56
PRO A 122
LEU A 127
ALA A 157
 None
 0.99A 2vcvL-2d3yA:
undetectable		 2vcvL-2d3yA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvk UPF0130 PROTEIN
APE0816

(Aeropyrum
pernix) 		PF02676
(TYW3) 		4 PHE A 177
LEU A 107
ALA A 110
PHE A 115
 None
 0.67A 2vcvL-2dvkA:
undetectable		 2vcvL-2dvkA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ea1 RIBONUCLEASE I

(Escherichia
coli) 		PF00445
(Ribonuclease_T2) 		4 LEU A 164
ALA A 160
PHE A 181
PHE A 177
 None
 1.03A 2vcvL-2ea1A:
undetectable		 2vcvL-2ea1A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 PRO A 514
ALA A 562
LEU A 560
PHE A 177
 None
 0.97A 2vcvL-2fjaA:
undetectable		 2vcvL-2fjaA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 PHE A 205
ALA A 251
LEU A 191
ALA A 203
 None
 0.85A 2vcvL-2gkoA:
undetectable		 2vcvL-2gkoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE

(Salmonella
enterica) 		PF01263
(Aldose_epim) 		4 PHE A 141
LEU A 151
ALA A 139
PHE A 119
 None
 0.98A 2vcvL-2htbA:
undetectable		 2vcvL-2htbA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i00 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 PHE A 309
PRO A 372
LEU A 365
PHE A 320
 None
 0.96A 2vcvL-2i00A:
undetectable		 2vcvL-2i00A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9d CHLORAMPHENICOL
ACETYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00302
(CAT) 		4 PHE A 205
LEU A  58
ALA A  61
PHE A  67
 None
 0.86A 2vcvL-2i9dA:
undetectable		 2vcvL-2i9dA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		4 PHE A 389
LEU A 335
ALA A 338
PHE A 501
 None
 0.96A 2vcvL-2jgpA:
undetectable		 2vcvL-2jgpA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxx ACTIN-DEPOLYMERIZING
FACTOR 2, ISOFORM C

(Caenorhabditis
elegans) 		PF00241
(Cofilin_ADF) 		4 PHE A  29
ALA A  14
ALA A  71
PHE A  94
 None
 0.87A 2vcvL-2lxxA:
undetectable		 2vcvL-2lxxA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q03 UNCHARACTERIZED
PROTEIN

(Shewanella
denitrificans) 		PF11528
(DUF3224) 		4 ALA A 128
ALA A  96
PHE A  91
PHE A  66
 None
 0.87A 2vcvL-2q03A:
undetectable		 2vcvL-2q03A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsj DNA-BINDING RESPONSE
REGULATOR, LUXR
FAMILY

(Ruegeria
pomeroyi) 		PF00072
(Response_reg) 		4 PHE A 125
ALA A 107
LEU A 112
ALA A 115
 None
 0.78A 2vcvL-2qsjA:
undetectable		 2vcvL-2qsjA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		4 ALA A 449
LEU A 429
ALA A 432
PHE A 408
 None
 0.86A 2vcvL-2r4jA:
undetectable		 2vcvL-2r4jA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 PHE A 414
PRO A 350
LEU A 334
ALA A 337
 None
 0.81A 2vcvL-2xh1A:
undetectable		 2vcvL-2xh1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9s PEROXIREDOXIN-1

(Rattus
norvegicus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ALA A  19
LEU A 104
ALA A  76
PHE A  43
 None
 0.94A 2vcvL-2z9sA:
2.1		 2vcvL-2z9sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9s PEROXIREDOXIN-1

(Rattus
norvegicus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 PRO A 103
ALA A  19
LEU A 104
ALA A  76
 None
 1.07A 2vcvL-2z9sA:
2.1		 2vcvL-2z9sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhy ATP:COB(I)ALAMIN
ADENOSYLTRANSFERASE,
PUTATIVE

(Burkholderia
thailandensis) 		PF01923
(Cob_adeno_trans) 		4 PRO A  55
ALA A 169
LEU A 166
ALA A 115
 None
 1.08A 2vcvL-2zhyA:
undetectable		 2vcvL-2zhyA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anv D-SERINE DEHYDRATASE

(Gallus gallus) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 PRO A  90
LEU A  69
ALA A  72
PHE A 107
 None
 0.99A 2vcvL-3anvA:
undetectable		 2vcvL-3anvA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Rattus
norvegicus) 		PF06325
(PrmA) 		4 PRO A 297
LEU A 435
ALA A 429
PHE A 428
 None
 0.99A 2vcvL-3b3jA:
undetectable		 2vcvL-3b3jA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkh LYTIC
TRANSGLYCOSYLASE

