SIMILAR PATTERNS OF AMINO ACIDS FOR 2VCV_H_ASDH1224
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bou | 4,5-DIOXYGENASEALPHA CHAIN (Sphingomonaspaucimobilis) |
PF07746(LigA) | 5 | LEU A 37LEU A 61ALA A 73LEU A 75PHE A 53 | None | 1.22A | 2vcvH-1bouA:undetectable | 2vcvH-1bouA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dkd | GROEL (Escherichiacoli) |
PF00118(Cpn60_TCP1) | 5 | LEU A 221LEU A 237ALA A 275LEU A 262ALA A 258 | None | 1.16A | 2vcvH-1dkdA:undetectable | 2vcvH-1dkdA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ebv | PROSTAGLANDIN H2SYNTHASE (Ovis aries) |
PF00008(EGF)PF03098(An_peroxidase) | 5 | PHE A 478PRO A 172LEU A 177LEU A 494PHE A 181 | None | 1.16A | 2vcvH-1ebvA:undetectable | 2vcvH-1ebvA:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f0x | D-LACTATEDEHYDROGENASE (Escherichiacoli) |
PF01565(FAD_binding_4)PF09330(Lact-deh-memb) | 5 | PRO A 199LEU A 203LEU A 187ALA A 177PHE A 263 | None | 1.00A | 2vcvH-1f0xA:0.0 | 2vcvH-1f0xA:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g68 | BETA-LACTAMASE PSE-4 (Pseudomonasaeruginosa) |
PF13354(Beta-lactamase2) | 5 | PRO A 145LEU A 162LEU A 139ALA A 135PHE A 72 | None | 1.07A | 2vcvH-1g68A:undetectable | 2vcvH-1g68A:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h2t | 80 KDA NUCLEAR CAPBINDING PROTEIN (Homo sapiens) |
PF02854(MIF4G)PF09088(MIF4G_like)PF09090(MIF4G_like_2) | 5 | PHE C 292LEU C 376LEU C 391ALA C 394PHE C 356 | None | 1.21A | 2vcvH-1h2tC:2.4 | 2vcvH-1h2tC:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1htj | KIAA0380 (Homo sapiens) |
PF09128(RGS-like) | 5 | LEU F 383LEU F 369ALA F 397ALA F 346PHE F 342 | None | 0.98A | 2vcvH-1htjF:0.2 | 2vcvH-1htjF:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i51 | CASPASE-7 SUBUNITP11CASPASE-7 SUBUNITP20 (Homo sapiens) |
PF00656(Peptidase_C14) | 5 | PHE A 106LEU B 299LEU B 262LEU B 249PHE A 182 | None | 1.26A | 2vcvH-1i51A:undetectable | 2vcvH-1i51A:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ihm | CAPSID PROTEIN (Norwalk virus) |
PF00915(Calici_coat)PF08435(Calici_coat_C) | 5 | LEU A1437LEU A1233LEU A1459ALA A1457PHE A1231 | None | 1.21A | 2vcvH-1ihmA:0.0 | 2vcvH-1ihmA:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k86 | CASPASE-7 (Homo sapiens) |
PF00656(Peptidase_C14) | 5 | PHE A 106LEU A 299LEU A 262LEU A 249PHE A 182 | None | 1.27A | 2vcvH-1k86A:undetectable | 2vcvH-1k86A:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ka9 | IMIDAZOLE GLYCEROLPHOSPHATE SYNTHASE (Thermusthermophilus) |
PF00117(GATase) | 5 | PRO H 175LEU H 166LEU H 173ALA H 193PHE H 130 | None | 1.28A | 2vcvH-1ka9H:undetectable | 2vcvH-1ka9H:24.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1la1 | GROEL (Escherichiacoli) |
PF00118(Cpn60_TCP1) | 5 | LEU A 221LEU A 237ALA A 275LEU A 262ALA A 258 | None | 1.07A | 2vcvH-1la1A:undetectable | 2vcvH-1la1A:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m66 | GLYCEROL-3-PHOSPHATEDEHYDROGENASE (Leishmaniamexicana) |
