SIMILAR PATTERNS OF AMINO ACIDS FOR 2VCV_H_ASDH1224

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE
ALPHA CHAIN


(Sphingomonas
paucimobilis)
PF07746
(LigA)
5 LEU A  37
LEU A  61
ALA A  73
LEU A  75
PHE A  53
None
1.22A 2vcvH-1bouA:
undetectable
2vcvH-1bouA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkd GROEL

(Escherichia
coli)
PF00118
(Cpn60_TCP1)
5 LEU A 221
LEU A 237
ALA A 275
LEU A 262
ALA A 258
None
1.16A 2vcvH-1dkdA:
undetectable
2vcvH-1dkdA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE


(Ovis aries)
PF00008
(EGF)
PF03098
(An_peroxidase)
5 PHE A 478
PRO A 172
LEU A 177
LEU A 494
PHE A 181
None
1.16A 2vcvH-1ebvA:
undetectable
2vcvH-1ebvA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE


(Escherichia
coli)
PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb)
5 PRO A 199
LEU A 203
LEU A 187
ALA A 177
PHE A 263
None
1.00A 2vcvH-1f0xA:
0.0
2vcvH-1f0xA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g68 BETA-LACTAMASE PSE-4

(Pseudomonas
aeruginosa)
PF13354
(Beta-lactamase2)
5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
None
1.07A 2vcvH-1g68A:
undetectable
2vcvH-1g68A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN


(Homo sapiens)
PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2)
5 PHE C 292
LEU C 376
LEU C 391
ALA C 394
PHE C 356
None
1.21A 2vcvH-1h2tC:
2.4
2vcvH-1h2tC:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htj KIAA0380

(Homo sapiens)
PF09128
(RGS-like)
5 LEU F 383
LEU F 369
ALA F 397
ALA F 346
PHE F 342
None
0.98A 2vcvH-1htjF:
0.2
2vcvH-1htjF:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i51 CASPASE-7 SUBUNIT
P11
CASPASE-7 SUBUNIT
P20


(Homo sapiens)
PF00656
(Peptidase_C14)
5 PHE A 106
LEU B 299
LEU B 262
LEU B 249
PHE A 182
None
1.26A 2vcvH-1i51A:
undetectable
2vcvH-1i51A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihm CAPSID PROTEIN

(Norwalk virus)
PF00915
(Calici_coat)
PF08435
(Calici_coat_C)
5 LEU A1437
LEU A1233
LEU A1459
ALA A1457
PHE A1231
None
1.21A 2vcvH-1ihmA:
0.0
2vcvH-1ihmA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k86 CASPASE-7

(Homo sapiens)
PF00656
(Peptidase_C14)
5 PHE A 106
LEU A 299
LEU A 262
LEU A 249
PHE A 182
None
1.27A 2vcvH-1k86A:
undetectable
2vcvH-1k86A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE


(Thermus
thermophilus)
PF00117
(GATase)
5 PRO H 175
LEU H 166
LEU H 173
ALA H 193
PHE H 130
None
1.28A 2vcvH-1ka9H:
undetectable
2vcvH-1ka9H:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la1 GROEL

(Escherichia
coli)
PF00118
(Cpn60_TCP1)
5 LEU A 221
LEU A 237
ALA A 275
LEU A 262
ALA A 258
None
1.07A 2vcvH-1la1A:
undetectable
2vcvH-1la1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE


(Leishmania
mexicana)
PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C)
5 LEU A 339
LEU A 321
ALA A 220
LEU A 233
ALA A 232
PLM  A 402 ( 4.9A)
None
PLM  A 402 ( 4.0A)
PLM  A 402 ( 4.3A)
PLM  A 402 ( 4.0A)
1.19A 2vcvH-1m66A:
undetectable
2vcvH-1m66A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n9b BETA-LACTAMASE SHV-2