(Pseudomonas
virus phiKZ) 		PF01464
(SLT)
PF01471
(PG_binding_1) 		4 PHE A 133
LEU A 109
ALA A 112
PHE A 118
 None
 0.94A 2vcvL-3bkhA:
undetectable		 2vcvL-3bkhA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 PHE A1269
LEU A1186
ALA A1189
PHE A1330
 None
 0.82A 2vcvL-3c1xA:
undetectable		 2vcvL-3c1xA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 LEU A 675
ALA A 678
PHE A 598
PHE A 706
 None
 0.95A 2vcvL-3dwbA:
2.8		 2vcvL-3dwbA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		4 ALA A 167
ALA A 299
PHE A 344
PHE A 347
 None
 0.99A 2vcvL-3e1tA:
undetectable		 2vcvL-3e1tA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvr ACETYL XYLAN
ESTERASE

(Bacillus
pumilus) 		PF05448
(AXE1) 		4 PRO A 197
ALA A 190
ALA A 160
PHE A 113
 None
 1.02A 2vcvL-3fvrA:
undetectable		 2vcvL-3fvrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvr ACETYL XYLAN
ESTERASE

(Bacillus
pumilus) 		PF05448
(AXE1) 		4 PRO A 197
LEU A 161
ALA A 157
PHE A  88
 None
 0.92A 2vcvL-3fvrA:
undetectable		 2vcvL-3fvrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2i ESTERASE

(Xanthomonas
oryzae) 		PF03583
(LIP) 		4 PHE A 310
PRO A 208
LEU A 139
ALA A 238
 None
 1.09A 2vcvL-3h2iA:
undetectable		 2vcvL-3h2iA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 PHE A 104
ALA A 178
LEU A   6
ALA A 106
 None
 0.94A 2vcvL-3hd8A:
undetectable		 2vcvL-3hd8A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG

(Homo sapiens) 		PF03932
(CutC) 		4 LEU A 264
ALA A 268
PHE A  26
PHE A 221
 None
 1.09A 2vcvL-3iwpA:
undetectable		 2vcvL-3iwpA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 PHE A 149
ALA A 112
LEU A 116
ALA A 119
 None
 0.84A 2vcvL-3jb9A:
undetectable		 2vcvL-3jb9A:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 PHE A 226
ALA A 326
PHE A 323
PHE A 259
 None
 0.94A 2vcvL-3js8A:
undetectable		 2vcvL-3js8A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu INTEGRIN-LINKED
KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 PHE A 378
LEU A 299
ALA A 302
PHE A 439
 None
 0.83A 2vcvL-3kmuA:
undetectable		 2vcvL-3kmuA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 GASTRIC INTRINSIC
FACTOR

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		4 PRO A 188
LEU A 151
ALA A 154
PHE A 199
 None
 0.98A 2vcvL-3kq4A:
2.2		 2vcvL-3kq4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l76 ASPARTOKINASE

(Synechocystis
sp. PCC 6803) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		4 PHE A 547
LEU A 581
ALA A 584
PHE A 588
 None
 0.44A 2vcvL-3l76A:
undetectable		 2vcvL-3l76A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		4 PRO A 160
ALA A 215
LEU A 211
ALA A 178
 None
 1.06A 2vcvL-3m6xA:
undetectable		 2vcvL-3m6xA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzy RNA POLYMERASE
SIGMA-H FACTOR

(Fusobacterium
nucleatum) 		PF04542
(Sigma70_r2) 		4 LEU A  55
ALA A  58
PHE A  72
PHE A  69
 None
 1.04A 2vcvL-3mzyA:
undetectable		 2vcvL-3mzyA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY

(Shewanella
oneidensis) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 PHE A  68
PRO A 157
ALA A  71
PHE A  49
 None
 0.97A 2vcvL-3on7A:
undetectable		 2vcvL-3on7A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pi7 NADH OXIDOREDUCTASE

(Mesorhizobium
loti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PHE A 109
PRO A 348
ALA A  58
ALA A 123
 None
 0.95A 2vcvL-3pi7A:
undetectable		 2vcvL-3pi7A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 PHE A1273
LEU A1190
ALA A1193
PHE A1334
 None
 0.81A 2vcvL-3plsA:
undetectable		 2vcvL-3plsA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 4 PHE B 734
LEU B 757
ALA B 760
PHE B 767
 None
 0.66A 2vcvL-3tixB:
undetectable		 2vcvL-3tixB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3utn THIOSULFATE
SULFURTRANSFERASE
TUM1

(Saccharomyces
cerevisiae) 		PF00581
(Rhodanese) 		4 ALA X 271
LEU X 238
ALA X 241
PHE X 245
 None
 0.80A 2vcvL-3utnX:
undetectable		 2vcvL-3utnX:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 PHE A2593
LEU A2516
ALA A2519
PHE A2528
 None
 0.50A 2vcvL-3vkgA:
undetectable		 2vcvL-3vkgA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bev COPPER EFFLUX ATPASE