PF01210(NAD_Gly3P_dh_N)PF07479(NAD_Gly3P_dh_C) | 5 | LEU A 339LEU A 321ALA A 220LEU A 233ALA A 232 | PLM A 402 ( 4.9A)NonePLM A 402 ( 4.0A)PLM A 402 ( 4.3A)PLM A 402 ( 4.0A) | 1.19A | 2vcvH-1m66A:undetectable | 2vcvH-1m66A:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n9b | BETA-LACTAMASE SHV-2 (Klebsiellapneumoniae) |
PF13354(Beta-lactamase2) | 5 | PRO A 145LEU A 162LEU A 139ALA A 135PHE A 72 | None | 1.02A | 2vcvH-1n9bA:undetectable | 2vcvH-1n9bA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q15 | CARA (Pectobacteriumcarotovorum) |
PF00733(Asn_synthase)PF09147(DUF1933) | 5 | LEU A 231LEU A 227ALA A 256LEU A 253PHE A 397 | None | 1.26A | 2vcvH-1q15A:undetectable | 2vcvH-1q15A:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rhi | HUMAN RHINOVIRUS 3COAT PROTEIN (Rhinovirus B) |
PF00073(Rhv) | 5 | TYR 1 128LEU 1 116ALA 1 75ALA 1 247PHE 1 124 | None | 1.29A | 2vcvH-1rhi1:undetectable | 2vcvH-1rhi1:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vki | HYPOTHETICAL PROTEINATU3699 (Agrobacteriumfabrum) |
PF04073(tRNA_edit) | 5 | LEU A 16LEU A 151ALA A 157LEU A 155ALA A 111 | None | 1.15A | 2vcvH-1vkiA:undetectable | 2vcvH-1vkiA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkn | N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Thermotogamaritima) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | TYR A 260LEU A 129LEU A 214LEU A 158ALA A 157 | None | 1.24A | 2vcvH-1vknA:undetectable | 2vcvH-1vknA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xa0 | PUTATIVE NADPHDEPENDENTOXIDOREDUCTASES (Geobacillusstearothermophilus) |
PF00107(ADH_zinc_N) | 5 | PRO A 293LEU A 295ALA A 135LEU A 165ALA A 130 | NoneNoneNoneNoneSO4 A 329 ( 4.2A) | 1.29A | 2vcvH-1xa0A:undetectable | 2vcvH-1xa0A:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xls | ORPHAN NUCLEARRECEPTOR NR1I3 (Mus musculus) |
PF00104(Hormone_recep) | 5 | LEU E 123LEU E 189LEU E 277ALA E 273PHE E 185 | None | 1.26A | 2vcvH-1xlsE:undetectable | 2vcvH-1xlsE:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yq3 | SUCCINATEDEHYDROGENASE IPSUBUNIT (Gallus gallus) |
PF13085(Fer2_3)PF13534(Fer4_17) | 5 | LEU B 203LEU B 212ALA B 187LEU B 184ALA B 234 | None | 1.03A | 2vcvH-1yq3B:undetectable | 2vcvH-1yq3B:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7z | HUMAN COXSACKIEVIRUSA21 (Enterovirus C) |
PF00073(Rhv) | 5 | PRO 3 88LEU 3 94LEU 3 86ALA 3 167PHE 3 115 | None | 1.23A | 2vcvH-1z7z3:undetectable | 2vcvH-1z7z3:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zg4 | BETA-LACTAMASE TEM (Escherichiacoli) |
PF13354(Beta-lactamase2) | 5 | PRO A 145LEU A 162LEU A 139ALA A 135PHE A 72 | None | 1.01A | 2vcvH-1zg4A:undetectable | 2vcvH-1zg4A:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a8x | DIHYDROLIPOYLDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | PHE A 350LEU A 316PRO A 346LEU A 420ALA A 417 | FAD A 480 ( 4.8A)FAD A 480 (-3.7A)NoneNoneNone | 1.29A | 2vcvH-2a8xA:undetectable | 2vcvH-2a8xA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2am2 | UDP-N-ACETYLMURAMOYLALANINE-D-GLUTAMYL-LYSINE-D-ALANYL-D-ALANINE LIGASE, MURFPROTEIN (Streptococcuspneumoniae) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | PHE A 256LEU A 121LEU A 286ALA A 258PHE A 260 | None | 1.28A | 2vcvH-2am2A:undetectable | 2vcvH-2am2A:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2azk | GERANYLGERANYLPYROPHOSPHATESYNTHETASE (Sulfolobussolfataricus) |