(Klebsiella
pneumoniae)
PF13354
(Beta-lactamase2)
5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
None
1.02A 2vcvH-1n9bA:
undetectable
2vcvH-1n9bA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum)
PF00733
(Asn_synthase)
PF09147
(DUF1933)
5 LEU A 231
LEU A 227
ALA A 256
LEU A 253
PHE A 397
None
1.26A 2vcvH-1q15A:
undetectable
2vcvH-1q15A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhi HUMAN RHINOVIRUS 3
COAT PROTEIN


(Rhinovirus B)
PF00073
(Rhv)
5 TYR 1 128
LEU 1 116
ALA 1  75
ALA 1 247
PHE 1 124
None
1.29A 2vcvH-1rhi1:
undetectable
2vcvH-1rhi1:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vki HYPOTHETICAL PROTEIN
ATU3699


(Agrobacterium
fabrum)
PF04073
(tRNA_edit)
5 LEU A  16
LEU A 151
ALA A 157
LEU A 155
ALA A 111
None
1.15A 2vcvH-1vkiA:
undetectable
2vcvH-1vkiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE


(Thermotoga
maritima)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 TYR A 260
LEU A 129
LEU A 214
LEU A 158
ALA A 157
None
1.24A 2vcvH-1vknA:
undetectable
2vcvH-1vknA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES


(Geobacillus
stearothermophilus)
PF00107
(ADH_zinc_N)
5 PRO A 293
LEU A 295
ALA A 135
LEU A 165
ALA A 130
None
None
None
None
SO4  A 329 ( 4.2A)
1.29A 2vcvH-1xa0A:
undetectable
2vcvH-1xa0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls ORPHAN NUCLEAR
RECEPTOR NR1I3


(Mus musculus)
PF00104
(Hormone_recep)
5 LEU E 123
LEU E 189
LEU E 277
ALA E 273
PHE E 185
None
1.26A 2vcvH-1xlsE:
undetectable
2vcvH-1xlsE:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq3 SUCCINATE
DEHYDROGENASE IP
SUBUNIT


(Gallus gallus)
PF13085
(Fer2_3)
PF13534
(Fer4_17)
5 LEU B 203
LEU B 212
ALA B 187
LEU B 184
ALA B 234
None
1.03A 2vcvH-1yq3B:
undetectable
2vcvH-1yq3B:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z HUMAN COXSACKIEVIRUS
A21


(Enterovirus C)
PF00073
(Rhv)
5 PRO 3  88
LEU 3  94
LEU 3  86
ALA 3 167
PHE 3 115
None
1.23A 2vcvH-1z7z3:
undetectable
2vcvH-1z7z3:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli)
PF13354
(Beta-lactamase2)
5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
None
1.01A 2vcvH-1zg4A:
undetectable
2vcvH-1zg4A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 PHE A 350
LEU A 316
PRO A 346
LEU A 420
ALA A 417
FAD  A 480 ( 4.8A)
FAD  A 480 (-3.7A)
None
None
None
1.29A 2vcvH-2a8xA:
undetectable
2vcvH-2a8xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN


(Streptococcus
pneumoniae)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 PHE A 256
LEU A 121
LEU A 286
ALA A 258
PHE A 260
None
1.28A 2vcvH-2am2A:
undetectable
2vcvH-2am2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Sulfolobus
solfataricus)
PF00348
(polyprenyl_synt)
5 LEU A 186
LEU A 167
ALA A 173
LEU A 171
ALA A 128
None
1.18A 2vcvH-2azkA:
1.7
2vcvH-2azkA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3t PROTEIN
METHYLTRANSFERASE
HEMK


(Escherichia
coli)
PF13847
(Methyltransf_31)
6 TYR A 255
LEU A 236
LEU A 116
LEU A 114
ALA A 227
PHE A 169
None
1.29A 2vcvH-2b3tA:
undetectable
2vcvH-2b3tA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE


(Thermus
thermophilus)
PF00155
(Aminotran_1_2)
5 LEU A 357
LEU A 361
ALA A 367
LEU A 365
ALA A 299
None
SO4  A 502 (-4.3A)
None
None
None
1.07A 2vcvH-2douA:
undetectable
2vcvH-2douA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU


(Escherichia
coli)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
5 LEU A 357
LEU A 355
ALA A 344
LEU A 405
ALA A 401
None
1.07A 2vcvH-2frxA:
2.2
2vcvH-2frxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9i HYPOTHETICAL PROTEIN

(Helicobacter
pylori)
PF05211
(NLBH)
5 TYR A 241
LEU A 141
LEU A 252
ALA A 248
PHE A 178
None
1.26A 2vcvH-2i9iA:
undetectable
2vcvH-2i9iA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
GAMMA-SUBUNIT


(Aromatoleum
aromaticum)
PF09459
(EB_dh)
5 PHE C 187
LEU C 177
ALA C  62
ALA C  95
PHE C  97
None
1.13A 2vcvH-2ivfC:
undetectable
2vcvH-2ivfC:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE


(Homo sapiens)
PF01053
(Cys_Met_Meta_PP)
5 LEU A 329
LEU A 376
ALA A 393
LEU A 390
PHE A 316
None
1.27A 2vcvH-2nmpA:
undetectable
2vcvH-2nmpA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E


(Homo sapiens)
PF00089
(Trypsin)
5 LEU A  46
ALA A 106
LEU A 108
ALA A  66
PHE A  68
None
1.25A 2vcvH-2oq5A:
undetectable
2vcvH-2oq5A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica)
PF00781
(DAGK_cat)
5 PRO A  92
LEU A  93
ALA A 112
LEU A 109
ALA A  24
None
1.29A 2vcvH-2p1rA:
1.8
2vcvH-2p1rA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2w CITRATE SYNTHASE

(Thermotoga
maritima)
PF00285
(Citrate_synt)
5 LEU A  98
ALA A 202
LEU A 203
ALA A 322
PHE A 122
None
1.04A 2vcvH-2p2wA:
undetectable
2vcvH-2p2wA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2w CITRATE SYNTHASE

(Thermotoga
maritima)
PF00285
(Citrate_synt)
5 LEU A 195
LEU A  98
ALA A 202
LEU A 203
PHE A 122
None
1.15A 2vcvH-2p2wA:
undetectable
2vcvH-2p2wA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p90 HYPOTHETICAL PROTEIN
CGL1923


(Corynebacterium
glutamicum)
PF09754
(PAC2)
5 PRO A 110
LEU A  91
LEU A  32
ALA A 179
PHE A 119
None
1.23A 2vcvH-2p90A:
undetectable
2vcvH-2p90A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN


(Deinococcus
radiodurans)
PF00773
(RNB)
5 PHE A  75
PRO A 341
LEU A 348
ALA A 121
ALA A 125
None
0.98A 2vcvH-2r7dA:
undetectable
2vcvH-2r7dA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens)
PF08933
(DUF1864)
5 LEU A 279
LEU A 299
ALA A 273
LEU A 236
PHE A 303
None
1.28A 2vcvH-2x66A:
3.6
2vcvH-2x66A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE


(Methanosarcina
mazei)
PF00875
(DNA_photolyase)
5 LEU A 396
PRO A 392
LEU A 386
LEU A 333
ALA A 329
None
1.17A 2vcvH-2xryA:
undetectable
2vcvH-2xryA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE


(Plasmodium
vivax)
PF01233
(NMT)
PF02799
(NMT_C)
5 TYR A 315
LEU A  91
LEU A 112
ALA A 115
PHE A 162
None
1.25A 2vcvH-2yneA:
undetectable
2vcvH-2yneA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N


(Rhodobacter
capsulatus)
PF00148
(Oxidored_nitro)
5 LEU A 117
LEU A 121
ALA A  85
LEU A  89
ALA A  72
None
1.29A 2vcvH-3aeuA:
undetectable
2vcvH-3aeuA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahx BETA-GLUCOSIDASE A

(Clostridium
cellulovorans)
PF00232
(Glyco_hydro_1)
5 PHE A 281
PRO A 167
LEU A 221
ALA A 194
ALA A 253
None
1.27A 2vcvH-3ahxA:
undetectable
2vcvH-3ahxA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq2 6B PROTEIN