(Legionella
pneumophila) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 PRO A 383
ALA A 685
LEU A 386
ALA A 336
 None
 1.05A 2vcvL-4bevA:
undetectable		 2vcvL-4bevA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A

(Escherichia
coli) 		PF03749
(SfsA) 		4 PHE A 177
ALA A  92
LEU A  88
ALA A 179
 None
 1.00A 2vcvL-4dapA:
undetectable		 2vcvL-4dapA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli) 		PF00294
(PfkB) 		4 PHE A 282
LEU A 252
ALA A 241
PHE A 211
 None
 1.02A 2vcvL-4e3aA:
undetectable		 2vcvL-4e3aA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 PHE A 320
LEU A 129
ALA A 132
PHE A  58
 None
 0.77A 2vcvL-4jzaA:
undetectable		 2vcvL-4jzaA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 PRO A 119
ALA A 115
LEU A  75
ALA A  96
 None
 0.97A 2vcvL-4k9qA:
undetectable		 2vcvL-4k9qA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt3 UNCHARACTERIZED
PROTEIN

(Pseudomonas
protegens) 		PF01832
(Glucosaminidase) 		4 PHE A  85
LEU A  63
ALA A  66
PHE A  40
 None
 0.81A 2vcvL-4kt3A:
undetectable		 2vcvL-4kt3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nyn RIBONUCLEASE HI

(Halobacterium
salinarum) 		PF13456
(RVT_3) 		4 LEU A 123
ALA A 126
PHE A 131
PHE A 172
 None
 0.81A 2vcvL-4nynA:
undetectable		 2vcvL-4nynA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6q HASAP

(Pseudomonas
aeruginosa) 		PF06438
(HasA) 		4 LEU A  85
ALA A  75
PHE A  51
PHE A  46
 HEM  A 202 (-3.7A)
FMT  A 201 (-3.6A)
HEM  A 202 ( 4.9A)
None
 0.86A 2vcvL-4o6qA:
undetectable		 2vcvL-4o6qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh7 ORNITHINE
CARBAMOYLTRANSFERASE

(Brucella
melitensis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 171
ALA A 174
PHE A 178
PHE A 180
 None
 0.54A 2vcvL-4oh7A:
undetectable		 2vcvL-4oh7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 ALA A 795
LEU A 792
ALA A 867
PHE A 865
 None
 1.02A 2vcvL-4pd3A:
2.4		 2vcvL-4pd3A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlv ADP-RIBOSYLATING
TOXIN CARDS

(Mycoplasma
pneumoniae) 		PF02917
(Pertussis_S1) 		4 PHE A 127
PRO A 210
ALA A 213
ALA A 122
 None
 0.89A 2vcvL-4tlvA:
undetectable		 2vcvL-4tlvA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5

(Homo sapiens) 		PF01088
(Peptidase_C12) 		4 LEU A 130
ALA A  80
PHE A  79
PHE A  78
 None
 0.95A 2vcvL-4wlpA:
undetectable		 2vcvL-4wlpA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		4 ALA A 299
LEU A 295
ALA A  67
PHE A  63
 None
None
None
X9X  A 401 (-3.5A)
 0.91A 2vcvL-4wt7A:
3.0		 2vcvL-4wt7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9e DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Escherichia
coli) 		PF01966
(HD) 		4 PHE A  55
LEU A 277
ALA A 280
PHE A 286
 None
 0.98A 2vcvL-4x9eA:
undetectable		 2vcvL-4x9eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00632
(HECT) 		4 PHE A 502
ALA A 732
LEU A 734
PHE A 740
 None
 0.88A 2vcvL-4y07A:
2.3		 2vcvL-4y07A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yok PUTATIVE FLAGELLAR
PROTEIN FLIS

(Parabacteroides
merdae) 		PF12866
(DUF3823) 		4 ALA A 189
LEU A 187
ALA A 140
PHE A 142
 None
 0.99A 2vcvL-4yokA:
undetectable		 2vcvL-4yokA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avo HOMOSERINE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 PHE A 195
ALA A 106
ALA A 198
PHE A 220
 None
 1.02A 2vcvL-5avoA:
undetectable		 2vcvL-5avoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		4 LEU A 115
ALA A 118
PHE A 122
PHE A 229
 None
 0.95A 2vcvL-5ck7A:
undetectable		 2vcvL-5ck7A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1w RV3249C
TRANSCRIPTIONAL
REGULATOR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 LEU A 168
ALA A 202
PHE A  97
PHE A 101
 None
None
None
PLM  A 301 (-4.8A)
 0.92A 2vcvL-5d1wA:
2.3		 2vcvL-5d1wA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG

(Homo sapiens) 		PF02724
(CDC45) 		4 ALA A  32
LEU A  36
PHE A   6
PHE A  10
 None
 0.84A 2vcvL-5dgoA:
1.4		 2vcvL-5dgoA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diz PROTEINACEOUS RNASE
P 2