PF00348(polyprenyl_synt) | 5 | LEU A 186LEU A 167ALA A 173LEU A 171ALA A 128 | None | 1.18A | 2vcvH-2azkA:1.7 | 2vcvH-2azkA:24.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3t | PROTEINMETHYLTRANSFERASEHEMK (Escherichiacoli) |
PF13847(Methyltransf_31) | 6 | TYR A 255LEU A 236LEU A 116LEU A 114ALA A 227PHE A 169 | None | 1.29A | 2vcvH-2b3tA:undetectable | 2vcvH-2b3tA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dou | PROBABLEN-SUCCINYLDIAMINOPIMELATEAMINOTRANSFERASE (Thermusthermophilus) |
PF00155(Aminotran_1_2) | 5 | LEU A 357LEU A 361ALA A 367LEU A 365ALA A 299 | NoneSO4 A 502 (-4.3A)NoneNoneNone | 1.07A | 2vcvH-2douA:undetectable | 2vcvH-2douA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 5 | LEU A 357LEU A 355ALA A 344LEU A 405ALA A 401 | None | 1.07A | 2vcvH-2frxA:2.2 | 2vcvH-2frxA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9i | HYPOTHETICAL PROTEIN (Helicobacterpylori) |
PF05211(NLBH) | 5 | TYR A 241LEU A 141LEU A 252ALA A 248PHE A 178 | None | 1.26A | 2vcvH-2i9iA:undetectable | 2vcvH-2i9iA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ivf | ETHYLBENZENEDEHYDROGENASEGAMMA-SUBUNIT (Aromatoleumaromaticum) |
PF09459(EB_dh) | 5 | PHE C 187LEU C 177ALA C 62ALA C 95PHE C 97 | None | 1.13A | 2vcvH-2ivfC:undetectable | 2vcvH-2ivfC:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nmp | CYSTATHIONINEGAMMA-LYASE (Homo sapiens) |
PF01053(Cys_Met_Meta_PP) | 5 | LEU A 329LEU A 376ALA A 393LEU A 390PHE A 316 | None | 1.27A | 2vcvH-2nmpA:undetectable | 2vcvH-2nmpA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oq5 | TRANSMEMBRANEPROTEASE, SERINE 11E (Homo sapiens) |
PF00089(Trypsin) | 5 | LEU A 46ALA A 106LEU A 108ALA A 66PHE A 68 | None | 1.25A | 2vcvH-2oq5A:undetectable | 2vcvH-2oq5A:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p1r | LIPID KINASE YEGS (Salmonellaenterica) |
PF00781(DAGK_cat) | 5 | PRO A 92LEU A 93ALA A 112LEU A 109ALA A 24 | None | 1.29A | 2vcvH-2p1rA:1.8 | 2vcvH-2p1rA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p2w | CITRATE SYNTHASE (Thermotogamaritima) |
PF00285(Citrate_synt) | 5 | LEU A 98ALA A 202LEU A 203ALA A 322PHE A 122 | None | 1.04A | 2vcvH-2p2wA:undetectable | 2vcvH-2p2wA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p2w | CITRATE SYNTHASE (Thermotogamaritima) |
PF00285(Citrate_synt) | 5 | LEU A 195LEU A 98ALA A 202LEU A 203PHE A 122 | None | 1.15A | 2vcvH-2p2wA:undetectable | 2vcvH-2p2wA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p90 | HYPOTHETICAL PROTEINCGL1923 (Corynebacteriumglutamicum) |
PF09754(PAC2) | 5 | PRO A 110LEU A 91LEU A 32ALA A 179PHE A 119 | None | 1.23A | 2vcvH-2p90A:undetectable | 2vcvH-2p90A:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r7d | RIBONUCLEASE IIFAMILY PROTEIN (Deinococcusradiodurans) |