(Agrobacterium
vitis)
PF02027
(RolB_RolC)
5 LEU A  20
ALA A  27
LEU A  24
ALA A 133
PHE A 131
None
1.12A 2vcvH-3aq2A:
undetectable
2vcvH-3aq2A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfz UPF0100 PROTEIN
MJ1186


(Methanocaldococcus
jannaschii)
PF13531
(SBP_bac_11)
5 PRO A  51
LEU A 317
LEU A  48
ALA A  93
PHE A 115
None
1.13A 2vcvH-3cfzA:
undetectable
2vcvH-3cfzA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cij UPF0100 PROTEIN
AF_0094


(Archaeoglobus
fulgidus)
PF13531
(SBP_bac_11)
5 PRO A  46
LEU A 315
LEU A  43
ALA A  88
PHE A 110
None
1.18A 2vcvH-3cijA:
undetectable
2vcvH-3cijA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA


(Candida
albicans)
PF01239
(PPTA)
5 LEU A 245
LEU A 250
ALA A 260
LEU A 261
ALA A 265
None
1.14A 2vcvH-3draA:
1.6
2vcvH-3draA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj7 MAJOR ANTIGENIC
PEPTIDE PEB3


(Campylobacter
jejuni)
PF13531
(SBP_bac_11)
5 LEU A 234
ALA A  33
LEU A  34
ALA A  38
PHE A 230
None
1.26A 2vcvH-3fj7A:
undetectable
2vcvH-3fj7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs2 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE


(Brucella
melitensis)
PF00793
(DAHP_synth_1)
5 PHE A 236
LEU A 186
ALA A 227
LEU A 224
ALA A 200
None
1.13A 2vcvH-3fs2A:
undetectable
2vcvH-3fs2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7n LIPASE

(Penicillium
expansum)
PF01764
(Lipase_3)
5 TYR A 194
PHE A 162
PRO A 102
LEU A 137
ALA A 136
None
1.25A 2vcvH-3g7nA:
undetectable
2vcvH-3g7nA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE


(Homo sapiens)
PF03747
(ADP_ribosyl_GH)
5 LEU A 292
LEU A  43
ALA A 307
LEU A  17
ALA A  13
None
CL  A 360 (-4.7A)
None
None
None
1.24A 2vcvH-3hfwA:
undetectable
2vcvH-3hfwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE


(Homo sapiens)
PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2)
5 PHE A 505
LEU A 403
LEU A 414
ALA A 421
ALA A 518
None
1.27A 2vcvH-3ibjA:
undetectable
2vcvH-3ibjA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1


(Homo sapiens)
PF01233
(NMT)
PF02799
(NMT_C)
5 TYR A 401
LEU A 176
LEU A 197
ALA A 200
PHE A 247
None
1.20A 2vcvH-3iu1A:
undetectable
2vcvH-3iu1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jab GAFB DOMAIN OF
PHOSPHODIESTERASE 2A


(Bos taurus)
PF01590
(GAF)
5 PHE B 505
LEU B 403
LEU B 414
ALA B 421
ALA B 518
None
1.14A 2vcvH-3jabB:
3.3
2vcvH-3jabB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kio RIBONUCLEASE H2
SUBUNIT C


(Mus musculus)
PF08615
(RNase_H2_suC)
5 PRO C  33
LEU C  32
LEU C  68
ALA C  61
PHE C  48
None
1.12A 2vcvH-3kioC:
undetectable
2vcvH-3kioC:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE


(Coccidioides
immitis)
PF13409
(GST_N_2)
PF14497
(GST_C_3)
5 TYR A  31
PHE A  24
ALA A  84
LEU A  85
ALA A  23
None
1.24A 2vcvH-3lg6A:
16.7
2vcvH-3lg6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkr COATOMER SUBUNIT
ALPHA


