SIMILAR PATTERNS OF AMINO ACIDS FOR 2VCV_K_ASDK1224

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b74 GLUTAMATE RACEMASE

(Aquifex
pyrophilus) 		PF01177
(Asp_Glu_race) 		4 PHE A   6
LEU A  78
LEU A  52
ALA A  55
 None
 0.96A 2vcvK-1b74A:
2.0		 2vcvK-1b74A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpc C-PHYCOCYANIN (BETA
SUBUNIT)

(Microchaete
diplosiphon) 		PF00502
(Phycobilisome) 		4 LEU B  92
ALA B 139
LEU B 141
ALA B 144
 None
 0.93A 2vcvK-1cpcB:
undetectable		 2vcvK-1cpcB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dub 2-ENOYL-COA
HYDRATASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 PHE A 160
LEU A 218
ALA A 132
ALA A 138
 None
 0.93A 2vcvK-1dubA:
undetectable		 2vcvK-1dubA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ga8 GALACTOSYL
TRANSFERASE LGTC

(Neisseria
meningitidis) 		PF01501
(Glyco_transf_8) 		4 LEU A 271
PRO A 275
ALA A  47
ALA A  12
 None
 0.94A 2vcvK-1ga8A:
0.0		 2vcvK-1ga8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 LEU A  22
ALA A 324
LEU A 621
ALA A 620
 None
 0.97A 2vcvK-1h39A:
4.0		 2vcvK-1h39A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la1 GROEL

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		4 LEU A 221
ALA A 275
LEU A 262
ALA A 258
 None
 0.89A 2vcvK-1la1A:
undetectable		 2vcvK-1la1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A  30
ALA A  35
LEU A  56
ALA A  43
 None
 0.84A 2vcvK-1mdfA:
undetectable		 2vcvK-1mdfA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 LEU E 196
ALA E 190
LEU E 187
ALA E 220
 None
 0.84A 2vcvK-1nfiE:
1.0		 2vcvK-1nfiE:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 PHE A  98
ALA A 168
LEU A 169
ALA A  97
 None
 0.89A 2vcvK-1nowA:
undetectable		 2vcvK-1nowA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 285
ALA A 131
LEU A 150
ALA A 281
 None
 0.93A 2vcvK-1pxtA:
undetectable		 2vcvK-1pxtA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1

(Homo sapiens) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		4 LEU A 215
ALA A 253
LEU A 250
ALA A 192
 None
 0.97A 2vcvK-1q8kA:
undetectable		 2vcvK-1q8kA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhf PROTEIN
(PHOSPHOGLYCERATE
MUTASE)

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		4 LEU A  52
PRO A  49
LEU A  42
ALA A  38
 None
 0.94A 2vcvK-1qhfA:
undetectable		 2vcvK-1qhfA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
ALPHA-SUBUNIT

(Pseudomonas
putida) 		PF00676
(E1_dh)
PF12573
(OxoDH_E1alpha_N) 		4 LEU A 301
PRO A 299
ALA A 228
ALA A 191
 None
 0.92A 2vcvK-1qs0A:
undetectable		 2vcvK-1qs0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
ALPHA-SUBUNIT