PF00773(RNB) | 5 | PHE A 75PRO A 341LEU A 348ALA A 121ALA A 125 | None | 0.98A | 2vcvH-2r7dA:undetectable | 2vcvH-2r7dA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x66 | PRNB (Pseudomonasfluorescens) |
PF08933(DUF1864) | 5 | LEU A 279LEU A 299ALA A 273LEU A 236PHE A 303 | None | 1.28A | 2vcvH-2x66A:3.6 | 2vcvH-2x66A:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xry | DEOXYRIBODIPYRIMIDINE PHOTOLYASE (Methanosarcinamazei) |
PF00875(DNA_photolyase) | 5 | LEU A 396PRO A 392LEU A 386LEU A 333ALA A 329 | None | 1.17A | 2vcvH-2xryA:undetectable | 2vcvH-2xryA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yne | GLYCYLPEPTIDEN-TETRADECANOYLTRANSFERASE (Plasmodiumvivax) |
PF01233(NMT)PF02799(NMT_C) | 5 | TYR A 315LEU A 91LEU A 112ALA A 115PHE A 162 | None | 1.25A | 2vcvH-2yneA:undetectable | 2vcvH-2yneA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aeu | LIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASE SUBUNIT N (Rhodobactercapsulatus) |
PF00148(Oxidored_nitro) | 5 | LEU A 117LEU A 121ALA A 85LEU A 89ALA A 72 | None | 1.29A | 2vcvH-3aeuA:undetectable | 2vcvH-3aeuA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahx | BETA-GLUCOSIDASE A (Clostridiumcellulovorans) |
PF00232(Glyco_hydro_1) | 5 | PHE A 281PRO A 167LEU A 221ALA A 194ALA A 253 | None | 1.27A | 2vcvH-3ahxA:undetectable | 2vcvH-3ahxA:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aq2 | 6B PROTEIN (Agrobacteriumvitis) |
PF02027(RolB_RolC) | 5 | LEU A 20ALA A 27LEU A 24ALA A 133PHE A 131 | None | 1.12A | 2vcvH-3aq2A:undetectable | 2vcvH-3aq2A:23.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cfz | UPF0100 PROTEINMJ1186 (Methanocaldococcusjannaschii) |
PF13531(SBP_bac_11) | 5 | PRO A 51LEU A 317LEU A 48ALA A 93PHE A 115 | None | 1.13A | 2vcvH-3cfzA:undetectable | 2vcvH-3cfzA:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cij | UPF0100 PROTEINAF_0094 (Archaeoglobusfulgidus) |
PF13531(SBP_bac_11) | 5 | PRO A 46LEU A 315LEU A 43ALA A 88PHE A 110 | None | 1.18A | 2vcvH-3cijA:undetectable | 2vcvH-3cijA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dra | PROTEINFARNESYLTRANSFERASE/GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNITALPHA (Candidaalbicans) |
PF01239(PPTA) | 5 | LEU A 245LEU A 250ALA A 260LEU A 261ALA A 265 | None | 1.14A | 2vcvH-3draA:1.6 | 2vcvH-3draA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fj7 | MAJOR ANTIGENICPEPTIDE PEB3 (Campylobacterjejuni) |
PF13531(SBP_bac_11) | 5 | LEU A 234ALA A 33LEU A 34ALA A 38PHE A 230 | None | 1.26A | 2vcvH-3fj7A:undetectable | 2vcvH-3fj7A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fs2 | 2-DEHYDRO-3-DEOXYPHOSPHOOCTONATEALDOLASE (Brucellamelitensis) |
PF00793(DAHP_synth_1) | 5 | PHE A 236LEU A 186ALA A 227LEU A 224ALA A 200 | None | 1.13A | 2vcvH-3fs2A:undetectable | 2vcvH-3fs2A:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7n | LIPASE (Penicilliumexpansum) |
PF01764(Lipase_3) | 5 | TYR A 194PHE A 162PRO A 102LEU A 137ALA A 136 | None | 1.25A | 2vcvH-3g7nA:undetectable | 2vcvH-3g7nA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hfw | PROTEINADP-RIBOSYLARGININEHYDROLASE (Homo sapiens) |