(Bos taurus)
PF06957
(COPI_C)
5 LEU B1034
PRO B1037
LEU B1038
LEU B 943
PHE B 959
None
1.11A 2vcvH-3mkrB:
1.1
2vcvH-3mkrB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nog DESIGNED ANKYRIN
REPEAT PROTEIN


(synthetic
construct)
PF00023
(Ank)
PF12796
(Ank_2)
5 LEU D 126
LEU D 133
ALA D 120
LEU D 117
ALA D 149
None
1.14A 2vcvH-3nogD:
undetectable
2vcvH-3nogD:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE


(Oryctolagus
cuniculus)
PF00365
(PFK)
5 LEU A 136
LEU A 156
LEU A 105
ALA A 101
PHE A 128
None
1.21A 2vcvH-3o8lA:
undetectable
2vcvH-3o8lA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Burkholderia
pseudomallei)
PF00155
(Aminotran_1_2)
5 PHE A 210
LEU A 236
LEU A  72
ALA A 208
PHE A 195
None
1.19A 2vcvH-3p1tA:
undetectable
2vcvH-3p1tA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3q MMOQ

(Methylococcus
capsulatus)
PF08668
(HDOD)
5 LEU A 207
PRO A 213
ALA A  87
ALA A 153
PHE A 237
None
1.16A 2vcvH-3p3qA:
undetectable
2vcvH-3p3qA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae)
PF01497
(Peripla_BP_2)
5 TYR A 340
LEU A 181
LEU A 161
LEU A 307
ALA A 306
None
1.15A 2vcvH-3pshA:
undetectable
2vcvH-3pshA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxz ENOYL-COA
HYDRATASE/ISOMERASE


(Mycobacteroides
abscessus)
PF00378
(ECH_1)
5 TYR A 127
LEU A  18
ALA A 100
LEU A  53
ALA A 113
None
1.13A 2vcvH-3qxzA:
undetectable
2vcvH-3qxzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re1 UROPORPHYRINOGEN-III
SYNTHETASE


(Pseudomonas
syringae group
genomosp. 3)
PF02602
(HEM4)
5 LEU A  18
LEU A   6
LEU A 247
ALA A 246
PHE A 214
None
1.28A 2vcvH-3re1A:
undetectable
2vcvH-3re1A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)


(Escherichia
coli)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF13193
(AMP-binding_C)
5 LEU A 305
LEU A 299
LEU A 290
ALA A 289
PHE A 265
None
1.04A 2vcvH-3rg2A:
undetectable
2vcvH-3rg2A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sir CASPASE

(Drosophila
melanogaster)
PF00656
(Peptidase_C14)
5 PHE A  58
LEU A 253
LEU A 215
LEU A 202
PHE A 134
None
1.17A 2vcvH-3sirA:
undetectable
2vcvH-3sirA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1


(Schizosaccharomyces
pombe)
no annotation 5 PHE B 734
LEU B 743
LEU B 757
ALA B 760
PHE B 767
None
1.09A 2vcvH-3tixB:
undetectable
2vcvH-3tixB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC


(Oryza sativa)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48)
5 LEU A 265
LEU A 256
LEU A 221
ALA A 186
PHE A 203
None
1.04A 2vcvH-3vu2A:
undetectable
2vcvH-3vu2A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdj ENCA BETA-LACTAMASE

(synthetic
construct)
PF13354
(Beta-lactamase2)
5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
None
1.01A 2vcvH-3zdjA:
undetectable
2vcvH-3zdjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1


(Serratia
fonticola)
PF13354
(Beta-lactamase2)
5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
None
0.98A 2vcvH-4ev4A:
undetectable
2vcvH-4ev4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exb PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
PF00248
(Aldo_ket_red)
5 LEU A  25
ALA A  55
LEU A  53
ALA A  50
PHE A  30
None
1.29A 2vcvH-4exbA:
undetectable
2vcvH-4exbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN


(Legionella
pneumophila)
no annotation 6 PRO A 222
LEU A 336
ALA A 225
LEU A 338
ALA A 355
PHE A 359
None
1.33A 2vcvH-4eziA:
undetectable
2vcvH-4eziA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9s INHIBITOR OF G-TYPE
LYSOZYME