(Pseudomonas
putida) 		PF00676
(E1_dh)
PF12573
(OxoDH_E1alpha_N) 		4 PHE A 188
PRO A 299
ALA A 228
ALA A 209
 None
 0.97A 2vcvK-1qs0A:
undetectable		 2vcvK-1qs0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 PHE A 295
ALA A  73
LEU A  75
ALA A  78
 None
 0.88A 2vcvK-1r9jA:
undetectable		 2vcvK-1r9jA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		4 PHE A 223
LEU A 251
ALA A 258
LEU A 260
 None
 0.94A 2vcvK-1up2A:
undetectable		 2vcvK-1up2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 249
PRO A 237
ALA A 233
LEU A 236
ALA A 272
 None
None
None
MYR  A1001 ( 4.4A)
None
 1.48A 2vcvK-1v26A:
1.3		 2vcvK-1v26A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF00291
(PALP) 		4 LEU A  88
ALA A 136
LEU A 130
ALA A 127
 None
 0.82A 2vcvK-1ve1A:
undetectable		 2vcvK-1ve1A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		4 PHE A 372
LEU A 394
ALA A 389
ALA A 362
 None
 0.78A 2vcvK-1vefA:
undetectable		 2vcvK-1vefA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		4 LEU A 105
ALA A  92
LEU A  62
ALA A 135
 None
 0.95A 2vcvK-1wcxA:
undetectable		 2vcvK-1wcxA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz8 ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		4 LEU A  75
ALA A 118
LEU A  42
ALA A  43
 MPD  A3003 (-4.7A)
MPD  A3003 ( 3.8A)
None
None
 0.97A 2vcvK-1wz8A:
undetectable		 2vcvK-1wz8A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x77 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF03358
(FMN_red) 		4 PHE A 156
LEU A 114
ALA A 167
ALA A 152
 None
None
None
FMN  A 200 ( 4.8A)
 0.83A 2vcvK-1x77A:
undetectable		 2vcvK-1x77A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm9 PLAKOPHILIN 1

(Homo sapiens) 		PF00514
(Arm) 		4 LEU A 465
ALA A 550
LEU A 458
ALA A 527
 None
 0.99A 2vcvK-1xm9A:
3.5		 2vcvK-1xm9A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF01717
(Meth_synt_2) 		4 PRO A 140
ALA A 224
LEU A 165
ALA A 162
 None
 0.89A 2vcvK-1ypxA:
undetectable		 2vcvK-1ypxA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq3 SUCCINATE
DEHYDROGENASE IP
SUBUNIT

(Gallus gallus) 		PF13085
(Fer2_3)
PF13534
(Fer4_17) 		4 LEU B 203
ALA B 187
LEU B 184
ALA B 234
 None
 0.92A 2vcvK-1yq3B:
undetectable		 2vcvK-1yq3B:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		4 LEU A 132
ALA A 139
LEU A 141
ALA A 145
 None
 0.93A 2vcvK-1yt8A:
undetectable		 2vcvK-1yt8A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zud ADENYLYLTRANSFERASE
THIF

(Escherichia
coli) 		PF00899
(ThiF) 		4 LEU 1  36
ALA 1  43
LEU 1  45
ALA 1  48
 None
 0.92A 2vcvK-1zud1:
undetectable		 2vcvK-1zud1:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 350
LEU A 316
PRO A 346
LEU A 420
ALA A 417
 FAD  A 480 ( 4.8A)
FAD  A 480 (-3.7A)
None
None
None
 1.17A 2vcvK-2a8xA:
1.8		 2vcvK-2a8xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 245
ALA A 215
LEU A 276
ALA A 278
 None
 0.94A 2vcvK-2ag1A:
undetectable		 2vcvK-2ag1A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bco SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio
parahaemolyticus) 		PF04952
(AstE_AspA) 		4 PHE A 184
LEU A 154
ALA A 167
ALA A 188
 None
 0.99A 2vcvK-2bcoA:
undetectable		 2vcvK-2bcoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkk DESIGNED ANKYRIN
REPEAT INHIBITOR
AR_3A

(synthetic
construct) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU B 126
ALA B 120
LEU B 117
ALA B 149
 None
 0.92A 2vcvK-2bkkB:
undetectable		 2vcvK-2bkkB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzn GMP REDUCTASE 2

(Homo sapiens) 		PF00478
(IMPDH) 		4 PHE A 266
ALA A  53
LEU A 245
ALA A 246
 None
IMP  A1338 (-3.4A)
None
None
 0.93A 2vcvK-2bznA:
undetectable		 2vcvK-2bznA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 PHE A 471
LEU A 451
ALA A 435
LEU A 483
 None
 0.99A 2vcvK-2cfmA:
undetectable		 2vcvK-2cfmA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 LEU A 357
ALA A 367
LEU A 365
ALA A 299
 None
 0.95A 2vcvK-2douA:
undetectable		 2vcvK-2douA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		4 PHE A 113
LEU A 313
ALA A  96
LEU A  93
 None
 0.89A 2vcvK-2e7uA:
undetectable		 2vcvK-2e7uA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ed7 NETRIN RECEPTOR DCC