PF03747(ADP_ribosyl_GH) | 5 | LEU A 292LEU A 43ALA A 307LEU A 17ALA A 13 | None CL A 360 (-4.7A)NoneNoneNone | 1.24A | 2vcvH-3hfwA:undetectable | 2vcvH-3hfwA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibj | CGMP-DEPENDENT3',5'-CYCLICPHOSPHODIESTERASE (Homo sapiens) |
PF00233(PDEase_I)PF01590(GAF)PF13185(GAF_2) | 5 | PHE A 505LEU A 403LEU A 414ALA A 421ALA A 518 | None | 1.27A | 2vcvH-3ibjA:undetectable | 2vcvH-3ibjA:15.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iu1 | GLYCYLPEPTIDEN-TETRADECANOYLTRANSFERASE 1 (Homo sapiens) |
PF01233(NMT)PF02799(NMT_C) | 5 | TYR A 401LEU A 176LEU A 197ALA A 200PHE A 247 | None | 1.20A | 2vcvH-3iu1A:undetectable | 2vcvH-3iu1A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jab | GAFB DOMAIN OFPHOSPHODIESTERASE 2A (Bos taurus) |
PF01590(GAF) | 5 | PHE B 505LEU B 403LEU B 414ALA B 421ALA B 518 | None | 1.14A | 2vcvH-3jabB:3.3 | 2vcvH-3jabB:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kio | RIBONUCLEASE H2SUBUNIT C (Mus musculus) |
PF08615(RNase_H2_suC) | 5 | PRO C 33LEU C 32LEU C 68ALA C 61PHE C 48 | None | 1.12A | 2vcvH-3kioC:undetectable | 2vcvH-3kioC:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lg6 | PUTATIVE GLUTATHIONETRANSFERASE (Coccidioidesimmitis) |
PF13409(GST_N_2)PF14497(GST_C_3) | 5 | TYR A 31PHE A 24ALA A 84LEU A 85ALA A 23 | None | 1.24A | 2vcvH-3lg6A:16.7 | 2vcvH-3lg6A:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mkr | COATOMER SUBUNITALPHA (Bos taurus) |
PF06957(COPI_C) | 5 | LEU B1034PRO B1037LEU B1038LEU B 943PHE B 959 | None | 1.11A | 2vcvH-3mkrB:1.1 | 2vcvH-3mkrB:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nog | DESIGNED ANKYRINREPEAT PROTEIN (syntheticconstruct) |
PF00023(Ank)PF12796(Ank_2) | 5 | LEU D 126LEU D 133ALA D 120LEU D 117ALA D 149 | None | 1.14A | 2vcvH-3nogD:undetectable | 2vcvH-3nogD:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8l | 6-PHOSPHOFRUCTOKINASE, MUSCLE TYPE (Oryctolaguscuniculus) |
PF00365(PFK) | 5 | LEU A 136LEU A 156LEU A 105ALA A 101PHE A 128 | None | 1.21A | 2vcvH-3o8lA:undetectable | 2vcvH-3o8lA:15.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p1t | PUTATIVEHISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Burkholderiapseudomallei) |
PF00155(Aminotran_1_2) | 5 | PHE A 210LEU A 236LEU A 72ALA A 208PHE A 195 | None | 1.19A | 2vcvH-3p1tA:undetectable | 2vcvH-3p1tA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p3q | MMOQ (Methylococcuscapsulatus) |
PF08668(HDOD) | 5 | LEU A 207PRO A 213ALA A 87ALA A 153PHE A 237 | None | 1.16A | 2vcvH-3p3qA:undetectable | 2vcvH-3p3qA:25.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psh | PROTEIN HI_1472 (Haemophilusinfluenzae) |
PF01497(Peripla_BP_2) | 5 | TYR A 340LEU A 181LEU A 161LEU A 307ALA A 306 | None | 1.15A | 2vcvH-3pshA:undetectable | 2vcvH-3pshA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qxz | ENOYL-COAHYDRATASE/ISOMERASE (Mycobacteroidesabscessus) |
PF00378(ECH_1) | 5 | TYR A 127LEU A 18ALA A 100LEU A 53ALA A 113 | None | 1.13A | 2vcvH-3qxzA:undetectable | 2vcvH-3qxzA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3re1 | UROPORPHYRINOGEN-IIISYNTHETASE (Pseudomonassyringae groupgenomosp. 3) |