(Escherichia
coli)
PF04151
(PPC)
5 LEU B  75
ALA B 103
LEU B 101
ALA B  56
PHE B  54
None
1.23A 2vcvH-4g9sB:
undetectable
2vcvH-4g9sB:
23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hj2 GLUTATHIONE
S-TRANSFERASE A1


(Homo sapiens)
PF00043
(GST_C)
PF02798
(GST_N)
6 TYR A   9
PHE A  10
LEU A 107
PRO A 110
LEU A 213
ALA A 216
LZ6  A 301 (-4.6A)
None
LZ6  A 301 (-4.4A)
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
0.83A 2vcvH-4hj2A:
36.4
2vcvH-4hj2A:
90.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN


(Lactobacillus
acidophilus)
PF06100
(MCRA)
5 PHE A 178
LEU A 194
ALA A 201
LEU A 152
PHE A 169
None
1.20A 2vcvH-4ia5A:
undetectable
2vcvH-4ia5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 SILKWORM STORAGE
PROTEIN


(Bombyx mori)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
5 PHE A 105
LEU A 140
LEU A  25
ALA A 109
PHE A 121
None
1.24A 2vcvH-4l37A:
undetectable
2vcvH-4l37A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC


(Homo sapiens)
PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N)
5 LEU A 355
ALA A 206
LEU A 207
ALA A 211
PHE A 351
None
1.20A 2vcvH-4l87A:
2.8
2vcvH-4l87A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2j AMINOTRANSFERASE

(Streptomyces
lavendulae)
PF00155
(Aminotran_1_2)
5 LEU A 291
LEU A 375
LEU A 345
ALA A 357
PHE A 317
None
1.08A 2vcvH-4m2jA:
undetectable
2vcvH-4m2jA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mll BETA-LACTAMASE OXA-1

(Escherichia
coli)
PF00905
(Transpeptidase)
5 PHE A  69
LEU A 184
LEU A  75
ALA A  72
PHE A 175
None
1.27A 2vcvH-4mllA:
undetectable
2vcvH-4mllA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4u PUTATIVE ABC
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN


(Bordetella
bronchiseptica)
PF03480
(DctP)
5 LEU A 153
LEU A 223
LEU A 156
ALA A 178
PHE A 174
None
1.29A 2vcvH-4n4uA:
undetectable
2vcvH-4n4uA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1


(Homo sapiens)
PF05994
(FragX_IP)
PF07159
(DUF1394)
5 PHE A 359
LEU A 612
LEU A 255
ALA A 394
LEU A 395
None
1.20A 2vcvH-4n78A:
4.5
2vcvH-4n78A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE


(Streptococcus
thermophilus)
PF00464
(SHMT)
5 PHE A 277
LEU A 233
ALA A 268
LEU A 269
PHE A  80
None
1.24A 2vcvH-4wxbA:
undetectable
2vcvH-4wxbA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaj MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR
RECEPTOR SUBFAMILY 2
GROUP E MEMBER 1


(Escherichia
coli;
Homo sapiens)
PF00104
(Hormone_recep)
PF13416
(SBP_bac_8)
5 LEU A1346
LEU A1288
LEU A1228
ALA A1231
PHE A1285
None
1.26A 2vcvH-4xajA:
undetectable
2vcvH-4xajA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgc KELCH PROTEIN

(Plasmodium
falciparum)
PF01344
(Kelch_1)
PF02214
(BTB_2)
PF13418
(Kelch_4)
5 LEU A 514
ALA A 427
LEU A 429
ALA A 432
PHE A 439
None
0.95A 2vcvH-4zgcA:
undetectable
2vcvH-4zgcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE


(Pseudomonas
aeruginosa)
PF00149
(Metallophos)
5 LEU A  75
ALA A  67
LEU A  63
ALA A  60
PHE A  88
None
1.19A 2vcvH-5b4cA:
undetectable
2vcvH-5b4cA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdk CHAPERONIN 60B1