(Homo sapiens) 		PF00041
(fn3) 		4 LEU A  74
PRO A  21
ALA A  93
ALA A  44
 None
 0.98A 2vcvK-2ed7A:
undetectable		 2vcvK-2ed7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 464
LEU A 177
PRO A 174
LEU A 492
ALA A 494
 None
 1.48A 2vcvK-2f9qA:
undetectable		 2vcvK-2f9qA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 PHE A  51
LEU A   5
ALA A 288
LEU A  86
ALA A  85
 None
 1.36A 2vcvK-2ffhA:
undetectable		 2vcvK-2ffhA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqz R.ECL18KI

(Enterobacter
cloacae) 		PF09019
(EcoRII-C) 		4 LEU A 161
ALA A 255
LEU A 252
ALA A 135
 None
 0.99A 2vcvK-2fqzA:
1.4		 2vcvK-2fqzA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 PHE A  65
ALA A 135
LEU A 136
ALA A  64
 None
 0.93A 2vcvK-2gjxA:
undetectable		 2vcvK-2gjxA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l52 METHANOSARCINA
ACETIVORANS SAMP1
HOMOLOG

(Methanosarcina
acetivorans) 		PF02597
(ThiS) 		4 PRO A  94
ALA A  12
LEU A  14
ALA A  17
 None
 0.86A 2vcvK-2l52A:
undetectable		 2vcvK-2l52A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l5v PROTEASOMAL
UBIQUITIN RECEPTOR
ADRM1

(Homo sapiens) 		PF16550
(RPN13_C) 		4 PHE A 377
LEU A 301
LEU A 361
ALA A 365
 None
 0.94A 2vcvK-2l5vA:
undetectable		 2vcvK-2l5vA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n2z NON-SPECIFIC
LIPID-TRANSFER
PROTEIN

(Anethum
graveolens) 		PF00234
(Tryp_alpha_amyl) 		4 LEU A  10
ALA A  49
LEU A   1
ALA A  39
 None
 0.96A 2vcvK-2n2zA:
undetectable		 2vcvK-2n2zA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 PHE A  51
LEU A   5
ALA A 288
LEU A  86
ALA A  85
 None
 1.33A 2vcvK-2ng1A:
undetectable		 2vcvK-2ng1A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 344
PRO A 290
ALA A 317
LEU A 320
 None
 0.68A 2vcvK-2og9A:
undetectable		 2vcvK-2og9A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		4 PHE A 209
LEU A 270
ALA A 251
ALA A 224
 None
 0.91A 2vcvK-2pkgA:
3.0		 2vcvK-2pkgA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsj DNA-BINDING RESPONSE
REGULATOR, LUXR
FAMILY

(Ruegeria
pomeroyi) 		PF00072
(Response_reg) 		4 PHE A 125
ALA A 107
LEU A 112
ALA A 115
 None
 0.98A 2vcvK-2qsjA:
undetectable		 2vcvK-2qsjA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A 243
ALA A 103
LEU A  99
ALA A  34
 None
 0.97A 2vcvK-2r9lA:
undetectable		 2vcvK-2r9lA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfk AKAP18 DELTA

(Homo sapiens) 		PF10469
(AKAP7_NLS) 		4 LEU A 171
ALA A 196
LEU A 198
ALA A 201
 None
 0.89A 2vcvK-2vfkA:
undetectable		 2vcvK-2vfkA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 LEU A 422
ALA A 254
LEU A 256
ALA A 259
 None
 0.98A 2vcvK-2vxoA:
undetectable		 2vcvK-2vxoA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1z ROP2

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		4 PHE A 325
LEU A 405
LEU A 321
ALA A 317
 None
 0.88A 2vcvK-2w1zA:
undetectable		 2vcvK-2w1zA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00342
(PGI) 		4 PRO A 201
ALA A 232
LEU A 229
ALA A 237
 None
 0.97A 2vcvK-2wu8A:
undetectable		 2vcvK-2wu8A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 PHE A 414
PRO A 350
LEU A 334
ALA A 337
 None
 0.86A 2vcvK-2xh1A:
undetectable		 2vcvK-2xh1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS

(Mycobacterium
tuberculosis) 		PF12282
(H_kinase_N) 		5 PHE A 181
LEU A 265
ALA A 150
LEU A 148
ALA A 145
 None
None
None
BR  A1302 ( 4.9A)
BR  A1302 ( 4.2A)
 1.31A 2vcvK-2ykfA:
undetectable		 2vcvK-2ykfA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF00106
(adh_short) 		4 LEU A 193
ALA A  15
LEU A  12
ALA A  73
 None
None
NAP  A 500 (-4.0A)
NAP  A 500 (-4.1A)
 0.94A 2vcvK-2yutA:
undetectable		 2vcvK-2yutA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvx MG2+ TRANSPORTER
MGTE

(Thermus
thermophilus) 		PF00571
(CBS)
PF01769
(MgtE)
PF03448
(MgtE_N) 		4 LEU A 366
ALA A 401
LEU A 403
ALA A 406
 None
 0.89A 2vcvK-2yvxA:
undetectable		 2vcvK-2yvxA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 PHE A  86
LEU A  77
ALA A 138
LEU A  84
ALA A 117
 None
 1.45A 2vcvK-2yxzA:
undetectable		 2vcvK-2yxzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhy ATP:COB(I)ALAMIN
ADENOSYLTRANSFERASE,
PUTATIVE

(Burkholderia
thailandensis) 		PF01923
(Cob_adeno_trans) 		4 PRO A  55
ALA A 169
LEU A 166
ALA A 115
 None
 0.87A 2vcvK-2zhyA:
undetectable		 2vcvK-2zhyA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 LEU A 165
ALA A 102
LEU A 139
ALA A 142
 FPP  A1002 ( 4.6A)
FPP  A1002 (-4.1A)
None
None
 0.91A 2vcvK-3aq0A:
1.0		 2vcvK-3aq0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 LEU A 197
ALA A 102
LEU A 139
ALA A 142
 None
FPP  A1002 (-4.1A)
None
None
 0.87A 2vcvK-3aq0A:
1.0		 2vcvK-3aq0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		4 LEU B 174
ALA B  79
LEU B 116
ALA B 119
 None
2DE  B 329 ( 4.4A)
2DE  B 329 ( 4.6A)
None
 0.97A 2vcvK-3aqcB:
undetectable		 2vcvK-3aqcB:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		4 LEU A 513
PRO A 469
LEU A 466
ALA A 491
 None
 0.98A 2vcvK-3auoA:
undetectable		 2vcvK-3auoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3avs LYSINE-SPECIFIC
DEMETHYLASE 6A

(Homo sapiens) 		PF02373
(JmjC) 		4 LEU A 956
PRO A1107
LEU A 977
ALA A 976
 None
 0.90A 2vcvK-3avsA:
0.4		 2vcvK-3avsA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		PF00073
(Rhv)
no annotation 		4 LEU A 113
ALA B 103
LEU B 100
ALA B  48
 None
 0.98A 2vcvK-3cjiA:
undetectable		 2vcvK-3cjiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cm1 SSGA-LIKE
SPORULATION-SPECIFIC
CELL DIVISION
PROTEIN

(Thermobifida
fusca) 		PF04686
(SsgA) 		4 PHE A  44
LEU A  61
ALA A 102
ALA A  28
 None
 0.98A 2vcvK-3cm1A:
undetectable		 2vcvK-3cm1A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dad FH1/FH2
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 4 PHE A 146
LEU A 124
LEU A 139
ALA A 183
 None
 0.90A 2vcvK-3dadA:
2.1		 2vcvK-3dadA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2n CYTOCHROME C
PEROXIDASE