PF02602(HEM4) | 5 | LEU A 18LEU A 6LEU A 247ALA A 246PHE A 214 | None | 1.28A | 2vcvH-3re1A:undetectable | 2vcvH-3re1A:25.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rg2 | ENTEROBACTINSYNTHASE COMPONENT E(ENTE),2,3-DIHYDRO-2,3-DIHYDROXYBENZOATESYNTHETASE,ISOCHROISMATASE(ENTB) (Escherichiacoli) |
PF00501(AMP-binding)PF00550(PP-binding)PF13193(AMP-binding_C) | 5 | LEU A 305LEU A 299LEU A 290ALA A 289PHE A 265 | None | 1.04A | 2vcvH-3rg2A:undetectable | 2vcvH-3rg2A:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sir | CASPASE (Drosophilamelanogaster) |
PF00656(Peptidase_C14) | 5 | PHE A 58LEU A 253LEU A 215LEU A 202PHE A 134 | None | 1.17A | 2vcvH-3sirA:undetectable | 2vcvH-3sirA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tix | CHROMODOMAIN-CONTAININGPROTEIN 1 (Schizosaccharomycespombe) |
no annotation | 5 | PHE B 734LEU B 743LEU B 757ALA B 760PHE B 767 | None | 1.09A | 2vcvH-3tixB:undetectable | 2vcvH-3tixB:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vu2 | 1,4-ALPHA-GLUCAN-BRANCHING ENZYME,CHLOROPLASTIC/AMYLOPLASTIC (Oryza sativa) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C)PF02922(CBM_48) | 5 | LEU A 265LEU A 256LEU A 221ALA A 186PHE A 203 | None | 1.04A | 2vcvH-3vu2A:undetectable | 2vcvH-3vu2A:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zdj | ENCA BETA-LACTAMASE (syntheticconstruct) |
PF13354(Beta-lactamase2) | 5 | PRO A 145LEU A 162LEU A 139ALA A 135PHE A 72 | None | 1.01A | 2vcvH-3zdjA:undetectable | 2vcvH-3zdjA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ev4 | CARBAPENEM-HYDROLIZING BETA-LACTAMASESFC-1 (Serratiafonticola) |
PF13354(Beta-lactamase2) | 5 | PRO A 145LEU A 162LEU A 139ALA A 135PHE A 72 | None | 0.98A | 2vcvH-4ev4A:undetectable | 2vcvH-4ev4A:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4exb | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF00248(Aldo_ket_red) | 5 | LEU A 25ALA A 55LEU A 53ALA A 50PHE A 30 | None | 1.29A | 2vcvH-4exbA:undetectable | 2vcvH-4exbA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ezi | UNCHARACTERIZEDPROTEIN (Legionellapneumophila) |
no annotation | 6 | PRO A 222LEU A 336ALA A 225LEU A 338ALA A 355PHE A 359 | None | 1.33A | 2vcvH-4eziA:undetectable | 2vcvH-4eziA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g9s | INHIBITOR OF G-TYPELYSOZYME (Escherichiacoli) |
PF04151(PPC) | 5 | LEU B 75ALA B 103LEU B 101ALA B 56PHE B 54 | None | 1.23A | 2vcvH-4g9sB:undetectable | 2vcvH-4g9sB:23.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hj2 | GLUTATHIONES-TRANSFERASE A1 (Homo sapiens) |
PF00043(GST_C)PF02798(GST_N) | 6 | TYR A 9PHE A 10LEU A 107PRO A 110LEU A 213ALA A 216 | LZ6 A 301 (-4.6A)NoneLZ6 A 301 (-4.4A)LZ6 A 301 (-3.5A)NoneLZ6 A 301 ( 4.6A) | 0.83A | 2vcvH-4hj2A:36.4 | 2vcvH-4hj2A:90.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ia5 | MYOSIN-CROSSREACTIVEANTIGEN (Lactobacillusacidophilus) |