(Chlamydomonas
reinhardtii)
PF00118
(Cpn60_TCP1)
5 LEU A  29
LEU A  45
ALA A  83
LEU A  70
ALA A  66
None
1.11A 2vcvH-5cdkA:
undetectable
2vcvH-5cdkA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e43 BETA-LACTAMASE

(Streptosporangium
roseum)
PF13354
(Beta-lactamase2)
5 PRO A 146
LEU A 163
LEU A 140
ALA A 136
PHE A  72
None
1.01A 2vcvH-5e43A:
undetectable
2vcvH-5e43A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE


(Rhodobacter
sphaeroides)
PF03170
(BcsB)
5 LEU B 234
LEU B 230
ALA B 204
ALA B 256
PHE B 196
None
1.19A 2vcvH-5ej1B:
undetectable
2vcvH-5ej1B:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa)
PF13354
(Beta-lactamase2)
5 PRO A 138
LEU A 155
LEU A 132
ALA A 128
PHE A  64
None
1.11A 2vcvH-5eoeA:
undetectable
2vcvH-5eoeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
BIOSYNTHESIS PROTEIN
YBDZ
ENTEROBACTIN
SYNTHASE COMPONENT F


(Escherichia
coli)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF03621
(MbtH)
PF13193
(AMP-binding_C)
5 PHE B   7
PRO B  34
LEU B  33
ALA A 826
LEU B  17
None
1.24A 2vcvH-5ja1B:
undetectable
2vcvH-5ja1B:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1b WD REPEAT-CONTAINING
PROTEIN 48


(Homo sapiens)
PF00400
(WD40)
PF11816
(DUF3337)
5 LEU B 460
LEU B 390
LEU B 466
ALA B 469
PHE B 507
None
1.25A 2vcvH-5k1bB:
undetectable
2vcvH-5k1bB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ll7 BETA-LACTAMASE

(Escherichia
coli)
no annotation 5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
None
1.07A 2vcvH-5ll7A:
undetectable
2vcvH-5ll7A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1


(Homo sapiens)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
5 LEU A4042
PRO A4040
LEU A4124
ALA A4141
LEU A4113
None
1.00A 2vcvH-5nugA:
undetectable
2vcvH-5nugA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oaf RUVB-LIKE 1

(Homo sapiens)
no annotation 5 LEU A 315
ALA A 324
LEU A 319
ALA A  65
PHE A 329
None
1.26A 2vcvH-5oafA:
undetectable
2vcvH-5oafA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5via PSEUDOPEROXIDASE

(Leishmania
major)
PF00141
(peroxidase)
5 PHE A  74
LEU A 155
ALA A 140
LEU A 138
ALA A  70
None
1.28A 2vcvH-5viaA:
undetectable
2vcvH-5viaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0s 60 KDA CHAPERONIN

(Escherichia
coli)
PF00118
(Cpn60_TCP1)
5 LEU A 221
LEU A 237
ALA A 275
LEU A 262
ALA A 258
None
1.04A 2vcvH-5w0sA:
undetectable
2vcvH-5w0sA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7k LIPASE B

(Serratia
marcescens)
no annotation 5 LEU A 522
PRO A 494
LEU A 506
LEU A 411
ALA A 481
None
1.27A 2vcvH-5x7kA:
undetectable
2vcvH-5x7kA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN


(Thermus
thermophilus)
no annotation 5 PHE A 163
LEU A  24
PRO A  26
LEU A 112
ALA A 113
None
1.15A 2vcvH-5xpgA:
undetectable
2vcvH-5xpgA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blj SERINE-TRNA LIGASE

(Naegleria
fowleri)
no annotation 5 LEU A 359
ALA A 219
LEU A 220
ALA A 224
PHE A 355
None
1.10A 2vcvH-6bljA:
undetectable
2vcvH-6bljA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis)
no annotation 5 PHE A 644
LEU A 581
ALA A 587
LEU A 585
ALA A 613
None
1.08A 2vcvH-6co7A:
undetectable
2vcvH-6co7A:
17.21