(Pisum sativum;
Saccharomyces
cerevisiae) 		PF00141
(peroxidase) 		5 PHE A 259
LEU A 170
ALA A 108
LEU A  39
ALA A  43
 None
HEM  A 296 ( 4.8A)
None
None
None
 1.44A 2vcvK-3e2nA:
undetectable		 2vcvK-3e2nA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs2 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Brucella
melitensis) 		PF00793
(DAHP_synth_1) 		5 PHE A 236
LEU A 186
ALA A 227
LEU A 224
ALA A 200
 None
 1.17A 2vcvK-3fs2A:
undetectable		 2vcvK-3fs2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbh NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Staphylococcus
epidermidis) 		PF00881
(Nitroreductase) 		4 LEU A  78
ALA A 187
LEU A  85
ALA A  56
 None
 0.80A 2vcvK-3gbhA:
undetectable		 2vcvK-3gbhA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbp GALACTOSE-BINDING
PROTEIN

(Salmonella
enterica) 		PF13407
(Peripla_BP_4) 		4 LEU A  67
ALA A  98
LEU A  99
ALA A 105
 None
 0.98A 2vcvK-3gbpA:
undetectable		 2vcvK-3gbpA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvz UNCHARACTERIZED
PROTEIN CV2077

(Chromobacterium
violaceum) 		PF03417
(AAT) 		4 LEU A 218
ALA A  43
LEU A  41
ALA A  31
 None
 0.83A 2vcvK-3gvzA:
undetectable		 2vcvK-3gvzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 PHE C 260
LEU C 253
ALA C 267
ALA C 309
 None
 0.92A 2vcvK-3gzdC:
undetectable		 2vcvK-3gzdC:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 LEU A 549
ALA A 399
LEU A 396
ALA A 373
 None
NA  A 574 (-3.6A)
None
None
 0.99A 2vcvK-3hwwA:
undetectable		 2vcvK-3hwwA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4r A-KINASE ANCHOR
PROTEIN 18

(Homo sapiens) 		PF10469
(AKAP7_NLS)
PF10470
(AKAP7_RIRII_bdg) 		4 LEU A 171
ALA A 196
LEU A 198
ALA A 201
 None
 0.93A 2vcvK-3j4rA:
undetectable		 2vcvK-3j4rA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		4 LEU A 383
ALA A 437
LEU A 439
ALA A 442
 None
 0.93A 2vcvK-3k5wA:
undetectable		 2vcvK-3k5wA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 PHE E 423
LEU E 247
ALA E 450
LEU E 447
 None
 0.66A 2vcvK-3kfuE:
undetectable		 2vcvK-3kfuE:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		4 PHE B 592
LEU B 621
ALA B 602
ALA B 633
 None
None
EDO  B 913 (-3.6A)
None
 0.78A 2vcvK-3l91B:
undetectable		 2vcvK-3l91B:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0o MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
B-0618) 		PF01266
(DAO) 		4 LEU A 197
ALA A 361
LEU A 357
ALA A  18
 None
 0.98A 2vcvK-3m0oA:
undetectable		 2vcvK-3m0oA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		4 LEU A 334
ALA A 485
LEU A 466
ALA A 469
 None
 0.91A 2vcvK-3m8uA:
undetectable		 2vcvK-3m8uA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Saccharomyces
cerevisiae) 		PF00443
(UCH)
PF02148
(zf-UBP) 		4 PHE A 183
LEU A 152
LEU A 220
ALA A 223
 None
 0.98A 2vcvK-3m99A:
undetectable		 2vcvK-3m99A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 PHE A 168
LEU A 137
PRO A 208
LEU A 146
ALA A 171
 None
 1.26A 2vcvK-3mi9A:
undetectable		 2vcvK-3mi9A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mz1 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Sinorhizobium
meliloti) 		PF03466
(LysR_substrate) 		4 LEU A 245
ALA A 236
LEU A 224
ALA A 227
 None
 0.96A 2vcvK-3mz1A:
undetectable		 2vcvK-3mz1A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 PHE A 596
LEU A 662
LEU A 580
ALA A 567
 None
 0.96A 2vcvK-3nafA:
undetectable		 2vcvK-3nafA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhi D7 PROTEIN

(Anopheles
stephensi) 		PF01395
(PBP_GOBP) 		4 LEU A 100
ALA A 116
LEU A 113
ALA A  53
 None
None
None
EAH  A   1 ( 4.3A)
 0.93A 2vcvK-3nhiA:
undetectable		 2vcvK-3nhiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nog DESIGNED ANKYRIN
REPEAT PROTEIN