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		4 ALA A 429
LEU A 426
PHE A 454
PHE A 455
 None
 0.97A 2vcvL-5dizA:
2.6		 2vcvL-5dizA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ

(Salmonella
enterica) 		PF01832
(Glucosaminidase) 		4 PHE A 204
LEU A 178
ALA A 181
PHE A 155
 None
 0.88A 2vcvL-5dn5A:
undetectable		 2vcvL-5dn5A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2e BETA-LACTAMASE

(Yersinia
enterocolitica) 		PF13354
(Beta-lactamase2) 		4 PHE A 128
ALA A 175
ALA A  55
PHE A  51
 None
 0.76A 2vcvL-5e2eA:
undetectable		 2vcvL-5e2eA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		4 PHE A 207
ALA A 253
LEU A 193
ALA A 205
 None
 0.93A 2vcvL-5ffnA:
undetectable		 2vcvL-5ffnA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 LINOLEATE
11-LIPOXYGENASE

(Gaeumannomyces
avenae) 		PF00305
(Lipoxygenase) 		4 PRO A 609
LEU A 404
ALA A 407
PHE A 575
 None
 0.99A 2vcvL-5fx8A:
1.2		 2vcvL-5fx8A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw9 GRANULOCYTE
COLONY-STIMULATING
FACTOR

(Homo sapiens) 		PF16647
(GCSF) 		4 PRO A  58
LEU A  89
ALA A  92
PHE A 141
 None
 0.84A 2vcvL-5gw9A:
undetectable		 2vcvL-5gw9A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h55 MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Kluyveromyces
lactis) 		no annotation 4 PRO A 166
LEU A 136
ALA A 138
PHE A  66
 None
 1.05A 2vcvL-5h55A:
undetectable		 2vcvL-5h55A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 PHE A1269
LEU A1186
ALA A1189
PHE A1330
 None
 0.82A 2vcvL-5horA:
undetectable		 2vcvL-5horA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ji5 BUPHA.10154.A.B1

(Paraburkholderia
phymatum) 		PF00850
(Hist_deacetyl) 		4 LEU A  95
ALA A  94
PHE A 137
PHE A 138
 None
 1.07A 2vcvL-5ji5A:
undetectable		 2vcvL-5ji5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 PHE A 298
ALA A 336
ALA A 300
PHE A 289
 None
 0.84A 2vcvL-5k6oA:
undetectable		 2vcvL-5k6oA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN

(Mus musculus) 		PF08205
(C2-set_2)
PF13927
(Ig_3) 		4 PHE A 221
LEU A 172
ALA A 219
PHE A 228
 None
 1.07A 2vcvL-5lfrA:
undetectable		 2vcvL-5lfrA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 PHE A 279
ALA A 264
LEU A 261
PHE A  42
 None
None
MLY  A 256 ( 4.9A)
None
 0.93A 2vcvL-5thmA:
undetectable		 2vcvL-5thmA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqz GLUCAN-BINDING
PROTEIN C, GBPC

(Streptococcus
mutans) 		no annotation 4 PRO A 416
ALA A 457
ALA A 453
PHE A 452
 None
 0.92A 2vcvL-5uqzA:
undetectable		 2vcvL-5uqzA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		4 PHE A 111
PRO A 302
LEU A 226
PHE A 145
 None
 0.84A 2vcvL-5w1uA:
undetectable		 2vcvL-5w1uA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		4 LEU A 102
ALA A 105
PHE A  81
PHE A  82
 None
 0.83A 2vcvL-5xwbA:
undetectable		 2vcvL-5xwbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y5a KLLA0F20702P

(Kluyveromyces
lactis) 		no annotation 4 PHE A 432
LEU A 473
ALA A 476
PHE A 577
 None
 0.98A 2vcvL-5y5aA:
4.0		 2vcvL-5y5aA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bg8 IG DOMAIN PROTEIN,
GROUP 2 DOMAIN
PROTEIN

(Shewanella
frigidimarina) 		no annotation 4 PRO A 116
LEU A 119
PHE A 154
PHE A 156
 None
 0.88A 2vcvL-6bg8A:
undetectable		 2vcvL-6bg8A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 4 PRO A 635
ALA A 466
PHE A 619
PHE A 622
 None
 1.02A 2vcvL-6c0tA:
undetectable		 2vcvL-6c0tA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo sapiens) 		no annotation 4 PRO A 296
LEU A 434
ALA A 428
PHE A 427
 None
 0.97A 2vcvL-6d2lA:
undetectable		 2vcvL-6d2lA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 PRO A 371
LEU A 376
ALA A 379
PHE A 384
 None
 0.97A 2vcvL-6etzA:
undetectable		 2vcvL-6etzA:
17.45