PF06100(MCRA) | 5 | PHE A 178LEU A 194ALA A 201LEU A 152PHE A 169 | None | 1.20A | 2vcvH-4ia5A:undetectable | 2vcvH-4ia5A:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l37 | SILKWORM STORAGEPROTEIN (Bombyx mori) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 5 | PHE A 105LEU A 140LEU A 25ALA A 109PHE A 121 | None | 1.24A | 2vcvH-4l37A:undetectable | 2vcvH-4l37A:16.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l87 | SERINE--TRNA LIGASE,CYTOPLASMIC (Homo sapiens) |
PF00587(tRNA-synt_2b)PF02403(Seryl_tRNA_N) | 5 | LEU A 355ALA A 206LEU A 207ALA A 211PHE A 351 | None | 1.20A | 2vcvH-4l87A:2.8 | 2vcvH-4l87A:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m2j | AMINOTRANSFERASE (Streptomyceslavendulae) |
PF00155(Aminotran_1_2) | 5 | LEU A 291LEU A 375LEU A 345ALA A 357PHE A 317 | None | 1.08A | 2vcvH-4m2jA:undetectable | 2vcvH-4m2jA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mll | BETA-LACTAMASE OXA-1 (Escherichiacoli) |
PF00905(Transpeptidase) | 5 | PHE A 69LEU A 184LEU A 75ALA A 72PHE A 175 | None | 1.27A | 2vcvH-4mllA:undetectable | 2vcvH-4mllA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n4u | PUTATIVE ABCTRANSPORTERPERIPLASMICSOLUTE-BINDINGPROTEIN (Bordetellabronchiseptica) |
PF03480(DctP) | 5 | LEU A 153LEU A 223LEU A 156ALA A 178PHE A 174 | None | 1.29A | 2vcvH-4n4uA:undetectable | 2vcvH-4n4uA:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n78 | CYTOPLASMICFMR1-INTERACTINGPROTEIN 1 (Homo sapiens) |
PF05994(FragX_IP)PF07159(DUF1394) | 5 | PHE A 359LEU A 612LEU A 255ALA A 394LEU A 395 | None | 1.20A | 2vcvH-4n78A:4.5 | 2vcvH-4n78A:11.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wxb | SERINEHYDROXYMETHYLTRANSFERASE (Streptococcusthermophilus) |
PF00464(SHMT) | 5 | PHE A 277LEU A 233ALA A 268LEU A 269PHE A 80 | None | 1.24A | 2vcvH-4wxbA:undetectable | 2vcvH-4wxbA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xaj | MALTOSE-BINDINGPERIPLASMICPROTEIN,NUCLEARRECEPTOR SUBFAMILY 2GROUP E MEMBER 1 (Escherichiacoli;Homo sapiens) |
PF00104(Hormone_recep)PF13416(SBP_bac_8) | 5 | LEU A1346LEU A1288LEU A1228ALA A1231PHE A1285 | None | 1.26A | 2vcvH-4xajA:undetectable | 2vcvH-4xajA:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zgc | KELCH PROTEIN (Plasmodiumfalciparum) |
PF01344(Kelch_1)PF02214(BTB_2)PF13418(Kelch_4) | 5 | LEU A 514ALA A 427LEU A 429ALA A 432PHE A 439 | None | 0.95A | 2vcvH-4zgcA:undetectable | 2vcvH-4zgcA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b4c | UDP-2,3-DIACYLGLUCOSAMINE HYDROLASE (Pseudomonasaeruginosa) |
PF00149(Metallophos) | 5 | LEU A 75ALA A 67LEU A 63ALA A 60PHE A 88 | None | 1.19A | 2vcvH-5b4cA:undetectable | 2vcvH-5b4cA:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cdk | CHAPERONIN 60B1 (Chlamydomonasreinhardtii) |
PF00118(Cpn60_TCP1) | 5 | LEU A 29LEU A 45ALA A 83LEU A 70ALA A 66 | None | 1.11A | 2vcvH-5cdkA:undetectable | 2vcvH-5cdkA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e43 | BETA-LACTAMASE (Streptosporangiumroseum) |
PF13354(Beta-lactamase2) | 5 | PRO A 146LEU A 163LEU A 140ALA A 136PHE A 72 | None | 1.01A | 2vcvH-5e43A:undetectable | 2vcvH-5e43A:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ej1 | PUTATIVE CELLULOSESYNTHASE (Rhodobactersphaeroides) |