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 LEU D 126
ALA D 120
LEU D 117
ALA D 149
 None
 0.98A 2vcvK-3nogD:
undetectable		 2vcvK-3nogD:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc7 ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 PHE A 174
LEU A 155
PRO A 148
ALA A 138
 None
 0.98A 2vcvK-3oc7A:
undetectable		 2vcvK-3oc7A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 SEMAPHORIN-4D

(Homo sapiens) 		PF00047
(ig)
PF01403
(Sema)
PF01437
(PSI) 		4 LEU A 288
PRO A 411
ALA A 324
ALA A  25
 None
 0.99A 2vcvK-3ol2A:
undetectable		 2vcvK-3ol2A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pve AGRIN, AGRIN PROTEIN

(Mus musculus) 		PF00054
(Laminin_G_1) 		4 PHE A1461
LEU A1469
ALA A1628
ALA A1459
 None
 0.91A 2vcvK-3pveA:
undetectable		 2vcvK-3pveA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1t ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 LEU A  80
ALA A 123
LEU A  47
ALA A  48
 None
 0.98A 2vcvK-3q1tA:
undetectable		 2vcvK-3q1tA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q41 GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
ZETA-1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 LEU A  91
ALA A  62
LEU A  60
ALA A  49
 None
NAG  A 405 (-4.8A)
None
None
 0.96A 2vcvK-3q41A:
undetectable		 2vcvK-3q41A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE

(Pseudomonas
aeruginosa) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M)
PF14790
(THDPS_N) 		5 PHE A 170
LEU A 125
PRO A 100
ALA A 106
LEU A 131
 NPI  A 381 (-4.7A)
None
None
None
None
 1.41A 2vcvK-3r5bA:
undetectable		 2vcvK-3r5bA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb9 DNA POLYMERASE III
SUBUNIT BETA

(Mycobacterium
tuberculosis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PHE A 301
LEU A 340
ALA A 363
ALA A 273
 None
 0.91A 2vcvK-3rb9A:
undetectable		 2vcvK-3rb9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s97 CONTACTIN-1

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 LEU C 266
PRO C 271
ALA C 312
ALA C 293
 None
 0.98A 2vcvK-3s97C:
undetectable		 2vcvK-3s97C:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		4 PHE A 464
LEU A 310
ALA A 340
LEU A 344
 None
 0.96A 2vcvK-3slkA:
2.5		 2vcvK-3slkA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE

(Ascaris suum) 		PF13085
(Fer2_3)
PF13534
(Fer4_17) 		4 LEU B 227
ALA B 211
LEU B 208
ALA B 258
 None
 0.95A 2vcvK-3vrbB:
undetectable		 2vcvK-3vrbB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg8 PENICILLIN-BINDING
PROTEIN 4

(Listeria
monocytogenes) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		4 LEU B 399
PRO B 392
ALA B 495
ALA B 604
 None
 0.99A 2vcvK-3zg8B:
undetectable		 2vcvK-3zg8B:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amm DYNE8

(Micromonospora
chersina) 		PF00698
(Acyl_transf_1) 		4 LEU A 576
ALA A 817
LEU A 819
ALA A 863
 None
 0.99A 2vcvK-4ammA:
undetectable		 2vcvK-4ammA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c5n PHOSPHOMETHYLPYRIMID
INE KINASE

(Staphylococcus
aureus) 		PF08543
(Phos_pyr_kin) 		4 PHE A 102
LEU A  81
LEU A 130
ALA A 133
 None
 0.91A 2vcvK-4c5nA:
1.4		 2vcvK-4c5nA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckg ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3) 		4 PHE A 329
PRO A 257
LEU A 347
ALA A 342
 None
 0.98A 2vcvK-4ckgA:
undetectable		 2vcvK-4ckgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn2 NITROREDUCTASE

(Geobacter
metallireducens) 		PF00881
(Nitroreductase) 		4 PHE A  16
ALA A  79
LEU A  83
ALA A  86
 None
FMN  A 300 (-3.3A)
None
None
 0.93A 2vcvK-4dn2A:
undetectable		 2vcvK-4dn2A:
21.72