PF03170(BcsB) | 5 | LEU B 234LEU B 230ALA B 204ALA B 256PHE B 196 | None | 1.19A | 2vcvH-5ej1B:undetectable | 2vcvH-5ej1B:14.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eoe | BETA-LACTAMASE (Pseudomonasaeruginosa) |
PF13354(Beta-lactamase2) | 5 | PRO A 138LEU A 155LEU A 132ALA A 128PHE A 64 | None | 1.11A | 2vcvH-5eoeA:undetectable | 2vcvH-5eoeA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ja1 | ENTEROBACTINBIOSYNTHESIS PROTEINYBDZENTEROBACTINSYNTHASE COMPONENT F (Escherichiacoli) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF03621(MbtH)PF13193(AMP-binding_C) | 5 | PHE B 7PRO B 34LEU B 33ALA A 826LEU B 17 | None | 1.24A | 2vcvH-5ja1B:undetectable | 2vcvH-5ja1B:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k1b | WD REPEAT-CONTAININGPROTEIN 48 (Homo sapiens) |
PF00400(WD40)PF11816(DUF3337) | 5 | LEU B 460LEU B 390LEU B 466ALA B 469PHE B 507 | None | 1.25A | 2vcvH-5k1bB:undetectable | 2vcvH-5k1bB:14.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ll7 | BETA-LACTAMASE (Escherichiacoli) |
no annotation | 5 | PRO A 145LEU A 162LEU A 139ALA A 135PHE A 72 | None | 1.07A | 2vcvH-5ll7A:undetectable | 2vcvH-5ll7A:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nug | CYTOPLASMIC DYNEIN 1HEAVY CHAIN 1 (Homo sapiens) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | LEU A4042PRO A4040LEU A4124ALA A4141LEU A4113 | None | 1.00A | 2vcvH-5nugA:undetectable | 2vcvH-5nugA:3.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oaf | RUVB-LIKE 1 (Homo sapiens) |
no annotation | 5 | LEU A 315ALA A 324LEU A 319ALA A 65PHE A 329 | None | 1.26A | 2vcvH-5oafA:undetectable | 2vcvH-5oafA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5via | PSEUDOPEROXIDASE (Leishmaniamajor) |
PF00141(peroxidase) | 5 | PHE A 74LEU A 155ALA A 140LEU A 138ALA A 70 | None | 1.28A | 2vcvH-5viaA:undetectable | 2vcvH-5viaA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w0s | 60 KDA CHAPERONIN (Escherichiacoli) |
PF00118(Cpn60_TCP1) | 5 | LEU A 221LEU A 237ALA A 275LEU A 262ALA A 258 | None | 1.04A | 2vcvH-5w0sA:undetectable | 2vcvH-5w0sA:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7k | LIPASE B (Serratiamarcescens) |
no annotation | 5 | LEU A 522PRO A 494LEU A 506LEU A 411ALA A 481 | None | 1.27A | 2vcvH-5x7kA:undetectable | 2vcvH-5x7kA:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xpg | UNCHARACTERIZEDPROTEIN (Thermusthermophilus) |
no annotation | 5 | PHE A 163LEU A 24PRO A 26LEU A 112ALA A 113 | None | 1.15A | 2vcvH-5xpgA:undetectable | 2vcvH-5xpgA:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6blj | SERINE-TRNA LIGASE (Naegleriafowleri) |
no annotation | 5 | LEU A 359ALA A 219LEU A 220ALA A 224PHE A 355 | None | 1.10A | 2vcvH-6bljA:undetectable | 2vcvH-6bljA:13.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6co7 | PREDICTED PROTEIN (Nematostellavectensis) |
no annotation | 5 | PHE A 644LEU A 581ALA A 587LEU A 585ALA A 613 | None | 1.08A | 2vcvH-6co7A:undetectable | 2vcvH-6co7A:17.21 |